JP7161044B2 - 線維症における線維芽細胞活性化タンパク質（ｆａｐ）を標的とする撮像法および治療法 - Google Patents

線維症における線維芽細胞活性化タンパク質（ｆａｐ）を標的とする撮像法および治療法 Download PDF

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JP7161044B2
JP7161044B2 JP2021521113A JP2021521113A JP7161044B2 JP 7161044 B2 JP7161044 B2 JP 7161044B2 JP 2021521113 A JP2021521113 A JP 2021521113A JP 2021521113 A JP2021521113 A JP 2021521113A JP 7161044 B2 JP7161044 B2 JP 7161044B2
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fap
ipf
conjugate
fapl
fibrosis
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JP2022505171A5 (https=
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フィリップ エス． ロウ
スラジ ユー． ヘッティアラクチ
イェン－シン リ
ジョティ ロイ
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JP2021521113A 2018-10-17 2019-10-15 線維症における線維芽細胞活性化タンパク質（ｆａｐ）を標的とする撮像法および治療法 Active JP7161044B2 (ja)

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US201862746822P 2018-10-17 2018-10-17
US62/746,822 2018-10-17
US201962861028P 2019-06-13 2019-06-13
US62/861,028 2019-06-13
PCT/US2019/056257 WO2020081522A1 (en) 2018-10-17 2019-10-15 Fibroblast activation protein (fap) targeted imaging and therapy in fibrosis

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JP2022164850A Withdrawn JP2022191399A (ja) 2018-10-17 2022-10-13 線維症における線維芽細胞活性化タンパク質（ｆａｐ）を標的とする撮像法および治療法

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US11426472B2 (en) 2018-10-17 2022-08-30 Purdue Research Foundation Fibroblast activation protein (FAP) targeted imaging and therapy in fibrosis
WO2021155292A1 (en) * 2020-01-31 2021-08-05 Philip Stewart Low Fibroblast activation protein (fap) - targeted antifibrotic therapy
CN115697413B (zh) * 2020-03-24 2025-08-01 塔夫茨大学信托人 靶向fap的放射性药物和显像剂以及与之相关的用途
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CA3176497A1 (en) 2020-05-07 2021-11-11 Fatima MECHTA-GRIGORIOU Antxr1 as a biomarker of immunosuppressive fibroblast populations and its use for predicting response to immunotherapy
JP2024506644A (ja) * 2021-02-12 2024-02-14 フィロケム・アーゲー 標的送達に適用するための二価線維芽細胞活性化タンパク質リガンド
US20240238458A1 (en) * 2021-03-16 2024-07-18 Purdue Research Foundation Compounds targeting fibroblast-activation protein and methods of use thereof
CN114591395B (zh) * 2021-05-26 2023-10-31 南方医科大学南方医院 一种双配体化合物及其制备方法和应用
CN113880810B (zh) * 2021-09-24 2023-02-28 厦门大学 一种核素标记的配合物及其制备方法和应用
CN115368342B (zh) * 2022-08-24 2024-01-23 西南医科大学附属医院 成纤维细胞活性蛋白抑制剂、其放射性核素标记物及制备方法和应用
WO2024102956A1 (en) * 2022-11-09 2024-05-16 Purdue Research Foundation Keto-amide-based fibroblast activation protein-targeted ligand linked to an imaging or therapeutic agent, compositions and methods of use
JP2026508513A (ja) * 2023-03-03 2026-03-11 晶核生物医薬科技（南京）有限公司 窒素含有複素環系化合物およびその製造方法と使用
CN121752300A (zh) 2023-08-31 2026-03-27 荷兰拉德堡德大学学术医学中心 子宫内膜异位症示踪剂
WO2025102002A1 (en) * 2023-11-10 2025-05-15 Purdue Research Foundation Keto-amide-based fibroblast activation protein-targeted ligand linked to a pi3k inhibitor, compositions and methods of use
WO2025240868A1 (en) * 2024-05-16 2025-11-20 Purdue Research Foundation Method of using chemically stable keto-amide fibroblast activation protein-targeted conjugates and compositions comprising same to treat fibrosis

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