JPWO2020012339A5 - - Google Patents
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- JPWO2020012339A5 JPWO2020012339A5 JP2021500661A JP2021500661A JPWO2020012339A5 JP WO2020012339 A5 JPWO2020012339 A5 JP WO2020012339A5 JP 2021500661 A JP2021500661 A JP 2021500661A JP 2021500661 A JP2021500661 A JP 2021500661A JP WO2020012339 A5 JPWO2020012339 A5 JP WO2020012339A5
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- substituted
- cycloalkyl
- alkyl
- heterocycloalkyl
- unsubstituted
- Prior art date
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- 125000000217 alkyl group Chemical group 0.000 claims 48
- -1 azetidinyl-O- Chemical class 0.000 claims 39
- 125000000753 cycloalkyl group Chemical group 0.000 claims 34
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 32
- 150000001875 compounds Chemical class 0.000 claims 25
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 25
- 239000008194 pharmaceutical composition Substances 0.000 claims 24
- 125000001072 heteroaryl group Chemical group 0.000 claims 19
- 206010028980 Neoplasm Diseases 0.000 claims 18
- 201000010099 disease Diseases 0.000 claims 16
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 16
- 125000001424 substituent group Chemical group 0.000 claims 16
- 150000003839 salts Chemical class 0.000 claims 14
- LLUFRKBWNGVRTH-UHFFFAOYSA-N (4-chloro-3-fluorophenyl)carbamic acid Chemical compound OC(=O)NC1=CC=C(Cl)C(F)=C1 LLUFRKBWNGVRTH-UHFFFAOYSA-N 0.000 claims 12
- 201000011510 cancer Diseases 0.000 claims 12
- 230000001684 chronic effect Effects 0.000 claims 11
- 229910052739 hydrogen Inorganic materials 0.000 claims 11
- 239000001257 hydrogen Substances 0.000 claims 11
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 11
- 208000002780 macular degeneration Diseases 0.000 claims 10
- 125000003118 aryl group Chemical group 0.000 claims 9
- 208000032839 leukemia Diseases 0.000 claims 9
- GAWCRULEMQFHTI-UHFFFAOYSA-N (4-chlorophenyl)carbamic acid Chemical compound OC(=O)NC1=CC=C(Cl)C=C1 GAWCRULEMQFHTI-UHFFFAOYSA-N 0.000 claims 8
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 8
- 241000124008 Mammalia Species 0.000 claims 7
- 230000001154 acute effect Effects 0.000 claims 7
- 206010064930 age-related macular degeneration Diseases 0.000 claims 7
- 210000004027 cell Anatomy 0.000 claims 7
- 125000001153 fluoro group Chemical group F* 0.000 claims 7
- 208000011580 syndromic disease Diseases 0.000 claims 7
- FQFOMCJEGOBBCJ-UHFFFAOYSA-N 2-(4-chloro-3-fluorophenoxy)acetamide Chemical compound NC(=O)COC1=CC=C(Cl)C(F)=C1 FQFOMCJEGOBBCJ-UHFFFAOYSA-N 0.000 claims 6
- 201000009030 Carcinoma Diseases 0.000 claims 6
- 208000004051 Chronic Traumatic Encephalopathy Diseases 0.000 claims 6
- 208000017004 dementia pugilistica Diseases 0.000 claims 6
- 208000030533 eye disease Diseases 0.000 claims 6
- RHLHDNNWVXMDAF-UHFFFAOYSA-N 2-(4-chlorophenoxy)acetamide Chemical compound NC(=O)COC1=CC=C(Cl)C=C1 RHLHDNNWVXMDAF-UHFFFAOYSA-N 0.000 claims 5
- 206010061218 Inflammation Diseases 0.000 claims 5
- 208000009956 adenocarcinoma Diseases 0.000 claims 5
- 230000004054 inflammatory process Effects 0.000 claims 5
- 210000000056 organ Anatomy 0.000 claims 5
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 4
- 125000006716 (C1-C6) heteroalkyl group Chemical group 0.000 claims 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 4
- 229940034982 antineoplastic agent Drugs 0.000 claims 4
