AU2019381793B2 - Compounds for use as iron (III) MRI contrast agents containing anionic pendents and ancillary groups - Google Patents

Compounds for use as iron (III) MRI contrast agents containing anionic pendents and ancillary groups Download PDF

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Publication number
AU2019381793B2
AU2019381793B2 AU2019381793A AU2019381793A AU2019381793B2 AU 2019381793 B2 AU2019381793 B2 AU 2019381793B2 AU 2019381793 A AU2019381793 A AU 2019381793A AU 2019381793 A AU2019381793 A AU 2019381793A AU 2019381793 B2 AU2019381793 B2 AU 2019381793B2
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Australia
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substituted
group
iii
pendent
macrocyclic
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AU2019381793A1 (en
Inventor
Didar ASIK
Elizabeth A. KRAS
Zuiru LIN
Janet R. Morrow
Eric M. SNYDER
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Research Foundation of the State University of New York
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Research Foundation of the State University of New York
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F19/00—Metal compounds according to more than one of main groups C07F1/00 - C07F17/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
    • C07D255/02—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/02—Iron compounds
    • C07F15/025—Iron compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2019381793A 2018-11-16 2019-11-18 Compounds for use as iron (III) MRI contrast agents containing anionic pendents and ancillary groups Active AU2019381793B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862768823P 2018-11-16 2018-11-16
US62/768,823 2018-11-16
PCT/US2019/062077 WO2020102820A1 (en) 2018-11-16 2019-11-18 Compounds for use as iron (iii) mri contrast agents containing anionic pendents and ancillary groups

Publications (2)

Publication Number Publication Date
AU2019381793A1 AU2019381793A1 (en) 2021-06-24
AU2019381793B2 true AU2019381793B2 (en) 2025-02-27

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AU2019381793A Active AU2019381793B2 (en) 2018-11-16 2019-11-18 Compounds for use as iron (III) MRI contrast agents containing anionic pendents and ancillary groups

Country Status (7)

Country Link
US (1) US11344635B2 (https=)
EP (1) EP3880257A4 (https=)
JP (2) JP7582942B2 (https=)
KR (1) KR20210114932A (https=)
CN (1) CN113646009A (https=)
AU (1) AU2019381793B2 (https=)
WO (1) WO2020102820A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2019381793B2 (en) * 2018-11-16 2025-02-27 The Research Foundation For The State University Of New York Compounds for use as iron (III) MRI contrast agents containing anionic pendents and ancillary groups
US20240228524A1 (en) * 2021-03-20 2024-07-11 The Research Foundation For The State University Of New York Iron(iii) macrocyclic complexes with mixed hyroxyl pendants as mri contrast agents
WO2024097160A1 (en) * 2022-10-31 2024-05-10 Yale University Transition metal complexes for mri applications and methods of use
CN121698848A (zh) * 2026-02-09 2026-03-20 浙江大学衢州研究院 一种具有三氮杂环壬烷大环骨架的铁配合物及其制备方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997001360A2 (en) * 1995-06-26 1997-01-16 Concat, Ltd. Compounds with chelation affinity and selectivity for first transition series elements and their use in medical therapy and diagnosis
WO2015038943A1 (en) * 2013-09-12 2015-03-19 The Research Foundation For The State University Of New York University At Buffalo Macrocycles, cobalt and iron complexes of same, and methods of making and using same
WO2018213853A1 (en) * 2017-05-19 2018-11-22 The Research Foundation For The State University Of New York Compounds for use as iron(iii) mri contrast agents

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2091251T3 (es) * 1989-11-27 1996-11-01 Concat Ltd Perfeccionamiento de la imagen en la mri del hueso y del tejido emparentado utilizando complejos de cationes paramagneticos y ligandos polifosfonato.
US5236695A (en) 1989-11-27 1993-08-17 Concat, Ltd. MRI image enhancement of bone and related tissue using complexes of paramagnetic cations and polyphosphonate ligands
US5409689A (en) 1993-08-13 1995-04-25 Concat, Ltd. MRI image enhancement using complexes of paramagnetic cations and amine ligands containing a mixture of phosphonate and non-phosphonate pendant arms
US6264966B1 (en) 2000-02-22 2001-07-24 Concat, Ltd. Compounds with chelation affinity and selectivity for first transition elements and their use in cosmetics and personal care products, inhibition of metalloenzymes, and inhibition of reperfusion injury
US20050112066A1 (en) 2003-11-26 2005-05-26 Concat Lp, A California Limited Partnership Complexes of cyclic polyaza chelators with cations of alkaline earth metals for enhanced biological activity
WO2012027727A2 (en) * 2010-08-26 2012-03-01 Kunyuan Cui Lipomacrocycles and uses thereof
WO2013060793A1 (en) 2011-10-25 2013-05-02 Technische Universität München Bifunctional ligands for radiometals
CN104119402B (zh) 2014-08-01 2016-08-24 南京大学 具有单分子磁行为和荧光精细结构的有机膦酸镝配合物
AU2019381793B2 (en) * 2018-11-16 2025-02-27 The Research Foundation For The State University Of New York Compounds for use as iron (III) MRI contrast agents containing anionic pendents and ancillary groups

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997001360A2 (en) * 1995-06-26 1997-01-16 Concat, Ltd. Compounds with chelation affinity and selectivity for first transition series elements and their use in medical therapy and diagnosis
WO2015038943A1 (en) * 2013-09-12 2015-03-19 The Research Foundation For The State University Of New York University At Buffalo Macrocycles, cobalt and iron complexes of same, and methods of making and using same
WO2018213853A1 (en) * 2017-05-19 2018-11-22 The Research Foundation For The State University Of New York Compounds for use as iron(iii) mri contrast agents

Also Published As

Publication number Publication date
JP2022507519A (ja) 2022-01-18
AU2019381793A1 (en) 2021-06-24
WO2020102820A1 (en) 2020-05-22
CN113646009A (zh) 2021-11-12
JP7582942B2 (ja) 2024-11-13
JP2024178308A (ja) 2024-12-24
KR20210114932A (ko) 2021-09-24
US20210260222A1 (en) 2021-08-26
EP3880257A4 (en) 2022-07-27
US11344635B2 (en) 2022-05-31
EP3880257A1 (en) 2021-09-22

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