JPWO2020206189A5 - - Google Patents
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- JPWO2020206189A5 JPWO2020206189A5 JP2021559079A JP2021559079A JPWO2020206189A5 JP WO2020206189 A5 JPWO2020206189 A5 JP WO2020206189A5 JP 2021559079 A JP2021559079 A JP 2021559079A JP 2021559079 A JP2021559079 A JP 2021559079A JP WO2020206189 A5 JPWO2020206189 A5 JP WO2020206189A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- capsid protein
- raav
- amino acid
- domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962829608P | 2019-04-04 | 2019-04-04 | |
| US62/829,608 | 2019-04-04 | ||
| US201962833516P | 2019-04-12 | 2019-04-12 | |
| US62/833,516 | 2019-04-12 | ||
| US201962839368P | 2019-04-26 | 2019-04-26 | |
| US62/839,368 | 2019-04-26 | ||
| US201962924107P | 2019-10-21 | 2019-10-21 | |
| US62/924,107 | 2019-10-21 | ||
| US202062963512P | 2020-01-20 | 2020-01-20 | |
| US62/963,512 | 2020-01-20 | ||
| PCT/US2020/026485 WO2020206189A1 (en) | 2019-04-04 | 2020-04-02 | Recombinant adeno-associated viruses and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022528416A JP2022528416A (ja) | 2022-06-10 |
| JPWO2020206189A5 true JPWO2020206189A5 (hr) | 2023-04-11 |
Family
ID=70416587
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021559079A Pending JP2022528416A (ja) | 2019-04-04 | 2020-04-02 | 組換えアデノ随伴ウイルス及びその使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20220186256A1 (hr) |
| EP (1) | EP3947420A1 (hr) |
| JP (1) | JP2022528416A (hr) |
| CN (1) | CN114127089A (hr) |
| CA (1) | CA3135798A1 (hr) |
| IL (1) | IL286911A (hr) |
| MX (1) | MX2021011963A (hr) |
| TW (1) | TW202102526A (hr) |
| WO (1) | WO2020206189A1 (hr) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20210084459A (ko) | 2018-09-26 | 2021-07-07 | 캘리포니아 인스티튜트 오브 테크놀로지 | 표적화된 유전자 요법을 위한 아데노-연관 바이러스 조성물 |
| TW202208397A (zh) | 2020-05-13 | 2022-03-01 | 美商航海家醫療公司 | Aav蛋白殼之趨性重定向 |
| WO2022076750A2 (en) * | 2020-10-07 | 2022-04-14 | Regenxbio Inc. | Recombinant adeno-associated viruses for cns or muscle delivery |
| CA3193697A1 (en) * | 2020-10-07 | 2022-04-14 | Joseph Bruder | Adeno-associated viruses for ocular delivery of gene therapy |
| WO2022126188A1 (en) * | 2020-12-16 | 2022-06-23 | Children's Medical Research Institute | Aav capsids and vectors |
| CN114805594B (zh) * | 2021-01-19 | 2024-01-26 | 中国人民解放军军事科学院军事医学研究院 | 一种能够透过生物屏障且聚集核周的动力蛋白结合肽及其应用 |
| CN114805595B (zh) * | 2021-01-19 | 2024-01-26 | 中国人民解放军军事科学院军事医学研究院 | 具有生物屏障透过性和核内聚集特性的动力蛋白结合肽及其应用 |
| WO2022156531A1 (zh) * | 2021-01-19 | 2022-07-28 | 中国人民解放军军事科学院军事医学研究院 | 一种能够透过生物屏障的动力蛋白结合肽及其应用 |
| EP4291215A2 (en) * | 2021-02-09 | 2023-12-20 | Affinia Therapeutics Inc. | Recombinant aavs with improved tropism and specificity |
| CN113121651B (zh) * | 2021-04-19 | 2023-11-17 | 信念医药科技(上海)有限公司 | 低中和抗体腺相关病毒衣壳蛋白 |
| CN113121653B (zh) * | 2021-04-19 | 2021-11-19 | 上海信致医药科技有限公司 | 肌肉和视网膜特异性的新型腺相关病毒衣壳蛋白 |
| AU2022283898A1 (en) * | 2021-06-03 | 2024-01-04 | Dyno Therapeutics, Inc. | Capsid variants and methods of using the same |
| WO2023283962A1 (en) * | 2021-07-16 | 2023-01-19 | Huigene Therapeutics Co., Ltd. | Modified aav capsid for gene therapy and methods thereof |
