JP7762957B2 - Ｍｅｔｔｌ３阻害化合物 - Google Patents

Ｍｅｔｔｌ３阻害化合物

Info

Publication number
JP7762957B2
JP7762957B2 JP2021560410A JP2021560410A JP7762957B2 JP 7762957 B2 JP7762957 B2 JP 7762957B2 JP 2021560410 A JP2021560410 A JP 2021560410A JP 2021560410 A JP2021560410 A JP 2021560410A JP 7762957 B2 JP7762957 B2 JP 7762957B2
Authority
JP
Japan
Prior art keywords
methyl
pyridin
imidazo
carboxamide
oxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2021560410A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2020201773A5 (enExample
JP2022528562A (ja
Inventor
ピーター ブラッカビー，ウェズリー
ジェイムズ ハーディック，デイビッド
ジェーン トーマス，エリザベス
アーサー ブルックフィールド，フレデリック
ブバート，クリスティアン
シェパード，ジョン
ピーター リドギル，マーク
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Storm Therapeutics Ltd
Original Assignee
Storm Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1904848.7A external-priority patent/GB201904848D0/en
Priority claimed from GBGB1912603.6A external-priority patent/GB201912603D0/en
Priority claimed from GBGB1919095.8A external-priority patent/GB201919095D0/en
Application filed by Storm Therapeutics Ltd filed Critical Storm Therapeutics Ltd
Publication of JP2022528562A publication Critical patent/JP2022528562A/ja
Publication of JPWO2020201773A5 publication Critical patent/JPWO2020201773A5/ja
Application granted granted Critical
Publication of JP7762957B2 publication Critical patent/JP7762957B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2021560410A 2019-04-05 2020-04-03 Ｍｅｔｔｌ３阻害化合物 Active JP7762957B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB1904848.7 2019-04-05
GBGB1904848.7A GB201904848D0 (en) 2019-04-05 2019-04-05 Inhibitory compounds
GBGB1912603.6A GB201912603D0 (en) 2019-09-02 2019-09-02 Inhibitory compounds
GB1912603.6 2019-09-02
GBGB1919095.8A GB201919095D0 (en) 2019-12-20 2019-12-20 Inhibitory compounds
GB1919095.8 2019-12-20
PCT/GB2020/050898 WO2020201773A1 (en) 2019-04-05 2020-04-03 Mettl3 inhibitory compounds

Publications (3)

Publication Number Publication Date
JP2022528562A JP2022528562A (ja) 2022-06-14
JPWO2020201773A5 JPWO2020201773A5 (enExample) 2023-04-10
JP7762957B2 true JP7762957B2 (ja) 2025-10-31

Family

ID=70285722

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021560410A Active JP7762957B2 (ja) 2019-04-05 2020-04-03 Ｍｅｔｔｌ３阻害化合物

Country Status (5)

Country Link
US (1) US12358915B2 (enExample)
EP (1) EP3946618A1 (enExample)
JP (1) JP7762957B2 (enExample)
CN (1) CN113905787A (enExample)
WO (1) WO2020201773A1 (enExample)

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Publication number Priority date Publication date Assignee Title
WO2018165520A1 (en) 2017-03-10 2018-09-13 Vps-3, Inc. Metalloenzyme inhibitor compounds
HUE067314T2 (hu) 2017-09-22 2024-10-28 Jubilant Epipad LLC Heterociklusos vegyületek mint PAD gátlók
KR102782563B1 (ko) 2017-10-18 2025-03-14 주빌런트 에피파드 엘엘씨 Pad 억제제로서의 이미다조-피리딘 화합물
KR20200085836A (ko) 2017-11-06 2020-07-15 주빌런트 프로델 엘엘씨 Pd1/pd-l1 활성화 억제제로서의 피리미딘 유도체
BR112020010322A2 (pt) 2017-11-24 2020-11-17 Jubilant Episcribe Llc composto da fórmula i; composto da fórmula ia; composto da fórmula ib; processo de preparação de compostos da fórmula i; composição farmacêutica; método para o tratamento e/ou prevenção de várias doenças; uso dos compostos; método para o tratamento de câncer; e método para o tratamento e/ou prevenção de uma afecção mediada por prmt5 ou um distúrbio proliferativo ou câncer
SG11202008950PA (en) 2018-03-13 2020-10-29 Jubilant Prodel LLC Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation
KR20210125471A (ko) 2018-10-05 2021-10-18 안나푸르나 바이오, 인코포레이티드 Apj 수용체 활성과 관련된 병태를 치료하기 위한 화합물 및 조성물
BR112022010561A2 (pt) 2019-12-02 2022-11-16 Storm Therapeutics Ltd Compostos poli-heterocíclicos como inibidores de mettl3
US20230391770A1 (en) * 2020-10-06 2023-12-07 Storm Therapeutics Limited Mettl3 inhibitory compounds
US11944608B2 (en) * 2020-10-26 2024-04-02 New York University Targeting RNA viruses using inhibitors of METTL3
CA3219183A1 (en) * 2021-05-17 2022-11-24 Amedeo Caflisch N6-adenosine-methyltransferase inhibitors in cancer treatment
GB202107905D0 (en) * 2021-06-02 2021-07-14 Storm Therapeutics Ltd Processes for the preparation of inhibitory compounds
GB202107907D0 (en) * 2021-06-02 2021-07-14 Storm Therapeutics Ltd Combination therapies
WO2023104209A1 (zh) * 2021-12-10 2023-06-15 上海昂阔医药有限公司 Mettl3抑制剂化合物
CN118660890A (zh) * 2022-02-11 2024-09-17 西藏海思科制药有限公司 一种mettl3抑制剂及组合物及其在医药上的应用
CN114869891A (zh) * 2022-04-28 2022-08-09 复旦大学附属中山医院 Mettl3抑制剂在制备治疗肝癌药物中的应用
WO2023217109A1 (zh) * 2022-05-13 2023-11-16 中国科学院广州生物医药与健康研究院 m6A RNA甲基化酶抑制剂与免疫检查点抑制剂联合治疗肿瘤
JP2025530847A (ja) * 2022-09-16 2025-09-17 北京華益健康薬物研究中心 Ｍｅｔｔｌ３阻害剤化合物、その医薬組成物及び用途
WO2024107763A1 (en) * 2022-11-16 2024-05-23 University Of Zurich N6-adenosine-methyltransferase protacs and methods of use thereof
GB202218672D0 (en) 2022-12-12 2023-01-25 Storm Therapeutics Ltd Inhibitory compounds
CN120731203A (zh) 2023-01-20 2025-09-30 艾匹克治疗公司 作为mettl3抑制剂的哌啶衍生物
WO2024200835A1 (en) 2023-03-30 2024-10-03 Novalix Novel mettl3 inhibitors and use thereof in therapy
GB202316683D0 (en) * 2023-10-31 2023-12-13 Storm Therapeutics Ltd Inhibitory compounds
WO2025237957A1 (en) 2024-05-14 2025-11-20 Institut Curie Composition for treatment of estrogen-dependent cancer comprising a mettl-3 inhibitor and a topoisomerase-1 inhibitor

