JPWO2020102820A5 - - Google Patents
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- Publication number
- JPWO2020102820A5 JPWO2020102820A5 JP2021526521A JP2021526521A JPWO2020102820A5 JP WO2020102820 A5 JPWO2020102820 A5 JP WO2020102820A5 JP 2021526521 A JP2021526521 A JP 2021526521A JP 2021526521 A JP2021526521 A JP 2021526521A JP WO2020102820 A5 JPWO2020102820 A5 JP WO2020102820A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- group
- moiety
- tacn
- anionic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- ITWBWJFEJCHKSN-UHFFFAOYSA-N 1,4,7-triazonane Chemical compound C1CNCCNCCN1 ITWBWJFEJCHKSN-UHFFFAOYSA-N 0.000 claims 14
- 125000000129 anionic group Chemical group 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 6
- -1 Fe(III) cation Chemical class 0.000 claims 5
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 1
- 150000002170 ethers Chemical class 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims 1
- 150000002678 macrocyclic compounds Chemical class 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024163405A JP2024178308A (ja) | 2018-11-16 | 2024-09-20 | アニオン性ペンダントおよび補助基を含む、鉄（ｉｉｉ）ｍｒｉ造影剤として使用するための化合物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862768823P | 2018-11-16 | 2018-11-16 | |
| US62/768,823 | 2018-11-16 | ||
| PCT/US2019/062077 WO2020102820A1 (en) | 2018-11-16 | 2019-11-18 | Compounds for use as iron (iii) mri contrast agents containing anionic pendents and ancillary groups |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024163405A Division JP2024178308A (ja) | 2018-11-16 | 2024-09-20 | アニオン性ペンダントおよび補助基を含む、鉄（ｉｉｉ）ｍｒｉ造影剤として使用するための化合物 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022507519A JP2022507519A (ja) | 2022-01-18 |
| JP2022507519A5 JP2022507519A5 (https=) | 2022-09-29 |
| JPWO2020102820A5 true JPWO2020102820A5 (https=) | 2022-09-29 |
| JP7582942B2 JP7582942B2 (ja) | 2024-11-13 |
Family
ID=70730921
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021526521A Active JP7582942B2 (ja) | 2018-11-16 | 2019-11-18 | アニオン性ペンダントおよび補助基を含む、鉄（ｉｉｉ）ｍｒｉ造影剤として使用するための化合物 |
| JP2024163405A Pending JP2024178308A (ja) | 2018-11-16 | 2024-09-20 | アニオン性ペンダントおよび補助基を含む、鉄（ｉｉｉ）ｍｒｉ造影剤として使用するための化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024163405A Pending JP2024178308A (ja) | 2018-11-16 | 2024-09-20 | アニオン性ペンダントおよび補助基を含む、鉄（ｉｉｉ）ｍｒｉ造影剤として使用するための化合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11344635B2 (https=) |
| EP (1) | EP3880257A4 (https=) |
| JP (2) | JP7582942B2 (https=) |
| KR (1) | KR20210114932A (https=) |
| CN (1) | CN113646009A (https=) |
| AU (1) | AU2019381793B2 (https=) |
| WO (1) | WO2020102820A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2019381793B2 (en) * | 2018-11-16 | 2025-02-27 | The Research Foundation For The State University Of New York | Compounds for use as iron (III) MRI contrast agents containing anionic pendents and ancillary groups |
| US20240228524A1 (en) * | 2021-03-20 | 2024-07-11 | The Research Foundation For The State University Of New York | Iron(iii) macrocyclic complexes with mixed hyroxyl pendants as mri contrast agents |
| WO2024097160A1 (en) * | 2022-10-31 | 2024-05-10 | Yale University | Transition metal complexes for mri applications and methods of use |
| CN121698848A (zh) * | 2026-02-09 | 2026-03-20 | 浙江大学衢州研究院 | 一种具有三氮杂环壬烷大环骨架的铁配合物及其制备方法和应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2091251T3 (es) * | 1989-11-27 | 1996-11-01 | Concat Ltd | Perfeccionamiento de la imagen en la mri del hueso y del tejido emparentado utilizando complejos de cationes paramagneticos y ligandos polifosfonato. |
| US5236695A (en) | 1989-11-27 | 1993-08-17 | Concat, Ltd. | MRI image enhancement of bone and related tissue using complexes of paramagnetic cations and polyphosphonate ligands |
| US5409689A (en) | 1993-08-13 | 1995-04-25 | Concat, Ltd. | MRI image enhancement using complexes of paramagnetic cations and amine ligands containing a mixture of phosphonate and non-phosphonate pendant arms |
| EP0955044B1 (en) * | 1995-06-26 | 2005-11-16 | Chelator LLC | Method of inhibiting bacterial or fungal growth using a complexing agent |
| US6264966B1 (en) | 2000-02-22 | 2001-07-24 | Concat, Ltd. | Compounds with chelation affinity and selectivity for first transition elements and their use in cosmetics and personal care products, inhibition of metalloenzymes, and inhibition of reperfusion injury |
| US20050112066A1 (en) | 2003-11-26 | 2005-05-26 | Concat Lp, A California Limited Partnership | Complexes of cyclic polyaza chelators with cations of alkaline earth metals for enhanced biological activity |
| WO2012027727A2 (en) * | 2010-08-26 | 2012-03-01 | Kunyuan Cui | Lipomacrocycles and uses thereof |
| WO2013060793A1 (en) | 2011-10-25 | 2013-05-02 | Technische Universität München | Bifunctional ligands for radiometals |
| US10960088B2 (en) * | 2013-09-12 | 2021-03-30 | The Research Foundation For The State University Of New York | Macrocycles, cobalt and iron complexes of same, and methods of making and using same |
| CN104119402B (zh) | 2014-08-01 | 2016-08-24 | 南京大学 | 具有单分子磁行为和荧光精细结构的有机膦酸镝配合物 |
| EP3624859A4 (en) * | 2017-05-19 | 2021-03-03 | The Research Foundation for The State University of New York | Compounds for use as iron(iii) mri contrast agents |
| AU2019381793B2 (en) * | 2018-11-16 | 2025-02-27 | The Research Foundation For The State University Of New York | Compounds for use as iron (III) MRI contrast agents containing anionic pendents and ancillary groups |
-
2019
- 2019-11-18 AU AU2019381793A patent/AU2019381793B2/en active Active
- 2019-11-18 US US16/973,349 patent/US11344635B2/en active Active
- 2019-11-18 EP EP19884487.0A patent/EP3880257A4/en active Pending
- 2019-11-18 WO PCT/US2019/062077 patent/WO2020102820A1/en not_active Ceased
- 2019-11-18 KR KR1020217017914A patent/KR20210114932A/ko not_active Ceased
- 2019-11-18 JP JP2021526521A patent/JP7582942B2/ja active Active
- 2019-11-18 CN CN201980089289.XA patent/CN113646009A/zh active Pending
-
2024
- 2024-09-20 JP JP2024163405A patent/JP2024178308A/ja active Pending
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