| WO2023060113A1 (en) | 2021-10-05 | 2023-04-13 | Regenxbio Inc. | Compositions and methods for recombinant aav production |
| WO2023060272A2 (en) * | 2021-10-07 | 2023-04-13 | Regenxbio Inc. | Recombinant adeno-associated viruses for cns tropic delivery |
| WO2023060269A1 (en) * | 2021-10-07 | 2023-04-13 | Regenxbio Inc. | Recombinant adeno-associated viruses for targeted delivery |
| WO2023108507A1 (en) * | 2021-12-15 | 2023-06-22 | National Institute Of Biological Sciences, Beijing | Recombinant aav vectors and use thereof |
| WO2023121177A1 (ko) * | 2021-12-21 | 2023-06-29 | (주)큐리진 | 면역 회피성 항종양 아데노바이러스 |
| WO2023178220A1 (en) | 2022-03-16 | 2023-09-21 | Regenxbio Inc. | Compositions and methods for recombinant aav production |
| WO2023183623A1 (en) | 2022-03-25 | 2023-09-28 | Regenxbio Inc. | Dominant-negative tumor necrosis factor alpha adeno-associated virus gene therapy |
| WO2023201277A1 (en) * | 2022-04-14 | 2023-10-19 | Regenxbio Inc. | Recombinant adeno-associated viruses for cns tropic delivery |
| WO2023205610A2 (en) | 2022-04-18 | 2023-10-26 | Regenxbio Inc. | Hybrid aav capsids |
| WO2023230657A1 (en) * | 2022-05-31 | 2023-12-07 | Mount Spec Investments Pty Ltd | Modified adeno-associated virus capsid proteins and methods thereof |
| WO2023242633A2 (en) * | 2022-06-14 | 2023-12-21 | Vectory B.V. | Recombinant aav capsid proteins |
| WO2024016003A2 (en) * | 2022-07-14 | 2024-01-18 | The Broad Institute, Inc. | Aav capsids that enable cns-wide gene delivery through interactions with the transferrin receptor |
| WO2024026494A1 (en) * | 2022-07-29 | 2024-02-01 | Regeneron Pharmaceuticals, Inc. | Viral particles retargeted to transferrin receptor 1 |
| WO2024044725A2 (en) | 2022-08-24 | 2024-02-29 | Regenxbio Inc. | Recombinant adeno-associated viruses and uses thereof |
| CN116693633B (zh) * | 2023-02-21 | 2023-12-22 | 广州派真生物技术有限公司 | 腺相关病毒突变体及其应用 |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0092918B1 (en) | 1982-04-22 | 1988-10-19 | Imperial Chemical Industries Plc | Continuous release formulations |
| US5128326A (en) | 1984-12-06 | 1992-07-07 | Biomatrix, Inc. | Drug delivery systems based on hyaluronans derivatives thereof and their salts and methods of producing same |
| WO1991005548A1 (en) | 1989-10-10 | 1991-05-02 | Pitman-Moore, Inc. | Sustained release composition for macromolecular proteins |
| EP0550436A1 (en) | 1989-11-06 | 1993-07-14 | Alkermes Controlled Therapeutics, Inc. | Protein microspheres and methods of using them |
| US5912015A (en) | 1992-03-12 | 1999-06-15 | Alkermes Controlled Therapeutics, Inc. | Modulated release from biocompatible polymers |
| DE69630514D1 (de) | 1995-01-05 | 2003-12-04 | Univ Michigan | Oberflächen-modifizierte nanopartikel und verfahren für ihre herstellung und verwendung |
| US5916597A (en) | 1995-08-31 | 1999-06-29 | Alkermes Controlled Therapeutics, Inc. | Composition and method using solid-phase particles for sustained in vivo release of a biologically active agent |
| US5622699A (en) | 1995-09-11 | 1997-04-22 | La Jolla Cancer Research Foundation | Method of identifying molecules that home to a selected organ in vivo |
