KR20210114932A - 음이온 펜던트 및 보조기를 함유하는 철 (iii) mri 조영제로 사용하기 위한 화합물 - Google Patents

음이온 펜던트 및 보조기를 함유하는 철 (iii) mri 조영제로 사용하기 위한 화합물 Download PDF

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KR20210114932A
KR20210114932A KR1020217017914A KR20217017914A KR20210114932A KR 20210114932 A KR20210114932 A KR 20210114932A KR 1020217017914 A KR1020217017914 A KR 1020217017914A KR 20217017914 A KR20217017914 A KR 20217017914A KR 20210114932 A KR20210114932 A KR 20210114932A
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pendant
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자넷 알. 모로우
주이루 린
디다르 아시크
에릭 엠. 스나이더
엘리자베스 에이. 크라스
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더 리서치 파운데이션 포 더 스테이트 유니버시티 오브 뉴욕
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Publication of KR20210114932A publication Critical patent/KR20210114932A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F19/00—Metal compounds according to more than one of main groups C07F1/00 - C07F17/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
    • C07D255/02—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/02—Iron compounds
    • C07F15/025—Iron compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020217017914A 2018-11-16 2019-11-18 음이온 펜던트 및 보조기를 함유하는 철 (iii) mri 조영제로 사용하기 위한 화합물 Ceased KR20210114932A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862768823P 2018-11-16 2018-11-16
US62/768,823 2018-11-16
PCT/US2019/062077 WO2020102820A1 (en) 2018-11-16 2019-11-18 Compounds for use as iron (iii) mri contrast agents containing anionic pendents and ancillary groups

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KR20210114932A true KR20210114932A (ko) 2021-09-24

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Country Link
US (1) US11344635B2 (https=)
EP (1) EP3880257A4 (https=)
JP (2) JP7582942B2 (https=)
KR (1) KR20210114932A (https=)
CN (1) CN113646009A (https=)
AU (1) AU2019381793B2 (https=)
WO (1) WO2020102820A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2019381793B2 (en) * 2018-11-16 2025-02-27 The Research Foundation For The State University Of New York Compounds for use as iron (III) MRI contrast agents containing anionic pendents and ancillary groups
US20240228524A1 (en) * 2021-03-20 2024-07-11 The Research Foundation For The State University Of New York Iron(iii) macrocyclic complexes with mixed hyroxyl pendants as mri contrast agents
WO2024097160A1 (en) * 2022-10-31 2024-05-10 Yale University Transition metal complexes for mri applications and methods of use
CN121698848A (zh) * 2026-02-09 2026-03-20 浙江大学衢州研究院 一种具有三氮杂环壬烷大环骨架的铁配合物及其制备方法和应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2091251T3 (es) * 1989-11-27 1996-11-01 Concat Ltd Perfeccionamiento de la imagen en la mri del hueso y del tejido emparentado utilizando complejos de cationes paramagneticos y ligandos polifosfonato.
US5236695A (en) 1989-11-27 1993-08-17 Concat, Ltd. MRI image enhancement of bone and related tissue using complexes of paramagnetic cations and polyphosphonate ligands
US5409689A (en) 1993-08-13 1995-04-25 Concat, Ltd. MRI image enhancement using complexes of paramagnetic cations and amine ligands containing a mixture of phosphonate and non-phosphonate pendant arms
EP0955044B1 (en) * 1995-06-26 2005-11-16 Chelator LLC Method of inhibiting bacterial or fungal growth using a complexing agent
US6264966B1 (en) 2000-02-22 2001-07-24 Concat, Ltd. Compounds with chelation affinity and selectivity for first transition elements and their use in cosmetics and personal care products, inhibition of metalloenzymes, and inhibition of reperfusion injury
US20050112066A1 (en) 2003-11-26 2005-05-26 Concat Lp, A California Limited Partnership Complexes of cyclic polyaza chelators with cations of alkaline earth metals for enhanced biological activity
WO2012027727A2 (en) * 2010-08-26 2012-03-01 Kunyuan Cui Lipomacrocycles and uses thereof
WO2013060793A1 (en) 2011-10-25 2013-05-02 Technische Universität München Bifunctional ligands for radiometals
US10960088B2 (en) * 2013-09-12 2021-03-30 The Research Foundation For The State University Of New York Macrocycles, cobalt and iron complexes of same, and methods of making and using same
CN104119402B (zh) 2014-08-01 2016-08-24 南京大学 具有单分子磁行为和荧光精细结构的有机膦酸镝配合物
EP3624859A4 (en) * 2017-05-19 2021-03-03 The Research Foundation for The State University of New York Compounds for use as iron(iii) mri contrast agents
AU2019381793B2 (en) * 2018-11-16 2025-02-27 The Research Foundation For The State University Of New York Compounds for use as iron (III) MRI contrast agents containing anionic pendents and ancillary groups

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JP2022507519A (ja) 2022-01-18
AU2019381793A1 (en) 2021-06-24
WO2020102820A1 (en) 2020-05-22
CN113646009A (zh) 2021-11-12
AU2019381793B2 (en) 2025-02-27
JP7582942B2 (ja) 2024-11-13
JP2024178308A (ja) 2024-12-24
US20210260222A1 (en) 2021-08-26
EP3880257A4 (en) 2022-07-27
US11344635B2 (en) 2022-05-31
EP3880257A1 (en) 2021-09-22

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