JPWO2020204152A5 - - Google Patents

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Publication number
JPWO2020204152A5
JPWO2020204152A5 JP2021512315A JP2021512315A JPWO2020204152A5 JP WO2020204152 A5 JPWO2020204152 A5 JP WO2020204152A5 JP 2021512315 A JP2021512315 A JP 2021512315A JP 2021512315 A JP2021512315 A JP 2021512315A JP WO2020204152 A5 JPWO2020204152 A5 JP WO2020204152A5
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JP
Japan
Prior art keywords
arm
specifically binds
seq
amino acid
acid sequence
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JP2021512315A
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English (en)
Japanese (ja)
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JP7405139B2 (ja
JPWO2020204152A1 (enExample
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Priority claimed from PCT/JP2020/015266 external-priority patent/WO2020204152A1/ja
Publication of JPWO2020204152A1 publication Critical patent/JPWO2020204152A1/ja
Publication of JPWO2020204152A5 publication Critical patent/JPWO2020204152A5/ja
Priority to JP2023198746A priority Critical patent/JP7688805B2/ja
Application granted granted Critical
Publication of JP7405139B2 publication Critical patent/JP7405139B2/ja
Active legal-status Critical Current
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JP2021512315A 2019-04-04 2020-04-03 二重特異性抗体 Active JP7405139B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023198746A JP7688805B2 (ja) 2019-04-04 2023-11-24 二重特異性抗体

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2019071840 2019-04-04
JP2019071840 2019-04-04
JP2020022256 2020-02-13
JP2020022256 2020-02-13
PCT/JP2020/015266 WO2020204152A1 (ja) 2019-04-04 2020-04-03 二重特異性抗体

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023198746A Division JP7688805B2 (ja) 2019-04-04 2023-11-24 二重特異性抗体

Publications (3)

Publication Number Publication Date
JPWO2020204152A1 JPWO2020204152A1 (enExample) 2020-10-08
JPWO2020204152A5 true JPWO2020204152A5 (enExample) 2023-09-04
JP7405139B2 JP7405139B2 (ja) 2023-12-26

Family

ID=72669033

Family Applications (2)

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JP2021512315A Active JP7405139B2 (ja) 2019-04-04 2020-04-03 二重特異性抗体
JP2023198746A Active JP7688805B2 (ja) 2019-04-04 2023-11-24 二重特異性抗体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2023198746A Active JP7688805B2 (ja) 2019-04-04 2023-11-24 二重特異性抗体

Country Status (14)

Country Link
US (2) US12325746B2 (enExample)
EP (1) EP3978015A4 (enExample)
JP (2) JP7405139B2 (enExample)
KR (1) KR20210149044A (enExample)
CN (1) CN113660952B (enExample)
AU (1) AU2020251578A1 (enExample)
BR (1) BR112021019823A2 (enExample)
CA (1) CA3136395A1 (enExample)
IL (1) IL286918A (enExample)
MX (1) MX2021012061A (enExample)
PH (1) PH12021552501A1 (enExample)
SG (1) SG11202110993QA (enExample)
TW (2) TW202509079A (enExample)
WO (1) WO2020204152A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI804572B (zh) * 2018-02-09 2023-06-11 日商小野藥品工業股份有限公司 雙特異性抗體
US20220372148A1 (en) * 2019-07-05 2022-11-24 Ono Pharmaceutical Co., Ltd. A pharmaceutical composition for treating hematological cancer
JP7686180B2 (ja) 2020-04-17 2025-06-02 小野薬品工業株式会社 タンパク質製剤原薬の着色除去方法
LT4157876T (lt) 2020-05-26 2024-10-25 Boehringer Ingelheim International Gmbh Anti-pd-1 antikūnai

