JPWO2020145369A5 - - Google Patents
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- Publication number
- JPWO2020145369A5 JPWO2020145369A5 JP2020565216A JP2020565216A JPWO2020145369A5 JP WO2020145369 A5 JPWO2020145369 A5 JP WO2020145369A5 JP 2020565216 A JP2020565216 A JP 2020565216A JP 2020565216 A JP2020565216 A JP 2020565216A JP WO2020145369 A5 JPWO2020145369 A5 JP WO2020145369A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- aromatic heterocyclic
- aromatic
- aromatic carbocyclic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 49
- 125000003118 aryl group Chemical group 0.000 claims 43
- 125000002837 carbocyclic group Chemical group 0.000 claims 31
- -1 cyano, carboxy Chemical group 0.000 claims 31
- 150000003839 salts Chemical class 0.000 claims 21
- 125000000217 alkyl group Chemical group 0.000 claims 20
- 125000003545 alkoxy group Chemical group 0.000 claims 18
- 150000001875 compounds Chemical class 0.000 claims 16
- 229910052736 halogen Inorganic materials 0.000 claims 16
- 150000002367 halogens Chemical class 0.000 claims 16
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 15
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 15
- 229910052739 hydrogen Inorganic materials 0.000 claims 15
- 239000001257 hydrogen Substances 0.000 claims 15
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 13
- 150000002431 hydrogen Chemical class 0.000 claims 13
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 12
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 12
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 12
- 125000003342 alkenyl group Chemical group 0.000 claims 11
- 125000005090 alkenylcarbonyl group Chemical group 0.000 claims 10
- 125000003302 alkenyloxy group Chemical group 0.000 claims 10
- 125000005092 alkenyloxycarbonyl group Chemical group 0.000 claims 10
- 125000005136 alkenylsulfinyl group Chemical group 0.000 claims 10
- 125000005137 alkenylsulfonyl group Chemical group 0.000 claims 10
- 125000004644 alkyl sulfinyl group Chemical group 0.000 claims 10
- 125000004414 alkyl thio group Chemical group 0.000 claims 10
- 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 claims 10
- 125000001951 carbamoylamino group Chemical group C(N)(=O)N* 0.000 claims 10
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 claims 10
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 10
- 125000005193 alkenylcarbonyloxy group Chemical group 0.000 claims 8
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 claims 8
- 229910052760 oxygen Inorganic materials 0.000 claims 8
- 125000004093 cyano group Chemical group *C#N 0.000 claims 6
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 229910052717 sulfur Inorganic materials 0.000 claims 5
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 125000002947 alkylene group Chemical group 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 125000004434 sulfur atom Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019003073 | 2019-01-11 | ||
| JP2019003073 | 2019-01-11 | ||
| PCT/JP2020/000553 WO2020145369A1 (ja) | 2019-01-11 | 2020-01-10 | Ｍｇａｔ２阻害活性を有するジヒドロピラゾロピラジノン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPWO2020145369A1 JPWO2020145369A1 (ja) | 2021-11-25 |
| JPWO2020145369A5 true JPWO2020145369A5 (https=) | 2023-01-11 |
| JP7608166B2 JP7608166B2 (ja) | 2025-01-06 |
Family
ID=71520981
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020565216A Active JP7608166B2 (ja) | 2019-01-11 | 2020-01-10 | Ｍｇａｔ２阻害活性を有するジヒドロピラゾロピラジノン誘導体 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US12227509B2 (https=) |
| EP (1) | EP3909583A4 (https=) |
