JPWO2020081522A5 - - Google Patents
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- JPWO2020081522A5 JPWO2020081522A5 JP2021521113A JP2021521113A JPWO2020081522A5 JP WO2020081522 A5 JPWO2020081522 A5 JP WO2020081522A5 JP 2021521113 A JP2021521113 A JP 2021521113A JP 2021521113 A JP2021521113 A JP 2021521113A JP WO2020081522 A5 JPWO2020081522 A5 JP WO2020081522A5
- Authority
- JP
- Japan
- Prior art keywords
- conjugate
- present
- alkyl
- fap
- linker
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022164850A JP2022191399A (ja) | 2018-10-17 | 2022-10-13 | 線維症における線維芽細胞活性化タンパク質（ｆａｐ）を標的とする撮像法および治療法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862746822P | 2018-10-17 | 2018-10-17 | |
| US62/746,822 | 2018-10-17 | ||
| US201962861028P | 2019-06-13 | 2019-06-13 | |
| US62/861,028 | 2019-06-13 | ||
| PCT/US2019/056257 WO2020081522A1 (en) | 2018-10-17 | 2019-10-15 | Fibroblast activation protein (fap) targeted imaging and therapy in fibrosis |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022164850A Division JP2022191399A (ja) | 2018-10-17 | 2022-10-13 | 線維症における線維芽細胞活性化タンパク質（ｆａｐ）を標的とする撮像法および治療法 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022505171A JP2022505171A (ja) | 2022-01-14 |
| JP2022505171A5 JP2022505171A5 (https=) | 2022-07-19 |
| JPWO2020081522A5 true JPWO2020081522A5 (https=) | 2022-07-19 |
| JP7161044B2 JP7161044B2 (ja) | 2022-10-25 |
Family
ID=70284116
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021521113A Active JP7161044B2 (ja) | 2018-10-17 | 2019-10-15 | 線維症における線維芽細胞活性化タンパク質（ｆａｐ）を標的とする撮像法および治療法 |
| JP2022164850A Withdrawn JP2022191399A (ja) | 2018-10-17 | 2022-10-13 | 線維症における線維芽細胞活性化タンパク質（ｆａｐ）を標的とする撮像法および治療法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022164850A Withdrawn JP2022191399A (ja) | 2018-10-17 | 2022-10-13 | 線維症における線維芽細胞活性化タンパク質（ｆａｐ）を標的とする撮像法および治療法 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US11426472B2 (https=) |
| EP (1) | EP3867648A4 (https=) |
| JP (2) | JP7161044B2 (https=) |
| CN (1) | CN112912731A (https=) |
| AU (2) | AU2019360944B2 (https=) |
| CA (1) | CA3116313A1 (https=) |
| WO (1) | WO2020081522A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116474108A (zh) | 2016-12-14 | 2023-07-25 | 普渡研究基金会 | 成纤维细胞活化蛋白(fap)-靶向成像和治疗 |
| US11426472B2 (en) | 2018-10-17 | 2022-08-30 | Purdue Research Foundation | Fibroblast activation protein (FAP) targeted imaging and therapy in fibrosis |
| WO2021155292A1 (en) * | 2020-01-31 | 2021-08-05 | Philip Stewart Low | Fibroblast activation protein (fap) - targeted antifibrotic therapy |
| CN115697413B (zh) * | 2020-03-24 | 2025-08-01 | 塔夫茨大学信托人 | 靶向fap的放射性药物和显像剂以及与之相关的用途 |
| EP4132921A4 (en) * | 2020-04-09 | 2024-03-27 | Purdue Research Foundation | Pi3 kinase inhibitors and uses thereof |
| CA3176497A1 (en) | 2020-05-07 | 2021-11-11 | Fatima MECHTA-GRIGORIOU | Antxr1 as a biomarker of immunosuppressive fibroblast populations and its use for predicting response to immunotherapy |
| JP2024506644A (ja) * | 2021-02-12 | 2024-02-14 | フィロケム・アーゲー | 標的送達に適用するための二価線維芽細胞活性化タンパク質リガンド |
| US20240238458A1 (en) * | 2021-03-16 | 2024-07-18 | Purdue Research Foundation | Compounds targeting fibroblast-activation protein and methods of use thereof |
| CN114591395B (zh) * | 2021-05-26 | 2023-10-31 | 南方医科大学南方医院 | 一种双配体化合物及其制备方法和应用 |
| CN113880810B (zh) * | 2021-09-24 | 2023-02-28 | 厦门大学 | 一种核素标记的配合物及其制备方法和应用 |
