JPWO2019148036A5 - - Google Patents
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- Publication number
- JPWO2019148036A5 JPWO2019148036A5 JP2020540750A JP2020540750A JPWO2019148036A5 JP WO2019148036 A5 JPWO2019148036 A5 JP WO2019148036A5 JP 2020540750 A JP2020540750 A JP 2020540750A JP 2020540750 A JP2020540750 A JP 2020540750A JP WO2019148036 A5 JPWO2019148036 A5 JP WO2019148036A5
- Authority
- JP
- Japan
- Prior art keywords
- alkylene
- alkyl
- cycloalkyl
- membered
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023045583A JP2023082042A (ja) | 2018-01-26 | 2023-03-22 | キナーゼ依存的障害を処置するための化合物 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862622626P | 2018-01-26 | 2018-01-26 | |
| US201862622629P | 2018-01-26 | 2018-01-26 | |
| US62/622,629 | 2018-01-26 | ||
| US62/622,626 | 2018-01-26 | ||
| PCT/US2019/015289 WO2019148036A1 (en) | 2018-01-26 | 2019-01-25 | Compounds for the treatment of kinase-dependent disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023045583A Division JP2023082042A (ja) | 2018-01-26 | 2023-03-22 | キナーゼ依存的障害を処置するための化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021511359A JP2021511359A (ja) | 2021-05-06 |
| JPWO2019148036A5 true JPWO2019148036A5 (es) | 2022-02-24 |
| JP7307733B2 JP7307733B2 (ja) | 2023-07-12 |
Family
ID=65409542
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020540750A Active JP7307733B2 (ja) | 2018-01-26 | 2019-01-25 | キナーゼ依存的障害を処置するための化合物 |
| JP2023045583A Pending JP2023082042A (ja) | 2018-01-26 | 2023-03-22 | キナーゼ依存的障害を処置するための化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023045583A Pending JP2023082042A (ja) | 2018-01-26 | 2023-03-22 | キナーゼ依存的障害を処置するための化合物 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US11708367B2 (es) |
| EP (1) | EP3743068A1 (es) |
| JP (2) | JP7307733B2 (es) |
| KR (1) | KR20200124678A (es) |
| AU (1) | AU2019212719A1 (es) |
| BR (1) | BR112020015199A2 (es) |
| CA (1) | CA3088127A1 (es) |
| CL (1) | CL2020001930A1 (es) |
| CO (1) | CO2020010467A2 (es) |
| CR (1) | CR20200355A (es) |
| IL (2) | IL302626A (es) |
| MA (1) | MA51672A (es) |
| MX (2) | MX2020007759A (es) |
| PE (1) | PE20210044A1 (es) |
| PH (1) | PH12020551059A1 (es) |
| SG (1) | SG11202006945PA (es) |
| WO (1) | WO2019148036A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7480048B2 (ja) | 2018-01-26 | 2024-05-09 | エグゼリクシス， インコーポレイテッド | キナーゼ依存的障害を処置するための化合物 |
| US11708367B2 (en) * | 2018-01-26 | 2023-07-25 | Exelixis, Inc. | Compounds for the treatment of kinase-dependent disorders |
| CN111757735B (zh) * | 2018-01-26 | 2023-09-22 | 埃克塞里艾克西斯公司 | 用于治疗激酶依赖性病症的化合物 |
| CN112457308B (zh) | 2019-09-09 | 2024-01-02 | 上海长森药业有限公司 | 新型三环芳香杂环化合物，及其制备方法、药物组合物和应用 |
| WO2021180006A1 (zh) * | 2020-03-10 | 2021-09-16 | 南京明德新药研发有限公司 | 乙烯基取代吡啶类化合物 |
| GB202004960D0 (en) * | 2020-04-03 | 2020-05-20 | Kinsenus Ltd | Inhibitor compounds |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5804396A (en) | 1994-10-12 | 1998-09-08 | Sugen, Inc. | Assay for agents active in proliferative disorders |
