JPWO2020210658A5 - - Google Patents
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- JPWO2020210658A5 JPWO2020210658A5 JP2021559761A JP2021559761A JPWO2020210658A5 JP WO2020210658 A5 JPWO2020210658 A5 JP WO2020210658A5 JP 2021559761 A JP2021559761 A JP 2021559761A JP 2021559761 A JP2021559761 A JP 2021559761A JP WO2020210658 A5 JPWO2020210658 A5 JP WO2020210658A5
- Authority
- JP
- Japan
- Prior art keywords
- target analyte
- binding agent
- seq
- bioluminescent
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000012491 analyte Substances 0.000 claims description 360
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 239
- 239000000203 mixture Substances 0.000 claims description 165
- 239000011230 binding agent Substances 0.000 claims description 161
- 229920001184 polypeptide Polymers 0.000 claims description 147
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 147
- 238000001514 detection method Methods 0.000 claims description 129
- 239000000758 substrate Substances 0.000 claims description 84
- 239000000523 sample Substances 0.000 claims description 65
- 230000000295 complement effect Effects 0.000 claims description 55
- 238000000034 method Methods 0.000 claims description 44
- 238000005415 bioluminescence Methods 0.000 claims description 34
- 230000029918 bioluminescence Effects 0.000 claims description 34
- 108090000623 proteins and genes Proteins 0.000 claims description 33
- 102000004169 proteins and genes Human genes 0.000 claims description 33
- YHIPILPTUVMWQT-UHFFFAOYSA-N Oplophorus luciferin Chemical group C1=CC(O)=CC=C1CC(C(N1C=C(N2)C=3C=CC(O)=CC=3)=O)=NC1=C2CC1=CC=CC=C1 YHIPILPTUVMWQT-UHFFFAOYSA-N 0.000 claims description 27
- 239000012528 membrane Substances 0.000 claims description 16
- 101710085938 Matrix protein Proteins 0.000 claims description 12
- 101710127721 Membrane protein Proteins 0.000 claims description 12
- 101710120037 Toxin CcdB Proteins 0.000 claims description 12
- 108010026228 mRNA guanylyltransferase Proteins 0.000 claims description 12
- 229920000642 polymer Polymers 0.000 claims description 12
- HTBLMRUZSCCOLL-UHFFFAOYSA-N 8-benzyl-2-(furan-2-ylmethyl)-6-phenylimidazo[1,2-a]pyrazin-3-ol Chemical compound OC1=C(CC2=CC=CO2)N=C2N1C=C(N=C2CC1=CC=CC=C1)C1=CC=CC=C1 HTBLMRUZSCCOLL-UHFFFAOYSA-N 0.000 claims description 9
- 229920001218 Pullulan Polymers 0.000 claims description 9
- 239000004373 Pullulan Substances 0.000 claims description 9
- KAEGGIFPLJZUOZ-UHFFFAOYSA-N Renilla luciferin Chemical compound C1=CC(O)=CC=C1C(N1)=CN2C(=O)C(CC=3C=CC=CC=3)=NC2=C1CC1=CC=CC=C1 KAEGGIFPLJZUOZ-UHFFFAOYSA-N 0.000 claims description 9
- 239000001913 cellulose Substances 0.000 claims description 9
- 229920002678 cellulose Polymers 0.000 claims description 9
- 235000019423 pullulan Nutrition 0.000 claims description 9
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 8
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 8
- 229920002307 Dextran Polymers 0.000 claims description 8
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims description 8
- 239000004793 Polystyrene Substances 0.000 claims description 8
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 8
- -1 affimers Proteins 0.000 claims description 8
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 8
- 238000003556 assay Methods 0.000 claims description 8
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 claims description 8
- 229920000193 polymethacrylate Polymers 0.000 claims description 8
- 229920002223 polystyrene Polymers 0.000 claims description 8
- 108091023037 Aptamer Proteins 0.000 claims description 6
- 108700022150 Designed Ankyrin Repeat Proteins Proteins 0.000 claims description 6
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 6
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 6
- 108020005187 Oligonucleotide Probes Proteins 0.000 claims description 6
