JPWO2019147782A5 - - Google Patents
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- Publication number
- JPWO2019147782A5 JPWO2019147782A5 JP2020540798A JP2020540798A JPWO2019147782A5 JP WO2019147782 A5 JPWO2019147782 A5 JP WO2019147782A5 JP 2020540798 A JP2020540798 A JP 2020540798A JP 2020540798 A JP2020540798 A JP 2020540798A JP WO2019147782 A5 JPWO2019147782 A5 JP WO2019147782A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrrolidine
- triazine
- amino
- trifluoromethyl
- fluoro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862622415P | 2018-01-26 | 2018-01-26 | |
| US62/622,415 | 2018-01-26 | ||
| PCT/US2019/014918 WO2019147782A1 (fr) | 2018-01-26 | 2019-01-24 | Aminopyrrolotriazines en tant qu'inhibiteurs de kinase |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021511363A JP2021511363A (ja) | 2021-05-06 |
| JPWO2019147782A5 true JPWO2019147782A5 (fr) | 2022-01-28 |
| JP7307734B2 JP7307734B2 (ja) | 2023-07-12 |
Family
ID=65363405
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020540798A Active JP7307734B2 (ja) | 2018-01-26 | 2019-01-24 | キナーゼ阻害剤としてのアミノピロロトリアジン |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US11618753B2 (fr) |
| EP (1) | EP3743430B1 (fr) |
| JP (1) | JP7307734B2 (fr) |
| KR (1) | KR20200115550A (fr) |
| CN (1) | CN112262139B (fr) |
| AR (1) | AR114186A1 (fr) |
| AU (1) | AU2019211382B2 (fr) |
| BR (1) | BR112020014516A2 (fr) |
| CA (1) | CA3088548A1 (fr) |
| EA (1) | EA202091777A1 (fr) |
| ES (1) | ES2959399T3 (fr) |
| IL (1) | IL276269A (fr) |
| MX (1) | MX2020007531A (fr) |
| SG (1) | SG11202007035YA (fr) |
| TW (1) | TW201940485A (fr) |
| WO (1) | WO2019147782A1 (fr) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112019016635A2 (pt) | 2017-02-13 | 2020-04-07 | Bristol-Myers Squibb Company | aminotriazolopiridinas como inibidores da cinase |
| PL3704118T3 (pl) | 2017-10-30 | 2022-04-04 | Bristol-Myers Squibb Company | Aminotriazolopirydazyny jako inhibitory kinaz |
| JPWO2021157596A1 (fr) * | 2020-02-07 | 2021-08-12 | ||
| JP2023533771A (ja) * | 2020-07-10 | 2023-08-04 | ベイジン ファインドキュア バイオサイエンシーズ リミテッド | トリアジン系化合物およびその組成物と用途 |
| CN111925345B (zh) * | 2020-08-21 | 2023-09-29 | 上海科利生物医药有限公司 | 一种手性2-氨甲基四氢呋喃的制备方法 |
| AR123793A1 (es) | 2020-10-19 | 2023-01-11 | Bristol Myers Squibb Co | Compuestos de triazolopiridinilo como inhibidores de quinasas |
| WO2022172889A1 (fr) * | 2021-02-10 | 2022-08-18 | セントラル硝子株式会社 | Composition de résine, film de résine, matériau de base, polymère et monomère polymérisable |
| CN113563214B (zh) * | 2021-07-06 | 2024-02-02 | 山东鲁泰控股集团有限公司石墨烯高分子复合材料研发中心 | 一种氨基乙酸的合成方法 |
| CN113527220A (zh) * | 2021-07-26 | 2021-10-22 | 京博农化科技有限公司 | 一种脱硫丙硫菌唑异构体的合成方法 |
| CN114989079B (zh) * | 2022-06-21 | 2023-06-23 | 中国药科大学 | Ripk1激酶靶点抑制剂及其医药用途 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007056170A2 (fr) | 2005-11-02 | 2007-05-18 | Bayer Healthcare Ag | Derives pyrrolo-[2,1-f]-[1,2,4]-triazin-4-ylamines inhibiteurs de la igf-1r kinase pour le traitement des cancers et autres maladies hyperproliferatives |
| BRPI0618622A2 (pt) * | 2005-11-17 | 2011-09-06 | Osi Pharm Inc | composto, composição, e, uso de um composto |
| PE20070855A1 (es) | 2005-12-02 | 2007-10-14 | Bayer Pharmaceuticals Corp | Derivados de 4-amino-pirrolotriazina sustituida como inhibidores de quinasas |
