AU2019333119B2 - Small molecule stimulators of steroid receptor coactivator-3 and methods of their use as cardioprotective and/or vascular regenerative agents - Google Patents

Small molecule stimulators of steroid receptor coactivator-3 and methods of their use as cardioprotective and/or vascular regenerative agents Download PDF

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Publication number
AU2019333119B2
AU2019333119B2 AU2019333119A AU2019333119A AU2019333119B2 AU 2019333119 B2 AU2019333119 B2 AU 2019333119B2 AU 2019333119 A AU2019333119 A AU 2019333119A AU 2019333119 A AU2019333119 A AU 2019333119A AU 2019333119 B2 AU2019333119 B2 AU 2019333119B2
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AU2019333119A1 (en
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David Michael LONARD
Lisa Kay McCLENDON
Bert W. O'malley
Yongcheng Song
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Baylor College of Medicine
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Baylor College of Medicine
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/45—Non condensed piperidines, e.g. piperocaine having oxo groups directly attached to the heterocyclic ring, e.g. cycloheximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
AU2019333119A 2018-08-29 2019-08-29 Small molecule stimulators of steroid receptor coactivator-3 and methods of their use as cardioprotective and/or vascular regenerative agents Active AU2019333119B2 (en)

Priority Applications (1)

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AU2025226726A AU2025226726A1 (en) 2018-08-29 2025-09-03 Small molecule stimulators of steroid receptor coactivator-3 and methods of their use as cardioprotective and/or vascular regenerative agents

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862724281P 2018-08-29 2018-08-29
US62/724,281 2018-08-29
US201962825358P 2019-03-28 2019-03-28
US62/825,358 2019-03-28
PCT/US2019/048703 WO2020047186A1 (en) 2018-08-29 2019-08-29 Small molecule stimulators of steroid receptor coactivator-3 and methods of their use as cardioprotective and/or vascular regenerative agents

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AU2019333119A1 AU2019333119A1 (en) 2021-03-18
AU2019333119B2 true AU2019333119B2 (en) 2025-06-05

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AU2025226726A Pending AU2025226726A1 (en) 2018-08-29 2025-09-03 Small molecule stimulators of steroid receptor coactivator-3 and methods of their use as cardioprotective and/or vascular regenerative agents

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US (4) US10875841B2 (https=)
EP (1) EP3843843A1 (https=)
JP (3) JP7495138B2 (https=)
CN (2) CN120136844A (https=)
AU (2) AU2019333119B2 (https=)
CA (1) CA3110839A1 (https=)
WO (1) WO2020047186A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN120136844A (zh) * 2018-08-29 2025-06-13 贝勒医学院 类固醇受体共激活剂-3的小分子刺激剂以及它们用作心脏保护剂和/或血管再生剂的方法
KR20230093329A (ko) 2020-10-28 2023-06-27 베이롤 칼리지 오브 메드신 암의 치료를 위한 면역조절 치료제로서 면역 세포에서 src-3의 표적화
WO2025240566A1 (en) * 2024-05-17 2025-11-20 Baylor College Of Medicine Small molecule steroid receptor coactivator stimulators for use in repairing tissue

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102153508A (zh) * 2010-10-08 2011-08-17 福建医科大学 3,5-(e)-二亚苄基-n-环丙基哌啶-4-酮及其在制备治疗抗肿瘤药物中的应用
CN106083704A (zh) * 2016-06-06 2016-11-09 福建医科大学 3,5‑(E)‑ 二芳亚甲基‑N‑环丙基哌啶‑4‑酮类化合物作为Hsp90抑制剂的应用
WO2019097080A1 (en) * 2017-11-20 2019-05-23 Kiakos Konstantinos 3,5-diarylidenyl-n-substituted-piperid-4-one-derived inhibitors of stat3 pathway acitivty and uses therof

