JPWO2020160414A5 - - Google Patents
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- JPWO2020160414A5 JPWO2020160414A5 JP2021544183A JP2021544183A JPWO2020160414A5 JP WO2020160414 A5 JPWO2020160414 A5 JP WO2020160414A5 JP 2021544183 A JP2021544183 A JP 2021544183A JP 2021544183 A JP2021544183 A JP 2021544183A JP WO2020160414 A5 JPWO2020160414 A5 JP WO2020160414A5
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- Prior art keywords
- target region
- epigenetic
- cfdna
- region set
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 206010028980 Neoplasm Diseases 0.000 claims description 71
- 238000000034 method Methods 0.000 claims description 69
- 201000011510 cancer Diseases 0.000 claims description 66
- 230000001973 epigenetic effect Effects 0.000 claims description 65
- 239000000523 sample Substances 0.000 claims description 48
- 238000012163 sequencing technique Methods 0.000 claims description 31
- 238000012360 testing method Methods 0.000 claims description 29
- 238000011282 treatment Methods 0.000 claims description 11
- 238000004891 communication Methods 0.000 claims description 8
- 230000004076 epigenetic alteration Effects 0.000 claims description 7
- 102000016897 CCCTC-Binding Factor Human genes 0.000 claims description 6
- 108010014064 CCCTC-Binding Factor Proteins 0.000 claims description 6
- 108700009124 Transcription Initiation Site Proteins 0.000 claims description 6
- 108020004707 nucleic acids Proteins 0.000 claims description 6
- 102000039446 nucleic acids Human genes 0.000 claims description 6
- 150000007523 nucleic acids Chemical class 0.000 claims description 6
- 230000003321 amplification Effects 0.000 claims description 4
- 238000013507 mapping Methods 0.000 claims description 4
- 230000011987 methylation Effects 0.000 claims description 4
- 238000007069 methylation reaction Methods 0.000 claims description 4
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 4
- 238000012545 processing Methods 0.000 claims description 4
- 230000035772 mutation Effects 0.000 claims description 3
- 230000006607 hypermethylation Effects 0.000 claims description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 238000000638 solvent extraction Methods 0.000 claims 1
- 108020004414 DNA Proteins 0.000 description 29
- 210000004881 tumor cell Anatomy 0.000 description 11
- 230000001594 aberrant effect Effects 0.000 description 2
- 238000012217 deletion Methods 0.000 description 2
- 230000037430 deletion Effects 0.000 description 2
- 230000004927 fusion Effects 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 238000012549 training Methods 0.000 description 2
- 102000053602 DNA Human genes 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 238000010801 machine learning Methods 0.000 description 1
- 238000011176 pooling Methods 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024104756A JP2024125391A (ja) | 2019-01-31 | 2024-06-28 | 無細胞ｄｎａを単離するための組成物および方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962799637P | 2019-01-31 | 2019-01-31 | |
| US62/799,637 | 2019-01-31 | ||
| PCT/US2020/016120 WO2020160414A1 (en) | 2019-01-31 | 2020-01-31 | Compositions and methods for isolating cell-free dna |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024104756A Division JP2024125391A (ja) | 2019-01-31 | 2024-06-28 | 無細胞ｄｎａを単離するための組成物および方法 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022519045A JP2022519045A (ja) | 2022-03-18 |
| JP2022519045A5 JP2022519045A5 (https=) | 2023-02-08 |
| JPWO2020160414A5 true JPWO2020160414A5 (https=) | 2023-02-08 |
| JP7573536B2 JP7573536B2 (ja) | 2024-10-25 |
Family
ID=69740753
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021544183A Active JP7573536B2 (ja) | 2019-01-31 | 2020-01-31 | 無細胞ｄｎａを単離するための組成物および方法 |
| JP2024104756A Pending JP2024125391A (ja) | 2019-01-31 | 2024-06-28 | 無細胞ｄｎａを単離するための組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024104756A Pending JP2024125391A (ja) | 2019-01-31 | 2024-06-28 | 無細胞ｄｎａを単離するための組成物および方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11643693B2 (https=) |
| EP (2) | EP4567131A3 (https=) |
| JP (2) | JP7573536B2 (https=) |
| CN (1) | CN113661249B (https=) |
| AU (2) | AU2020216438A1 (https=) |
| CA (1) | CA3126428A1 (https=) |
| ES (1) | ES3013495T3 (https=) |
| WO (1) | WO2020160414A1 (https=) |
Families Citing this family (85)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP4035161A1 (en) * | 2019-09-23 | 2022-08-03 | Grail, LLC | Systems and methods for diagnosing a disease condition using on-target and off-target sequencing data |
| US11891653B2 (en) | 2019-09-30 | 2024-02-06 | Guardant Health, Inc. | Compositions and methods for analyzing cell-free DNA in methylation partitioning assays |
| WO2021231921A1 (en) | 2020-05-14 | 2021-11-18 | Guardant Health, Inc. | Homologous recombination repair deficiency detection |
| ES3018032T3 (en) | 2020-07-30 | 2025-05-14 | Guardant Health Inc | Methods for isolating cell-free dna |
| JP2023540221A (ja) * | 2020-08-25 | 2023-09-22 | ガーダント ヘルス， インコーポレイテッド | バリアントの起源を予測するための方法およびシステム |
| CN116438454A (zh) | 2020-09-21 | 2023-07-14 | 普罗根尼蒂公司 | 用于分离细胞游离dna的组合物和方法 |
| US20220154285A1 (en) | 2020-09-30 | 2022-05-19 | Guardant Health, Inc. | Analysis of methylated dna comprising methylation-sensitive or methylation-dependent restrictions |
| US12234518B2 (en) | 2020-10-23 | 2025-02-25 | Guardant Health, Inc. | Compositions and methods for analyzing DNA using partitioning and base conversion |
| EP4251765A1 (en) | 2020-11-30 | 2023-10-04 | Guardant Health, Inc. | Compositions and methods for enriching methylated polynucleotides |
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- 2020-01-31 WO PCT/US2020/016120 patent/WO2020160414A1/en not_active Ceased
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