JPWO2019178496A5 - - Google Patents
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- JPWO2019178496A5 JPWO2019178496A5 JP2020548776A JP2020548776A JPWO2019178496A5 JP WO2019178496 A5 JPWO2019178496 A5 JP WO2019178496A5 JP 2020548776 A JP2020548776 A JP 2020548776A JP 2020548776 A JP2020548776 A JP 2020548776A JP WO2019178496 A5 JPWO2019178496 A5 JP WO2019178496A5
- Authority
- JP
- Japan
- Prior art keywords
- target sequence
- seq
- tissue
- cancer
- methylation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 230000011987 methylation Effects 0.000 claims 26
- 238000007069 methylation reaction Methods 0.000 claims 26
- 210000001519 tissue Anatomy 0.000 claims 25
- 238000000034 method Methods 0.000 claims 21
- 239000012472 biological sample Substances 0.000 claims 14
- 108020004414 DNA Proteins 0.000 claims 13
- 239000000523 sample Substances 0.000 claims 13
- 239000000203 mixture Substances 0.000 claims 12
- 102000053602 DNA Human genes 0.000 claims 10
- 239000003550 marker Substances 0.000 claims 10
- 206010028980 Neoplasm Diseases 0.000 claims 9
- 201000011510 cancer Diseases 0.000 claims 9
- 210000001072 colon Anatomy 0.000 claims 8
- 238000003556 assay Methods 0.000 claims 7
- 210000004185 liver Anatomy 0.000 claims 7
- 230000003321 amplification Effects 0.000 claims 5
- 238000003199 nucleic acid amplification method Methods 0.000 claims 5
- 102000040430 polynucleotide Human genes 0.000 claims 4
- 108091033319 polynucleotide Proteins 0.000 claims 4
- 239000002157 polynucleotide Substances 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 claims 2
- 238000009396 hybridization Methods 0.000 claims 2
- 210000005228 liver tissue Anatomy 0.000 claims 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010005949 Bone cancer Diseases 0.000 claims 1
- 208000018084 Bone neoplasm Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 201000009030 Carcinoma Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 208000003445 Mouth Neoplasms Diseases 0.000 claims 1
- 206010028729 Nasal cavity cancer Diseases 0.000 claims 1
- 208000001894 Nasopharyngeal Neoplasms Diseases 0.000 claims 1
- 206010061306 Nasopharyngeal cancer Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical group NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 238000011156 evaluation Methods 0.000 claims 1
- 238000013467 fragmentation Methods 0.000 claims 1
- 238000006062 fragmentation reaction Methods 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 230000003394 haemopoietic effect Effects 0.000 claims 1
- 210000003128 head Anatomy 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 208000012987 lip and oral cavity carcinoma Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 244000052769 pathogen Species 0.000 claims 1
- 230000001717 pathogenic effect Effects 0.000 claims 1
- 206010038038 rectal cancer Diseases 0.000 claims 1
- 201000001275 rectum cancer Diseases 0.000 claims 1
- 238000012163 sequencing technique Methods 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 230000001052 transient effect Effects 0.000 claims 1
- 229940035893 uracil Drugs 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024109900A JP2024156679A (ja) | 2018-03-15 | 2024-07-08 | 組織特異的メチル化マーカー |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862643649P | 2018-03-15 | 2018-03-15 | |
| US62/643,649 | 2018-03-15 | ||
| US201862769928P | 2018-11-20 | 2018-11-20 | |
| US62/769,928 | 2018-11-20 | ||
| PCT/US2019/022504 WO2019178496A1 (en) | 2018-03-15 | 2019-03-15 | Tissue-specific methylation marker |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024109900A Division JP2024156679A (ja) | 2018-03-15 | 2024-07-08 | 組織特異的メチル化マーカー |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021518107A JP2021518107A (ja) | 2021-08-02 |
| JPWO2019178496A5 true JPWO2019178496A5 (https=) | 2022-03-22 |
| JP2021518107A5 JP2021518107A5 (https=) | 2022-03-22 |
| JP7620803B2 JP7620803B2 (ja) | 2025-01-24 |
Family
ID=67908065
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020548776A Active JP7620803B2 (ja) | 2018-03-15 | 2019-03-15 | 組織特異的メチル化マーカー |
| JP2024109900A Pending JP2024156679A (ja) | 2018-03-15 | 2024-07-08 | 組織特異的メチル化マーカー |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024109900A Pending JP2024156679A (ja) | 2018-03-15 | 2024-07-08 | 組織特異的メチル化マーカー |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US11884966B2 (https=) |