- 108091093037 Peptide nucleic acid Proteins 0.000 claims description 6
- 239000002751 oligonucleotide probe Substances 0.000 claims description 6
- 108020001580 protein domains Proteins 0.000 claims description 6
- 235000013361 beverage Nutrition 0.000 claims description 5
- 210000004369 blood Anatomy 0.000 claims description 5
- 239000008280 blood Substances 0.000 claims description 5
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims description 5
- 210000003722 extracellular fluid Anatomy 0.000 claims description 5
- 239000012530 fluid Substances 0.000 claims description 5
- 239000003921 oil Substances 0.000 claims description 5
- 210000002381 plasma Anatomy 0.000 claims description 5
- 210000003296 saliva Anatomy 0.000 claims description 5
- 210000002966 serum Anatomy 0.000 claims description 5
- 239000002689 soil Substances 0.000 claims description 5
- 210000001519 tissue Anatomy 0.000 claims description 5
- 210000002700 urine Anatomy 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 150000001350 alkyl halides Chemical class 0.000 claims description 4
- 239000007791 liquid phase Substances 0.000 claims description 4
- 238000011002 quantification Methods 0.000 claims description 4
- 239000000872 buffer Substances 0.000 claims description 3
- 201000010099 disease Diseases 0.000 claims description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 3
- 244000052769 pathogen Species 0.000 claims description 3
- 230000001717 pathogenic effect Effects 0.000 claims description 3
- 230000001225 therapeutic effect Effects 0.000 claims description 3
- 239000003053 toxin Substances 0.000 claims description 3
- 231100000765 toxin Toxicity 0.000 claims description 3
- 239000000427 antigen Substances 0.000 claims description 2
- 108091007433 antigens Proteins 0.000 claims description 2
- 102000036639 antigens Human genes 0.000 claims description 2
- 229920001400 block copolymer Polymers 0.000 claims description 2
- 239000002738 chelating agent Substances 0.000 claims description 2
- 239000003638 chemical reducing agent Substances 0.000 claims description 2
- 230000021615 conjugation Effects 0.000 claims description 2
- 125000004122 cyclic group Chemical group 0.000 claims description 2
- 229920001282 polysaccharide Polymers 0.000 claims description 2
- 239000002516 radical scavenger Substances 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 claims description 2
- 239000003599 detergent Substances 0.000 claims 1
- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 claims 1
- 238000009472 formulation Methods 0.000 description 30
- 239000012669 liquid formulation Substances 0.000 description 26
- 238000004020 luminiscence type Methods 0.000 description 10
- 239000000126 substance Substances 0.000 description 10
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 description 10
- 108060001084 Luciferase Proteins 0.000 description 8
- 239000005089 Luciferase Substances 0.000 description 8
- 241001443978 Oplophorus Species 0.000 description 8
- 238000001035 drying Methods 0.000 description 6
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Natural products NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 5
- 239000007790 solid phase Substances 0.000 description 4
- 229920001059 synthetic polymer Polymers 0.000 description 4
- 108091008108 affimer Proteins 0.000 description 3
- 229920001222 biopolymer Polymers 0.000 description 3
- 239000004677 Nylon Substances 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 229920001778 nylon Polymers 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 229920000742 Cotton Polymers 0.000 description 1
- 229920004934 Dacron® Polymers 0.000 description 1
- CTKXFMQHOOWWEB-UHFFFAOYSA-N Ethylene oxide/propylene oxide copolymer Chemical group CCCOC(C)COCCO CTKXFMQHOOWWEB-UHFFFAOYSA-N 0.000 description 1
