JPWO2019241002A5 - - Google Patents
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- Publication number
- JPWO2019241002A5 JPWO2019241002A5 JP2020569001A JP2020569001A JPWO2019241002A5 JP WO2019241002 A5 JPWO2019241002 A5 JP WO2019241002A5 JP 2020569001 A JP2020569001 A JP 2020569001A JP 2020569001 A JP2020569001 A JP 2020569001A JP WO2019241002 A5 JPWO2019241002 A5 JP WO2019241002A5
- Authority
- JP
- Japan
- Prior art keywords
- heavy chain
- variable domain
- transgenic
- transgenic chicken
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000287828 Gallus gallus Species 0.000 claims description 39
- 230000009261 transgenic effect Effects 0.000 claims description 38
- 108091008109 Pseudogenes Proteins 0.000 claims description 21
- 102000057361 Pseudogenes Human genes 0.000 claims description 21
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims description 18
- 241001465754 Metazoa Species 0.000 claims description 14
- 210000003719 b-lymphocyte Anatomy 0.000 claims description 13
- 235000001014 amino acid Nutrition 0.000 claims description 11
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims description 11
- 150000001413 amino acids Chemical class 0.000 claims description 9
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 8
- 108020004707 nucleic acids Proteins 0.000 claims description 8
- 150000007523 nucleic acids Chemical class 0.000 claims description 8
- 102000039446 nucleic acids Human genes 0.000 claims description 8
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims description 7
- 238000006243 chemical reaction Methods 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- 108090000623 proteins and genes Proteins 0.000 claims description 7
- 239000000427 antigen Substances 0.000 claims description 6
- 108091007433 antigens Proteins 0.000 claims description 6
- 102000036639 antigens Human genes 0.000 claims description 6
- 239000002773 nucleotide Substances 0.000 claims description 6
- 125000003729 nucleotide group Chemical group 0.000 claims description 6
- 238000011144 upstream manufacturing Methods 0.000 claims description 6
- 108091026890 Coding region Proteins 0.000 claims description 4
- 108700005091 Immunoglobulin Genes Proteins 0.000 claims description 4
- 210000004602 germ cell Anatomy 0.000 claims description 4
- 238000012217 deletion Methods 0.000 claims description 2
- 230000037430 deletion Effects 0.000 claims description 2
- 230000003053 immunization Effects 0.000 claims description 2
- 238000006467 substitution reaction Methods 0.000 claims description 2
- 210000004408 hybridoma Anatomy 0.000 description 4
- 238000012216 screening Methods 0.000 description 2
- 230000002068 genetic effect Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862684669P | 2018-06-13 | 2018-06-13 | |
| US62/684,669 | 2018-06-13 | ||
| PCT/US2019/035540 WO2019241002A1 (en) | 2018-06-13 | 2019-06-05 | Transgenic chicken that makes antibodies with long cdr-h3s stabilized by multiple disulfide bridges and diversified by gene conversion |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021526830A JP2021526830A (ja) | 2021-10-11 |
| JP2021526830A5 JP2021526830A5 (https=) | 2022-06-09 |
| JPWO2019241002A5 true JPWO2019241002A5 (https=) | 2022-06-09 |
| JP7515410B2 JP7515410B2 (ja) | 2024-07-12 |
Family
ID=68842113
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020569001A Active JP7515410B2 (ja) | 2018-06-13 | 2019-06-05 | 複数のジスルフィド架橋によって安定化され、遺伝子変換によって多様化された長いｃｄｒ－ｈ３ｓで抗体を作製するトランスジェニックニワトリ |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US12428471B2 (https=) |
| EP (1) | EP3813520A4 (https=) |
| JP (1) | JP7515410B2 (https=) |
| KR (1) | KR20210021002A (https=) |
| AU (2) | AU2019284256B2 (https=) |
| CA (1) | CA3102125A1 (https=) |
| WO (1) | WO2019241002A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202430558A (zh) | 2023-01-18 | 2024-08-01 | 美商基利科學股份有限公司 | 人類免疫球蛋白重鏈長cdr3轉殖基因構築體及其用途 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US6492107B1 (en) | 1986-11-20 | 2002-12-10 | Stuart Kauffman | Process for obtaining DNA, RNA, peptides, polypeptides, or protein, by recombinant DNA technique |
| GB2183661B (en) | 1985-03-30 | 1989-06-28 | Marc Ballivet | Method for obtaining dna, rna, peptides, polypeptides or proteins by means of a dna recombinant technique |
