JP2018537968A5 - - Google Patents
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- Publication number
- JP2018537968A5 JP2018537968A5 JP2018522020A JP2018522020A JP2018537968A5 JP 2018537968 A5 JP2018537968 A5 JP 2018537968A5 JP 2018522020 A JP2018522020 A JP 2018522020A JP 2018522020 A JP2018522020 A JP 2018522020A JP 2018537968 A5 JP2018537968 A5 JP 2018537968A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- light chain
- antibody
- rabbit
- immunoglobulin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000283973 Oryctolagus cuniculus Species 0.000 claims description 16
- 230000009261 transgenic effect Effects 0.000 claims description 16
- 108060003951 Immunoglobulin Proteins 0.000 claims description 15
- 102000018358 immunoglobulin Human genes 0.000 claims description 15
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 8
- 108091026890 Coding region Proteins 0.000 claims description 6
- 108700019146 Transgenes Proteins 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 150000001413 amino acids Chemical class 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 239000000427 antigen Substances 0.000 claims description 3
- 108091007433 antigens Proteins 0.000 claims description 3
- 102000036639 antigens Human genes 0.000 claims description 3
- 230000035772 mutation Effects 0.000 claims description 3
- 102100021569 Apoptosis regulator Bcl-2 Human genes 0.000 claims description 2
- 101000971171 Homo sapiens Apoptosis regulator Bcl-2 Proteins 0.000 claims description 2
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims description 2
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims description 2
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims description 2
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims description 2
- 101150117115 V gene Proteins 0.000 claims description 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims description 2
- 239000012634 fragment Substances 0.000 claims description 2
- 230000004777 loss-of-function mutation Effects 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15192002.2A EP3184547A1 (en) | 2015-10-29 | 2015-10-29 | Anti-tpbg antibodies and methods of use |
| EP15192002.2 | 2015-10-29 | ||
| EP16162580 | 2016-03-29 | ||
| EP16162580.1 | 2016-03-29 | ||
| PCT/EP2016/075882 WO2017072208A1 (en) | 2015-10-29 | 2016-10-27 | Transgenic rabbit with common light chain |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018537968A JP2018537968A (ja) | 2018-12-27 |
| JP2018537968A5 true JP2018537968A5 (https=) | 2019-11-21 |
| JP7085992B2 JP7085992B2 (ja) | 2022-06-17 |
Family
ID=57233408
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018522020A Active JP7085992B2 (ja) | 2015-10-29 | 2016-10-27 | 共通軽鎖を有するトランスジェニックウサギ |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20230332175A1 (https=) |
| EP (1) | EP3367786A1 (https=) |
| JP (1) | JP7085992B2 (https=) |
| CN (3) | CN113862300A (https=) |
| HK (1) | HK1258306A1 (https=) |
| SG (2) | SG11201802698XA (https=) |
| WO (1) | WO2017072208A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11202008399QA (en) | 2018-03-12 | 2020-09-29 | Genmab As | Antibodies |
| WO2020132557A1 (en) * | 2018-12-21 | 2020-06-25 | Compass Therapeutics Llc | Transgenic mouse expressing common human light chain |
| KR20230018439A (ko) * | 2020-06-02 | 2023-02-07 | 바이오사이토젠 파마슈티컬스 (베이징) 컴퍼니 리미티드 | 공동 경쇄 면역글로불린 좌위를 갖는 유전자 변형 비인간 동물 |
| JP2023551113A (ja) * | 2020-11-06 | 2023-12-07 | バイオ－テラ ソリュ－ションズ，エルティーディー． | 二重特異性抗体及びその応用 |
