US7763609B2
(en)
|
2003-12-15 |
2010-07-27 |
Schering Corporation |
Heterocyclic aspartyl protease inhibitors
|
WO2006138217A1
(en)
|
2005-06-14 |
2006-12-28 |
Schering Corporation |
Aspartyl protease inhibitors
|
ES2476027T3
(es)
|
2005-10-25 |
2014-07-11 |
Shionogi & Co., Ltd. |
Derivados de aminodihidrotriazina
|
ES2476605T3
(es)
|
2007-04-24 |
2014-07-15 |
Shionogi & Co., Ltd. |
Derivados de aminohidrotiazina sustituidos con grupos cíclicos
|
WO2008133273A1
(ja)
|
2007-04-24 |
2008-11-06 |
Shionogi & Co., Ltd. |
アルツハイマー症治療用医薬組成物
|
TWI431004B
(zh)
|
2008-05-02 |
2014-03-21 |
Lilly Co Eli |
Bace抑制劑
|
AU2009258496B8
(en)
|
2008-06-13 |
2014-06-26 |
Shionogi & Co., Ltd. |
Sulfur-containing heterocyclic derivative having beta-secretase-inhibiting activity
|
JPWO2010047372A1
(ja)
|
2008-10-22 |
2012-03-22 |
塩野義製薬株式会社 |
Bace1阻害活性を有する2−アミノピリミジン−4−オンおよび2−アミノピリジン誘導体
|
WO2010113848A1
(ja)
|
2009-03-31 |
2010-10-07 |
塩野義製薬株式会社 |
Bace1阻害作用を有するイソチオウレア誘導体またはイソウレア誘導体
|
UA108363C2
(uk)
|
2009-10-08 |
2015-04-27 |
|
Похідні імінотіадіазиндіоксиду як інгібітори bace, композиція на їх основі і їх застосування
|
CN102686584A
(zh)
|
2009-11-13 |
2012-09-19 |
盐野义制药株式会社 |
具有氨基连接基的氨基噻嗪或氨基噁嗪衍生物
|
JPWO2011070781A1
(ja)
|
2009-12-09 |
2013-04-22 |
塩野義製薬株式会社 |
置換アミノチアジン誘導体
|
WO2011071057A1
(ja)
|
2009-12-09 |
2011-06-16 |
塩野義製薬株式会社 |
含硫黄複素環誘導体を含有するアルツハイマー症の治療用または予防用医薬組成物
|
US7964594B1
(en)
|
2009-12-10 |
2011-06-21 |
Hoffmann-La Roche Inc. |
Amino oxazine derivatives
|
US8999980B2
(en)
|
2009-12-11 |
2015-04-07 |
Shionogi & Co., Ltd. |
Oxazine derivatives
|
EP2511269A4
(en)
|
2009-12-11 |
2013-04-24 |
Shionogi & Co |
FUSED HETEROCYCLIC COMPOUND HAVING AN AMINO GROUP
|
UA103272C2
(uk)
|
2009-12-11 |
2013-09-25 |
Ф. Хоффманн-Ля Рош Аг |
2-аміно-5,5-дифтор-5,6-дигідро-4h-оксазини як інгібітори bace1 і/або bace2
|
EP2518059A4
(en)
|
2009-12-24 |
2013-05-29 |
Shionogi & Co |
4-AMINO-1,3-THIAZINE OR OXAZINE DERIVATIVE
|
US9320793B2
(en)
|
2010-07-14 |
2016-04-26 |
Acumen Pharmaceuticals, Inc. |
Method for treating a disease associated with soluble, oligomeric species of amyloid beta 1-42
|
EP2634186A4
(en)
|
2010-10-29 |
2014-03-26 |
Shionogi & Co |
naphthyridine
|
EP2634188A4
(en)
|
2010-10-29 |
2014-05-07 |
Shionogi & Co |
FUSIONED AMINODIHYDROPYRIMIDINE DERIVATIVE
|
US8404680B2
(en)
|
2011-02-08 |
2013-03-26 |
Hoffmann-La Roche Inc. |
N-[3-(5-amino-3,3a,7,7a-tetrahydro-1H-2,4-dioxa-6-aza-inden-7-yl)-phenyl]-amides as BACE1 and/or BACE2 inhibitors
|
US8754075B2
(en)
|
2011-04-11 |
2014-06-17 |
Hoffmann-La Roche Inc. |
1,3-oxazines as BACE1 and/or BACE2 inhibitors
|
JP2014514302A
(ja)
|
2011-04-13 |
2014-06-19 |
メルク・シャープ・アンド・ドーム・コーポレーション |
Bace阻害薬としての5−置換されたイミノチアジン類およびそれのモノおよびジオキシド、組成物およびそれらの使用
|
JPWO2012147762A1
(ja)
|
2011-04-26 |
2014-07-28 |
塩野義製薬株式会社 |
ピリジン誘導体およびそれを含有するbace1阻害剤
|
TW201247635A
(en)
|
2011-04-26 |
2012-12-01 |
Shionogi & Co |