| WO2007064931A2 (fr) | 2005-12-02 | 2007-06-07 | Bayer Healthcare Llc | Derives substitues de 4-amino-pyrrolotriazine utiles dans le traitement de troubles hyperproliferatifs et de maladies associees a l'angiogenese |
| WO2009046448A1 (fr) * | 2007-10-04 | 2009-04-09 | Intellikine, Inc. | Entités chimiques et leurs utilisations thérapeutiques |
| WO2010126960A1 (fr) | 2009-04-29 | 2010-11-04 | Locus Pharmaceuticals, Inc. | Composés de pyrrolotriazine |
| TW201107329A (en) * | 2009-07-30 | 2011-03-01 | Oncotherapy Science Inc | Fused imidazole derivative having ttk inhibitory action |
| EP3070077B1 (fr) | 2009-10-06 | 2018-11-28 | Millennium Pharmaceuticals, Inc. | Composés hétérocycliques utiles comme inhibiteurs de pdk1 |
| US8791257B2 (en) * | 2010-03-31 | 2014-07-29 | Bristol-Myers Squibb Company | Substituted pyrrolotriazines as protein kinase inhibitors |
| EP2897949B1 (fr) | 2012-09-18 | 2018-01-10 | Bristol-Myers Squibb Company | Antagonistes d'iap |
| WO2015054358A1 (fr) | 2013-10-11 | 2015-04-16 | Bristol-Myers Squibb Company | Inhibiteurs de pyrrolotriazine kinase |
| EP3209665B1 (fr) * | 2014-10-22 | 2019-08-14 | Bristol-Myers Squibb Company | Composés pyrrolotriaziniques aminés substitués en tant qu'inhibiteurs de pi3k |
| US10214537B2 (en) | 2014-10-22 | 2019-02-26 | Bristol-Myers Squibb Company | Bicyclic heteroaryl amine compounds |
| SI3436461T1 (sl) | 2016-03-28 | 2024-03-29 | Incyte Corporation | Pirolotriazinske spojine kot tam-inhibitorji |
| WO2018017435A1 (fr) | 2016-07-22 | 2018-01-25 | Accro Bioscience Inc. | Composés hétéroaryliques utilisés comme inhibiteurs de la nécrose, composition et application associées |
| BR112019016635A2 (pt) | 2017-02-13 | 2020-04-07 | Bristol-Myers Squibb Company | aminotriazolopiridinas como inibidores da cinase |
| PL3704118T3 (pl) | 2017-10-30 | 2022-04-04 | Bristol-Myers Squibb Company | Aminotriazolopirydazyny jako inhibitory kinaz |
| BR112021004385A2 (pt) | 2018-09-13 | 2021-07-20 | Bristol-Myers Squibb Company | 1h-indazol carboxamidas como inibidores de proteína quinase de interação com o receptor 1 (ripk1) |
| US20210309633A1 (en) | 2018-09-13 | 2021-10-07 | Bristol-Myers Squibb Company | Indazole carboxamides as kinase inhibitors |
-
2019
- 2019-01-24 JP JP2020540798A patent/JP7307734B2/ja active Active
- 2019-01-24 EP EP19704524.8A patent/EP3743430B1/fr active Active
- 2019-01-24 KR KR1020207024141A patent/KR20200115550A/ko not_active Application Discontinuation
- 2019-01-24 BR BR112020014516-5A patent/BR112020014516A2/pt not_active Application Discontinuation
- 2019-01-24 AU AU2019211382A patent/AU2019211382B2/en active Active
- 2019-01-24 EA EA202091777A patent/EA202091777A1/ru unknown
- 2019-01-24 AR ARP190100156A patent/AR114186A1/es unknown
- 2019-01-24 MX MX2020007531A patent/MX2020007531A/es unknown
- 2019-01-24 CN CN201980019863.4A patent/CN112262139B/zh active Active
- 2019-01-24 ES ES19704524T patent/ES2959399T3/es active Active
- 2019-01-24 US US16/963,886 patent/US11618753B2/en active Active
- 2019-01-24 WO PCT/US2019/014918 patent/WO2019147782A1/fr unknown
- 2019-01-24 SG SG11202007035YA patent/SG11202007035YA/en unknown
- 2019-01-24 CA CA3088548A patent/CA3088548A1/fr active Pending
- 2019-01-25 TW TW108102873A patent/TW201940485A/zh unknown
-
2020
- 2020-07-24 IL IL276269A patent/IL276269A/en unknown
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