JPWO2020047186A5 - - Google Patents
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- JPWO2020047186A5 JPWO2020047186A5 JP2021510959A JP2021510959A JPWO2020047186A5 JP WO2020047186 A5 JPWO2020047186 A5 JP WO2020047186A5 JP 2021510959 A JP2021510959 A JP 2021510959A JP 2021510959 A JP2021510959 A JP 2021510959A JP WO2020047186 A5 JPWO2020047186 A5 JP WO2020047186A5
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- JP
- Japan
- Prior art keywords
- compound
- substituted
- unsubstituted
- composition
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims description 63
- 238000000034 method Methods 0.000 claims description 30
- 125000000217 alkyl group Chemical group 0.000 claims description 26
- 150000002431 hydrogen Chemical class 0.000 claims description 26
- 229910052739 hydrogen Inorganic materials 0.000 claims description 26
- 239000001257 hydrogen Substances 0.000 claims description 26
- 208000010125 myocardial infarction Diseases 0.000 claims description 26
- 229940002612 prodrug Drugs 0.000 claims description 18
- 239000000651 prodrug Substances 0.000 claims description 18
- 150000003839 salts Chemical class 0.000 claims description 18
- 208000037906 ischaemic injury Diseases 0.000 claims description 16
- 125000003545 alkoxy group Chemical group 0.000 claims description 14
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 14
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 14
- 229910052736 halogen Inorganic materials 0.000 claims description 14
- 150000002367 halogens Chemical class 0.000 claims description 14
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 14
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 14
- 210000003169 central nervous system Anatomy 0.000 claims description 4
- 230000002526 effect on cardiovascular system Effects 0.000 claims description 4
- 230000010412 perfusion Effects 0.000 claims description 4
- 210000004413 cardiac myocyte Anatomy 0.000 claims description 2
- 210000000748 cardiovascular system Anatomy 0.000 claims description 2
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 2
- 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 2
- 125000000640 cyclooctyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 2
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 2
- 206010020871 hypertrophic cardiomyopathy Diseases 0.000 claims description 2
- 230000001737 promoting effect Effects 0.000 claims description 2
- 230000002792 vascular Effects 0.000 claims description 2
- 230000004218 vascular function Effects 0.000 claims description 2
- 230000029663 wound healing Effects 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 21
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024080082A JP7777263B2 (ja) | 2018-08-29 | 2024-05-16 | ステロイド受容体コアクチベーター－３の小分子刺激因子ならびに心臓保護剤及び／または血管再生剤としてのそれらの使用方法 |
| JP2025153392A JP2025183370A (ja) | 2018-08-29 | 2025-09-16 | ステロイド受容体コアクチベーター－３の小分子刺激因子ならびに心臓保護剤及び／または血管再生剤としてのそれらの使用方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862724281P | 2018-08-29 | 2018-08-29 | |
| US62/724,281 | 2018-08-29 | ||
| US201962825358P | 2019-03-28 | 2019-03-28 | |
| US62/825,358 | 2019-03-28 | ||
