JPWO2020154533A5 - - Google Patents

Download PDF

Info

Publication number
JPWO2020154533A5
JPWO2020154533A5 JP2021543274A JP2021543274A JPWO2020154533A5 JP WO2020154533 A5 JPWO2020154533 A5 JP WO2020154533A5 JP 2021543274 A JP2021543274 A JP 2021543274A JP 2021543274 A JP2021543274 A JP 2021543274A JP WO2020154533 A5 JPWO2020154533 A5 JP WO2020154533A5
Authority
JP
Japan
Prior art keywords
cells
time
period
pluripotent stem
growth factor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2021543274A
Other languages
English (en)
Japanese (ja)
Other versions
JP7469317B2 (ja
JP2022520722A5 (https=
JP2022520722A (ja
Publication date
Application filed filed Critical
Priority claimed from PCT/US2020/014834 external-priority patent/WO2020154533A1/en
Publication of JP2022520722A publication Critical patent/JP2022520722A/ja
Publication of JPWO2020154533A5 publication Critical patent/JPWO2020154533A5/ja
Publication of JP2022520722A5 publication Critical patent/JP2022520722A5/ja
Priority to JP2024060751A priority Critical patent/JP2024096785A/ja
Application granted granted Critical
Publication of JP7469317B2 publication Critical patent/JP7469317B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2021543274A 2019-01-23 2020-01-23 ヒト多能性幹細胞からの背側由来オリゴデンドロサイト前駆細胞 Active JP7469317B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024060751A JP2024096785A (ja) 2019-01-23 2024-04-04 ヒト多能性幹細胞からの背側由来オリゴデンドロサイト前駆細胞

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962796077P 2019-01-23 2019-01-23
US62/796,077 2019-01-23
PCT/US2020/014834 WO2020154533A1 (en) 2019-01-23 2020-01-23 Dorsally-derived oligodendrocyte progenitor cells from human pluripotent stem cells

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024060751A Division JP2024096785A (ja) 2019-01-23 2024-04-04 ヒト多能性幹細胞からの背側由来オリゴデンドロサイト前駆細胞

Publications (4)

Publication Number Publication Date
JP2022520722A JP2022520722A (ja) 2022-04-01
JPWO2020154533A5 true JPWO2020154533A5 (https=) 2024-02-06
JP2022520722A5 JP2022520722A5 (https=) 2024-02-06
JP7469317B2 JP7469317B2 (ja) 2024-04-16

Family

ID=71609769

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2021543274A Active JP7469317B2 (ja) 2019-01-23 2020-01-23 ヒト多能性幹細胞からの背側由来オリゴデンドロサイト前駆細胞
JP2024060751A Pending JP2024096785A (ja) 2019-01-23 2024-04-04 ヒト多能性幹細胞からの背側由来オリゴデンドロサイト前駆細胞

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2024060751A Pending JP2024096785A (ja) 2019-01-23 2024-04-04 ヒト多能性幹細胞からの背側由来オリゴデンドロサイト前駆細胞

Country Status (9)

Country Link
US (2) US11603518B2 (https=)
EP (1) EP3914264A4 (https=)
JP (2) JP7469317B2 (https=)
KR (2) KR20260020476A (https=)
CN (2) CN113474451B (https=)
AU (1) AU2020210757B2 (https=)
CA (1) CA3127213A1 (https=)
SG (1) SG11202107732XA (https=)
WO (1) WO2020154533A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116121189A (zh) 2016-03-30 2023-05-16 阿斯特利亚斯生物治疗股份公司 少突胶质细胞祖细胞组合物
IL281628B2 (en) 2018-09-19 2025-06-01 Lineage Cell Therapeutics Inc Methods for differentiating pluripotent stem cells in dynamic suspension culture
WO2020154533A1 (en) 2019-01-23 2020-07-30 Asterias Biotherapeutics, Inc. Dorsally-derived oligodendrocyte progenitor cells from human pluripotent stem cells
AU2022212124A1 (en) * 2021-01-28 2023-08-10 Asterias Biotherapeutics, Inc. Compositions and methods for treating spinal cord injuries
IL305737A (en) * 2021-03-10 2023-11-01 Lineage Cell Therapeutics Inc Methods for generating oligodendrocyte progenitor cells and their use
WO2023147512A2 (en) * 2022-01-28 2023-08-03 Asterias Biotherapeutics, Inc. Compositions and methods for treating spinal cord injuries
CA3256595A1 (en) * 2022-05-24 2023-11-30 Bluerock Therapeutics Lp METHODS FOR MANUFACTURED OLIGODENDROCYTE PROGENITOR CELLS
WO2025049991A1 (en) * 2023-08-31 2025-03-06 The Board Of Trustees Of The Leland Stanford Junior University Compositions comprising neurons and methods of using the same
KR20250094234A (ko) * 2023-12-18 2025-06-25 ㈜바이오솔빅스 콘케이브와 진탕배양 기법으로 형성된 전분화능 줄기세포 유래 신경세포 제조방법 및 이에 의해 제조된 3d 신경 오가노이드를 통한 약물 독성 평가방법

