JP2022505171A5 - - Google Patents
Info
- Publication number
- JP2022505171A5 JP2022505171A5 JP2021521113A JP2021521113A JP2022505171A5 JP 2022505171 A5 JP2022505171 A5 JP 2022505171A5 JP 2021521113 A JP2021521113 A JP 2021521113A JP 2021521113 A JP2021521113 A JP 2021521113A JP 2022505171 A5 JP2022505171 A5 JP 2022505171A5
- Authority
- JP
- Japan
- Prior art keywords
- present
- conjugate
- fap
- linker
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022164850A JP2022191399A (ja) | 2018-10-17 | 2022-10-13 | 線維症における線維芽細胞活性化タンパク質（ｆａｐ）を標的とする撮像法および治療法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862746822P | 2018-10-17 | 2018-10-17 | |
| US62/746,822 | 2018-10-17 | ||
| US201962861028P | 2019-06-13 | 2019-06-13 | |
| US62/861,028 | 2019-06-13 | ||
| PCT/US2019/056257 WO2020081522A1 (en) | 2018-10-17 | 2019-10-15 | Fibroblast activation protein (fap) targeted imaging and therapy in fibrosis |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022164850A Division JP2022191399A (ja) | 2018-10-17 | 2022-10-13 | 線維症における線維芽細胞活性化タンパク質（ｆａｐ）を標的とする撮像法および治療法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022505171A JP2022505171A (ja) | 2022-01-14 |
| JP2022505171A5 true JP2022505171A5 (https=) | 2022-07-19 |
| JP7161044B2 JP7161044B2 (ja) | 2022-10-25 |
Family
ID=70284116
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021521113A Active JP7161044B2 (ja) | 2018-10-17 | 2019-10-15 | 線維症における線維芽細胞活性化タンパク質（ｆａｐ）を標的とする撮像法および治療法 |
| JP2022164850A Withdrawn JP2022191399A (ja) | 2018-10-17 | 2022-10-13 | 線維症における線維芽細胞活性化タンパク質（ｆａｐ）を標的とする撮像法および治療法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022164850A Withdrawn JP2022191399A (ja) | 2018-10-17 | 2022-10-13 | 線維症における線維芽細胞活性化タンパク質（ｆａｐ）を標的とする撮像法および治療法 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US11426472B2 (https=) |
| EP (1) | EP3867648A4 (https=) |
| JP (2) | JP7161044B2 (https=) |
| CN (1) | CN112912731A (https=) |
| AU (2) | AU2019360944B2 (https=) |
| CA (1) | CA3116313A1 (https=) |
| WO (1) | WO2020081522A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116474108A (zh) | 2016-12-14 | 2023-07-25 | 普渡研究基金会 | 成纤维细胞活化蛋白(fap)-靶向成像和治疗 |
| US11426472B2 (en) | 2018-10-17 | 2022-08-30 | Purdue Research Foundation | Fibroblast activation protein (FAP) targeted imaging and therapy in fibrosis |
| EP4096677A4 (en) * | 2020-01-31 | 2024-02-28 | Purdue Research Foundation | Fibroblast activation protein (fap) - targeted antifibrotic therapy |
| EP4126053A4 (en) * | 2020-03-24 | 2024-11-20 | Trustees Of Tufts College | IMAGING AGENTS AND RADIOPHARMACEUTICALS TARGETING FAP, AND USES THEREOF |
| WO2021207682A2 (en) * | 2020-04-09 | 2021-10-14 | Philip Stewart Low | Pi3 kinase inhibitors and uses thereof |
| CN115943312A (zh) | 2020-05-07 | 2023-04-07 | 法国居里学院 | 免疫抑制性成纤维细胞群体的生物标志物antxr1及其在预测对免疫疗法的反应中的用途 |
| CA3207999A1 (en) * | 2021-02-12 | 2022-08-18 | Samuele CAZZAMALLI | Bivalent fibroblast activation protein ligands for targeted delivery applications |
| JP2024510267A (ja) * | 2021-03-16 | 2024-03-06 | パーデュー・リサーチ・ファウンデーション | 線維芽細胞活性化タンパク質を標的とする化合物、およびその使用方法 |
| CN114591395B (zh) * | 2021-05-26 | 2023-10-31 | 南方医科大学南方医院 | 一种双配体化合物及其制备方法和应用 |
| CN113880810B (zh) * | 2021-09-24 | 2023-02-28 | 厦门大学 | 一种核素标记的配合物及其制备方法和应用 |
| CN115368342B (zh) * | 2022-08-24 | 2024-01-23 | 西南医科大学附属医院 | 成纤维细胞活性蛋白抑制剂、其放射性核素标记物及制备方法和应用 |