Citations (8)

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Publication number Priority date Publication date Assignee Title
JP2003506387A (ja) 1999-08-04 2003-02-18 アイカゲン インコーポレイテッド カリウムチャンネルオープナーとしてのベンズアニリド
JP2004517080A (ja) 2000-11-29 2004-06-10 グラクソ グループ リミテッド Ｔｉｅ−２および／またはｖｅｇｆｒ−２の阻害剤として有用なベンゾイミダゾール誘導体
JP2005509003A (ja) 2001-11-09 2005-04-07 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド タンパク質キナーゼインヒビターとして有用なベンゾイミダゾール化合物
WO2008016131A1 (en) 2006-08-04 2008-02-07 Takeda Pharmaceutical Company Limited Fused heterocyclic compound
JP2009530233A (ja) 2006-02-14 2009-08-27 ノバルティス アーゲー Ｐｉ−３キナーゼインヒビターおよびそれらの使用方法
JP2010527909A (ja) 2007-06-05 2010-08-19 武田薬品工業株式会社 キナーゼ阻害剤としての二環式複素環化合物
JP2011509250A (ja) 2008-01-02 2011-03-24 サノフイ−アベンテイス Ｎ−複素環式イミダゾ［１，２−ａ］ピリジン−２−カルボキサミドの誘導体、この調製およびこの治療的用途
WO2018169994A1 (en) 2017-03-13 2018-09-20 City Of Hope m6A mRNA MODIFICATION IN CANCER TREATMENT

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JP2003506387A (ja) 1999-08-04 2003-02-18 アイカゲン インコーポレイテッド カリウムチャンネルオープナーとしてのベンズアニリド
JP2004517080A (ja) 2000-11-29 2004-06-10 グラクソ グループ リミテッド Ｔｉｅ−２および／またはｖｅｇｆｒ−２の阻害剤として有用なベンゾイミダゾール誘導体
JP2005509003A (ja) 2001-11-09 2005-04-07 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド タンパク質キナーゼインヒビターとして有用なベンゾイミダゾール化合物
JP2009530233A (ja) 2006-02-14 2009-08-27 ノバルティス アーゲー Ｐｉ−３キナーゼインヒビターおよびそれらの使用方法
WO2008016131A1 (en) 2006-08-04 2008-02-07 Takeda Pharmaceutical Company Limited Fused heterocyclic compound
JP2010527909A (ja) 2007-06-05 2010-08-19 武田薬品工業株式会社 キナーゼ阻害剤としての二環式複素環化合物
JP2011509250A (ja) 2008-01-02 2011-03-24 サノフイ−アベンテイス Ｎ−複素環式イミダゾ［１，２−ａ］ピリジン−２−カルボキサミドの誘導体、この調製およびこの治療的用途
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Also Published As

Publication number Publication date
CN113905787A (zh) 2022-01-07
EP3946618A1 (en) 2022-02-09
JP2022528562A (ja) 2022-06-14
US20230085408A1 (en) 2023-03-16
US12358915B2 (en) 2025-07-15
WO2020201773A1 (en) 2020-10-08

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