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998048001A1 (en) * 1997-04-24 1998-10-29 California Institute Of Technology Methods for differentiating neural stem cells
US6361996B1 (en) * 1997-05-07 2002-03-26 University Of Utah Research Foundation Neuroepithelial stem cells and glial-restricted intermediate precursors
AU729377B2 (en) 1997-10-23 2001-02-01 Asterias Biotherapeutics, Inc. Methods and materials for the growth of primate-derived primordial stem cells in feeder-free culture
US7410798B2 (en) 2001-01-10 2008-08-12 Geron Corporation Culture system for rapid expansion of human embryonic stem cells
US6667176B1 (en) 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
CA2388736A1 (en) 1999-10-22 2001-04-26 Washington University Oligodendrocyte cell cultures and methods for their preparation and use
US6280718B1 (en) 1999-11-08 2001-08-28 Wisconsin Alumni Reasearch Foundation Hematopoietic differentiation of human pluripotent embryonic stem cells
CA2403000C (en) 2000-03-14 2015-06-23 Es Cell International Pte Ltd Embryonic stem cells and neural progenitor cells derived therefrom
AU2003211063A1 (en) 2002-02-15 2003-09-09 Cornell Research Foundation, Inc. Myelination of congenitally dysmyelinated forebrains using oligodendrocyte progenitor cells
US7285415B2 (en) 2002-07-11 2007-10-23 The Regents Of The University Of California Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury
US20050101014A1 (en) 2002-07-11 2005-05-12 Keirstead Hans S. Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury
US7390659B2 (en) * 2002-07-16 2008-06-24 The Trustees Of Columbia University In The City Of New York Methods for inducing differentiation of embryonic stem cells and uses thereof
US20050031598A1 (en) 2002-12-10 2005-02-10 Shulamit Levenberg Engineering three-dimensional tissue structures using differentiating embryonic stem cells
EP2399990B1 (en) 2003-06-27 2015-07-22 DePuy Synthes Products, Inc. Cells derived from post-partum umbilical cord for use in treatment of disease of the heart and circulatory system
CN101084303A (zh) 2004-11-17 2007-12-05 神经干公司 用于治疗神经变性症状的人类神经细胞的移植
US8709797B2 (en) 2006-06-20 2014-04-29 Cook General Biotechnology Llc Systems and methods for cryopreservation of cells
WO2009008928A2 (en) 2007-04-13 2009-01-15 Stemnion, Inc. Methods for treating nervous system injury and disease
EP2028268A1 (en) * 2007-08-20 2009-02-25 Université Libre De Bruxelles Generation of neuronal cells from pluripotent stem cells
KR100941036B1 (ko) 2007-10-05 2010-02-05 고려대학교 산학협력단 인간 배아줄기세포로부터 척수신경계 희소돌기 아교세포생산을 위한 삼단계 분화기법
EP2217252A2 (en) 2007-10-29 2010-08-18 Hadasit Medical Research Services & Development Limited Human stem cell-derived neural precursors for treatment of autoimmune diseases of the central nervous system
US8227247B2 (en) 2007-12-20 2012-07-24 Wisconsin Alumni Research Foundation Method of generating myelinating oligodendrocytes
CA2714010C (en) 2008-01-30 2020-06-16 Corning Incorporated Synthetic surfaces for culturing stem cell derived oligodendrocyte progenitor cells
KR20110011658A (ko) 2008-05-08 2011-02-08 유니버시티 오브 로체스터 최적화된 세포 제제에 의한 수초 질환의 치료
CN102083964B (zh) 2008-05-09 2013-06-12 格拉斯哥大学大学行政评议会 与基于细胞的疗法相关的材料和方法
US20100158878A1 (en) 2008-12-23 2010-06-24 Alexandra Capela Target populations of oligodendrocyte precursor cells and methods of making and using same
CN102803472B (zh) 2009-06-25 2014-04-23 吉隆公司 去除了外来表型的由多能干细胞分化的子代细胞
WO2011059920A2 (en) 2009-11-10 2011-05-19 The J. David Gladstone Institutes Methods of generating neural stem cells
CN102160546B (zh) 2010-02-24 2016-01-20 库克通用生物科技有限责任公司 冷冻保存细胞的系统和方法
WO2012021818A2 (en) 2010-08-13 2012-02-16 Georgetown University Ggf2 and methods of use
CN103429734A (zh) 2010-10-26 2013-12-04 卡斯西部储备大学 用于产生神经胶质细胞的群体的分化方法
CN103384680B (zh) 2010-12-17 2015-08-26 拜奥拉米那公司 细胞培养基
TWI586805B (zh) 2011-01-12 2017-06-11 城戶常雄 獲得及維持在體外易於分化為寡樹突細胞－族系細胞之哺乳類神經幹細胞及／或神經祖源細胞的純或增富族群之培養方法
ES2666503T3 (es) 2012-05-16 2018-05-04 Becton, Dickinson And Company Características distintivas de superficie celular para aislar neuronas de cultivos celulares derivados de células madre pluripotentes
EP2954046B1 (en) 2013-02-06 2025-10-15 University Of Rochester Induced pluripotent cell-derived oligodendrocyte progenitor cells for the treatment of myelin disorders
US10160950B2 (en) 2013-03-01 2018-12-25 Wisconsin Alumni Research Foundation Methods of maintaining, expanding and differentiating neuronal subtype specific progenitors
KR20230058556A (ko) 2013-03-15 2023-05-03 아스텔라스 인스티튜트 포 리제너러티브 메디슨 만능 줄기 세포로부터 제조된 광수용기 및 광수용기 전구체
WO2015088625A2 (en) 2013-09-25 2015-06-18 Case Western Reserve University Compounds and methods of promoting myelination
WO2015143342A1 (en) 2014-03-21 2015-09-24 Cellular Dynamics International, Inc. Production of midbrain dopaminergic neurons and methods for the use thereof
KR102585909B1 (ko) 2014-05-22 2023-10-05 뉴욕 스템 셀 파운데이션, 인코포레이티드 다능성 줄기 세포로부터 유래된 기능성 희소돌기아교세포 및 이의 제조 및 사용 방법
WO2016063985A1 (ja) * 2014-10-24 2016-04-28 大日本住友製薬株式会社 神経組織の製造方法
CN105624116B (zh) * 2014-11-07 2020-04-07 中国科学院上海生命科学研究院 利用多能干细胞制备神经前体细胞的方法
WO2016103269A1 (en) 2014-12-23 2016-06-30 Ramot At Tel-Aviv University Ltd. Populations of neural progenitor cells and methods of producing and using same
US10286009B2 (en) 2015-05-16 2019-05-14 Asterias Biotherapeutics, Inc. Pluripotent stem cell-derived oligodendrocyte progenitor cells for the treatment of spinal cord injury
AU2017211858B2 (en) * 2016-01-27 2023-05-18 Memorial Sloan-Kettering Cancer Center Differentiation of cortical neurons from human pluripotent stem cells
CN116121189A (zh) 2016-03-30 2023-05-16 阿斯特利亚斯生物治疗股份公司 少突胶质细胞祖细胞组合物
IL281628B2 (en) 2018-09-19 2025-06-01 Lineage Cell Therapeutics Inc Methods for differentiating pluripotent stem cells in dynamic suspension culture
WO2020154533A1 (en) 2019-01-23 2020-07-30 Asterias Biotherapeutics, Inc. Dorsally-derived oligodendrocyte progenitor cells from human pluripotent stem cells