- 239000002246 antineoplastic agent Substances 0.000 claims 4
- 125000002393 azetidinyl group Chemical group 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 206010012601 diabetes mellitus Diseases 0.000 claims 4
- 208000005017 glioblastoma Diseases 0.000 claims 4
- 125000004474 heteroalkylene group Chemical group 0.000 claims 4
- 201000001441 melanoma Diseases 0.000 claims 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 238000002054 transplantation Methods 0.000 claims 4
- ZGYCYELHORMCHT-UHFFFAOYSA-N 2-(3,4-dichlorophenoxy)acetamide Chemical compound NC(=O)COC1=CC=C(Cl)C(Cl)=C1 ZGYCYELHORMCHT-UHFFFAOYSA-N 0.000 claims 3
- 208000030090 Acute Disease Diseases 0.000 claims 3
- 208000024827 Alzheimer disease Diseases 0.000 claims 3
- 201000001320 Atherosclerosis Diseases 0.000 claims 3
- 208000024172 Cardiovascular disease Diseases 0.000 claims 3
- 208000017667 Chronic Disease Diseases 0.000 claims 3
- SBUKLPSBNFWJCU-UHFFFAOYSA-N ClIBr Chemical compound ClIBr SBUKLPSBNFWJCU-UHFFFAOYSA-N 0.000 claims 3
- 208000028698 Cognitive impairment Diseases 0.000 claims 3
- 206010012289 Dementia Diseases 0.000 claims 3
- 206010016654 Fibrosis Diseases 0.000 claims 3
- 206010018404 Glucagonoma Diseases 0.000 claims 3
- 208000023105 Huntington disease Diseases 0.000 claims 3
- 208000032382 Ischaemic stroke Diseases 0.000 claims 3
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 3
- 206010033799 Paralysis Diseases 0.000 claims 3
- 208000018737 Parkinson disease Diseases 0.000 claims 3
- 208000024777 Prion disease Diseases 0.000 claims 3
- 208000006011 Stroke Diseases 0.000 claims 3
- 208000030886 Traumatic Brain injury Diseases 0.000 claims 3
- 230000006793 arrhythmia Effects 0.000 claims 3
- 206010003119 arrhythmia Diseases 0.000 claims 3
- 208000010877 cognitive disease Diseases 0.000 claims 3
- 230000004761 fibrosis Effects 0.000 claims 3
- 230000000762 glandular Effects 0.000 claims 3
- 206010022498 insulinoma Diseases 0.000 claims 3
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 210000003205 muscle Anatomy 0.000 claims 3
- 208000010125 myocardial infarction Diseases 0.000 claims 3
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- 208000008443 pancreatic carcinoma Diseases 0.000 claims 3
- 208000021255 pancreatic insulinoma Diseases 0.000 claims 3
- 230000000750 progressive effect Effects 0.000 claims 3
- 125000004076 pyridyl group Chemical group 0.000 claims 3
- 208000020431 spinal cord injury Diseases 0.000 claims 3
- 230000009529 traumatic brain injury Effects 0.000 claims 3
- VTAQLGRULYHNQX-UHFFFAOYSA-N (3,4-dichlorophenyl)carbamic acid Chemical compound OC(=O)NC1=CC=C(Cl)C(Cl)=C1 VTAQLGRULYHNQX-UHFFFAOYSA-N 0.000 claims 2
- XOOUNMBHFMARDR-UHFFFAOYSA-N (3,4-difluorophenyl)carbamic acid Chemical compound OC(=O)NC1=CC=C(F)C(F)=C1 XOOUNMBHFMARDR-UHFFFAOYSA-N 0.000 claims 2
- PCICJIGMKIYFBJ-UHFFFAOYSA-N 2-(3,4-difluorophenoxy)acetamide Chemical compound NC(=O)COC1=CC=C(F)C(F)=C1 PCICJIGMKIYFBJ-UHFFFAOYSA-N 0.000 claims 2
- PNGGWQMSHKIEAF-UHFFFAOYSA-N 2-(4-fluorophenoxy)acetamide Chemical compound NC(=O)COC1=CC=C(F)C=C1 PNGGWQMSHKIEAF-UHFFFAOYSA-N 0.000 claims 2
- 208000003174 Brain Neoplasms Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000012609 Cowden disease Diseases 0.000 claims 2
- 206010051066 Gastrointestinal stromal tumour Diseases 0.000 claims 2
- 208000010412 Glaucoma Diseases 0.000 claims 2
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 2