- 102000018658 Myotonin-Protein Kinase Human genes 0.000 description 1
- 108010052185 Myotonin-Protein Kinase Proteins 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 229920001219 Polysorbate 40 Polymers 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920001993 poloxamer 188 Polymers 0.000 description 1
- 229940044519 poloxamer 188 Drugs 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 235000010483 polyoxyethylene sorbitan monopalmitate Nutrition 0.000 description 1
- 239000000249 polyoxyethylene sorbitan monopalmitate Substances 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229940068977 polysorbate 20 Drugs 0.000 description 1
- 229940101027 polysorbate 40 Drugs 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 229940068968 polysorbate 80 Drugs 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025033971A JP2025133108A (ja) | 2019-04-10 | 2025-03-04 | 生物発光を使用した分析物検出のための組成物及び方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962832052P | 2019-04-10 | 2019-04-10 | |
| US62/832,052 | 2019-04-10 | ||
| PCT/US2020/027711 WO2020210658A1 (en) | 2019-04-10 | 2020-04-10 | Compositions and methods for analyte detection using bioluminescence |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025033971A Division JP2025133108A (ja) | 2019-04-10 | 2025-03-04 | 生物発光を使用した分析物検出のための組成物及び方法 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022526013A JP2022526013A (ja) | 2022-05-20 |
| JP2022526013A5 JP2022526013A5 (https=) | 2023-04-17 |
| JPWO2020210658A5 true JPWO2020210658A5 (https=) | 2023-04-17 |
| JP7645812B2 JP7645812B2 (ja) | 2025-03-14 |
Family
ID=72751365
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021559761A Active JP7645812B2 (ja) | 2019-04-10 | 2020-04-10 | 生物発光を使用した分析物検出のための組成物及び方法 |
| JP2025033971A Pending JP2025133108A (ja) | 2019-04-10 | 2025-03-04 | 生物発光を使用した分析物検出のための組成物及び方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025033971A Pending JP2025133108A (ja) | 2019-04-10 | 2025-03-04 | 生物発光を使用した分析物検出のための組成物及び方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20200386748A1 (https=) |
| EP (1) | EP3953374A4 (https=) |
| JP (2) | JP7645812B2 (https=) |
| KR (1) | KR20220007058A (https=) |
| CN (1) | CN113891895A (https=) |
| AU (2) | AU2020272037B2 (https=) |
| BR (1) | BR112021020354A2 (https=) |
| CA (1) | CA3135195A1 (https=) |
| IL (1) | IL287261A (https=) |
| SG (1) | SG11202110773RA (https=) |
| WO (1) | WO2020210658A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3395803A1 (en) | 2017-04-28 | 2018-10-31 | Institut Pasteur | Imidazopyrazine derivatives, process for preparation thereof, and their uses as luciferins |
| CA3158729A1 (en) * | 2019-11-27 | 2021-06-03 | Virginia Kincaid | Multipartite luciferase peptides and polypeptides |
| US12606863B2 (en) | 2021-05-13 | 2026-04-21 | Promega Corporation | Bioluminescent detection of DNA synthesis |
| WO2023028175A1 (en) * | 2021-08-24 | 2023-03-02 | Kaya17 Inc. | System and method for detecting presence of a target bioparticle in a sample via a vertical flow assay |
| CN113786873B (zh) * | 2021-08-31 | 2022-09-23 | 广西横县张一元饮品有限公司 | 一种用于食品安全检测的试管 |
| EP4411377A4 (en) * | 2021-09-29 | 2024-12-04 | FUJIFILM Corporation | Immunochromatography kit and testing device |
| CN114231401B (zh) * | 2022-02-21 | 2022-05-03 | 北京芯迈微生物技术有限公司 | 一种核酸检测试剂盒及检测方法 |
| WO2023200703A1 (en) * | 2022-04-15 | 2023-10-19 | Siemens Healthcare Diagnostics Inc. | Creatinine lateral flow assay devices and methods of production and use thereof |
| GB2619059A (en) * | 2022-05-26 | 2023-11-29 | Univ Leeds Innovations Ltd | Split reporter complex |
| EP4597108A4 (en) * | 2022-09-26 | 2026-01-14 | Fujifilm Corp | IMMUNOCHROMATOGRAPHIC CARTRIDGE |