Similar Documents

Publication Publication Date Title
US11421203B2 (en) Method of producing human retinal pigment epithelial cells
EP2470645B1 (en) Substantially pure human retinal progenitor, forebrain progenitor, and retinal pigment epithelium cell cultures and methods of making the same
JP4439396B2 (ja) 神経系細胞の製造方法
JP2024178446A (ja) 動的懸濁培養において多能性幹細胞を分化させるための方法
CN113474451B (zh) 来自人多能干细胞的背源性少突胶质祖细胞
JP2022501049A5 (https=)
CN104195108B (zh) 蛋白激酶抑制剂在从非神经细胞制备神经细胞中的用途
CN105392881B (zh) 体细胞基于小分子转化为神经嵴细胞
Lowry et al. Multipotent embryonic spinal cord stem cells expanded by endothelial factors and Shh/RA promote functional recovery after spinal cord injury
CN108570448B (zh) 一种高效的hPSCs向MSCs分化的方法
KR20230165846A (ko) 도파민성 전구세포 및 사용 방법
CN112626023A (zh) 脊髓olig2+神经祖细胞诱导及自我更新培养体系、诱导方法及应用
CN104928247A (zh) 一种神经干细胞培养基及神经干细胞贴壁培养方法
CN118475685A (zh) 神经嵴细胞的培养方法及制造方法
CN113272422B (zh) 用于无载体3d球体悬浮培养中视网膜神经元生成的方法和组合物
JPWO2020154533A5 (https=)
CN108865997B (zh) 一种用于体外培养星形胶质细胞的培养基及培养方法
US20260002124A1 (en) Enhancing neuronal differentiation of ventral midbrain neural progenitor cells
CN105121633B (zh) 一种建立神经上皮干细胞的培养基、方法及其应用
CN113528441A (zh) 快速高效的临床级色素上皮细胞诱导方法、试剂盒及应用
JPWO2020061371A5 (https=)
TW202330906A (zh) 片狀視網膜組織之製造方法
CN117157388A (zh) 卵巢体细胞样细胞的制造方法及将灵长类多能干细胞分化诱导成卵巢体细胞样细胞的方法
CN117769591A (zh) 源自人多能干细胞的大脑皮质细胞制剂的制造方法
WO2000068359A1 (en) Lineage-restricted precursor cells isolated from mouse neural tube and mouse embryonic stem cells