| JP (1) | JP7608166B2 (https=) |
| KR (1) | KR20210114001A (https=) |
| CN (2) | CN119409703A (https=) |
| AU (1) | AU2020207716A1 (https=) |
| BR (1) | BR112021012428A2 (https=) |
| CA (1) | CA3126334A1 (https=) |
| MX (1) | MX2021008050A (https=) |
| TW (1) | TWI840489B (https=) |
| WO (1) | WO2020145369A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022016394A (ja) * | 2020-07-10 | 2022-01-21 | 塩野義製薬株式会社 | Ｍｇａｔ２阻害活性を有するジヒドロピラゾロピラジノン誘導体を含有する医薬組成物 |
| WO2023038039A1 (ja) | 2021-09-08 | 2023-03-16 | 塩野義製薬株式会社 | 抗肥満作用の関与する疾患の予防及び治療用医薬 |
| WO2026008045A1 (zh) * | 2024-07-04 | 2026-01-08 | 苏州信诺维医药科技股份有限公司 | 一种含有炔基的螺环化合物及其用途 |
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| CN1747949A (zh) | 2002-12-20 | 2006-03-15 | 法马西亚公司 | 无环吡唑化合物 |
| RU2318818C1 (ru) | 2006-04-12 | 2008-03-10 | Общество С Ограниченной Ответственностью "Исследовательский Институт Химического Разнообразия" | Азагетероциклы, комбинаторная библиотека, фокусированная библиотека, фармацевтическая композиция и способ получения (варианты) |
| US8232282B2 (en) | 2006-09-28 | 2012-07-31 | Dainippon Sumitomo Pharma Co., Ltd. | Compound having bicyclic pyrimidine structure and pharmaceutical composition comprising the same |
| AU2007342368A1 (en) | 2007-01-04 | 2008-07-17 | Merck & Co., Inc. | Bicyclic spiropiperidine beta-secretase inhibitors for the treatment of Alzheimer's disease |
| US8389533B2 (en) | 2008-04-07 | 2013-03-05 | Amgen Inc. | Gem-disubstituted and spirocyclic amino pyridines/pyrimidines as cell cycle inhibitors |
| US20110275647A1 (en) | 2009-02-23 | 2011-11-10 | Msd K.K. | Pyrimidin-4-(3h)-one derivatives |
| KR20100097077A (ko) | 2009-02-25 | 2010-09-02 | 주식회사 중외제약 | Ｈｓｐ90에 대한 억제 효능을 갖는 피리디논 유도체 |
| SG181857A1 (en) | 2009-12-23 | 2012-07-30 | Takeda Pharmaceutical | Fused heteroaromatic pyrrolidinones as syk inhibitors |
| JP2014051434A (ja) | 2010-12-28 | 2014-03-20 | Dainippon Sumitomo Pharma Co Ltd | 二環性ピリミジン誘導体 |
| JP5853033B2 (ja) | 2011-03-01 | 2016-02-09 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプＪａｎｓｓｅｎ Ｐｈａｒｍａｃｅｕｔｉｃａ Ｎａａｍｌｏｚｅ Ｖｅｎｎｏｏｔｓｃｈａｐ | β−セクレターゼ（ＢＡＣＥ）の阻害剤として有用な６，７−ジヒドロ−ピラゾロ［１，５−ａ］ピラジン−４−イルアミン誘導体 |
| WO2012124744A1 (ja) | 2011-03-14 | 2012-09-20 | 大正製薬株式会社 | 含窒素縮合複素環化合物 |
| JP6042060B2 (ja) | 2011-09-26 | 2016-12-14 | サノフイ | ピラゾロキノリノン誘導体、その調製および治療上の使用 |
| PT2573073E (pt) | 2011-09-26 | 2015-02-05 | Sanofi Sa | Derivados de pirazoloquinolinona, sua preparação e sua utilização terapêutica |
| CN103012397B (zh) | 2011-09-26 | 2017-03-01 | 赛诺菲 | 吡唑并喹啉酮衍生物、其制备方法及其治疗用途 |
| US8791091B2 (en) | 2011-12-02 | 2014-07-29 | Bristol-Myers Squibb Company | Aryl dihydropyridinone and piperidinone MGAT2 inhibitors |
| US9073856B2 (en) | 2012-01-23 | 2015-07-07 | Eli Lilly And Company | Phenyl methanesulfonamide derivatives useful as MGAT-2 inhibitors |
| AR089771A1 (es) | 2012-01-31 | 2014-09-17 | Lilly Co Eli | Derivados de bencil sulfonamida utiles como inhibidores de mogat-2 |
| JP5852269B2 (ja) | 2012-01-31 | 2016-02-03 | イーライ リリー アンド カンパニー | Ｍｏｇａｔ−２阻害剤として有用な新規モルホリニル誘導体 |
| US9394297B2 (en) | 2012-02-28 | 2016-07-19 | Amgen Inc. | Amides as pim inhibitors |
| EP2855483B1 (en) | 2012-05-24 | 2017-10-25 | Novartis AG | Pyrrolopyrrolidinone compounds |
| JP2014005245A (ja) | 2012-06-26 | 2014-01-16 | Dainippon Sumitomo Pharma Co Ltd | 二環性ピリミジン誘導体を含有する医薬組成物 |
| JP2014009165A (ja) | 2012-06-27 | 2014-01-20 | Dainippon Sumitomo Pharma Co Ltd | 二環性ピリミジン化合物 |
| EP2903985A1 (en) | 2012-10-03 | 2015-08-12 | Advinus Therapeutics Limited | Spirocyclic compounds, compositions and medicinal applications thereof |
