JP2011182801A5 - - Google Patents

Download PDF

Info

Publication number
JP2011182801A5
JP2011182801A5 JP2011131898A JP2011131898A JP2011182801A5 JP 2011182801 A5 JP2011182801 A5 JP 2011182801A5 JP 2011131898 A JP2011131898 A JP 2011131898A JP 2011131898 A JP2011131898 A JP 2011131898A JP 2011182801 A5 JP2011182801 A5 JP 2011182801A5
Authority
JP
Japan
Prior art keywords
gene segment
humanized
locus
gene
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2011131898A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011182801A (ja
JP6017763B2 (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2011182801A publication Critical patent/JP2011182801A/ja
Publication of JP2011182801A5 publication Critical patent/JP2011182801A5/ja
Application granted granted Critical
Publication of JP6017763B2 publication Critical patent/JP6017763B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP2011131898A 2003-07-15 2011-06-14 ヒト化免疫グロブリン遺伝子座 Expired - Lifetime JP6017763B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48773303P 2003-07-15 2003-07-15
US60/487,733 2003-07-15

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2006520411A Division JP2007537704A (ja) 2003-07-15 2004-07-15 ヒト化免疫グロブリン遺伝子座

Publications (3)

Publication Number Publication Date
JP2011182801A JP2011182801A (ja) 2011-09-22
JP2011182801A5 true JP2011182801A5 (https=) 2012-07-19
JP6017763B2 JP6017763B2 (ja) 2016-11-02

Family

ID=34079388

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2006520411A Withdrawn JP2007537704A (ja) 2003-07-15 2004-07-15 ヒト化免疫グロブリン遺伝子座
JP2011131898A Expired - Lifetime JP6017763B2 (ja) 2003-07-15 2011-06-14 ヒト化免疫グロブリン遺伝子座

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2006520411A Withdrawn JP2007537704A (ja) 2003-07-15 2004-07-15 ヒト化免疫グロブリン遺伝子座

Country Status (10)

