CN112955217B - 类固醇受体共激活剂-3的小分子刺激剂以及它们用作心脏保护剂和/或血管再生剂的方法 - Google Patents

类固醇受体共激活剂-3的小分子刺激剂以及它们用作心脏保护剂和/或血管再生剂的方法 Download PDF

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CN112955217B
CN112955217B CN201980071611.6A CN201980071611A CN112955217B CN 112955217 B CN112955217 B CN 112955217B CN 201980071611 A CN201980071611 A CN 201980071611A CN 112955217 B CN112955217 B CN 112955217B
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mcb
myocardial infarction
compound
compounds
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CN112955217A (zh
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B·W·奥马利
D·M·罗纳德
Y·宋
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Baylor College of Medicine
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/45—Non condensed piperidines, e.g. piperocaine having oxo groups directly attached to the heterocyclic ring, e.g. cycloheximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
CN201980071611.6A 2018-08-29 2019-08-29 类固醇受体共激活剂-3的小分子刺激剂以及它们用作心脏保护剂和/或血管再生剂的方法 Active CN112955217B (zh)

Priority Applications (1)

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CN202510314712.9A CN120136844A (zh) 2018-08-29 2019-08-29 类固醇受体共激活剂-3的小分子刺激剂以及它们用作心脏保护剂和/或血管再生剂的方法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862724281P 2018-08-29 2018-08-29
US62/724281 2018-08-29
US201962825358P 2019-03-28 2019-03-28
US62/825358 2019-03-28
PCT/US2019/048703 WO2020047186A1 (en) 2018-08-29 2019-08-29 Small molecule stimulators of steroid receptor coactivator-3 and methods of their use as cardioprotective and/or vascular regenerative agents

Related Child Applications (1)

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CN202510314712.9A Division CN120136844A (zh) 2018-08-29 2019-08-29 类固醇受体共激活剂-3的小分子刺激剂以及它们用作心脏保护剂和/或血管再生剂的方法

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CN112955217A CN112955217A (zh) 2021-06-11
CN112955217B true CN112955217B (zh) 2025-04-08

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CN202510314712.9A Pending CN120136844A (zh) 2018-08-29 2019-08-29 类固醇受体共激活剂-3的小分子刺激剂以及它们用作心脏保护剂和/或血管再生剂的方法

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US (4) US10875841B2 (https=)
EP (1) EP3843843A1 (https=)
JP (3) JP7495138B2 (https=)
CN (2) CN112955217B (https=)
AU (2) AU2019333119B2 (https=)
CA (1) CA3110839A1 (https=)
WO (1) WO2020047186A1 (https=)

Families Citing this family (3)

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Publication number Priority date Publication date Assignee Title
JP7495138B2 (ja) * 2018-08-29 2024-06-04 ベイラー カレッジ オブ メディスン ステロイド受容体コアクチベーター－３の小分子刺激因子ならびに心臓保護剤及び／または血管再生剤としてのそれらの使用方法
CN116600818A (zh) 2020-10-28 2023-08-15 贝勒医学院 靶向免疫细胞中的src-3作为治疗癌症的免疫调节治疗剂
WO2025240566A1 (en) * 2024-05-17 2025-11-20 Baylor College Of Medicine Small molecule steroid receptor coactivator stimulators for use in repairing tissue

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CN106083704A (zh) * 2016-06-06 2016-11-09 福建医科大学 3,5‑(E)‑ 二芳亚甲基‑N‑环丙基哌啶‑4‑酮类化合物作为Hsp90抑制剂的应用

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CN102153508A (zh) * 2010-10-08 2011-08-17 福建医科大学 3,5-(e)-二亚苄基-n-环丙基哌啶-4-酮及其在制备治疗抗肿瘤药物中的应用
CN106083704A (zh) * 2016-06-06 2016-11-09 福建医科大学 3,5‑(E)‑ 二芳亚甲基‑N‑环丙基哌啶‑4‑酮类化合物作为Hsp90抑制剂的应用

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US20200071300A1 (en) 2020-03-05
JP2021534221A (ja) 2021-12-09
JP7495138B2 (ja) 2024-06-04
US20230357200A1 (en) 2023-11-09
CN120136844A (zh) 2025-06-13
JP7777263B2 (ja) 2025-11-28
AU2019333119B2 (en) 2025-06-05
JP2024102352A (ja) 2024-07-30
US20210115017A1 (en) 2021-04-22
CA3110839A1 (en) 2020-03-05
EP3843843A1 (en) 2021-07-07
US20250282755A1 (en) 2025-09-11
JP2025183370A (ja) 2025-12-16
AU2019333119A1 (en) 2021-03-18
AU2025226726A1 (en) 2025-09-25
US10875841B2 (en) 2020-12-29
WO2020047186A1 (en) 2020-03-05
US11708350B2 (en) 2023-07-25
CN112955217A (zh) 2021-06-11
US12338229B2 (en) 2025-06-24

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Inventor after: B.W. Omary

Inventor after: D.M. Ronald

Inventor after: Y.Song

Inventor after: L.K. McClendon

Inventor before: B.W. Omary

Inventor before: D.M. Ronald

Inventor before: Y.Song