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL112205A0 (en) 1994-01-06 1995-03-15 Res Dev Foundation Curcumin, analogues of curcumin and novel uses thereof
CA2393440A1 (en) 1999-12-03 2001-06-07 Emory University Curcumin analogs with anti-tumor and anti-angiogenic properties
CA2395191A1 (en) 1999-12-23 2001-06-28 Tedman Ehlers Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states
US20070010488A1 (en) 2005-04-13 2007-01-11 Khairia Youssef Compounds for modulating cell proliferation
CN102381951B (zh) 2007-01-22 2013-09-04 温州医学院生物与天然药物开发中心有限公司 含环己酮的姜黄素单羰基结构类似物及其用途
EP2170311A4 (en) 2007-05-16 2011-10-19 Avalon Pharmaceuticals COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING AUTOIMMUNE DISEASES
WO2008150899A1 (en) 2007-05-29 2008-12-11 Emory University Combination therapies for treatment of cancer and inflammatory diseases
US20100197584A1 (en) 2007-07-27 2010-08-05 Research Foundations of the City University of- New York Use of curcumin to block brain tumor formation in mice
WO2009144220A1 (en) 2008-05-29 2009-12-03 Universite Libre De Bruxelles Water soluble curcumin compositions for use in anti-cancer and anti-inflammatory therapy
US8420118B2 (en) * 2009-09-10 2013-04-16 The Board Of Regents Of The University Of Oklahoma Anionic lipids and lipid nano-structures and methods of producing and using same
WO2011029359A1 (zh) 2009-09-12 2011-03-17 温州医学院 含11β-羟基甾体脱氢酶1双重调节剂的药物及其应用
JP2011074024A (ja) * 2009-09-30 2011-04-14 Shiseido Co Ltd ヘパラナーゼ活性阻害剤並びにそれを含有するしわ改善剤及び医薬組成物
WO2011127333A2 (en) 2010-04-09 2011-10-13 University Of Louisville Research Foundation, Inc. Compounds for treating disease, for administering, and for pharmaceutical compositions
WO2012021692A1 (en) 2010-08-11 2012-02-16 Rutgers, The State University Of New Jersey Curcumin analogs and methods of use thereof
CN103012088B (zh) 2012-11-28 2017-01-11 江苏药兴医药股份有限公司 α-(3,5-二甲氧基苯亚甲基)-α'-烃基亚甲基环酮及其制备方法
ITMI20130075A1 (it) 2013-01-21 2014-07-22 Altergon Sa Combinazione orale per la prevenzione e il trattamento di patologie vescicali, pelviche e dell¿apparato uro-genitale
CN103181922A (zh) * 2013-04-02 2013-07-03 温州医学院 一类含哌啶酮的单羰基姜黄素类化合物在制备抗炎药物中的应用
WO2016109470A1 (en) 2014-12-30 2016-07-07 Baylor College Of Medicine Small molecule stimulators of steroid receptor coactivator proteins and their use in the treatment of cancer
WO2017062751A1 (en) * 2015-10-08 2017-04-13 The Regents Of The University Of California Compounds and methods for promoting stress resistance
CN120136844A (zh) * 2018-08-29 2025-06-13 贝勒医学院 类固醇受体共激活剂-3的小分子刺激剂以及它们用作心脏保护剂和/或血管再生剂的方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102153508A (zh) * 2010-10-08 2011-08-17 福建医科大学 3,5-(e)-二亚苄基-n-环丙基哌啶-4-酮及其在制备治疗抗肿瘤药物中的应用
CN106083704A (zh) * 2016-06-06 2016-11-09 福建医科大学 3,5‑(E)‑ 二芳亚甲基‑N‑环丙基哌啶‑4‑酮类化合物作为Hsp90抑制剂的应用
WO2019097080A1 (en) * 2017-11-20 2019-05-23 Kiakos Konstantinos 3,5-diarylidenyl-n-substituted-piperid-4-one-derived inhibitors of stat3 pathway acitivty and uses therof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Huang, L. et al.; Eur. J. Med. Chem., 143, 1165-1173 (2018); DOI: 10.1016/j.ejmech.2017.09.028. *

Also Published As

Publication number Publication date
JP2024102352A (ja) 2024-07-30
EP3843843A1 (en) 2021-07-07
JP2021534221A (ja) 2021-12-09
CN120136844A (zh) 2025-06-13
US20230357200A1 (en) 2023-11-09
CN112955217B (zh) 2025-04-08
AU2025226726A1 (en) 2025-09-25
CN112955217A (zh) 2021-06-11
US20250282755A1 (en) 2025-09-11
AU2019333119A1 (en) 2021-03-18
US12338229B2 (en) 2025-06-24
JP2025183370A (ja) 2025-12-16
WO2020047186A1 (en) 2020-03-05
JP7495138B2 (ja) 2024-06-04
US10875841B2 (en) 2020-12-29
JP7777263B2 (ja) 2025-11-28
US11708350B2 (en) 2023-07-25
US20200071300A1 (en) 2020-03-05
US20210115017A1 (en) 2021-04-22
CA3110839A1 (en) 2020-03-05

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DA2 Applications for amendment section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE NAME OF THE INVENTOR TO READ O'MALLEY, BERT W.; LONARD, DAVID MICHAEL; SONG, YONGCHENG AND MCCLENDON, LISA KAY

DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE NAME OF THE INVENTOR TO READ O'MALLEY, BERT W.; LONARD, DAVID MICHAEL; SONG, YONGCHENG AND MCCLENDON, LISA KAY