JP2021526828A5 - - Google Patents
Info
- Publication number
- JP2021526828A5 JP2021526828A5 JP2020568981A JP2020568981A JP2021526828A5 JP 2021526828 A5 JP2021526828 A5 JP 2021526828A5 JP 2020568981 A JP2020568981 A JP 2020568981A JP 2020568981 A JP2020568981 A JP 2020568981A JP 2021526828 A5 JP2021526828 A5 JP 2021526828A5
- Authority
- JP
- Japan
- Prior art keywords
- transgenic animal
- heavy chain
- variable domain
- animal according
- pseudogene
- Prior art date
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024036618A JP2024081672A (ja) | 2018-06-13 | 2024-03-11 | 遺伝子変換による自律型重鎖可変ドメインの改変による抗体の産生 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862684607P | 2018-06-13 | 2018-06-13 | |
| US62/684,607 | 2018-06-13 | ||
| PCT/US2019/035521 WO2019240998A1 (en) | 2018-06-13 | 2019-06-05 | Production of antibodies by modification of an autonomous heavy chain variable domain by gene conversion |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024036618A Division JP2024081672A (ja) | 2018-06-13 | 2024-03-11 | 遺伝子変換による自律型重鎖可変ドメインの改変による抗体の産生 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021526828A JP2021526828A (ja) | 2021-10-11 |
| JP2021526828A5 true JP2021526828A5 (https=) | 2022-06-09 |
| JPWO2019240998A5 JPWO2019240998A5 (https=) | 2022-06-09 |
| JP7572861B2 JP7572861B2 (ja) | 2024-10-24 |
Family
ID=68842067
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020568981A Active JP7572861B2 (ja) | 2018-06-13 | 2019-06-05 | 遺伝子変換による自律型重鎖可変ドメインの改変による抗体の産生 |
| JP2024036618A Pending JP2024081672A (ja) | 2018-06-13 | 2024-03-11 | 遺伝子変換による自律型重鎖可変ドメインの改変による抗体の産生 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024036618A Pending JP2024081672A (ja) | 2018-06-13 | 2024-03-11 | 遺伝子変換による自律型重鎖可変ドメインの改変による抗体の産生 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US12588664B2 (https=) |
| EP (1) | EP3806630A4 (https=) |
| JP (2) | JP7572861B2 (https=) |
| KR (1) | KR20210021024A (https=) |
| AU (2) | AU2019284252B2 (https=) |
| CA (1) | CA3101859A1 (https=) |
| WO (1) | WO2019240998A1 (https=) |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| GB2183661B (en) | 1985-03-30 | 1989-06-28 | Marc Ballivet | Method for obtaining dna, rna, peptides, polypeptides or proteins by means of a dna recombinant technique |
| US6492107B1 (en) | 1986-11-20 | 2002-12-10 | Stuart Kauffman | Process for obtaining DNA, RNA, peptides, polypeptides, or protein, by recombinant DNA technique |
| US5618920A (en) | 1985-11-01 | 1997-04-08 | Xoma Corporation | Modular assembly of antibody genes, antibodies prepared thereby and use |
| DE3600905A1 (de) | 1986-01-15 | 1987-07-16 | Ant Nachrichtentech | Verfahren zum dekodieren von binaersignalen sowie viterbi-dekoder und anwendungen |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US4977081A (en) | 1987-05-04 | 1990-12-11 | Adi Diagnostics, Inc. | Stable rabbit-mouse hybridomas and secretion products thereof |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| WO1990014443A1 (en) | 1989-05-16 | 1990-11-29 | Huse William D | Co-expression of heteromeric receptors |
| CA2016842A1 (en) | 1989-05-16 | 1990-11-16 | Richard A. Lerner | Method for tapping the immunological repertoire |
| CA2016841C (en) | 1989-05-16 | 1999-09-21 | William D. Huse | A method for producing polymers having a preselected activity |
