JPWO2020174443A5 - - Google Patents

Info

Publication number

JPWO2020174443A5

JPWO2020174443A5 JP2021532151A JP2021532151A JPWO2020174443A5 JP WO2020174443 A5 JPWO2020174443 A5 JP WO2020174443A5 JP 2021532151 A JP2021532151 A JP 2021532151A JP 2021532151 A JP2021532151 A JP 2021532151A JP WO2020174443 A5 JPWO2020174443 A5 JP WO2020174443A5

Authority

JP

Japan

Prior art keywords

patch

abaloparatide

zncl

transdermal

subject

Prior art date

2023-03-01

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• BVISQZFBLRSESR-XSCWXTNMSA-N abaloparatide Chemical compound C([C@@H](C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NC(C)(C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)C1=CN=CN1 BVISQZFBLRSESR-XSCWXTNMSA-N 0.000 claims 15
• 229950001959 abaloparatide Drugs 0.000 claims 15
• 108010038051 abaloparatide Proteins 0.000 claims 15
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 12
• 238000009472 formulation Methods 0.000 claims 7
• 239000000203 mixture Substances 0.000 claims 7
• JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 claims 6
• 210000000689 upper leg Anatomy 0.000 claims 3
• 235000005074 zinc chloride Nutrition 0.000 claims 3
• 239000011592 zinc chloride Substances 0.000 claims 3
• 208000001132 Osteoporosis Diseases 0.000 claims 2
• 238000010254 subcutaneous injection Methods 0.000 claims 2
• 239000007929 subcutaneous injection Substances 0.000 claims 2
• 239000013011 aqueous formulation Substances 0.000 claims 1
• 239000011248 coating agent Substances 0.000 claims 1
• 238000000576 coating method Methods 0.000 claims 1
• 230000037317 transdermal delivery Effects 0.000 claims 1
• 229940100640 transdermal system Drugs 0.000 claims 1