| US5989463A (en) | 1997-09-24 | 1999-11-23 | Alkermes Controlled Therapeutics, Inc. | Methods for fabricating polymer-based controlled release devices |
| SE512663C2 (sv) | 1997-10-23 | 2000-04-17 | Biogram Ab | Inkapslingsförfarande för aktiv substans i en bionedbrytbar polymer |
| DK1916258T3 (da) | 1999-08-09 | 2014-07-28 | Genzyme Corp | Forøgelse af ekspression af en enkeltstrenget, heterolog nukleotidsekvens fra rekombinante, virale vektorer ved en sådan udformning af sekvensen at den danner intrastrengbasepar |
| CA2449412C (en) | 2000-11-30 | 2013-04-02 | Uab Research Foundation | Receptor-mediated uptake of peptides that bind the human transferrin receptor |
| CA2406745C (en) | 2001-11-13 | 2006-01-10 | The Trustees Of The University Of Pennsylvania | A method of detecting and/or identifying adeno-associated virus (aav) sequences and isolating novel sequences identified thereby |
| FI3517134T3 (fi) | 2001-12-17 | 2024-04-03 | Univ Pennsylvania | Adeno-assosioituneen viruksen (aav) serotyypin 8 sekvenssejä, niitä sisältäviä vektoreita ja niiden käyttöjä |
| EP3211085B1 (en) | 2003-09-30 | 2021-03-31 | The Trustees of The University of Pennsylvania | Adeno-associated virus (aav) clades, sequences, vectors containing same, and uses therefor |
| US7183969B2 (en) | 2004-12-22 | 2007-02-27 | Raytheon Company | System and technique for calibrating radar arrays |
| EP2357010B1 (en) | 2005-04-07 | 2013-06-12 | The Trustees of The University of Pennsylvania | Method of increasing the function of an AAV vector |
| WO2006119150A2 (en) * | 2005-04-29 | 2006-11-09 | Beth Israel Deaconess Medical Center | Compositions and methods for targeting of viral vectors |
| JP4495210B2 (ja) | 2005-06-09 | 2010-06-30 | パナソニック株式会社 | 振幅誤差補償装置及び直交度誤差補償装置 |
| ES2602610T3 (es) * | 2007-05-31 | 2017-02-21 | Medigene Ag | Proteína estructural mutada de un parvovirus |
| EP2012122A1 (en) * | 2007-07-06 | 2009-01-07 | Medigene AG | Mutated parvovirus structural proteins as vaccines |
| ES2929031T3 (es) | 2008-02-19 | 2022-11-24 | Uniqure Ip Bv | Optimización de la expresión de las proteínas rep y cap parvovirales en células de insecto |
| ES2724122T3 (es) | 2009-04-30 | 2019-09-06 | Univ Pennsylvania | Composiciones para dirigir células de las vías respiratorias de conducción que comprenden construcciones de virus adenoasociado |
| WO2010138263A2 (en) | 2009-05-28 | 2010-12-02 | University Of Massachusetts | Novel aav 's and uses thereof |
| US8628966B2 (en) | 2010-04-30 | 2014-01-14 | City Of Hope | CD34-derived recombinant adeno-associated vectors for stem cell transduction and systemic therapeutic gene transfer |
| US8927514B2 (en) | 2010-04-30 | 2015-01-06 | City Of Hope | Recombinant adeno-associated vectors for targeted treatment |
| JP5704361B2 (ja) | 2010-10-27 | 2015-04-22 | 学校法人自治医科大学 | 神経系細胞への遺伝子導入のためのアデノ随伴ウイルスビリオン |
| WO2012109570A1 (en) * | 2011-02-10 | 2012-08-16 | The University Of North Carolina At Chapel Hill | Viral vectors with modified transduction profiles and methods of making and using the same |