Country Link
US (4) US7585668B2 (https=)
EP (1) EP1644417B1 (https=)
JP (2) JP2007537704A (https=)
CN (2) CN1852925A (https=)
AU (1) AU2004257292A1 (https=)
CA (1) CA2532117C (https=)
ES (1) ES2473596T3 (https=)
IL (1) IL172885A0 (https=)
MX (1) MXPA06000562A (https=)
WO (1) WO2005007696A2 (https=)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050144655A1 (en) 2000-10-31 2005-06-30 Economides Aris N. Methods of modifying eukaryotic cells
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
EP1644417B1 (en) * 2003-07-15 2014-04-30 Therapeutic Human Polyclonals, Inc. Humanized immunoglobulin loci
EP2029729A2 (en) * 2006-05-31 2009-03-04 Genzyme Corporation Methods of using anti-thymocyte globulin and related agents
US20090053210A1 (en) * 2006-09-01 2009-02-26 Roland Buelow Enhanced expression of human or humanized immunoglobulin in non-human transgenic animals
ATE536374T1 (de) * 2006-09-01 2011-12-15 Therapeutic Human Polyclonals Inc Erhöhte expression von humanem oder humanisiertem immunglobulin bei nicht-humanen transgenen tieren
DK2602323T3 (en) * 2007-06-01 2018-04-16 Open Monoclonal Tech Inc Compositions and Methods for Inhibiting Endogenous Immunoglobin Genes and Producing Transgenic Human Idiotypic Antibodies
WO2009097006A2 (en) * 2007-08-10 2009-08-06 Medarex, Inc. Hco32 and hco27 and related examples
WO2009023800A1 (en) * 2007-08-14 2009-02-19 Origen Therapeutics Transgenic chickens with an inactivated endogenous gene locus
EP2108696A1 (en) * 2008-04-10 2009-10-14 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH Cis-acting diversification activator and method for selective diversification of nucleic acids
JP5827127B2 (ja) * 2008-12-18 2015-12-02 エラスムス・ユニヴァーシティ・メディカル・センター・ロッテルダム ヒト化抗体を発現する非ヒトトランスジェニック動物及びその使用
BR112012000536A2 (pt) * 2009-07-08 2020-08-11 Kymab Limited métodos para produção de anticorpo ou cadeia leve ou pesada de anticorpo específico para um antígeno desejado, para produção de anticorpo ou cadeia de anticorpo e seu uso, composição farmacêutica e derivado de anticorpo quimérico
US8592644B2 (en) * 2009-08-13 2013-11-26 Crystal Bioscience Inc. Transgenic animal for production of antibodies having minimal CDRS
US8865462B2 (en) 2010-01-20 2014-10-21 Crystal Bioscience Inc. Sustained culture of avian gonocytes
SI2501817T2 (sl) 2010-02-08 2021-09-30 Regeneron Pharmaceuticals, Inc. Miš z navadno lahko verigo
US20130045492A1 (en) 2010-02-08 2013-02-21 Regeneron Pharmaceuticals, Inc. Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain
US9796788B2 (en) 2010-02-08 2017-10-24 Regeneron Pharmaceuticals, Inc. Mice expressing a limited immunoglobulin light chain repertoire
KR102203727B1 (ko) 2010-03-31 2021-01-18 아블렉시스, 엘엘씨 키메라 항체의 제조를 위한 비-인간 동물의 유전적 조작
US9012717B2 (en) 2010-06-22 2015-04-21 Regeneron Pharmaceuticals, Inc. Human lambda light chain mice
SG10201912639SA (en) 2010-08-02 2020-02-27 Regeneron Pharma Mice that make binding proteins comprising vl domains
CN102250239B (zh) * 2011-06-13 2013-04-17 中国农业科学院哈尔滨兽医研究所 一种与兔出血症病毒vp60蛋白相结合的蛋白及其应用
RS59728B1 (sr) 2011-08-05 2020-02-28 Regeneron Pharma Humanizovani miševi univerzalnog lakog lanca
BR112014006394A2 (pt) * 2011-09-19 2017-03-28 Kymab Ltd manipulação de diversidade genética de imunoglobulina e terapêuticos multi-anticorpos
KR20160098514A (ko) 2011-10-17 2016-08-18 리제너론 파아마슈티컬스, 인크. 제한된 면역글로불린 중쇄 마우스
RU2664181C2 (ru) 2011-12-20 2018-08-15 Регенерон Фармасьютикалз, Инк. Мыши с гуманизированной легкой цепью
WO2013092720A1 (en) 2011-12-22 2013-06-27 F. Hoffmann-La Roche Ag Full length antibody display system for eukaryotic cells and its use
RS62023B1 (sr) * 2012-02-01 2021-07-30 Regeneron Pharma Humanizovani glodari koji eksprimiraju teške lance koji sadrže vl domene
KR102228296B1 (ko) 2012-03-16 2021-03-17 리제너론 파마슈티칼스 인코포레이티드 히스티딘 공학처리된 경쇄 항체 및 그것을 생성하기 위한 유전자 변형된 비-사람 동물
SG10201700360VA (en) 2012-03-16 2017-03-30 Regeneron Pharma Non-human animals expressing ph-sensitive immunoglobulin sequences
PT3597037T (pt) 2012-06-12 2021-06-01 Regeneron Pharma Animais não humanos humanizados com lócus de cadeia pesada de imunoglobulina restrito
KR102159163B1 (ko) 2012-08-03 2020-09-23 에스에이비, 엘엘씨 유전자삽입 동물에서 인간 항체의 제조를 위한 복합 염색체 조작
EP2840892B1 (en) 2013-02-20 2018-04-18 Regeneron Pharmaceuticals, Inc. Non-human animals with modified immunoglobulin heavy chain sequences
CN105189545A (zh) * 2013-03-13 2015-12-23 瑞泽恩制药公司 常见轻链小鼠
WO2014160202A1 (en) * 2013-03-13 2014-10-02 Regeneron Pharmaceuticals, Inc. Mice expressing a limited immunoglobulin light chain repertoire
EP3092007A4 (en) * 2014-01-10 2017-06-07 Allermabs Co. Ltd. Transgenic animals capable of producing humanized ige at much higher levels than mouse ige
WO2015143406A2 (en) 2014-03-21 2015-09-24 Regeneron Pharmaceuticals, Inc. Vl antigen binding proteins exhibiting distinct binding characteristics
KR102276752B1 (ko) 2014-03-21 2021-07-13 리제너론 파마슈티칼스 인코포레이티드 단일 도메인 결합 단백질을 생산하는 비-인간 동물
US20170058029A1 (en) * 2014-05-02 2017-03-02 Chiome Bioscience Inc. Human antibody-producing cell
EP3271403A1 (en) 2015-03-19 2018-01-24 Regeneron Pharmaceuticals, Inc. Non-human animals that select for light chain variable regions that bind antigen
CN113862300A (zh) * 2015-10-29 2021-12-31 豪夫迈·罗氏有限公司 具有共同轻链的转基因兔
WO2018128691A1 (en) * 2016-11-04 2018-07-12 Regeneron Pharmaceuticals, Inc. Non-human animals having an engineered immunoglobulin lambda light chain locus
WO2018104068A1 (en) 2016-12-05 2018-06-14 Koninklijke Philips N.V. Foreign object detection in a wireless power transfer system
NZ755816A (en) * 2017-01-19 2026-03-27 Omniab Inc Human antibodies from transgenic rodents with multiple heavy chain immunoglobulin loci
WO2019129679A1 (en) 2017-12-29 2019-07-04 F. Hoffmann-La Roche Ag Method for improving vegf-receptor blocking selectivity of an anti-vegf antibody
US20210000088A1 (en) * 2018-03-21 2021-01-07 Crystal Bioscience Inc. Transgenic chicken that produces human antibodies
JP7354306B2 (ja) 2019-06-27 2023-10-02 エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト 新規icos抗体及びそれらを含む腫瘍標的化抗原結合分子
AR119382A1 (es) 2019-07-12 2021-12-15 Hoffmann La Roche Anticuerpos de pre-direccionamiento y métodos de uso
AR119393A1 (es) 2019-07-15 2021-12-15 Hoffmann La Roche Anticuerpos que se unen a nkg2d
CN110540996B (zh) * 2019-08-29 2022-01-28 华中农业大学 一种克氏原螯虾i型溶菌酶gLysi2基因、其编码的gLysi2蛋白及其应用
WO2021127068A1 (en) * 2019-12-18 2021-06-24 Bristol-Myers Squibb Company Bcr transgenic mice with a common leader sequence
CR20240246A (es) 2021-12-20 2024-07-19 Hoffmann La Roche Anticuerpos agonistas anti-ltbr y anticuerpos biespecificos que los comprenden
CN114854901B (zh) * 2022-06-22 2025-11-07 华南农业大学 与苦瓜全雌性状共分离的分子标记、引物及其应用
KR20260026086A (ko) 2023-06-21 2026-02-25 에프. 호프만-라 로슈 아게 Fap 표적화 림포톡신 베타 수용체 작용제를 이용한 조합 요법