| WO2024102956A1 (en) * | 2022-11-09 | 2024-05-16 | Purdue Research Foundation | Keto-amide-based fibroblast activation protein-targeted ligand linked to an imaging or therapeutic agent, compositions and methods of use |
| JP2026508513A (ja) * | 2023-03-03 | 2026-03-11 | 晶核生物医薬科技（南京）有限公司 | 窒素含有複素環系化合物およびその製造方法と使用 |
| WO2025046043A1 (en) | 2023-08-31 | 2025-03-06 | Stichting Radboud Universitair Medisch Centrum | Endometriosis tracer |
| WO2025102002A1 (en) * | 2023-11-10 | 2025-05-15 | Purdue Research Foundation | Keto-amide-based fibroblast activation protein-targeted ligand linked to a pi3k inhibitor, compositions and methods of use |
| WO2025240868A1 (en) * | 2024-05-16 | 2025-11-20 | Purdue Research Foundation | Method of using chemically stable keto-amide fibroblast activation protein-targeted conjugates and compositions comprising same to treat fibrosis |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2725014C (en) * | 2008-05-30 | 2014-06-17 | Amgen Inc. | Inhibitors of pi3 kinase |
| US9295673B2 (en) | 2011-02-23 | 2016-03-29 | Intellikine Llc | Combination of mTOR inhibitors and P13-kinase inhibitors, and uses thereof |
| WO2013107820A1 (en) | 2012-01-17 | 2013-07-25 | Universiteit Antwerpen | Novel fap inhibitors |
| US20150320892A1 (en) * | 2012-06-29 | 2015-11-12 | Ge Healthcare Limited | Imaging fibrosis |
| CN103788071A (zh) * | 2012-11-01 | 2014-05-14 | 中国人民解放军第二军医大学 | N-(5-(喹啉-6-基)吡啶-3-基)苯磺酰胺衍生物、制备方法及治疗用途 |
| CN106573073B (zh) | 2014-06-13 | 2021-09-28 | 塔夫茨大学信托人 | Fap激活的治疗剂以及其相关用途 |
| US10806806B2 (en) | 2016-06-23 | 2020-10-20 | Cornell University | Trifunctional constructs with tunable pharmacokinetics useful in imaging and anti-tumor therapies |
| CN116474108A (zh) * | 2016-12-14 | 2023-07-25 | 普渡研究基金会 | 成纤维细胞活化蛋白(fap)-靶向成像和治疗 |
| EP3609541A4 (en) | 2017-04-05 | 2021-04-07 | Cornell University | Trifunctional constructs with tunable pharmacokinetics useful in imaging and anti-tumor therapies |
| EA202090776A1 (ru) | 2017-10-23 | 2020-07-27 | Дзе Джонс Хопкинс Юниверсити | Визуализирующие и радиотерапевтические агенты, нацеленные на фибробласт-активирующий белок-альфа (fapalpha) |
| US11426472B2 (en) | 2018-10-17 | 2022-08-30 | Purdue Research Foundation | Fibroblast activation protein (FAP) targeted imaging and therapy in fibrosis |
| WO2021207682A2 (en) * | 2020-04-09 | 2021-10-14 | Philip Stewart Low | Pi3 kinase inhibitors and uses thereof |
-
2019
- 2019-10-15 US US17/285,717 patent/US11426472B2/en active Active
- 2019-10-15 AU AU2019360944A patent/AU2019360944B2/en not_active Ceased
- 2019-10-15 CN CN201980068239.3A patent/CN112912731A/zh active Pending
- 2019-10-15 CA CA3116313A patent/CA3116313A1/en active Pending
- 2019-10-15 WO PCT/US2019/056257 patent/WO2020081522A1/en not_active Ceased
- 2019-10-15 JP JP2021521113A patent/JP7161044B2/ja active Active
- 2019-10-15 EP EP19874435.1A patent/EP3867648A4/en active Pending
-
2022
- 2022-06-29 US US17/809,810 patent/US11890357B2/en active Active
- 2022-08-30 AU AU2022224743A patent/AU2022224743A1/en not_active Abandoned
- 2022-10-13 JP JP2022164850A patent/JP2022191399A/ja not_active Withdrawn
-
2023
- 2023-12-22 US US18/395,366 patent/US20240165279A1/en not_active Abandoned
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