| TR2022019556A2 (tr) * | 2022-12-16 | 2023-01-23 | Duezce Ueniversitesi Rektoerluegue Strateji Gelistirme Daire Baskanligi | Zehi̇rli̇ mantarlarin ve mantar zehi̇rlenmeleri̇ni̇n teşhi̇si̇ne olanak sağlayan halusi̇nojeni̇k etki̇ye sahi̇p psi̇losi̇bi̇n molekülü i̇çi̇n bi̇r kart testi̇ |
| CN116218907B (zh) * | 2023-02-20 | 2025-04-22 | 复旦大学附属中山医院 | 带有HiBiT新型报告基因的肠道病毒感染性克隆及其构建方法和应用 |
| EP4695346A1 (en) * | 2023-04-12 | 2026-02-18 | Promega Corporation | Poloxamer-stabilized reagents |
| WO2025024530A1 (en) * | 2023-07-25 | 2025-01-30 | The General Hospital Corporation | Aldehyde binding optical imaging probes methods of use thereof |
| CN118033130B (zh) * | 2024-01-19 | 2024-07-30 | 武汉科技大学 | 同时检测艾滋病、梅毒和丙肝的表面、微孔板、组件、方法及应用 |
| CN118255903B (zh) * | 2024-05-07 | 2025-03-11 | 中国农业科学院兰州兽医研究所(中国动物卫生与流行病学中心兰州分中心) | 一种检测非洲猪瘟病毒抗体的融合抗原、制备方法及检测试剂盒 |
| CN118344492B (zh) * | 2024-05-07 | 2025-03-11 | 中国农业科学院兰州兽医研究所(中国动物卫生与流行病学中心兰州分中心) | 一种纳米荧光素酶融合抗原在非洲猪瘟病毒抗体检测中的应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3423290A (en) * | 1966-08-03 | 1969-01-21 | Nasa | Lyophilized reaction mixtures |
| US6045254A (en) * | 1996-12-26 | 2000-04-04 | M.L.I.S. Projects Ltd. | Container having two or more compartments |
| US7118878B1 (en) * | 2000-06-09 | 2006-10-10 | Promega Corporation | Method for increasing luminescence assay sensitivity |
| JP4485470B2 (ja) * | 2002-12-23 | 2010-06-23 | プロメガ コーポレイション | ルシフェラーゼ酵素活性を保護するための方法及びキット |
| US7829347B2 (en) * | 2005-08-31 | 2010-11-09 | Kimberly-Clark Worldwide, Inc. | Diagnostic test kits with improved detection accuracy |
| AU2007217765A1 (en) * | 2006-02-21 | 2007-08-30 | Nanogen, Inc. | Methods and compositions for analyte detection |
| US10067149B2 (en) * | 2012-12-12 | 2018-09-04 | Promega Corporation | Recognition of cellular target binding by a bioactive agent using intracellular bioluminescence resonance energy transfer |
| KR102292431B1 (ko) * | 2012-12-12 | 2021-08-20 | 프로메가 코포레이션 | 세포내 생물발광 공명 에너지 전이를 이용하여 생물활성제에 의한 세포 표적 결합의 인식 |
| ES2926463T3 (es) * | 2013-03-15 | 2022-10-26 | Promega Corp | Activación de la bioluminiscencia mediante complementación estructural |
| JP6814132B2 (ja) * | 2014-09-12 | 2021-01-13 | プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ | 内部タンパク質タグ |
| WO2016127100A1 (en) * | 2015-02-05 | 2016-08-11 | Promega Corporation | Luciferase-based thermal shift assays |
| WO2017143323A1 (en) * | 2016-02-19 | 2017-08-24 | Insight Instruments, Inc. | Assay systems for point of care detection of ocular analytes |
| WO2017189751A1 (en) * | 2016-04-26 | 2017-11-02 | The University Of Utah Research Foundation | Target-binding activated split reporter systems for analyte detection and related components and methods |
| US11327072B2 (en) * | 2017-02-09 | 2022-05-10 | Promega Corporation | Analyte detection immunoassay |
| JP6990369B2 (ja) * | 2017-05-19 | 2022-02-03 | 国立大学法人 熊本大学 | 遺伝性腎疾患アルポート症候群治療薬に係る評価系 |
-
2020
- 2020-04-10 SG SG11202110773RA patent/SG11202110773RA/en unknown
- 2020-04-10 AU AU2020272037A patent/AU2020272037B2/en active Active
- 2020-04-10 CA CA3135195A patent/CA3135195A1/en active Pending
- 2020-04-10 US US16/845,802 patent/US20200386748A1/en not_active Abandoned
- 2020-04-10 CN CN202080040317.1A patent/CN113891895A/zh active Pending
- 2020-04-10 BR BR112021020354A patent/BR112021020354A2/pt unknown
- 2020-04-10 JP JP2021559761A patent/JP7645812B2/ja active Active
- 2020-04-10 WO PCT/US2020/027711 patent/WO2020210658A1/en not_active Ceased
- 2020-04-10 EP EP20788198.8A patent/EP3953374A4/en active Pending
- 2020-04-10 KR KR1020217036614A patent/KR20220007058A/ko active Pending
-
2021
- 2021-10-07 IL IL287261A patent/IL287261A/en unknown
-
2025
- 2025-03-04 JP JP2025033971A patent/JP2025133108A/ja active Pending
- 2025-03-06 US US19/072,777 patent/US20250264464A1/en active Pending
-
2026
- 2026-02-26 AU AU2026201457A patent/AU2026201457A1/en active Pending
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