| EP (1) | EP3766076A4 (https=) |
| JP (2) | JP7620803B2 (https=) |
| CN (2) | CN112534506B (https=) |
| AU (1) | AU2019233897B2 (https=) |
| CA (1) | CA3093971A1 (https=) |
| IL (1) | IL277306A (https=) |
| PH (1) | PH12020551712A1 (https=) |
| SG (1) | SG11202008957VA (https=) |
| TW (1) | TWI848941B (https=) |
| WO (1) | WO2019178496A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7620803B2 (ja) | 2018-03-15 | 2025-01-24 | グレイル インコーポレイテッド | 組織特異的メチル化マーカー |
| KR102155044B1 (ko) * | 2019-10-08 | 2020-09-11 | 주식회사 레피다인 | 생물학적 시료의 간암 조직 기원 여부를 판별하는 방법 |
| KR102103885B1 (ko) * | 2019-10-08 | 2020-04-24 | 주식회사 레피다인 | 생물학적 시료의 간 조직 유래 여부를 판별하는 방법 |
| JP2023516525A (ja) * | 2019-12-26 | 2023-04-20 | 広州市基准医療有限公司 | Ｄｎａメチル化バイオマーカーの組み合わせ、検出方法および試薬キット |
| GB2612447B (en) * | 2020-04-24 | 2025-08-13 | Univ Cornell | Methods for detecting tissue damage, graft versus host disease, and infections using cell-free DNA profiling |
| EP4291677A2 (en) | 2021-02-09 | 2023-12-20 | F. Hoffmann-La Roche AG | Methods for base-level detection of methylation in nucleic acids |
| WO2023144704A1 (en) * | 2022-01-25 | 2023-08-03 | Gene Solutions Joint Stock Company | Systems and methods for detecting tumor dna in mammalian blood |
| EP4540408A1 (en) | 2022-06-14 | 2025-04-23 | F. Hoffmann-La Roche AG | Detection of epigenetic cytosine modification |
| WO2024112741A1 (en) * | 2022-11-23 | 2024-05-30 | Salk Institute For Biological Studies | Dna methylation barcodes for identifying brain cells |
| CN117476222B (zh) * | 2023-09-28 | 2024-10-25 | 上海交通大学医学院附属瑞金医院 | 一种肠癌肝转移的风险预测方法、系统和电子设备 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX349568B (es) | 2010-11-30 | 2017-08-03 | Univ Hong Kong Chinese | Deteccion de aberraciones geneticas o moleculares asociadas con el cancer. |
| BR122021021823B1 (pt) | 2012-09-20 | 2023-04-25 | The Chinese University Of Hong Kong | Método para determinar um primeiro perfil de metilação de uma amostra biológica de um organismo, e, meio de armazenamento de memória |
| US9732390B2 (en) * | 2012-09-20 | 2017-08-15 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of fetus or tumor from plasma |
| CN106232833A (zh) | 2014-01-30 | 2016-12-14 | 加利福尼亚大学董事会 | 用于非侵入性诊断的甲基化单体型分析(monod) |
| EP3132055A2 (en) * | 2014-04-14 | 2017-02-22 | Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. | A method and kit for determining the tissue or cell origin of dna |
| WO2015169947A1 (en) | 2014-05-09 | 2015-11-12 | Lifecodexx Ag | Detection of dna that originates from a specific cell-type and related methods |
| EP2942400A1 (en) * | 2014-05-09 | 2015-11-11 | Lifecodexx AG | Multiplex detection of DNA that originates from a specific cell-type |
| JP6722659B2 (ja) | 2014-06-04 | 2020-07-15 | クエスト ダイアグノスティクス インベストメンツ インコーポレイテッド | 結腸直腸癌のためのメチル化マーカー |
| ES2741400T3 (es) | 2014-07-18 | 2020-02-10 | Univ Hong Kong Chinese | Análisis de patrones de metilación de tejidos en mezcla de ADN |
| ES2879964T3 (es) * | 2014-12-12 | 2021-11-23 | Exact Sciences Dev Co Llc | Composiciones y métodos para realizar ensayos de detección de metilación |
| CN109312404A (zh) | 2016-01-29 | 2019-02-05 | 表观基因组股份有限公司 | 用于检测血液样品中肿瘤来源DNA的CpG甲基化的方法 |
| JP2019521673A (ja) | 2016-06-07 | 2019-08-08 | ザ リージェンツ オブ ザ ユニヴァーシティー オブ カリフォルニア | 疾患および状態の分析のためのセルフリーｄｎａメチル化パターン |
| JP7620803B2 (ja) | 2018-03-15 | 2025-01-24 | グレイル インコーポレイテッド | 組織特異的メチル化マーカー |
-
2019
- 2019-03-15 JP JP2020548776A patent/JP7620803B2/ja active Active
- 2019-03-15 SG SG11202008957VA patent/SG11202008957VA/en unknown
- 2019-03-15 WO PCT/US2019/022504 patent/WO2019178496A1/en not_active Ceased
- 2019-03-15 CN CN201980032333.3A patent/CN112534506B/zh active Active
- 2019-03-15 CN CN202510148128.0A patent/CN119955906A/zh active Pending
- 2019-03-15 CA CA3093971A patent/CA3093971A1/en active Pending
- 2019-03-15 EP EP19768415.2A patent/EP3766076A4/en active Pending
- 2019-03-15 TW TW108108991A patent/TWI848941B/zh active
- 2019-03-15 AU AU2019233897A patent/AU2019233897B2/en active Active
- 2019-03-15 US US16/354,799 patent/US11884966B2/en active Active
-
2020
- 2020-09-13 IL IL277306A patent/IL277306A/en unknown
- 2020-10-15 PH PH12020551712A patent/PH12020551712A1/en unknown
-
2023
- 2023-12-13 US US18/538,995 patent/US20240191282A1/en active Pending
-
2024
- 2024-07-08 JP JP2024109900A patent/JP2024156679A/ja active Pending
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