- 208000019693 Lung disease Diseases 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 206010025323 Lymphomas Diseases 0.000 claims 2
- 208000008770 Multiple Hamartoma Syndrome Diseases 0.000 claims 2
- 208000034578 Multiple myelomas Diseases 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 208000002193 Pain Diseases 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 206010038389 Renal cancer Diseases 0.000 claims 2
- 230000002491 angiogenic effect Effects 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 201000011243 gastrointestinal stromal tumor Diseases 0.000 claims 2
- 201000010536 head and neck cancer Diseases 0.000 claims 2
- 208000014829 head and neck neoplasm Diseases 0.000 claims 2
- 201000010985 invasive ductal carcinoma Diseases 0.000 claims 2
- 210000003734 kidney Anatomy 0.000 claims 2
- 201000010982 kidney cancer Diseases 0.000 claims 2
- 208000017169 kidney disease Diseases 0.000 claims 2
- 201000010901 lateral sclerosis Diseases 0.000 claims 2
- 201000007270 liver cancer Diseases 0.000 claims 2
- 208000019423 liver disease Diseases 0.000 claims 2
- 208000014018 liver neoplasm Diseases 0.000 claims 2
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- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 208000005264 motor neuron disease Diseases 0.000 claims 2
- 230000004770 neurodegeneration Effects 0.000 claims 2
- 230000007823 neuropathy Effects 0.000 claims 2
- 201000001119 neuropathy Diseases 0.000 claims 2
- 208000033808 peripheral neuropathy Diseases 0.000 claims 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 2
- 230000001568 sexual effect Effects 0.000 claims 2
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 2
- 210000004500 stellate cell Anatomy 0.000 claims 2
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 2
- PHVSUUGFGMGZPE-UHFFFAOYSA-N (4-bromophenyl)carbamic acid Chemical compound OC(=O)NC1=CC=C(Br)C=C1 PHVSUUGFGMGZPE-UHFFFAOYSA-N 0.000 claims 1
- VWOVELKWMFTNCE-UHFFFAOYSA-N (4-chloro-3-methylphenyl)carbamic acid Chemical compound CC1=CC(NC(O)=O)=CC=C1Cl VWOVELKWMFTNCE-UHFFFAOYSA-N 0.000 claims 1
- 125000005940 1,4-dioxanyl group Chemical group 0.000 claims 1
- WGGWGRFTWDRLRP-UHFFFAOYSA-N 2,2-difluoro-1,3-benzodioxole-5-carboxamide Chemical compound NC(=O)C1=CC=C2OC(F)(F)OC2=C1 WGGWGRFTWDRLRP-UHFFFAOYSA-N 0.000 claims 1
- NIGZDFRJTRMXBQ-UHFFFAOYSA-N 2-(4-chlorophenoxy)-N-[[3-[[[2-(4-chlorophenoxy)acetyl]amino]methyl]-1-bicyclo[1.1.1]pentanyl]methyl]acetamide Chemical compound C12(CC(C1)(C2)CNC(COC1=CC=C(C=C1)Cl)=O)CNC(COC1=CC=C(C=C1)Cl)=O NIGZDFRJTRMXBQ-UHFFFAOYSA-N 0.000 claims 1
- KCLUIEYNHKSQNW-UHFFFAOYSA-N 2-(4-chlorophenoxy)-N-[[4-[[[2-(4-chlorophenoxy)acetyl]amino]methyl]-1-bicyclo[2.1.1]hexanyl]methyl]acetamide Chemical compound C1=C(C=CC(=C1)OCC(=O)NCC12CC(CC2)(CNC(=O)COC2=CC=C(C=C2)Cl)C1)Cl KCLUIEYNHKSQNW-UHFFFAOYSA-N 0.000 claims 1
- BFYGROHYLCZLGS-UHFFFAOYSA-N 2-(4-chlorophenyl)acetamide Chemical compound NC(=O)CC1=CC=C(Cl)C=C1 BFYGROHYLCZLGS-UHFFFAOYSA-N 0.000 claims 1
- NDXGAMPNAVLVQW-UHFFFAOYSA-N 6-chloro-3,4-dihydro-2H-1,4-benzoxazine-2-carboxamide Chemical compound C1C(OC2=C(N1)C=C(C=C2)Cl)C(=O)N NDXGAMPNAVLVQW-UHFFFAOYSA-N 0.000 claims 1
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 1
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 1
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
