JPWO2020098968A5 - - Google Patents
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- Publication number
- JPWO2020098968A5 JPWO2020098968A5 JP2021525070A JP2021525070A JPWO2020098968A5 JP WO2020098968 A5 JPWO2020098968 A5 JP WO2020098968A5 JP 2021525070 A JP2021525070 A JP 2021525070A JP 2021525070 A JP2021525070 A JP 2021525070A JP WO2020098968 A5 JPWO2020098968 A5 JP WO2020098968A5
- Authority
- JP
- Japan
- Prior art keywords
- absent
- nucleic acid
- acid molecule
- nucleotides
- cxcl8
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000523 sample Substances 0.000 claims 21
- 239000002773 nucleotide Substances 0.000 claims 19
- 125000003729 nucleotide group Chemical group 0.000 claims 19
- 102100006847 CXCL8 Human genes 0.000 claims 17
- 101710026285 CXCL8 Proteins 0.000 claims 17
- XKTZWUACRZHVAN-VADRZIEHSA-N Interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 claims 17
- 238000001514 detection method Methods 0.000 claims 9
- 229920001850 Nucleic acid sequence Polymers 0.000 claims 5
- 230000003042 antagnostic Effects 0.000 claims 5
- 239000005557 antagonist Substances 0.000 claims 5
- 230000000694 effects Effects 0.000 claims 5
- 230000001404 mediated Effects 0.000 claims 5
- 239000002202 Polyethylene glycol Substances 0.000 claims 3
- 230000000295 complement Effects 0.000 claims 3
- 239000000032 diagnostic agent Substances 0.000 claims 3
- 229920001223 polyethylene glycol Polymers 0.000 claims 3
- 230000036081 Excretion rate Effects 0.000 claims 2
- 238000006065 biodegradation reaction Methods 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 230000014759 maintenance of location Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 claims 1
- 229940039227 DIAGNOSTIC AGENTS Drugs 0.000 claims 1
- 229920001612 Hydroxyethyl starch Polymers 0.000 claims 1
- 229940074730 OPHTHAMOLOGIC DIAGNOSTIC AGENTS Drugs 0.000 claims 1
- 229920001451 Polypropylene glycol Polymers 0.000 claims 1
- 229920001914 Ribonucleotide Polymers 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 230000003247 decreasing Effects 0.000 claims 1
- 238000010790 dilution Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 150000004676 glycans Polymers 0.000 claims 1
- 229940050526 hydroxyethylstarch Drugs 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 238000006011 modification reaction Methods 0.000 claims 1
- 239000000546 pharmaceutic aid Substances 0.000 claims 1
- -1 polyoxypropylenes Polymers 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 150000004804 polysaccharides Polymers 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 239000002336 ribonucleotide Substances 0.000 claims 1
- 125000002652 ribonucleotide group Chemical group 0.000 claims 1
- 150000003432 sterols Chemical class 0.000 claims 1
- 235000003702 sterols Nutrition 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18205750 | 2018-11-12 | ||
| EP18205750.5 | 2018-11-12 | ||
| PCT/EP2019/000312 WO2020098968A1 (en) | 2018-11-12 | 2019-11-12 | Cxcl8 binding nucleic acids |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022512969A JP2022512969A (ja) | 2022-02-07 |
| JPWO2020098968A5 true JPWO2020098968A5 (ko) | 2022-11-18 |
Family
ID=64308548
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021525070A Pending JP2022512969A (ja) | 2018-11-12 | 2019-11-12 | Ｃｘｃｌ８結合核酸 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20210403913A1 (ko) |
| EP (1) | EP3880822A1 (ko) |
| JP (1) | JP2022512969A (ko) |
| KR (1) | KR20210113173A (ko) |
| CN (1) | CN113383079A (ko) |
| AU (1) | AU2019378732A1 (ko) |
| BR (1) | BR112021007724A2 (ko) |
| CA (1) | CA3119357A1 (ko) |
| IL (1) | IL282494A (ko) |
| MX (1) | MX2021005525A (ko) |
| SG (1) | SG11202104432YA (ko) |
| WO (1) | WO2020098968A1 (ko) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104136612A (zh) * | 2012-01-10 | 2014-11-05 | 诺松制药股份公司 | 特异性结合cgrp的核酸 |
| KR102034203B1 (ko) * | 2012-01-10 | 2019-10-18 | 아프타리온 바이오테크 아게 | 새로운 C5a 결합 핵산 |
| KR101458947B1 (ko) * | 2013-03-05 | 2014-11-12 | 국립암센터 | 인터루킨-８ 앱타머 및 이의 용도 |
| WO2015169811A2 (en) * | 2014-05-06 | 2015-11-12 | Medimmune Limited | Anti-cxc chemokine receptor-2 binding molecules and uses thereof |
| FI20165814A (fi) * | 2016-10-27 | 2018-04-28 | Tilt Biotherapeutics Oy | Interleukiini 8 (il-8) prognostisena ja ennustavana biomarkkerina ja koostumukset ja vektorit käytettäväksi onkolyyttisessa immunoterapiassa |
| BR112019015244A2 (pt) * | 2017-03-24 | 2020-04-14 | Curevac Ag | ácidos nucleicos codificando proteínas associadas a crispr e usos dos mesmos |
-
2019
- 2019-11-12 SG SG11202104432YA patent/SG11202104432YA/en unknown
- 2019-11-12 BR BR112021007724-3A patent/BR112021007724A2/pt unknown
- 2019-11-12 AU AU2019378732A patent/AU2019378732A1/en not_active Abandoned
- 2019-11-12 CA CA3119357A patent/CA3119357A1/en active Pending
- 2019-11-12 JP JP2021525070A patent/JP2022512969A/ja active Pending
- 2019-11-12 WO PCT/EP2019/000312 patent/WO2020098968A1/en unknown
- 2019-11-12 CN CN201980074218.2A patent/CN113383079A/zh active Pending
- 2019-11-12 MX MX2021005525A patent/MX2021005525A/es unknown
- 2019-11-12 KR KR1020217017560A patent/KR20210113173A/ko unknown
- 2019-11-12 EP EP19809699.2A patent/EP3880822A1/en active Pending
- 2019-11-12 US US17/293,065 patent/US20210403913A1/en active Pending
-
2021
- 2021-04-20 IL IL282494A patent/IL282494A/en unknown
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