| KR102121355B1 (ko) * | 2011-04-22 | 2020-06-11 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 변이체 캡시드를 지니는 아데노-관련 바이러스 및 이의 사용 방법 |
| EP3147295B2 (en) | 2011-08-24 | 2023-11-22 | The Board of Trustees of the Leland Stanford Junior University | New avv capsid proteins for nucleic acid transfer |
| EP3470523A1 (en) * | 2012-05-09 | 2019-04-17 | Oregon Health & Science University | Adeno associated virus plasmids and vectors |
| AU2014244167A1 (en) | 2013-03-13 | 2015-10-08 | The Children's Hospital Of Philadelphia | Adeno-associated virus vectors and methods of use thereof |
| DK2968605T3 (da) * | 2013-03-15 | 2022-09-26 | Univ North Carolina Chapel Hill | Fremgangsmåder og sammensætninger til dobbelte glycanbindende aav-vektorer |
| EP3461838A1 (en) | 2013-04-20 | 2019-04-03 | Research Institute at Nationwide Children's Hospital | Recombinant adeno-associated virus delivery of exon 2-targeted u7snrna polynucleotide constructs |
| US9840719B2 (en) | 2013-07-22 | 2017-12-12 | The Children's Hospital Of Philadelphia | Variant AAV and compositions, methods and uses for gene transfer to cells, organs and tissues |
| EP3561062A1 (en) * | 2013-09-13 | 2019-10-30 | California Institute of Technology | Selective recovery |
| EP3744730A1 (en) | 2013-10-11 | 2020-12-02 | Massachusetts Eye & Ear Infirmary | Methods of predicting ancestral virus sequences and uses thereof |
| WO2015164757A1 (en) | 2014-04-25 | 2015-10-29 | Oregon Health & Science University | Methods of viral neutralizing antibody epitope mapping |
| EP3151866B1 (en) | 2014-06-09 | 2023-03-08 | Voyager Therapeutics, Inc. | Chimeric capsids |
| CN113667696A (zh) | 2014-09-24 | 2021-11-19 | 希望之城 | 用于高效基因组编辑的腺相关病毒载体变异体和其方法 |
| WO2016119150A1 (zh) | 2015-01-28 | 2016-08-04 | 宇龙计算机通信科技(深圳)有限公司 | 具有多摄像头的移动终端的拍摄方法和移动终端 |
| JP6665466B2 (ja) | 2015-09-26 | 2020-03-13 | 日亜化学工業株式会社 | 半導体発光素子及びその製造方法 |
| WO2017070491A1 (en) | 2015-10-23 | 2017-04-27 | Applied Genetic Technologies Corporation | Ophthalmic formulations |
| EP3469073B1 (en) * | 2016-06-09 | 2024-01-10 | Centre National de la Recherche Scientifique (CNRS) | Raav with chemically modified capsid |
| EP3528785A4 (en) | 2016-10-19 | 2020-12-02 | Adverum Biotechnologies, Inc. | MODIFIED AAV CASPIDS AND USES THEREOF |
| AU2018221738A1 (en) * | 2017-02-15 | 2019-08-22 | The University Of North Carolina At Chapel Hill | Methods and compositions for gene transfer across the vasculature |
| CA3054687A1 (en) * | 2017-02-28 | 2018-09-07 | Adverum Biotechnologies, Inc. | Modified aav capsids and uses thereof |
-
2020
- 2020-04-01 TW TW109111391A patent/TW202102526A/zh unknown
- 2020-04-02 EP EP20721074.1A patent/EP3947420A1/en active Pending
- 2020-04-02 CN CN202080031981.XA patent/CN114127089A/zh active Pending
- 2020-04-02 MX MX2021011963A patent/MX2021011963A/es unknown
- 2020-04-02 US US17/600,418 patent/US20220186256A1/en active Pending
- 2020-04-02 WO PCT/US2020/026485 patent/WO2020206189A1/en unknown
- 2020-04-02 CA CA3135798A patent/CA3135798A1/en active Pending
- 2020-04-02 JP JP2021559079A patent/JP2022528416A/ja active Pending
-
2021
- 2021-10-03 IL IL286911A patent/IL286911A/en unknown
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