JPWO2020201773A5 - - Google Patents
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- Publication number
- JPWO2020201773A5 JPWO2020201773A5 JP2021560410A JP2021560410A JPWO2020201773A5 JP WO2020201773 A5 JPWO2020201773 A5 JP WO2020201773A5 JP 2021560410 A JP2021560410 A JP 2021560410A JP 2021560410 A JP2021560410 A JP 2021560410A JP WO2020201773 A5 JPWO2020201773 A5 JP WO2020201773A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- pyridin
- imidazo
- carboxamide
- oxo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1904848.7A GB201904848D0 (en) | 2019-04-05 | 2019-04-05 | Inhibitory compounds |
| GB1904848.7 | 2019-04-05 | ||
| GB1912603.6 | 2019-09-02 | ||
| GBGB1912603.6A GB201912603D0 (en) | 2019-09-02 | 2019-09-02 | Inhibitory compounds |
| GBGB1919095.8A GB201919095D0 (en) | 2019-12-20 | 2019-12-20 | Inhibitory compounds |
| GB1919095.8 | 2019-12-20 | ||
| PCT/GB2020/050898 WO2020201773A1 (en) | 2019-04-05 | 2020-04-03 | Mettl3 inhibitory compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022528562A JP2022528562A (ja) | 2022-06-14 |
| JPWO2020201773A5 true JPWO2020201773A5 (enExample) | 2023-04-10 |
| JP7762957B2 JP7762957B2 (ja) | 2025-10-31 |
Family
ID=70285722
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021560410A Active JP7762957B2 (ja) | 2019-04-05 | 2020-04-03 | Ｍｅｔｔｌ３阻害化合物 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US12358915B2 (enExample) |
| EP (1) | EP3946618A1 (enExample) |
| JP (1) | JP7762957B2 (enExample) |
| CN (1) | CN113905787A (enExample) |
| WO (1) | WO2020201773A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018165520A1 (en) | 2017-03-10 | 2018-09-13 | Vps-3, Inc. | Metalloenzyme inhibitor compounds |
| BR112020005489A2 (pt) | 2017-09-22 | 2020-09-24 | Jubilant Epipad Llc, | composto da fórmula (i), composto de fórmula (ii), composto de fórmula (iii), processo de preparação de compostos de fórmula (i), processo de preparação de compostos de fórmula (ii), processo de preparação de compostos de fórmula (iii), composição farmacêutica, método para inibir uma ou mais famílias pad em uma célula, método para tratar uma afeção mediada por um ou mais pads, utilização do composto, método para o tratamento e/ou prevenção de uma afeção mediada por um ou mais distúrbios da família pad, método para o tratamento de artrite reumatoide e método de tratamento de câncer |
| CN111225915B (zh) | 2017-10-18 | 2023-03-07 | 朱比兰特埃皮帕德有限公司 | 作为pad抑制剂的咪唑并吡啶化合物 |
| EP3707135A1 (en) | 2017-11-06 | 2020-09-16 | Jubilant Prodel LLC | Pyrimidine derivatives as inhibitors of pd1/pd-l1 activation |
| IL274762B2 (en) | 2017-11-24 | 2023-10-01 | Jubilant Episcribe Llc | Novel heterocyclic compounds as prmt5 inhibitors |
| EP3765453A1 (en) | 2018-03-13 | 2021-01-20 | Jubilant Prodel LLC | Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation |
| HUE066335T2 (hu) | 2018-10-05 | 2024-07-28 | Annapurna Bio Inc | Vegyületek és készítmények APJ receptor aktivitáshoz kapcsolódó állapotok kezelésére |
| CN114727974A (zh) | 2019-07-30 | 2022-07-08 | 艾科尼佐治疗股份有限公司 | Hdac6抑制剂及其用途 |
| MX2022006700A (es) | 2019-12-02 | 2022-09-02 | Storm Therapeutics Ltd | Compuestos poliheterociclicos como inhibidores de mettl3. |
| WO2022074379A1 (en) * | 2020-10-06 | 2022-04-14 | Storm Therapeutics Limited | Mettl3 inhibitory compounds |
| US11944608B2 (en) * | 2020-10-26 | 2024-04-02 | New York University | Targeting RNA viruses using inhibitors of METTL3 |
| CA3219183A1 (en) * | 2021-05-17 | 2022-11-24 | Amedeo Caflisch | N6-adenosine-methyltransferase inhibitors in cancer treatment |
| GB202107907D0 (en) * | 2021-06-02 | 2021-07-14 | Storm Therapeutics Ltd | Combination therapies |
| GB202107905D0 (en) * | 2021-06-02 | 2021-07-14 | Storm Therapeutics Ltd | Processes for the preparation of inhibitory compounds |
| WO2023104209A1 (zh) * | 2021-12-10 | 2023-06-15 | 上海昂阔医药有限公司 | Mettl3抑制剂化合物 |
| CN118660890A (zh) * | 2022-02-11 | 2024-09-17 | 西藏海思科制药有限公司 | 一种mettl3抑制剂及组合物及其在医药上的应用 |
| CN114869891A (zh) * | 2022-04-28 | 2022-08-09 | 复旦大学附属中山医院 | Mettl3抑制剂在制备治疗肝癌药物中的应用 |
| CN117045801A (zh) * | 2022-05-13 | 2023-11-14 | 中国科学院广州生物医药与健康研究院 | m6A RNA甲基化酶抑制剂与免疫检查点抑制剂联合治疗肿瘤 |