| CN115702931A (zh) * | 2021-08-06 | 2023-02-17 | 百奥泰生物制药股份有限公司 | 抗pd-l1/cd47双特异抗体在治疗疾病中的应用 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4213224B2 (ja) * | 1997-05-02 | 2009-01-21 | ジェネンテック，インコーポレーテッド | ヘテロマルチマー及び共通成分を有する多重特異性抗体の製造方法 |
| ATE307830T1 (de) * | 1999-02-05 | 2005-11-15 | Therapeutic Human Polyclonals | Aus nicht-menschlichen transgenen tieren gewonnene menschliche polyklonale antikörper |
| EA013564B1 (ru) * | 2000-08-03 | 2010-06-30 | Терапеутик Хьюман Поликлоналз Инк. | Гуманизированный иммуноглобулин и содержащая его фармацевтическая композиция |
| EP1644417B1 (en) * | 2003-07-15 | 2014-04-30 | Therapeutic Human Polyclonals, Inc. | Humanized immunoglobulin loci |
| US20080184380A1 (en) * | 2004-10-22 | 2008-07-31 | Therapeutic Human Polyclonals Inc. | Suppression of Endogenous Immunoglobulin Expression in Non-Human Transgenic Animals |
| WO2007019223A1 (en) * | 2005-08-03 | 2007-02-15 | Therapeutic Human Polyclonals, Inc. | Suppression of b-cell apoptosis in transgenic animals expressing humanized immunoglobulin |
| ATE536374T1 (de) * | 2006-09-01 | 2011-12-15 | Therapeutic Human Polyclonals Inc | Erhöhte expression von humanem oder humanisiertem immunglobulin bei nicht-humanen transgenen tieren |
| WO2009082624A2 (en) * | 2007-12-10 | 2009-07-02 | Zymogenetics, Inc. | Antagonists of il-17a, il-17f, and il-23 and methods of using the same |
| NZ588850A (en) * | 2008-04-28 | 2012-12-21 | Kalobios Pharmaceuticals Inc | Antibodies to granulocyte-macrophage colony-stimulating factor |
| CN102171247A (zh) * | 2008-07-02 | 2011-08-31 | 特鲁比昂药品公司 | TNF-α拮抗剂多靶点结合蛋白 |
| JP6058264B2 (ja) * | 2008-07-08 | 2017-01-11 | ジェウヌロ・エスエーＧｅＮｅｕｒｏ ＳＡ | Ｍｓｒｖ関連疾患の特異的なリガンドの治療上の使用 |
| CA2737667A1 (en) * | 2008-09-19 | 2010-03-25 | Medimmune, Llc | Targeted binding agents directed to cd105 and uses thereof |
| US20130045492A1 (en) * | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| SG191039A1 (en) * | 2010-12-15 | 2013-08-30 | Wyeth Llc | Anti-notch1 antibodies |
| SI2838917T1 (sl) * | 2012-04-20 | 2019-11-29 | Merus Nv | Postopki in sredstva za produkcijo heterodimernih IG-podobnih molekul |
| US20150203591A1 (en) * | 2012-08-02 | 2015-07-23 | Regeneron Pharmaceuticals, Inc. | Mutivalent antigen-binding proteins |
| EP3470431A1 (en) * | 2012-09-27 | 2019-04-17 | Merus N.V. | Bispecific igg antibodies as t cell engagers |
| JP6267792B2 (ja) * | 2013-06-28 | 2018-01-24 | アムジエン・インコーポレーテツド | ホモ接合性家族性高コレステロール血症の治療方法 |
| MY184154A (en) * | 2013-12-12 | 2021-03-23 | Shanghai hengrui pharmaceutical co ltd | Pd-1 antibody, antigen-binding fragment thereof, and medical application thereof |
| EP3786186A1 (en) * | 2014-02-28 | 2021-03-03 | Merus N.V. | Antibodies that bind egfr and erbb3 |
| EP3126384B1 (en) * | 2014-04-01 | 2020-12-02 | Adimab, LLC | Multispecific antibody analogs comprising a common light chain, and methods of their preparation and use |
-
2016
- 2016-10-27 CN CN202111174951.7A patent/CN113862300A/zh active Pending
- 2016-10-27 SG SG11201802698XA patent/SG11201802698XA/en unknown
- 2016-10-27 JP JP2018522020A patent/JP7085992B2/ja active Active
- 2016-10-27 CN CN201680063211.7A patent/CN108347906A/zh active Pending
- 2016-10-27 WO PCT/EP2016/075882 patent/WO2017072208A1/en not_active Ceased
- 2016-10-27 HK HK19100672.4A patent/HK1258306A1/zh unknown
- 2016-10-27 CN CN202111178978.3A patent/CN113897371A/zh active Pending
- 2016-10-27 SG SG10202006332PA patent/SG10202006332PA/en unknown
- 2016-10-27 EP EP16790926.6A patent/EP3367786A1/en active Pending
-
2022
- 2022-11-02 US US18/052,113 patent/US20230332175A1/en active Pending
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