| US5618920A (en) | 1985-11-01 | 1997-04-08 | Xoma Corporation | Modular assembly of antibody genes, antibodies prepared thereby and use |
| DE3600905A1 (de) | 1986-01-15 | 1987-07-16 | Ant Nachrichtentech | Verfahren zum dekodieren von binaersignalen sowie viterbi-dekoder und anwendungen |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US4977081A (en) | 1987-05-04 | 1990-12-11 | Adi Diagnostics, Inc. | Stable rabbit-mouse hybridomas and secretion products thereof |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| WO1990014443A1 (en) | 1989-05-16 | 1990-11-29 | Huse William D | Co-expression of heteromeric receptors |
| CA2016842A1 (en) | 1989-05-16 | 1990-11-16 | Richard A. Lerner | Method for tapping the immunological repertoire |
| CA2016841C (en) | 1989-05-16 | 1999-09-21 | William D. Huse | A method for producing polymers having a preselected activity |
| WO1992001043A1 (en) | 1990-07-10 | 1992-01-23 | Nkk Corporation | Hybridoma which produces avian specific immunoglobulin g |
| US7041871B1 (en) | 1995-10-10 | 2006-05-09 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| EP1291360A1 (en) | 1991-12-13 | 2003-03-12 | Xoma Corporation | Methods and materials for preparation of modified antibody variable domains and therapeutic uses thereof |
| EP0583980A1 (en) | 1992-08-20 | 1994-02-23 | Eli Lilly And Company | Method for generating monoclonal antibodies from rabbits |
| WO1997016537A1 (en) | 1995-10-30 | 1997-05-09 | Spectral Diagnostics, Inc. | Stable chicken b-cell line and method of use thereof |
| US5714352A (en) | 1996-03-20 | 1998-02-03 | Xenotech Incorporated | Directed switch-mediated DNA recombination |
| EP1644416A4 (en) | 2003-06-30 | 2007-08-29 | Centocor Inc | ANTI-TARGET AND GENETICALLY MODIFIED IMMUNOGLOBULIN-DERIVED PROTEINS, COMPOSITIONS, METHODS AND USES |
| DK2602323T3 (en) * | 2007-06-01 | 2018-04-16 | Open Monoclonal Tech Inc | Compositions and Methods for Inhibiting Endogenous Immunoglobin Genes and Producing Transgenic Human Idiotypic Antibodies |
| JP5470817B2 (ja) | 2008-03-10 | 2014-04-16 | 日産自動車株式会社 | 電池用電極およびこれを用いた電池、並びにその製造方法 |
| WO2010101802A2 (en) | 2009-03-02 | 2010-09-10 | University Of Georgia Research Foundation, Inc. | Method to alter sex ratios in avian offspring |
| GB0905023D0 (en) | 2009-03-24 | 2009-05-06 | Univ Erasmus Medical Ct | Binding molecules |
| US8592644B2 (en) * | 2009-08-13 | 2013-11-26 | Crystal Bioscience Inc. | Transgenic animal for production of antibodies having minimal CDRS |
| US8754287B2 (en) * | 2009-12-10 | 2014-06-17 | Regeneron Pharmaceuticals, Inc. | Mice that make heavy chain antibodies |
| US9394372B2 (en) * | 2011-10-21 | 2016-07-19 | Crystal Bioscience Inc. | In vivo method for generating diversity in a protein scaffold |
| US10774132B2 (en) * | 2012-01-09 | 2020-09-15 | The Scripps Research Instittue | Ultralong complementarity determining regions and uses thereof |
| JP6136279B2 (ja) | 2013-01-15 | 2017-05-31 | 株式会社ジェイテクト | 転がり軸受装置 |
| TWI503850B (zh) | 2013-03-22 | 2015-10-11 | Polytronics Technology Corp | 過電流保護元件 |
| AU2014290361B2 (en) | 2013-07-18 | 2019-04-18 | Taurus Biosciences, Llc | Humanized antibodies with ultralong complementarity determining regions |
| TWI510996B (zh) | 2013-10-03 | 2015-12-01 | Acer Inc | 控制觸控面板的方法以及使用該方法的可攜式電腦 |
| US20170058029A1 (en) * | 2014-05-02 | 2017-03-02 | Chiome Bioscience Inc. | Human antibody-producing cell |
| US9816280B1 (en) | 2016-11-02 | 2017-11-14 | Matthew Reitnauer | Portable floor |
-
2019
- 2019-06-05 KR KR1020217000705A patent/KR20210021002A/ko not_active Ceased
- 2019-06-05 CA CA3102125A patent/CA3102125A1/en active Pending
- 2019-06-05 EP EP19819135.5A patent/EP3813520A4/en active Pending
- 2019-06-05 WO PCT/US2019/035540 patent/WO2019241002A1/en not_active Ceased
- 2019-06-05 JP JP2020569001A patent/JP7515410B2/ja active Active
- 2019-06-05 AU AU2019284256A patent/AU2019284256B2/en active Active
- 2019-06-05 US US15/734,955 patent/US12428471B2/en active Active
-
2025
- 2025-08-25 US US19/309,500 patent/US20250388651A1/en active Pending
- 2025-11-21 AU AU2025271118A patent/AU2025271118A1/en active Pending
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