JPWO2020002540A5 - - Google Patents
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- Publication number
- JPWO2020002540A5 JPWO2020002540A5 JP2020573481A JP2020573481A JPWO2020002540A5 JP WO2020002540 A5 JPWO2020002540 A5 JP WO2020002540A5 JP 2020573481 A JP2020573481 A JP 2020573481A JP 2020573481 A JP2020573481 A JP 2020573481A JP WO2020002540 A5 JPWO2020002540 A5 JP WO2020002540A5
- Authority
- JP
- Japan
- Prior art keywords
- exosome
- cells
- lipid
- modified rna
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000001808 Exosomes Anatomy 0.000 claims 29
- 210000004027 cells Anatomy 0.000 claims 19
- 150000002632 lipids Chemical class 0.000 claims 19
- 229920000160 (ribonucleotides)n+m Polymers 0.000 claims 15
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- HVYWMOMLDIMFJA-DPAQBDIFSA-N (3β)-Cholest-5-en-3-ol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 150000003904 phospholipids Chemical class 0.000 claims 4
- 229920001223 polyethylene glycol Polymers 0.000 claims 4
- 210000000130 stem cell Anatomy 0.000 claims 4
- 238000000338 in vitro Methods 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 239000002105 nanoparticle Substances 0.000 claims 3
- NRJAVPSFFCBXDT-HUESYALOSA-N 1,2-distearoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC NRJAVPSFFCBXDT-HUESYALOSA-N 0.000 claims 2
- 210000003719 B-Lymphocytes Anatomy 0.000 claims 2
- 229940107161 Cholesterol Drugs 0.000 claims 2
- 210000001744 T-Lymphocytes Anatomy 0.000 claims 2
- 235000012000 cholesterol Nutrition 0.000 claims 2
- 210000002919 epithelial cells Anatomy 0.000 claims 2
- 210000002865 immune cell Anatomy 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 210000001616 Monocytes Anatomy 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862691348P | 2018-06-28 | 2018-06-28 | |
| US62/691,348 | 2018-06-28 | ||
| PCT/EP2019/067232 WO2020002540A1 (fr) | 2018-06-28 | 2019-06-27 | Vésicules extracellulaires exosomales et procédés d'utilisation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021528096A JP2021528096A (ja) | 2021-10-21 |
| JPWO2020002540A5 true JPWO2020002540A5 (fr) | 2022-07-04 |
Family
ID=67139730
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020573481A Pending JP2021528096A (ja) | 2018-06-28 | 2019-06-27 | エキソソーム細胞外小胞及びその使用方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20210315819A1 (fr) |
| EP (1) | EP3813798A1 (fr) |
| JP (1) | JP2021528096A (fr) |
| CN (1) | CN112543629A (fr) |
| WO (1) | WO2020002540A1 (fr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3638215A4 (fr) | 2017-06-15 | 2021-03-24 | Modernatx, Inc. | Formulations d'arn |
| MX2020002348A (es) | 2017-08-31 | 2020-10-08 | Modernatx Inc | Métodos de elaboración de nanopartículas lipídicas. |
| US20230277457A1 (en) * | 2020-08-06 | 2023-09-07 | Modernatx, Inc. | Methods of preparing lipid nanoparticles |
| WO2023178500A1 (fr) * | 2022-03-22 | 2023-09-28 | Beijing Theraxyte Bioscience Co. Ltd. | Vésicules thérapeutiques et leurs méthodes de traitement |
| CN114848608B (zh) * | 2022-05-17 | 2024-01-30 | 东南大学 | 一种蛋白或多肽递送载体及其制备方法与应用 |
| CN115887758B (zh) * | 2022-11-15 | 2024-01-26 | 西南交通大学 | 负载外泌体促进糖尿病创面修复的共聚水凝胶 |
| CN117679354B (zh) * | 2024-02-04 | 2024-05-28 | 知想(山东)医疗科技有限公司 | 金花茶外泌体制剂及其制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3569254B1 (fr) * | 2009-04-17 | 2022-07-20 | Oxford University Innovation Limited | Composition d'administration de matériau génétique |
| JP2010285426A (ja) * | 2009-05-11 | 2010-12-24 | National Cancer Center | 核酸導入方法 |
| AU2010259984B2 (en) | 2009-06-10 | 2017-03-09 | Arbutus Biopharma Corporation | Improved lipid formulation |
| US8518907B2 (en) | 2010-08-02 | 2013-08-27 | Merck Sharp & Dohme Corp. | RNA interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (CTNNB1) gene expression using short interfering nucleic acid (siNA) |
| US8691750B2 (en) | 2011-05-17 | 2014-04-08 | Axolabs Gmbh | Lipids and compositions for intracellular delivery of biologically active compounds |
| ES2923757T3 (es) * | 2011-12-16 | 2022-09-30 | Modernatx Inc | Composiciones de ARNm modificado |
| KR102541164B1 (ko) * | 2014-01-21 | 2023-06-08 | 안자리움 바이오사이언시스 아게 | 하이브리도좀, 이를 포함하는 조성물, 이의 제조 방법 및 이의 용도 |
| RS63848B1 (sr) | 2014-06-25 | 2023-01-31 | Acuitas Therapeutics Inc | Novi lipidi i formulacije lipidnih nanočestica za isporuku nukleinskih kiselina |
| AU2016209295B2 (en) * | 2015-01-21 | 2021-08-12 | Genevant Sciences Gmbh | Methods, compositions, and systems for delivering therapeutic and diagnostic agents into cells |
| US20210290556A1 (en) * | 2016-08-22 | 2021-09-23 | Codiak Biosciences, Inc. | Methods of suppressing delivery of exosomes to liver and spleen |
| EP3292861A1 (fr) * | 2016-09-13 | 2018-03-14 | Centre National De La Recherche Scientifique (Cnrs) | Procede in vitro destine a obtenir un vecteur bio-hybride |
-
2019
- 2019-06-27 EP EP19735277.6A patent/EP3813798A1/fr active Pending
- 2019-06-27 WO PCT/EP2019/067232 patent/WO2020002540A1/fr active Application Filing
- 2019-06-27 US US16/972,190 patent/US20210315819A1/en active Pending
- 2019-06-27 CN CN201980042830.1A patent/CN112543629A/zh active Pending
- 2019-06-27 JP JP2020573481A patent/JP2021528096A/ja active Pending
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