| PCT/US2019/048703 WO2020047186A1 (en) | 2018-08-29 | 2019-08-29 | Small molecule stimulators of steroid receptor coactivator-3 and methods of their use as cardioprotective and/or vascular regenerative agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024080082A Division JP7777263B2 (ja) | 2018-08-29 | 2024-05-16 | ステロイド受容体コアクチベーター－３の小分子刺激因子ならびに心臓保護剤及び／または血管再生剤としてのそれらの使用方法 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021534221A JP2021534221A (ja) | 2021-12-09 |
| JP2021534221A5 JP2021534221A5 (https=) | 2022-09-02 |
| JPWO2020047186A5 true JPWO2020047186A5 (https=) | 2022-09-02 |
| JP7495138B2 JP7495138B2 (ja) | 2024-06-04 |
Family
ID=67982135
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021510959A Active JP7495138B2 (ja) | 2018-08-29 | 2019-08-29 | ステロイド受容体コアクチベーター－３の小分子刺激因子ならびに心臓保護剤及び／または血管再生剤としてのそれらの使用方法 |
| JP2024080082A Active JP7777263B2 (ja) | 2018-08-29 | 2024-05-16 | ステロイド受容体コアクチベーター－３の小分子刺激因子ならびに心臓保護剤及び／または血管再生剤としてのそれらの使用方法 |
| JP2025153392A Pending JP2025183370A (ja) | 2018-08-29 | 2025-09-16 | ステロイド受容体コアクチベーター－３の小分子刺激因子ならびに心臓保護剤及び／または血管再生剤としてのそれらの使用方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024080082A Active JP7777263B2 (ja) | 2018-08-29 | 2024-05-16 | ステロイド受容体コアクチベーター－３の小分子刺激因子ならびに心臓保護剤及び／または血管再生剤としてのそれらの使用方法 |
| JP2025153392A Pending JP2025183370A (ja) | 2018-08-29 | 2025-09-16 | ステロイド受容体コアクチベーター－３の小分子刺激因子ならびに心臓保護剤及び／または血管再生剤としてのそれらの使用方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US10875841B2 (https=) |
| EP (1) | EP3843843A1 (https=) |
| JP (3) | JP7495138B2 (https=) |
| CN (2) | CN120136844A (https=) |
| AU (2) | AU2019333119B2 (https=) |
| CA (1) | CA3110839A1 (https=) |
| WO (1) | WO2020047186A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN120136844A (zh) * | 2018-08-29 | 2025-06-13 | 贝勒医学院 | 类固醇受体共激活剂-3的小分子刺激剂以及它们用作心脏保护剂和/或血管再生剂的方法 |
| KR20230093329A (ko) | 2020-10-28 | 2023-06-27 | 베이롤 칼리지 오브 메드신 | 암의 치료를 위한 면역조절 치료제로서 면역 세포에서 src-3의 표적화 |
| WO2025240566A1 (en) * | 2024-05-17 | 2025-11-20 | Baylor College Of Medicine | Small molecule steroid receptor coactivator stimulators for use in repairing tissue |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL112205A0 (en) | 1994-01-06 | 1995-03-15 | Res Dev Foundation | Curcumin, analogues of curcumin and novel uses thereof |
| CA2393440A1 (en) | 1999-12-03 | 2001-06-07 | Emory University | Curcumin analogs with anti-tumor and anti-angiogenic properties |
| CA2395191A1 (en) | 1999-12-23 | 2001-06-28 | Tedman Ehlers | Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states |
| US20070010488A1 (en) | 2005-04-13 | 2007-01-11 | Khairia Youssef | Compounds for modulating cell proliferation |
| CN102381951B (zh) | 2007-01-22 | 2013-09-04 | 温州医学院生物与天然药物开发中心有限公司 | 含环己酮的姜黄素单羰基结构类似物及其用途 |
| EP2170311A4 (en) | 2007-05-16 | 2011-10-19 | Avalon Pharmaceuticals | COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING AUTOIMMUNE DISEASES |
| WO2008150899A1 (en) | 2007-05-29 | 2008-12-11 | Emory University | Combination therapies for treatment of cancer and inflammatory diseases |
| US20100197584A1 (en) | 2007-07-27 | 2010-08-05 | Research Foundations of the City University of- New York | Use of curcumin to block brain tumor formation in mice |