Oxazine derivatives and a pharmaceutical composition for inhibiting BAC1 containing them
|
US8785436B2
(en)
|
2011-05-16 |
2014-07-22 |
Hoffmann-La Roche Inc. |
1,3-oxazines as BACE 1 and/or BACE2 inhibitors
|
JP2012250933A
(ja)
|
2011-06-03 |
2012-12-20 |
Shionogi & Co Ltd |
オキサジン誘導体を含有するアルツハイマー症治療用または予防用医薬組成物
|
CA2837252A1
(en)
|
2011-06-07 |
2012-12-13 |
F. Hoffmann-La Roche Ag |
Halogen-alkyl-1,3 oxazines as bace1 and/or bace2 inhibitors
|
EP2718287A1
(en)
|
2011-06-07 |
2014-04-16 |
F.Hoffmann-La Roche Ag |
[1,3]oxazines
|
EP2747769B1
(en)
|
2011-08-22 |
2017-08-02 |
Merck Sharp & Dohme Corp. |
2-spiro-substituted iminothiazines and their mono-and dioxides as bace inhibitors, compositions and their use
|
UY34278A
(es)
|
2011-08-25 |
2013-04-05 |
Novartis Ag |
Derivados novedosos de oxazina y su uso en el tratamiento de enfermedades
|
US20130073953A1
(en)
|
2011-09-21 |
2013-03-21 |
Timothy Onyenobi |
News headline screenshot viewing system
|
UA113538C2
(xx)
|
2012-01-26 |
2017-02-10 |
|
Фторметил-5,6-дигідро-4h-$1,3]оксазини
|
CA2872179A1
(en)
|
2012-05-24 |
2013-11-28 |
F. Hoffmann-La Roche Ag |
5-amino[1,4]thiazines as bace 1 inhibitors
|
KR20150023450A
(ko)
*
|
2012-06-26 |
2015-03-05 |
에프. 호프만-라 로슈 아게 |
Bace1 억제제로서의 다이플루오로-헥사하이드로-사이클로펜타옥사진일 및 다이플루오로-헥사하이드로-벤조옥사진일
|
WO2014010748A1
(en)
|
2012-07-10 |
2014-01-16 |
Shionogi & Co., Ltd. |
Cyclopropane derivative having bace1 inhibiting activity
|
WO2014059185A1
(en)
|
2012-10-12 |
2014-04-17 |
Amgen Inc. |
Amino - dihydrothiazine and amino - dioxido dihydrothiazine compounds as beta-secretase antagonists and methods of use
|
JP2014101354A
(ja)
|
2012-10-24 |
2014-06-05 |
Shionogi & Co Ltd |
Bace1阻害作用を有するオキサジン誘導体
|
WO2014065434A1
(en)
|
2012-10-24 |
2014-05-01 |
Shionogi & Co., Ltd. |
Dihydrooxazine or oxazepine derivatives having bace1 inhibitory activity
|
JP2014101353A
(ja)
|
2012-10-26 |
2014-06-05 |
Shionogi & Co Ltd |
オキサジン誘導体を含有するアルツハイマー症治療用または予防用医薬組成物
|
US9447085B2
(en)
|
2012-12-14 |
2016-09-20 |
Merck Sharp & Dohme Corp. |
Iminothiadiazine dioxides containing a thioamide, amidine, or amide oxime group as BACE inhibitors, compositions, and their use
|
WO2014098831A1
(en)
|
2012-12-19 |
2014-06-26 |
Bristol-Myers Squibb Company |
4,6-diarylaminothiazines as bace1 inhibitors and their use for the reduction of beta-amyloid production
|
WO2014099794A1
(en)
|
2012-12-20 |
2014-06-26 |
Merck Sharp & Dohme Corp. |
C5, c6 oxacyclic-fused iminothiazine dioxide compounds as bace inhibitors
|
EP2745876A1
(en)
|
2012-12-21 |
2014-06-25 |
Prous Institute for Biomedical Research, S.A. |
Hydroxy aliphatic substituted phenyl aminoalkyl ether derivatives
|
JP2016505055A
(ja)
|
2013-01-22 |
2016-02-18 |
エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft |
Bace1阻害剤としてのフルオロ−[1,3]オキサジン
|
WO2014120658A1
(en)
|
2013-01-29 |
2014-08-07 |
Amgen Inc. |