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992001043A1 (en) 1990-07-10 1992-01-23 Nkk Corporation Hybridoma which produces avian specific immunoglobulin g
ATE300615T1 (de) * 1990-08-29 2005-08-15 Genpharm Int Transgene mäuse fähig zur produktion heterologer antikörper
EP0583980A1 (en) 1992-08-20 1994-02-23 Eli Lilly And Company Method for generating monoclonal antibodies from rabbits
WO1997016537A1 (en) 1995-10-30 1997-05-09 Spectral Diagnostics, Inc. Stable chicken b-cell line and method of use thereof
ATE307830T1 (de) 1999-02-05 2005-11-15 Therapeutic Human Polyclonals Aus nicht-menschlichen transgenen tieren gewonnene menschliche polyklonale antikörper
WO2000075300A2 (en) 1999-06-04 2000-12-14 Tranxenogen, Inc. Methods for manipulating the avian genome
WO2001019394A2 (en) 1999-09-15 2001-03-22 Therapeutic Human Polyclonals, Inc. Immunotherapy with substantially human polyclonal antibody preparations purified from genetically engineered birds
EA013564B1 (ru) * 2000-08-03 2010-06-30 Терапеутик Хьюман Поликлоналз Инк. Гуманизированный иммуноглобулин и содержащая его фармацевтическая композиция
ATE430756T1 (de) 2002-06-26 2009-05-15 Transgenrx Inc Genregulation in transgenen tieren unter verwendung eines vektors auf transposonbasis
EP1644417B1 (en) * 2003-07-15 2014-04-30 Therapeutic Human Polyclonals, Inc. Humanized immunoglobulin loci
EP1782360A4 (en) 2004-08-27 2009-03-18 Medic4All Ag METHOD AND SYSTEM FOR THE USE OF A MOBILE DEVICE AS A PORTABLE PERSONAL TERMINAL FOR MEDICAL INFORMATION
US20110077965A1 (en) 2009-09-25 2011-03-31 Cerner Innovation, Inc. Processing event information of various sources
US20120306653A1 (en) 2011-06-02 2012-12-06 Nokia Siemens Networks Oy Medical sensor
US20130021154A1 (en) 2011-07-21 2013-01-24 Solomon Clifford T Medical parameters notification system

Similar Documents

Publication Publication Date Title
JP2011182801A5 (https=)
US12291798B2 (en) Generation of binding molecules
CA2532117A1 (en) Humanized immunoglobulin loci
EP3648587B1 (en) Cells, vertebrates, populations & methods
Ching et al. Chickens with humanized immunoglobulin genes generate antibodies with high affinity and broad epitope coverage to conserved targets
RU2018119366A (ru) Мыши с гуманизированной легкой цепью
JP2015505477A5 (https=)
RU2014153673A (ru) Гуманизированные не относящиеся к человеку животные с ограниченными локусами тяжелой цепи иммуноглобулина
JP2015519076A5 (https=)
JP2015502177A5 (https=)
JP2014524243A5 (https=)
JP2020530760A5 (https=)
WO2008122886A2 (en) Transgenic non-human mammal with homodimeric vh binding complex
JP2017114866A5 (https=)
HRP20171357T1 (hr) Ograničeni teški lanac imunoglobulina u miševa
JP2014110814A5 (https=)
JP2010529042A5 (https=)
HRP20201403T1 (hr) Neljudske životinje koje imaju genetski modificiran lokus imunoglobulinskog lambda lakog lanca
HRP20150262T1 (hr) Miševi sa adam6
Drabek et al. Expression cloning and production of human heavy-chain-only antibodies from murine transgenic plasma cells
EP3770261B1 (en) Nucleic acid molecule and application thereof in preparing human single-domain antibody
JP2014500725A5 (https=)
Ching et al. Common light chain chickens produce human antibodies of high affinity and broad epitope coverage for the engineering of bispecifics
JP2018537968A5 (https=)
JPWO2021244522A5 (https=)