JPWO2019136309A5 - - Google Patents

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JPWO2019136309A5
JPWO2019136309A5 JP2020557125A JP2020557125A JPWO2019136309A5 JP WO2019136309 A5 JPWO2019136309 A5 JP WO2019136309A5 JP 2020557125 A JP2020557125 A JP 2020557125A JP 2020557125 A JP2020557125 A JP 2020557125A JP WO2019136309 A5 JPWO2019136309 A5 JP WO2019136309A5
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seq
antibody
human
set forth
sequence
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JP2020557125A
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JP2021509823A (ja
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Priority claimed from PCT/US2019/012427 external-priority patent/WO2019136309A1/fr
Publication of JP2021509823A publication Critical patent/JP2021509823A/ja
Publication of JPWO2019136309A5 publication Critical patent/JPWO2019136309A5/ja
Priority to JP2023110621A priority Critical patent/JP2023134565A/ja
Priority to JP2023142243A priority patent/JP2023175726A/ja
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JP2020557125A 2018-01-04 2019-01-04 抗組織因子抗体、抗体薬物コンジュゲート、及び関連する方法 Pending JP2021509823A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023110621A JP2023134565A (ja) 2018-01-04 2023-07-05 抗組織因子抗体、抗体薬物コンジュゲート、及び関連する方法
JP2023142243A JP2023175726A (ja) 2018-01-04 2023-09-01 抗組織因子抗体、抗体薬物コンジュゲート、及び関連する方法

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201862613545P 2018-01-04 2018-01-04
US201862613564P 2018-01-04 2018-01-04
US62/613,564 2018-01-04
US62/613,545 2018-01-04
US201862646788P 2018-03-22 2018-03-22
US62/646,788 2018-03-22
US201862713797P 2018-08-02 2018-08-02
US201862713804P 2018-08-02 2018-08-02
US62/713,804 2018-08-02
US62/713,797 2018-08-02
PCT/US2019/012427 WO2019136309A1 (fr) 2018-01-04 2019-01-04 Anticorps anti-facteur tissulaire, conjugués anticorps-médicament et procédés associés

Related Child Applications (1)

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JP2023110621A Division JP2023134565A (ja) 2018-01-04 2023-07-05 抗組織因子抗体、抗体薬物コンジュゲート、及び関連する方法

Publications (2)

Publication Number Publication Date
JP2021509823A JP2021509823A (ja) 2021-04-08
JPWO2019136309A5 true JPWO2019136309A5 (fr) 2022-01-13

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JP2020557125A Pending JP2021509823A (ja) 2018-01-04 2019-01-04 抗組織因子抗体、抗体薬物コンジュゲート、及び関連する方法
JP2023110621A Pending JP2023134565A (ja) 2018-01-04 2023-07-05 抗組織因子抗体、抗体薬物コンジュゲート、及び関連する方法
JP2023142243A Pending JP2023175726A (ja) 2018-01-04 2023-09-01 抗組織因子抗体、抗体薬物コンジュゲート、及び関連する方法

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JP2023110621A Pending JP2023134565A (ja) 2018-01-04 2023-07-05 抗組織因子抗体、抗体薬物コンジュゲート、及び関連する方法
JP2023142243A Pending JP2023175726A (ja) 2018-01-04 2023-09-01 抗組織因子抗体、抗体薬物コンジュゲート、及び関連する方法

Country Status (13)

Country Link
US (3) US20220153871A1 (fr)
EP (1) EP3735271A4 (fr)
JP (3) JP2021509823A (fr)
KR (1) KR20200118029A (fr)
CN (1) CN111818943A (fr)
AU (1) AU2019205330A1 (fr)
BR (1) BR112020013679A2 (fr)
CA (1) CA3087537A1 (fr)
IL (1) IL275765A (fr)
MX (1) MX2020007077A (fr)
PH (1) PH12020551037A1 (fr)
SG (1) SG11202006400UA (fr)
WO (1) WO2019136309A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111818943A (zh) 2018-01-04 2020-10-23 伊科尼克治疗公司 抗组织因子抗体、抗体-药物缀合物及相关方法
BR112021001691A2 (pt) * 2018-08-16 2021-05-04 Genmab A/S método de tratamento de câncer de ovário, câncer peritoneal ou câncer de trompa de falópio, e, kit
AU2020299398A1 (en) * 2019-07-03 2022-02-24 Iconic Therapeutics Llc Anti-tissue factor antibody-drug conjugates and related methods
TW202200618A (zh) * 2020-03-17 2022-01-01 美商西雅圖免疫公司 微型導引和導航控制(miniGNC)類抗體蛋白及其製造和使用方法
JPWO2021200131A1 (fr) * 2020-03-30 2021-10-07
JP2023534191A (ja) * 2020-07-10 2023-08-08 アイコニック セラピューティクス インコーポレイテッド 抗組織因子抗体を使用する炎症性疾患の治療法
TW202345906A (zh) * 2022-03-09 2023-12-01 美商艾克塞里克斯公司 以抗組織因子抗體藥物結合物治療實體腫瘤之方法
WO2024054821A2 (fr) * 2022-09-07 2024-03-14 Exelixis, Inc. Conjugués anticorps-médicament de facteur tissulaire et leurs utilisations