| JP2025530847A (ja) * | 2022-09-16 | 2025-09-17 | 北京華益健康薬物研究中心 | Ｍｅｔｔｌ３阻害剤化合物、その医薬組成物及び用途 |
| WO2024107763A1 (en) * | 2022-11-16 | 2024-05-23 | University Of Zurich | N6-adenosine-methyltransferase protacs and methods of use thereof |
| GB202218672D0 (en) | 2022-12-12 | 2023-01-25 | Storm Therapeutics Ltd | Inhibitory compounds |
| US12091400B2 (en) | 2023-01-20 | 2024-09-17 | Epics Therapeutics | Piperidine derivatives as METTL3 inhibitors |
| EP4688768A1 (en) | 2023-03-30 | 2026-02-11 | Novalix | Novel mettl3 inhibitors and use thereof in therapy |
| GB202316683D0 (en) * | 2023-10-31 | 2023-12-13 | Storm Therapeutics Ltd | Inhibitory compounds |
| WO2025237957A1 (en) | 2024-05-14 | 2025-11-20 | Institut Curie | Composition for treatment of estrogen-dependent cancer comprising a mettl-3 inhibitor and a topoisomerase-1 inhibitor |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3880874A (en) * | 1973-10-04 | 1975-04-29 | Syntex Inc | 2-Substituted -1,2,4-thiadiazolo-(2,3-a)benzimidazoles and process for their preparation |
| US3946031A (en) | 1973-10-04 | 1976-03-23 | Syntex Inc. | 2-Substituted-1,2,4-thiadiazolo-[2,3-a]-benzimidazoles |
| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| JP4471404B2 (ja) | 1996-02-13 | 2010-06-02 | アストラゼネカ ユーケイ リミテッド | Ｖｅｇｆインヒビターとしてのキナゾリン誘導体 |
| ATE211134T1 (de) | 1996-03-05 | 2002-01-15 | 4-anilinochinazolin derivate | |
| GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
| GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
| GB9900752D0 (en) | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
| DK1553097T3 (da) | 1999-02-10 | 2010-12-13 | Astrazeneca Ab | Quinazolinderivat som angiogeneseinhibitor og mellemprodukter dertil |
| EP1208085B1 (en) * | 1999-08-04 | 2007-12-05 | Icagen, Inc. | Benzanilides as potassium channel openers |
| DE19936780A1 (de) | 1999-08-09 | 2001-02-15 | Basf Ag | Neue Antagonisten von Integrinrezeptoren |
| NZ522074A (en) | 2000-05-31 | 2004-06-25 | Astrazeneca Ab | Indole derivatives with vascular damaging activity |
| UA73993C2 (uk) | 2000-06-06 | 2005-10-17 | Астразенека Аб | Хіназолінові похідні для лікування пухлин та фармацевтична композиція |
| JP2004502766A (ja) | 2000-07-07 | 2004-01-29 | アンギオジェン・ファーマシューティカルズ・リミテッド | 血管損傷剤としてのコルヒノール誘導体 |
| CA2410562A1 (en) | 2000-07-07 | 2002-01-31 | Angiogene Pharmaceuticals Limited | Colchinol derivatives as angiogenesis inhibitors |
| EP1341771A2 (en) | 2000-11-29 | 2003-09-10 | Glaxo Group Limited | Benzimidazole derivatives useful as tie-2 and/or vegfr-2 inhibitors |
| HRP20040416A2 (en) * | 2001-11-09 | 2005-04-30 | Boehringer Ingelheim Pharmaceuticals Inc. | Benzimidazoles useful as protein kinase inhibitors |
| PE20070978A1 (es) * | 2006-02-14 | 2007-11-15 | Novartis Ag | COMPUESTOS HETEROCICLICOS COMO INHIBIDORES DE FOSFATIDILINOSITOL 3-QUINASAS (PI3Ks) |
| EP2058309A4 (en) * | 2006-08-04 | 2010-12-22 | Takeda Pharmaceutical | CONDENSED HETEROCYCLIC COMPOUND |
| CA2689514C (en) * | 2007-06-05 | 2015-09-29 | Takeda Pharmaceutical Company Limited | Heterobicyclic compounds as kinase inhibitors |
| FR2925901B1 (fr) | 2008-01-02 | 2011-03-04 | Sanofi Aventis | DERIVES DE N-HETEROCYCLIQUE-IMIDAZO°1,2-a!PYRIDINE-2- CARBOXAMIDES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
| ES2572387T3 (es) | 2010-03-18 | 2016-05-31 | Pasteur Institut Korea | Compuestos anti-infecciosos |
| WO2018169994A1 (en) * | 2017-03-13 | 2018-09-20 | City Of Hope | m6A mRNA MODIFICATION IN CANCER TREATMENT |
| MX2022006700A (es) * | 2019-12-02 | 2022-09-02 | Storm Therapeutics Ltd | Compuestos poliheterociclicos como inhibidores de mettl3. |
-
2020
- 2020-04-03 EP EP20718757.6A patent/EP3946618A1/en active Pending
- 2020-04-03 WO PCT/GB2020/050898 patent/WO2020201773A1/en not_active Ceased
- 2020-04-03 US US17/601,292 patent/US12358915B2/en active Active
- 2020-04-03 CN CN202080040641.3A patent/CN113905787A/zh active Pending
- 2020-04-03 JP JP2021560410A patent/JP7762957B2/ja active Active
-
2025
- 2025-06-04 US US19/228,039 patent/US20250388577A1/en active Pending
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