Fused multicyclic 3-amino-5,6-dihydro-2h-1,4-thiazine derivatives and their use as beta-secretase inhibitors
|
US9296734B2
(en)
|
2013-03-01 |
2016-03-29 |
Amgen Inc. |
Perfluorinated 5,6-dihydro-4H-1,3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use
|
SG11201507196WA
(en)
|
2013-03-08 |
2015-10-29 |
Amgen Inc |
Perfluorinated cyclopropyl fused 1,3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use
|
EP2968353B1
(en)
|
2013-03-15 |
2018-12-19 |
Merck Sharp & Dohme Corp. |
C2-azaspiro iminothiazine dioxides as bace inhibitors
|
BR112015019412A8
(pt)
|
2013-04-11 |
2019-11-12 |
Hoffmann La Roche |
inibidores de bace1, seus usos, e composição farmacêutica
|
US9096615B2
(en)
|
2013-07-30 |
2015-08-04 |
Amgen Inc. |
Bridged bicyclic amino thiazine dioxide compounds as inhibitors of beta-secretase and methods of use thereof
|
EP3043802B1
(en)
|
2013-09-13 |
2018-04-18 |
Merck Sharp & Dohme Corp. |
C5-spiro iminothiazine dioxides as bace inhibitors, compositions, and their use
|
WO2015051239A1
(en)
|
2013-10-03 |
2015-04-09 |
The General Hospital Corporation |
Methods for increasing neuronal survival
|
CA2938152A1
(en)
|
2014-02-10 |
2015-08-13 |
Merck Sharp & Dohme Corp. |
Antibodies that bind to human tau and assay for quantifying human tau using the antibodies
|
US20140271911A1
(en)
|
2014-03-26 |
2014-09-18 |
James Wallace |
Lithium and a beta-secretase inhibitor for the treatment of alzheimer's disease
|
TW201623295A
(zh)
|
2014-04-11 |
2016-07-01 |
塩野義製藥股份有限公司 |
具有bace1抑制活性之二氫噻及二氫衍生物
|
WO2016025364A1
(en)
|
2014-08-14 |
2016-02-18 |
Merck Sharp & Dohme Corp. |
Novel crystalline forms of a bace inhibitor, compositions, and their use
|
WO2016040903A1
(en)
|
2014-09-11 |
2016-03-17 |
Board Of Regents Of The University Of Texas System |
Detection of misfolded amyloid beta protein
|
US20160213645A1
(en)
|
2015-04-04 |
2016-07-28 |
James Wallace |
Combination of levetiracetam and a beta-secretase (bace) inhibitor
|
TW201726651A
(zh)
|
2015-09-23 |
2017-08-01 |
健生藥品公司 |
2,3,4,5-四氫吡啶-6-胺衍生物
|
WO2017061534A1
(en)
|
2015-10-08 |
2017-04-13 |
Shionogi & Co., Ltd. |
Dihydrothiazine derivatives
|
JP2017071603A
(ja)
|
2015-10-09 |
2017-04-13 |
塩野義製薬株式会社 |
ジヒドロチアジンまたはジヒドロオキサジン誘導体を含有する医薬組成物
|
EP3414322A4
(en)
|
2015-12-23 |
2020-03-04 |
Memorial Sloan-Kettering Cancer Center |
CELL THERAPY AND DRUG DISCOVERY BASED ON CELL LINES DERIVED FROM HUMAN ENTERAL NEURAL CREST DERIVED FROM PLURIPOTENT STEM CELLS
|
CN108699051B
(zh)
|
2016-03-01 |
2021-12-24 |
豪夫迈·罗氏有限公司 |
Bace1抑制剂
|
MX2019007101A
(es)
|
2016-12-15 |
2019-12-16 |
Amgen Inc |
Derivados de oxazina como inhibidores de beta secretasa y metodos de uso.
|
JP2022511167A
(ja)
|
2018-04-23 |
2022-01-31 |
塩野義製薬株式会社 |
選択的bace1阻害活性を有する二環式複素環誘導体
|
JP2022532810A
(ja)
|
2018-07-06 |
2022-07-20 |
塩野義製薬株式会社 |
選択的bace1阻害活性を有する縮合複素環誘導体
|
JP2021075519A
(ja)
|
2019-10-24 |
2021-05-20 |
塩野義製薬株式会社 |
選択的bace1阻害活性を有するテトラヒドロピラノオキサジン誘導体を含有する医薬組成物
|