| MX2015005739A (es) | 2012-11-06 | 2015-09-16 | Lilly Co Eli | Compuestos novedosos de bencil sulfonamida utiles como inhibidores de mogat-2. |
| WO2014133134A1 (ja) | 2013-02-28 | 2014-09-04 | 味の素株式会社 | 新規テトラヒドロピリドピリミジノン誘導体 |
| CA2907532A1 (en) | 2013-03-25 | 2014-10-02 | Sanofi | Pyrazolonaphthyridinone derivatives as metap2 inhibitors (methionine aminopeptidase type-2) |
| CN104109160B (zh) | 2013-04-17 | 2017-12-15 | 上海翰森生物医药科技有限公司 | 吡咯并n杂环类化合物及其制备方法和医药用途 |
| SG11201509070YA (en) | 2013-05-29 | 2015-12-30 | Bristol Myers Squibb Co | Dihydropyridinone mgat2 inhibitors |
| AR098414A1 (es) | 2013-11-14 | 2016-05-26 | Bristol Myers Squibb Co | PIPERAZINAS DE PIRAZOLO SUSTITUIDO COMO INHIBIDORES DE CASEÍNA QUINASA 1 d/e |
| WO2015112465A1 (en) | 2014-01-24 | 2015-07-30 | Merck Sharp & Dohme Corp. | Isoquinoline derivatives as mgat2 inhibitors |
| EP3097095A1 (en) | 2014-01-24 | 2016-11-30 | AbbVie Inc. | Furo-3-carboxamide derivatives and methods of use |
| JP6513075B2 (ja) | 2014-02-27 | 2019-05-15 | 国立大学法人 東京大学 | オートタキシン阻害活性を有する縮合ピラゾール誘導体 |
| JP2017078024A (ja) | 2014-02-28 | 2017-04-27 | 味の素株式会社 | 新規テトラヒドロピリドピリミジノン誘導体 |
| SMT201900256T1 (it) | 2014-03-07 | 2019-07-11 | Bristol Myers Squibb Co | Inibitori dell'mgat2 diidropiridinonici sostituiti con tetrazolone |
| SG11201607392SA (en) | 2014-03-07 | 2016-10-28 | Bristol Myers Squibb Co | Dihydropyridinone mgat2 inhibitors for use in the treatment of metabolic disorders |
| EP3129376B1 (en) | 2014-03-27 | 2018-12-26 | Janssen Pharmaceutica NV | Substituted 4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazine derivatives and 5,6,7,8-tetrahydro-4h-pyrazolo[1,5-a][1,4]diazepine derivatives as ros1 inhibitors |
| WO2015191681A2 (en) | 2014-06-11 | 2015-12-17 | Bristol-Myers Squibb Company | Substituted pyridinones as mgat2 inhibitors |
| JP2017171579A (ja) * | 2014-08-11 | 2017-09-28 | 味の素株式会社 | 新規テトラヒドロピリドピリミジノン誘導体 |
| CN107205993B (zh) | 2014-12-06 | 2021-03-09 | 细胞内治疗公司 | 有机化合物 |
| WO2016106009A1 (en) | 2014-12-22 | 2016-06-30 | Eli Lilly And Company | Erk inhibitors |
| JP2018052818A (ja) * | 2015-01-28 | 2018-04-05 | 武田薬品工業株式会社 | スルホンアミド化合物 |
| JP2016164154A (ja) | 2015-02-26 | 2016-09-08 | 塩野義製薬株式会社 | オートタキシン阻害活性を有する７位無置換縮合ピラゾール誘導体 |
| WO2017069224A1 (ja) | 2015-10-22 | 2017-04-27 | 塩野義製薬株式会社 | Ｍｇａｔ２阻害活性を有するスピロ環誘導体 |
| US10335401B2 (en) * | 2015-12-21 | 2019-07-02 | Shionogi & Co., Ltd. | Non-aromatic heterocyclic derivative having MGAT2 inhibitory activity |
| JP6665575B2 (ja) | 2016-02-23 | 2020-03-13 | ブラザー工業株式会社 | プログラム |
| JP2020158390A (ja) * | 2017-06-20 | 2020-10-01 | 塩野義製薬株式会社 | Ｍｇａｔ２阻害活性を有する非芳香族複素環誘導体およびそれらを含有する医薬組成物 |
| TWI782056B (zh) * | 2017-07-14 | 2022-11-01 | 日商鹽野義製藥股份有限公司 | 具有ｍｇａｔ２抑制活性的縮合環衍生物 |
-
2020
- 2020-01-10 CA CA3126334A patent/CA3126334A1/en active Pending
- 2020-01-10 TW TW109100924A patent/TWI840489B/zh not_active IP Right Cessation
- 2020-01-10 BR BR112021012428-4A patent/BR112021012428A2/pt not_active Application Discontinuation
- 2020-01-10 CN CN202411241356.4A patent/CN119409703A/zh active Pending
- 2020-01-10 JP JP2020565216A patent/JP7608166B2/ja active Active
- 2020-01-10 MX MX2021008050A patent/MX2021008050A/es unknown
- 2020-01-10 US US17/422,108 patent/US12227509B2/en active Active
- 2020-01-10 CN CN202080018835.3A patent/CN113557021A/zh active Pending
- 2020-01-10 KR KR1020217023263A patent/KR20210114001A/ko not_active Withdrawn
- 2020-01-10 AU AU2020207716A patent/AU2020207716A1/en not_active Abandoned
- 2020-01-10 EP EP20739159.0A patent/EP3909583A4/en active Pending
- 2020-01-10 WO PCT/JP2020/000553 patent/WO2020145369A1/ja not_active Ceased
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