| CA2216796C (en) | 1995-03-30 | 2003-09-02 | Pfizer Inc. | Quinazoline derivatives |
| GB9508538D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| GB9508565D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quiazoline derivative |
| RO121900B1 (ro) | 1996-04-12 | 2008-07-30 | Warner-Lambert Company | Compuşi inhibitori, ireversibili, ai tirozin kinazelor, compoziţie farmaceutică care îi conţine şi utilizarea acestora |
| UA73073C2 (uk) | 1997-04-03 | 2005-06-15 | Уайт Холдінгз Корпорейшн | Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція |
| ZA986732B (en) | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitiors of tyrosine kinases |
| ZA986729B (en) | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitors of tyrosine kinases |
| TW436485B (en) | 1997-08-01 | 2001-05-28 | American Cyanamid Co | Substituted quinazoline derivatives |
| AU2004259009A1 (en) | 2003-07-23 | 2005-02-03 | Exelixis, Inc. | Azepine derivatives as pharmaceutical agents |
| CA2537812C (en) | 2003-09-26 | 2013-01-22 | Exelixis, Inc. | C-met modulators and method of use |
| CA2604238C (en) | 2005-04-15 | 2015-07-07 | Neogenix Oncology, Inc. | Recombinant monoclonal antibodies and corresponding antigens for colon and pancreatic cancers |
| EP3530736A3 (en) | 2005-05-09 | 2019-11-06 | ONO Pharmaceutical Co., Ltd. | Human monoclonal antibodies to programmed death 1 (pd-1) and methods for treating cancer using anti-pd-1 antibodies alone or in combination with other immunotherapeutics |
| EP2001880A2 (en) | 2006-03-07 | 2008-12-17 | Array Biopharma, Inc. | Heterobicyclic pyrazole compounds and methods of use |
| WO2010045095A1 (en) * | 2008-10-14 | 2010-04-22 | Ning Xi | Compounds and methods of use |
| EP2213686A1 (en) | 2009-01-28 | 2010-08-04 | Externautics S.p.A. | Tumor markers and methods of use thereof |
| EP2214019A1 (en) | 2009-01-28 | 2010-08-04 | Externautics S.p.A. | Tumor markers and methods of use thereof |
| UA108618C2 (uk) | 2009-08-07 | 2015-05-25 | Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку | |
| EP2494351B1 (en) | 2009-10-26 | 2016-06-08 | Externautics S.p.A. | Colon and rectal tumor markers and methods of use thereof |
| EP2494361B2 (en) | 2009-10-26 | 2019-01-09 | Externautics S.p.A. | Ovary tumor markers and methods of use thereof |
| EP2494362B1 (en) | 2009-10-26 | 2016-06-08 | Externautics S.p.A. | Prostate tumor markers and methods of use thereof |
| EP2493917B8 (en) | 2009-10-26 | 2020-03-04 | Externautics S.P.A. | Breast tumor markers and methods of use thereof |
| EP2493916B1 (en) | 2009-10-26 | 2016-06-08 | Externautics S.p.A. | Lung tumor markers and methods of use thereof |
| EP2383578A1 (en) | 2010-04-30 | 2011-11-02 | Externautics S.p.A. | Tumor marker and methods of use thereof |
| SG187064A1 (en) | 2010-07-14 | 2013-02-28 | Zhejiang Beta Pharma Inc | NOVEL FUSED HETEROCYCLIC DERIVATIVES USEFUL AS c-MET TYROSINE KINASE INHIBITORS |
| US8664244B2 (en) * | 2010-09-12 | 2014-03-04 | Advenchen Pharmaceuticals, LLC | Compounds as c-Met kinase inhibitors |