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4474893A (en) 1981-07-01 1984-10-02 The University of Texas System Cancer Center Recombinant monoclonal antibodies
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US4801687A (en) 1986-10-27 1989-01-31 Bioprobe International, Inc. Monoclonal antibody purification process using protein A
NZ226694A (en) 1987-10-28 1994-04-27 Oncogen Human immunoglobulin produced by recombinant dna techniques
US5476996A (en) 1988-06-14 1995-12-19 Lidak Pharmaceuticals Human immune system in non-human animal
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5151504A (en) 1989-11-17 1992-09-29 E. R. Squibb & Sons, Inc. Method for purification of monoclonal antibodies
EP1690935A3 (en) 1990-01-12 2008-07-30 Abgenix, Inc. Generation of xenogeneic antibodies
US6150584A (en) 1990-01-12 2000-11-21 Abgenix, Inc. Human antibodies derived from immunized xenomice
US6673986B1 (en) 1990-01-12 2004-01-06 Abgenix, Inc. Generation of xenogeneic antibodies
US6075181A (en) 1990-01-12 2000-06-13 Abgenix, Inc. Human antibodies derived from immunized xenomice
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US6172197B1 (en) 1991-07-10 2001-01-09 Medical Research Council Methods for producing members of specific binding pairs
JP2938569B2 (ja) 1990-08-29 1999-08-23 ジェンファーム インターナショナル,インコーポレイティド 異種免疫グロブリンを作る方法及びトランスジェニックマウス
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5874299A (en) 1990-08-29 1999-02-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5770429A (en) 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5814318A (en) 1990-08-29 1998-09-29 Genpharm International Inc. Transgenic non-human animals for producing heterologous antibodies
US5789650A (en) 1990-08-29 1998-08-04 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5877397A (en) 1990-08-29 1999-03-02 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
GB9022543D0 (en) 1990-10-17 1990-11-28 Wellcome Found Antibody production
DE69233104T2 (de) 1991-07-15 2004-05-13 The Wellcome Foundation Ltd., Greenford Herstellung von Antikörpern
WO1993011236A1 (en) 1991-12-02 1993-06-10 Medical Research Council Production of anti-self antibodies from antibody segment repertoires and displayed on phage
CA2370477C (en) 1999-04-15 2010-06-29 Crucell Holland B.V. Recombinant protein production in a human cell using sequences encoding adenovirus e1 protein
KR100857943B1 (ko) 2000-11-30 2008-09-09 메다렉스, 인코포레이티드 인간 항체의 제조를 위한 형질전환 트랜스염색체 설치류
AR036993A1 (es) 2001-04-02 2004-10-20 Wyeth Corp Uso de agentes que modulan la interaccion entre pd-1 y sus ligandos en la submodulacion de respuestas inmunologicas
NZ519012A (en) 2001-05-21 2003-10-31 Orgapack Gmbh Manually actuated strapping unit for wrapping a steel strap around a packaged item
JP4249013B2 (ja) 2001-07-31 2009-04-02 佑 本庶 Pd−1に対し特異性を有する物質
CN105884893A (zh) 2002-07-18 2016-08-24 莫鲁斯有限公司 抗体混合物的重组生产
JP2004072286A (ja) 2002-08-05 2004-03-04 Nippon Telegr & Teleph Corp <Ntt> 構造変化検出方法および通信網異常状態検出方法、並びに、その装置およびプログラム
WO2004072286A1 (ja) 2003-01-23 2004-08-26 Ono Pharmaceutical Co., Ltd. ヒトpd−1に対し特異性を有する物質
US20100069614A1 (en) * 2008-06-27 2010-03-18 Merus B.V. Antibody producing non-human mammals
US8101720B2 (en) 2004-10-21 2012-01-24 Xencor, Inc. Immunoglobulin insertions, deletions and substitutions
JP2008537941A (ja) * 2005-03-31 2008-10-02 ゼンコー・インコーポレイテッド 最適化特性を有するFc変異体
CA2602663A1 (en) 2005-03-31 2006-10-05 Xencor, Inc. Fc variants with optimized properties
WO2008092117A2 (en) * 2007-01-25 2008-07-31 Xencor, Inc. Immunoglobulins with modifications in the fcr binding region
CN101855242B (zh) 2007-09-14 2014-07-30 阿迪马布有限责任公司 合理设计的合成抗体文库及其用途
RU2526512C2 (ru) * 2007-09-26 2014-08-20 Чугаи Сейяку Кабусики Кайся Модифицированная константная область антитела
PL3456190T3 (pl) 2008-06-27 2022-06-06 Merus N.V. Wytwarzające przeciwciała transgeniczne zwierzę z gatunku myszy
EP3939613A1 (en) 2011-08-11 2022-01-19 ONO Pharmaceutical Co., Ltd. Therapeutic agent for autoimmune diseases comprising pd-1 agonist
PL2900694T3 (pl) * 2012-09-27 2018-12-31 Merus N.V. Dwuswoiste przeciwciała igg jako aktywatory komórek t
WO2017055391A1 (en) * 2015-10-02 2017-04-06 F. Hoffmann-La Roche Ag Bispecific t cell activating antigen binding molecules binding mesothelin and cd3
US11939394B2 (en) * 2015-10-23 2024-03-26 Merus N.V. Binding molecules that inhibit cancer growth
CN106939050B (zh) * 2017-03-27 2019-05-10 顺昊细胞生物技术(天津)股份有限公司 抗pd1和cd19双特异性抗体及其应用
EA202090003A1 (ru) 2017-07-06 2020-06-18 Мерус Н.В. Связывающие молекулы, модулирующие биологическую активность, которую проявляет клетка
EP3693013A4 (en) * 2017-10-06 2021-06-30 Ono Pharmaceutical Co., Ltd. BISPECIFIC ANTIBODY
TWI804572B (zh) * 2018-02-09 2023-06-11 日商小野藥品工業股份有限公司 雙特異性抗體

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