- 206010061692 Benign muscle neoplasm Diseases 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 208000014882 Carotid artery disease Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 208000005590 Choroidal Neovascularization Diseases 0.000 claims 1
- 206010060823 Choroidal neovascularisation Diseases 0.000 claims 1
- 102100023580 Cyclic AMP-dependent transcription factor ATF-4 Human genes 0.000 claims 1
- 229940123780 DNA topoisomerase I inhibitor Drugs 0.000 claims 1
- 229940124087 DNA topoisomerase II inhibitor Drugs 0.000 claims 1
- 101100072149 Drosophila melanogaster eIF2alpha gene Proteins 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 208000006168 Ewing Sarcoma Diseases 0.000 claims 1
- 208000002966 Giant Cell Tumor of Bone Diseases 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 101000905743 Homo sapiens Cyclic AMP-dependent transcription factor ATF-4 Proteins 0.000 claims 1
- 206010020631 Hypergammaglobulinaemia benign monoclonal Diseases 0.000 claims 1
- 208000019758 Hypergammaglobulinemia Diseases 0.000 claims 1
- 208000005726 Inflammatory Breast Neoplasms Diseases 0.000 claims 1
- 206010021980 Inflammatory carcinoma of the breast Diseases 0.000 claims 1
- 239000003798 L01XE11 - Pazopanib Substances 0.000 claims 1
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 1
- 208000001344 Macular Edema Diseases 0.000 claims 1
- 206010025415 Macular oedema Diseases 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- 208000003445 Mouth Neoplasms Diseases 0.000 claims 1
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 1
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- 208000001894 Nasopharyngeal Neoplasms Diseases 0.000 claims 1
- 206010061306 Nasopharyngeal cancer Diseases 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 1
- 206010069385 Ocular ischaemic syndrome Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 208000007452 Plasmacytoma Diseases 0.000 claims 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
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- 208000007135 Retinal Neovascularization Diseases 0.000 claims 1
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- 206010039491 Sarcoma Diseases 0.000 claims 1
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- 206010041067 Small cell lung cancer Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000000389 T-cell leukemia Diseases 0.000 claims 1
- 208000028530 T-cell lymphoblastic leukemia/lymphoma Diseases 0.000 claims 1
- 206010042971 T-cell lymphoma Diseases 0.000 claims 1
- 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 claims 1
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 1
- 206010057644 Testis cancer Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 239000000365 Topoisomerase I Inhibitor Substances 0.000 claims 1
- 239000000317 Topoisomerase II Inhibitor Substances 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 208000008383 Wilms tumor Diseases 0.000 claims 1
- 208000037833 acute lymphoblastic T-cell leukemia Diseases 0.000 claims 1
- 229940100198 alkylating agent Drugs 0.000 claims 1
- 239000002168 alkylating agent Substances 0.000 claims 1
- 208000007502 anemia Diseases 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 201000000053 blastoma Diseases 0.000 claims 1
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- 201000011143 bone giant cell tumor Diseases 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- KXDHJXZQYSOELW-UHFFFAOYSA-N carbonic acid monoamide Natural products NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 201000004948 cheek mucosa cancer Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 1