| CN102093421B (zh) | 2011-01-28 | 2014-07-02 | 北京康辰药业有限公司 | 一种含磷取代基的喹啉类化合物及其制备方法、以及含有该化合物的药物组合物及其应用 |
| CN102408411B (zh) | 2011-09-19 | 2014-10-22 | 北京康辰药业股份有限公司 | 一种含喹啉基的羟肟酸类化合物及其制备方法、以及含有该化合物的药物组合物及其应用 |
| BR112015007672A2 (pt) | 2012-10-04 | 2017-08-08 | Dana Farber Cancer Inst Inc | anticorpos anti-pd-l1 monoclonais humanos e métodos de uso |
| AU2014259719B2 (en) | 2013-05-02 | 2019-10-03 | Anaptysbio, Inc. | Antibodies directed against programmed death-1 (PD-1) |
| WO2014198919A2 (en) | 2013-06-14 | 2014-12-18 | Externautics S.P.A. | Tumor marker, monoclonal antibodies and methods of use thereof |
| EP3065772A4 (en) | 2013-11-05 | 2017-09-13 | Cognate Bioservices, Inc. | Combinations of checkpoint inhibitors and therapeutics to treat cancer |
| EP3134084B1 (en) | 2014-04-25 | 2021-03-17 | Exelixis, Inc. | Method of treating lung adenocarcinoma |
| CN104817497B (zh) | 2015-03-20 | 2017-03-08 | 南京众睿缘生物科技有限公司 | 一种炔代喹啉衍生物及其制备方法和用途 |
| CN106279147A (zh) * | 2015-05-21 | 2017-01-04 | 中国科学院上海药物研究所 | 一种吡啶并氮杂环化合物及其制备方法和用途 |
| US20180009758A1 (en) | 2015-06-29 | 2018-01-11 | Ontogenesis, Llc | Multi-Tyrosine Kinase Inhibitors Derivatives and Methods of Use |
| CN105797123A (zh) | 2016-05-18 | 2016-07-27 | 王超 | 一种治疗不孕不育的中药组合物 |
| CN106400155A (zh) | 2016-08-31 | 2017-02-15 | 飞佛特种纺织品（宁波）有限公司 | 一种防老化阳光面料 |
| CN107235896B (zh) | 2016-09-13 | 2019-11-05 | 上海翔锦生物科技有限公司 | 酪氨酸激酶抑制剂及其应用 |
| CN111511361A (zh) | 2017-12-20 | 2020-08-07 | 安杰斯制药公司 | 作为多激酶抑制剂的胺基碳酸盐及尿素化合物 |
| US11708367B2 (en) * | 2018-01-26 | 2023-07-25 | Exelixis, Inc. | Compounds for the treatment of kinase-dependent disorders |
-
2019
- 2019-01-25 US US16/964,228 patent/US11708367B2/en active Active
- 2019-01-25 KR KR1020207024577A patent/KR20200124678A/ko not_active Application Discontinuation
- 2019-01-25 WO PCT/US2019/015289 patent/WO2019148036A1/en active Application Filing
- 2019-01-25 CA CA3088127A patent/CA3088127A1/en active Pending
- 2019-01-25 SG SG11202006945PA patent/SG11202006945PA/en unknown
- 2019-01-25 IL IL302626A patent/IL302626A/en unknown
- 2019-01-25 MA MA051672A patent/MA51672A/fr unknown
- 2019-01-25 JP JP2020540750A patent/JP7307733B2/ja active Active
- 2019-01-25 MX MX2020007759A patent/MX2020007759A/es unknown
- 2019-01-25 EP EP19704968.7A patent/EP3743068A1/en active Pending
- 2019-01-25 BR BR112020015199-8A patent/BR112020015199A2/pt unknown
- 2019-01-25 AU AU2019212719A patent/AU2019212719A1/en active Pending
- 2019-01-25 CR CR20200355A patent/CR20200355A/es unknown
- 2019-01-25 PE PE2020001120A patent/PE20210044A1/es unknown
-
2020
- 2020-07-09 PH PH12020551059A patent/PH12020551059A1/en unknown
- 2020-07-13 IL IL276028A patent/IL276028A/en unknown
- 2020-07-22 MX MX2022014351A patent/MX2022014351A/es unknown
- 2020-07-23 CL CL2020001930A patent/CL2020001930A1/es unknown
- 2020-08-25 CO CONC2020/0010467A patent/CO2020010467A2/es unknown
-
2023
- 2023-03-22 JP JP2023045583A patent/JP2023082042A/ja active Pending
- 2023-06-13 US US18/334,113 patent/US20230374024A1/en active Pending
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