| WO2009144220A1 (en) | 2008-05-29 | 2009-12-03 | Universite Libre De Bruxelles | Water soluble curcumin compositions for use in anti-cancer and anti-inflammatory therapy |
| US8420118B2 (en) * | 2009-09-10 | 2013-04-16 | The Board Of Regents Of The University Of Oklahoma | Anionic lipids and lipid nano-structures and methods of producing and using same |
| WO2011029359A1 (zh) | 2009-09-12 | 2011-03-17 | 温州医学院 | 含11β-羟基甾体脱氢酶1双重调节剂的药物及其应用 |
| JP2011074024A (ja) * | 2009-09-30 | 2011-04-14 | Shiseido Co Ltd | ヘパラナーゼ活性阻害剤並びにそれを含有するしわ改善剤及び医薬組成物 |
| WO2011127333A2 (en) | 2010-04-09 | 2011-10-13 | University Of Louisville Research Foundation, Inc. | Compounds for treating disease, for administering, and for pharmaceutical compositions |
| WO2012021692A1 (en) | 2010-08-11 | 2012-02-16 | Rutgers, The State University Of New Jersey | Curcumin analogs and methods of use thereof |
| CN102153508B (zh) * | 2010-10-08 | 2013-01-09 | 福建医科大学 | 3,5-(e)-二亚苄基-n-环丙基哌啶-4-酮及其在制备治疗抗肿瘤药物中的应用 |
| CN103012088B (zh) | 2012-11-28 | 2017-01-11 | 江苏药兴医药股份有限公司 | α-(3,5-二甲氧基苯亚甲基)-α'-烃基亚甲基环酮及其制备方法 |
| ITMI20130075A1 (it) | 2013-01-21 | 2014-07-22 | Altergon Sa | Combinazione orale per la prevenzione e il trattamento di patologie vescicali, pelviche e dell¿apparato uro-genitale |
| CN103181922A (zh) * | 2013-04-02 | 2013-07-03 | 温州医学院 | 一类含哌啶酮的单羰基姜黄素类化合物在制备抗炎药物中的应用 |
| WO2016109470A1 (en) | 2014-12-30 | 2016-07-07 | Baylor College Of Medicine | Small molecule stimulators of steroid receptor coactivator proteins and their use in the treatment of cancer |
| WO2017062751A1 (en) * | 2015-10-08 | 2017-04-13 | The Regents Of The University Of California | Compounds and methods for promoting stress resistance |
| CN106083704B (zh) * | 2016-06-06 | 2018-07-27 | 福建医科大学 | 3,5-(E)-二芳亚甲基-N-环丙基哌啶-4-酮类化合物作为Hsp90抑制剂的应用 |
| EP3713916A1 (en) * | 2017-11-20 | 2020-09-30 | Kiakos, Konstantinos | 3,5-diarylidenyl-n-substituted-piperid-4-one-derived inhibitors of stat3 pathway acitivty and uses therof |
| CN120136844A (zh) * | 2018-08-29 | 2025-06-13 | 贝勒医学院 | 类固醇受体共激活剂-3的小分子刺激剂以及它们用作心脏保护剂和/或血管再生剂的方法 |
-
2019
- 2019-08-29 CN CN202510314712.9A patent/CN120136844A/zh active Pending
- 2019-08-29 CA CA3110839A patent/CA3110839A1/en active Pending
- 2019-08-29 EP EP19769618.0A patent/EP3843843A1/en active Pending
- 2019-08-29 WO PCT/US2019/048703 patent/WO2020047186A1/en not_active Ceased
- 2019-08-29 AU AU2019333119A patent/AU2019333119B2/en active Active
- 2019-08-29 US US16/554,733 patent/US10875841B2/en active Active
- 2019-08-29 CN CN201980071611.6A patent/CN112955217B/zh active Active
- 2019-08-29 JP JP2021510959A patent/JP7495138B2/ja active Active
-
2020
- 2020-09-24 US US17/030,924 patent/US11708350B2/en active Active
-
2023
- 2023-06-05 US US18/205,630 patent/US12338229B2/en active Active
-
2024
- 2024-05-16 JP JP2024080082A patent/JP7777263B2/ja active Active
-
2025
- 2025-05-22 US US19/215,832 patent/US20250282755A1/en active Pending
- 2025-09-03 AU AU2025226726A patent/AU2025226726A1/en active Pending
- 2025-09-16 JP JP2025153392A patent/JP2025183370A/ja active Pending
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