- 208000019425 cirrhosis of liver Diseases 0.000 claims 1
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- 125000001207 fluorophenyl group Chemical group 0.000 claims 1
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- 208000006454 hepatitis Diseases 0.000 claims 1
- 231100000283 hepatitis Toxicity 0.000 claims 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 239000002944 hormone and hormone analog Substances 0.000 claims 1
- 201000004653 inflammatory breast carcinoma Diseases 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
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- 208000012987 lip and oral cavity carcinoma Diseases 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
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- 201000010230 macular retinal edema Diseases 0.000 claims 1
- 230000002503 metabolic effect Effects 0.000 claims 1
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- 201000005328 monoclonal gammopathy of uncertain significance Diseases 0.000 claims 1
- 208000001491 myopia Diseases 0.000 claims 1
- 230000004379 myopia Effects 0.000 claims 1
- 201000008026 nephroblastoma Diseases 0.000 claims 1
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- 210000000440 neutrophil Anatomy 0.000 claims 1
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- 230000008816 organ damage Effects 0.000 claims 1
- 201000008968 osteosarcoma Diseases 0.000 claims 1
- 208000003154 papilloma Diseases 0.000 claims 1
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- CUIHSIWYWATEQL-UHFFFAOYSA-N pazopanib Chemical group C1=CC2=C(C)N(C)N=C2C=C1N(C)C(N=1)=CC=NC=1NC1=CC=C(C)C(S(N)(=O)=O)=C1 CUIHSIWYWATEQL-UHFFFAOYSA-N 0.000 claims 1
- 229960000639 pazopanib Drugs 0.000 claims 1
- 230000026731 phosphorylation Effects 0.000 claims 1
- 238000006366 phosphorylation reaction Methods 0.000 claims 1
- 229910052697 platinum Inorganic materials 0.000 claims 1
- 208000014081 polyp of colon Diseases 0.000 claims 1
- 230000002028 premature Effects 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 201000002025 prostate sarcoma Diseases 0.000 claims 1
- 230000001172 regenerating effect Effects 0.000 claims 1
- 230000003938 response to stress Effects 0.000 claims 1
- 210000001525 retina Anatomy 0.000 claims 1
- 230000002207 retinal effect Effects 0.000 claims 1
- 210000003079 salivary gland Anatomy 0.000 claims 1
- 230000019491 signal transduction Effects 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 201000003120 testicular cancer Diseases 0.000 claims 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 210000001685 thyroid gland Anatomy 0.000 claims 1
- KJAMZCVTJDTESW-UHFFFAOYSA-N tiracizine Chemical compound C1CC2=CC=CC=C2N(C(=O)CN(C)C)C2=CC(NC(=O)OCC)=CC=C21 KJAMZCVTJDTESW-UHFFFAOYSA-N 0.000 claims 1
- 230000000472 traumatic effect Effects 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
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- 230000002861 ventricular Effects 0.000 claims 1
- 208000006542 von Hippel-Lindau disease Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862695384P | 2018-07-09 | 2018-07-09 | |
| US62/695,384 | 2018-07-09 | ||
| PCT/IB2019/055811 WO2020012339A1 (en) | 2018-07-09 | 2019-07-08 | Chemical compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021529814A JP2021529814A (ja) | 2021-11-04 |