| WO1992001043A1 (en) | 1990-07-10 | 1992-01-23 | Nkk Corporation | Hybridoma which produces avian specific immunoglobulin g |
| EP1291360A1 (en) | 1991-12-13 | 2003-03-12 | Xoma Corporation | Methods and materials for preparation of modified antibody variable domains and therapeutic uses thereof |
| EP0583980A1 (en) | 1992-08-20 | 1994-02-23 | Eli Lilly And Company | Method for generating monoclonal antibodies from rabbits |
| WO1997016537A1 (en) | 1995-10-30 | 1997-05-09 | Spectral Diagnostics, Inc. | Stable chicken b-cell line and method of use thereof |
| US5714352A (en) | 1996-03-20 | 1998-02-03 | Xenotech Incorporated | Directed switch-mediated DNA recombination |
| EP1644416A4 (en) | 2003-06-30 | 2007-08-29 | Centocor Inc | ANTI-TARGET AND GENETICALLY MODIFIED IMMUNOGLOBULIN-DERIVED PROTEINS, COMPOSITIONS, METHODS AND USES |
| SI2311874T1 (sl) | 2004-07-22 | 2017-12-29 | Erasmus University Medical Center Rotterdam Department of Cell Biology and Genetics | Vezavne molekule |
| TWI404727B (zh) | 2006-01-25 | 2013-08-11 | 荷蘭鹿特丹Erasmus大學醫學中心 | 對偶基因排除 |
| JP2010528625A (ja) | 2007-06-01 | 2010-08-26 | ビューロウ リサーチ エンタープライザズ リミティド ライアビリティ カンパニー | トランスジェニック鳥においてヒトイディオタイプを有する抗体を生産するための組成物及び方法 |
| JP5470817B2 (ja) | 2008-03-10 | 2014-04-16 | 日産自動車株式会社 | 電池用電極およびこれを用いた電池、並びにその製造方法 |
| WO2010101802A2 (en) | 2009-03-02 | 2010-09-10 | University Of Georgia Research Foundation, Inc. | Method to alter sex ratios in avian offspring |
| GB0905023D0 (en) * | 2009-03-24 | 2009-05-06 | Univ Erasmus Medical Ct | Binding molecules |
| US8592644B2 (en) | 2009-08-13 | 2013-11-26 | Crystal Bioscience Inc. | Transgenic animal for production of antibodies having minimal CDRS |
| US8754287B2 (en) * | 2009-12-10 | 2014-06-17 | Regeneron Pharmaceuticals, Inc. | Mice that make heavy chain antibodies |
| US9394372B2 (en) * | 2011-10-21 | 2016-07-19 | Crystal Bioscience Inc. | In vivo method for generating diversity in a protein scaffold |
| JP6136279B2 (ja) | 2013-01-15 | 2017-05-31 | 株式会社ジェイテクト | 転がり軸受装置 |
| US10993420B2 (en) | 2013-03-15 | 2021-05-04 | Erasmus University Medical Center | Production of heavy chain only antibodies in transgenic mammals |
| TWI503850B (zh) | 2013-03-22 | 2015-10-11 | Polytronics Technology Corp | 過電流保護元件 |
| TWI510996B (zh) | 2013-10-03 | 2015-12-01 | Acer Inc | 控制觸控面板的方法以及使用該方法的可攜式電腦 |
| US20170058029A1 (en) * | 2014-05-02 | 2017-03-02 | Chiome Bioscience Inc. | Human antibody-producing cell |
| IL264941B2 (en) | 2016-08-24 | 2025-12-01 | Teneobio Inc | Transgenic non-human animals producing modified heavy chain-only antibodies |
| US9816280B1 (en) | 2016-11-02 | 2017-11-14 | Matthew Reitnauer | Portable floor |
-
2019
- 2019-06-05 AU AU2019284252A patent/AU2019284252B2/en active Active
- 2019-06-05 EP EP19819598.4A patent/EP3806630A4/en active Pending
- 2019-06-05 US US15/734,533 patent/US12588664B2/en active Active
- 2019-06-05 KR KR1020217001018A patent/KR20210021024A/ko active Pending
- 2019-06-05 JP JP2020568981A patent/JP7572861B2/ja active Active
- 2019-06-05 WO PCT/US2019/035521 patent/WO2019240998A1/en not_active Ceased
- 2019-06-05 CA CA3101859A patent/CA3101859A1/en active Pending
-
2024
- 2024-03-11 JP JP2024036618A patent/JP2024081672A/ja active Pending
-
2026
- 2026-01-08 AU AU2026200099A patent/AU2026200099A1/en active Pending
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