CN113453704A - 阿巴帕肽的透皮递送系统及其使用方法 - Google Patents

阿巴帕肽的透皮递送系统及其使用方法 Download PDF

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Publication number
CN113453704A
CN113453704A CN202080007632.4A CN202080007632A CN113453704A CN 113453704 A CN113453704 A CN 113453704A CN 202080007632 A CN202080007632 A CN 202080007632A CN 113453704 A CN113453704 A CN 113453704A
Authority
CN
China
Prior art keywords
abamectin
patch
formulation
zncl
minutes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202080007632.4A
Other languages
English (en)
Chinese (zh)
Inventor
K·布朗
E·哈梅德
A·哈里斯
G·哈特斯利
J·莫塞曼
J·萨伊
L·迪克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jindewa Drug Delivery Co ltd
Radius Health Inc
Original Assignee
Jindewa Drug Delivery Co ltd
Radius Health Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jindewa Drug Delivery Co ltd, Radius Health Inc filed Critical Jindewa Drug Delivery Co ltd
Publication of CN113453704A publication Critical patent/CN113453704A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CN202080007632.4A 2019-02-28 2020-02-27 阿巴帕肽的透皮递送系统及其使用方法 Pending CN113453704A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962812140P 2019-02-28 2019-02-28
US62/812,140 2019-02-28
PCT/IB2020/051699 WO2020174443A1 (en) 2019-02-28 2020-02-27 Transdermal system for the delivery of abaloparatide and method of use

Publications (1)

Publication Number Publication Date
CN113453704A true CN113453704A (zh) 2021-09-28

Family

ID=69811437

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080007632.4A Pending CN113453704A (zh) 2019-02-28 2020-02-27 阿巴帕肽的透皮递送系统及其使用方法

Country Status (14)

Country Link
US (1) US20210379162A1 (enExample)
EP (1) EP3930743A1 (enExample)
JP (1) JP2022521563A (enExample)
KR (1) KR20210134324A (enExample)
CN (1) CN113453704A (enExample)
AU (1) AU2020228339A1 (enExample)
BR (1) BR112021012283A2 (enExample)
CA (1) CA3122239A1 (enExample)
CO (1) CO2021007862A2 (enExample)
IL (1) IL284565A (enExample)
MX (1) MX2021007062A (enExample)
SG (1) SG11202106205YA (enExample)
TW (1) TW202037378A (enExample)
WO (1) WO2020174443A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024032454A1 (zh) * 2022-08-10 2024-02-15 成都奥达生物科技有限公司 一种长效阿巴洛肽化合物
CN119113134A (zh) * 2024-09-13 2024-12-13 南京羚诺生物医药技术研究院有限公司 一种提升阿巴帕肽半衰期的方法及其在治疗骨质疏松症中的用途

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021149012A1 (en) 2020-01-24 2021-07-29 Radius Health, Inc. Methods of stimulating bone growth with abalopartide and denosumab

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE416692T1 (de) * 2000-10-13 2008-12-15 Alza Corp Mikronadelelementhalter für schlagapplikator
CA2567056A1 (en) * 2004-05-10 2005-12-08 Nastech Pharmaceutical Company Inc. Compositions and methods for enhanced mucosal delivery of parathyroid hormone
CA2680690A1 (en) * 2006-03-15 2007-09-20 Alza Corporation Apparatus and method for transdermal delivery of parathyroid hormone agents to prevent or treat osteopenia
US8563513B2 (en) * 2009-03-27 2013-10-22 Van Andel Research Institute Parathyroid hormone peptides and parathyroid hormone-related protein peptides and methods of use
CA2857487C (en) * 2011-11-29 2021-09-21 Rutgers, The State University Of New Jersey Insulin-mimetics as therapeutic adjuncts for bone regeneration
US20180355319A1 (en) 2015-08-07 2018-12-13 Kyoto Prefectural Public University Corporation Method for preparing brown adipocyte
SMT202100411T1 (it) 2015-10-09 2021-11-12 Radius Health Inc Formulazioni di analoghi di pthrp, loro cerotti transdermici, e loro usi
ES2909043T3 (es) 2015-10-09 2022-05-05 Kindeva Drug Delivery Lp Composiciones de zinc para sistemas de microagujas recubiertos
AU2017253674B2 (en) * 2016-04-18 2021-07-29 Kindeva Drug Delivery L.P. Formulations of abaloparatide, transdermal patches thereof, and uses thereof

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024032454A1 (zh) * 2022-08-10 2024-02-15 成都奥达生物科技有限公司 一种长效阿巴洛肽化合物
CN119113134A (zh) * 2024-09-13 2024-12-13 南京羚诺生物医药技术研究院有限公司 一种提升阿巴帕肽半衰期的方法及其在治疗骨质疏松症中的用途
CN119113134B (zh) * 2024-09-13 2025-05-16 南京羚诺生物医药技术研究院有限公司 一种提升阿巴帕肽半衰期的制备方法及其在治疗骨质疏松症中的用途

Also Published As

Publication number Publication date
SG11202106205YA (en) 2021-07-29
US20210379162A1 (en) 2021-12-09
EP3930743A1 (en) 2022-01-05
WO2020174443A1 (en) 2020-09-03
JP2022521563A (ja) 2022-04-11
MX2021007062A (es) 2021-09-10
KR20210134324A (ko) 2021-11-09
BR112021012283A2 (pt) 2021-09-08
TW202037378A (zh) 2020-10-16
AU2020228339A1 (en) 2021-07-01
CO2021007862A2 (es) 2021-11-19
IL284565A (en) 2021-08-31
CA3122239A1 (en) 2020-09-03

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Application publication date: 20210928