| CN115368342B (zh) * | 2022-08-24 | 2024-01-23 | 西南医科大学附属医院 | 成纤维细胞活性蛋白抑制剂、其放射性核素标记物及制备方法和应用 |
| WO2024102956A1 (en) * | 2022-11-09 | 2024-05-16 | Purdue Research Foundation | Keto-amide-based fibroblast activation protein-targeted ligand linked to an imaging or therapeutic agent, compositions and methods of use |
| JP2026508513A (ja) * | 2023-03-03 | 2026-03-11 | 晶核生物医薬科技（南京）有限公司 | 窒素含有複素環系化合物およびその製造方法と使用 |
| CN121752300A (zh) | 2023-08-31 | 2026-03-27 | 荷兰拉德堡德大学学术医学中心 | 子宫内膜异位症示踪剂 |
| WO2025102002A1 (en) * | 2023-11-10 | 2025-05-15 | Purdue Research Foundation | Keto-amide-based fibroblast activation protein-targeted ligand linked to a pi3k inhibitor, compositions and methods of use |
| WO2025240868A1 (en) * | 2024-05-16 | 2025-11-20 | Purdue Research Foundation | Method of using chemically stable keto-amide fibroblast activation protein-targeted conjugates and compositions comprising same to treat fibrosis |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5599783B2 (ja) * | 2008-05-30 | 2014-10-01 | アムジエン・インコーポレーテツド | Ｐｉ３キナーゼの阻害薬 |
| US9295673B2 (en) * | 2011-02-23 | 2016-03-29 | Intellikine Llc | Combination of mTOR inhibitors and P13-kinase inhibitors, and uses thereof |
| WO2013107820A1 (en) | 2012-01-17 | 2013-07-25 | Universiteit Antwerpen | Novel fap inhibitors |
| US20150320892A1 (en) * | 2012-06-29 | 2015-11-12 | Ge Healthcare Limited | Imaging fibrosis |
| CN103788071A (zh) * | 2012-11-01 | 2014-05-14 | 中国人民解放军第二军医大学 | N-(5-(喹啉-6-基)吡啶-3-基)苯磺酰胺衍生物、制备方法及治疗用途 |
| JP6744826B2 (ja) * | 2014-06-13 | 2020-08-19 | バック バイオサイエンシーズ, エルエルシーBach BioSciences, LLC | Ｆａｐ活性化治療剤及びそれに関連する使用 |
| US10806806B2 (en) | 2016-06-23 | 2020-10-20 | Cornell University | Trifunctional constructs with tunable pharmacokinetics useful in imaging and anti-tumor therapies |
| CN116474108A (zh) | 2016-12-14 | 2023-07-25 | 普渡研究基金会 | 成纤维细胞活化蛋白(fap)-靶向成像和治疗 |
| IL315062A (en) | 2017-04-05 | 2024-10-01 | Univ Cornell | Trifunctional constructs with tunable pharmacokinetics useful in imaging and anti-tumor therapies |
| EA202090776A1 (ru) | 2017-10-23 | 2020-07-27 | Дзе Джонс Хопкинс Юниверсити | Визуализирующие и радиотерапевтические агенты, нацеленные на фибробласт-активирующий белок-альфа (fapalpha) |
| US11426472B2 (en) | 2018-10-17 | 2022-08-30 | Purdue Research Foundation | Fibroblast activation protein (FAP) targeted imaging and therapy in fibrosis |
| EP4132921A4 (en) * | 2020-04-09 | 2024-03-27 | Purdue Research Foundation | Pi3 kinase inhibitors and uses thereof |
-
2019
- 2019-10-15 US US17/285,717 patent/US11426472B2/en active Active
- 2019-10-15 JP JP2021521113A patent/JP7161044B2/ja active Active
- 2019-10-15 CA CA3116313A patent/CA3116313A1/en active Pending
- 2019-10-15 WO PCT/US2019/056257 patent/WO2020081522A1/en not_active Ceased
- 2019-10-15 AU AU2019360944A patent/AU2019360944B2/en not_active Ceased
- 2019-10-15 EP EP19874435.1A patent/EP3867648A4/en active Pending
- 2019-10-15 CN CN201980068239.3A patent/CN112912731A/zh active Pending
-
2022
- 2022-06-29 US US17/809,810 patent/US11890357B2/en active Active
- 2022-08-30 AU AU2022224743A patent/AU2022224743A1/en not_active Abandoned
- 2022-10-13 JP JP2022164850A patent/JP2022191399A/ja not_active Withdrawn
-
2023
- 2023-12-22 US US18/395,366 patent/US20240165279A1/en not_active Abandoned
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