JPWO2020011973A5 - - Google Patents

Info

Publication number

JPWO2020011973A5

JPWO2020011973A5 JP2020572642A JP2020572642A JPWO2020011973A5 JP WO2020011973 A5 JPWO2020011973 A5 JP WO2020011973A5 JP 2020572642 A JP2020572642 A JP 2020572642A JP 2020572642 A JP2020572642 A JP 2020572642A JP WO2020011973 A5 JPWO2020011973 A5 JP WO2020011973A5

Authority

JP

Japan

Prior art keywords

seq

antibody

antigen

binding fragment

acid sequence

Prior art date

2022-07-20

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 239000000427 antigen Substances 0.000 claims 59
• 102000036639 antigens Human genes 0.000 claims 59
• 108091007433 antigens Proteins 0.000 claims 59
• 239000012634 fragment Substances 0.000 claims 53
• 150000007523 nucleic acids Chemical class 0.000 claims 36
• 125000003275 alpha amino acid group Chemical group 0.000 claims 29
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 22
• 239000002299 complementary DNA Substances 0.000 claims 21
• 108020004707 nucleic acids Proteins 0.000 claims 14
• 102000039446 nucleic acids Human genes 0.000 claims 14
• 230000004927 fusion Effects 0.000 claims 9
• NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 7
• 230000002998 immunogenetic effect Effects 0.000 claims 7
• 239000008194 pharmaceutical composition Substances 0.000 claims 7
• 150000001413 amino acids Chemical class 0.000 claims 4
• 239000000203 mixture Substances 0.000 claims 4
• 239000013598 vector Substances 0.000 claims 4
• 108010047041 Complementarity Determining Regions Proteins 0.000 claims 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 102000050627 Glucocorticoid-Induced TNFR-Related Human genes 0.000 claims 2
• 101001137987 Homo sapiens Lymphocyte activation gene 3 protein Proteins 0.000 claims 2
• 102000053646 Inducible T-Cell Co-Stimulator Human genes 0.000 claims 2
• 108700013161 Inducible T-Cell Co-Stimulator Proteins 0.000 claims 2
• 102100020862 Lymphocyte activation gene 3 protein Human genes 0.000 claims 2
• 101710187882 Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims 2
• 210000004027 cell Anatomy 0.000 claims 2
• 229940027941 immunoglobulin g Drugs 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• 230000004048 modification Effects 0.000 claims 2
• 238000012986 modification Methods 0.000 claims 2
• 239000000546 pharmaceutical excipient Substances 0.000 claims 2
• 238000001959 radiotherapy Methods 0.000 claims 2
• 102000008096 B7-H1 Antigen Human genes 0.000 claims 1
• 108010074708 B7-H1 Antigen Proteins 0.000 claims 1
• 102100027207 CD27 antigen Human genes 0.000 claims 1
• 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims 1
• 102000037982 Immune checkpoint proteins Human genes 0.000 claims 1
• 108091008036 Immune checkpoint proteins Proteins 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 1
• 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 1
• 239000000556 agonist Substances 0.000 claims 1
• 239000005557 antagonist Substances 0.000 claims 1
• 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims 1
• 210000004899 c-terminal region Anatomy 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• 231100000433 cytotoxic Toxicity 0.000 claims 1
• 230000001472 cytotoxic effect Effects 0.000 claims 1
• 239000000032 diagnostic agent Substances 0.000 claims 1
• 229940039227 diagnostic agent Drugs 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 239000012642 immune effector Substances 0.000 claims 1
• 210000000987 immune system Anatomy 0.000 claims 1
• 229940121354 immunomodulator Drugs 0.000 claims 1
• 238000000338 in vitro Methods 0.000 claims 1
• 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1