| JPWO2020012339A5 true JPWO2020012339A5 (https=) | 2022-07-15 |
| JP2021529814A5 JP2021529814A5 (https=) | 2022-07-15 |
Family
ID=67997654
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021500661A Pending JP2021529814A (ja) | 2018-07-09 | 2019-07-08 | 化学化合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20210253528A1 (https=) |
| EP (1) | EP3820843A1 (https=) |
| JP (1) | JP2021529814A (https=) |
| CN (1) | CN112424167A (https=) |
| BR (1) | BR112021000332A2 (https=) |
| CA (1) | CA3105942A1 (https=) |
| WO (1) | WO2020012339A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3071024A1 (en) | 2017-08-09 | 2019-02-14 | Denali Therapeutics Inc. | Compounds, compositions and methods |
| CN111201245B (zh) | 2017-09-01 | 2024-04-05 | 戴纳立制药公司 | 化合物、组合物和方法 |
| WO2019090088A1 (en) | 2017-11-02 | 2019-05-09 | Calico Life Sciences Llc | Modulators of the integrated stress pathway |
| CN111757739A (zh) | 2017-12-13 | 2020-10-09 | 普拉西斯生物技术有限责任公司 | 整合应激反应路径抑制剂 |
| AU2019282253A1 (en) | 2018-06-05 | 2020-11-26 | Altos Labs, Inc. | Inhibitors of integrated stress response pathway |
| TW202545902A (zh) | 2018-10-11 | 2025-12-01 | 美商嘉來克生命科學有限責任公司 | 整合應激路徑之前藥調節劑 |
| SG11202108552QA (en) | 2019-02-13 | 2021-09-29 | Denali Therapeutics Inc | Compounds, compositions and methods |
| EP3924341A4 (en) | 2019-02-13 | 2022-11-02 | Denali Therapeutics Inc. | Compounds, compositions and methods |
| PE20220572A1 (es) * | 2019-04-30 | 2022-04-20 | Calico Life Sciences Llc | Moduladores de la via integrada del estres |
| WO2020252207A1 (en) | 2019-06-12 | 2020-12-17 | Praxis Biotech LLC | Modulators of integrated stress response pathway |
| CN115190813B (zh) | 2020-03-11 | 2024-10-15 | 埃沃特克国际有限责任公司 | 整合应激反应途径的调节剂 |
| EP4232447A1 (en) | 2020-10-22 | 2023-08-30 | Evotec International GmbH | Modulators of the integrated stress response pathway |
| RS66455B1 (sr) | 2020-10-22 | 2025-02-28 | Evotec Int Gmbh | Modulatori puta integrisanog odgovora na stres |
| EP4232153A1 (en) | 2020-10-22 | 2023-08-30 | Evotec International GmbH | Modulators of the integrated stress response pathway |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7605238B2 (en) | 1999-08-24 | 2009-10-20 | Medarex, Inc. | Human CTLA-4 antibodies and their uses |
| IL148079A0 (en) | 1999-08-24 | 2002-09-12 | Medarex Inc | Human ctla-4 antibodies and compositions containing the same |
| EP1343782B1 (en) | 2000-12-21 | 2009-05-06 | SmithKline Beecham Corporation | Pyrimidineamines as angiogenesis modulators |
| ES2350687T3 (es) | 2002-07-03 | 2011-01-26 | Ono Pharmaceutical Co., Ltd. | Composiciones de inmunopotenciación. |
| AU2003254157A1 (en) * | 2002-07-24 | 2004-02-09 | Ptc Therapeutics, Inc. | Acetylamino benzoic acid compounds and their use for nonsense suppression and the treatment of disease |
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-
2019
- 2019-07-08 WO PCT/IB2019/055811 patent/WO2020012339A1/en not_active Ceased
- 2019-07-08 CA CA3105942A patent/CA3105942A1/en active Pending
- 2019-07-08 EP EP19770173.3A patent/EP3820843A1/en not_active Withdrawn
- 2019-07-08 CN CN201980046203.5A patent/CN112424167A/zh active Pending
- 2019-07-08 US US16/973,587 patent/US20210253528A1/en not_active Abandoned
- 2019-07-08 BR BR112021000332-0A patent/BR112021000332A2/pt not_active Application Discontinuation
- 2019-07-08 JP JP2021500661A patent/JP2021529814A/ja active Pending
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