Family Cites Families (160)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4722848A (en) 1982-12-08 1988-02-02 Health Research, Incorporated Method for immunizing animals with synthetically modified vaccinia virus
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
GB8311018D0 (en) 1983-04-22 1983-05-25 Amersham Int Plc Detecting mutations in dna
US6090406A (en) 1984-04-12 2000-07-18 The Liposome Company, Inc. Potentiation of immune responses with liposomal adjuvants
US5019369A (en) 1984-10-22 1991-05-28 Vestar, Inc. Method of targeting tumors in humans
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5567610A (en) 1986-09-04 1996-10-22 Bioinvent International Ab Method of producing human monoclonal antibodies and kit therefor
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5223427A (en) * 1987-03-31 1993-06-29 The Scripps Research Institute Hybridomas producing monoclonal antibodies reactive with human tissue-factor glycoprotein heavy chain
US5132405A (en) 1987-05-21 1992-07-21 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5175384A (en) 1988-12-05 1992-12-29 Genpharm International Transgenic mice depleted in mature t-cells and methods for making transgenic mice
US5217879A (en) 1989-01-12 1993-06-08 Washington University Infectious Sindbis virus vectors
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
FR2650840B1 (fr) 1989-08-11 1991-11-29 Bertin & Cie Procede rapide de detection et/ou d'identification d'une seule base sur une sequence d'acide nucleique, et ses applications
US5208020A (en) 1989-10-25 1993-05-04 Immunogen Inc. Cytotoxic agents comprising maytansinoids and their therapeutic use
AU625013B2 (en) 1989-11-03 1992-06-25 Vanderbilt University Method of in vivo delivery of functioning foreign genes
IL97459A0 (en) 1990-03-09 1992-06-21 Hybritech Inc Trifunctional antibody-like compounds as a combined diagnostic and therapeutic agent
US5279833A (en) 1990-04-04 1994-01-18 Yale University Liposomal transfection of nucleic acids into animal cells
US5229275A (en) 1990-04-26 1993-07-20 Akzo N.V. In-vitro method for producing antigen-specific human monoclonal antibodies
US5204253A (en) 1990-05-29 1993-04-20 E. I. Du Pont De Nemours And Company Method and apparatus for introducing biological substances into living cells
US6004744A (en) 1991-03-05 1999-12-21 Molecular Tool, Inc. Method for determining nucleotide identity through extension of immobilized primer
US5565332A (en) 1991-09-23 1996-10-15 Medical Research Council Production of chimeric antibodies - a combinatorial approach
US6037135A (en) 1992-08-07 2000-03-14 Epimmune Inc. Methods for making HLA binding peptides and their uses
ATE244763T1 (de) 1992-02-11 2003-07-15 Cell Genesys Inc Erzielen von homozygotem durch zielgerichtete genetische ereignisse
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
IL105914A0 (en) 1992-06-04 1993-10-20 Univ California Methods and compositions for in vivo gene therapy
US9340577B2 (en) 1992-08-07 2016-05-17 Epimmune Inc. HLA binding motifs and peptides and their uses
US5662907A (en) 1992-08-07 1997-09-02 Cytel Corporation Induction of anti-tumor cytotoxic T lymphocytes in humans using synthetic peptide epitopes
AU5093593A (en) * 1992-08-28 1994-03-29 Scripps Research Institute, The Inhibition of tumor metastasis via neutralization of tissue factor function
US6413935B1 (en) 1993-09-14 2002-07-02 Epimmune Inc. Induction of immune response against desired determinants
JP3926839B2 (ja) 1993-09-14 2007-06-06 エピミューン,インコーポレイティド 万能dr−結合性ペプチドを用いる免疫応答の改変
US6015686A (en) 1993-09-15 2000-01-18 Chiron Viagene, Inc. Eukaryotic layered vector initiation systems
US5837484A (en) 1993-11-09 1998-11-17 Medical College Of Ohio Stable cell lines capable of expressing the adeno-associated virus replication gene
EP0787200B1 (fr) 1994-10-28 2005-04-20 The Trustees Of The University Of Pennsylvania Adenovirus ameliore et ses procedes d'utilisation
FR2726285B1 (fr) 1994-10-28 1996-11-29 Centre Nat Rech Scient Adenovirus depourvus de particules contaminantes viables, preparation et utilisation
US6071890A (en) 1994-12-09 2000-06-06 Genzyme Corporation Organ-specific targeting of cationic amphiphile/DNA complexes for gene therapy
US5849589A (en) 1996-03-11 1998-12-15 Duke University Culturing monocytes with IL-4, TNF-α and GM-CSF TO induce differentiation to dendric cells
WO1998000110A1 (fr) 1996-07-03 1998-01-08 University Of Pittsburgh Formulations d'emulsions pour des agents actifs hydrophiles
WO1998010087A1 (fr) 1996-09-06 1998-03-12 Trustees Of The University Of Pennsylvania Vecteurs d'adenovirus de chimpanze
US7732129B1 (en) 1998-12-01 2010-06-08 Crucell Holland B.V. Method for the production and purification of adenoviral vectors
US5849561A (en) 1997-05-22 1998-12-15 Cornell Research Foundation, Inc. Method for the production of non-group C adenoviral vectors
US6194551B1 (en) 1998-04-02 2001-02-27 Genentech, Inc. Polypeptide variants
JP2002510481A (ja) 1998-04-02 2002-04-09 ジェネンテック・インコーポレーテッド 抗体変異体及びその断片
IL138801A0 (en) * 1998-04-03 2001-10-31 Chugai Pharmaceutical Co Ltd Humanized antibody against human tissue factor and process for the preparation thereof
US20030072767A1 (en) 1998-09-30 2003-04-17 Alexander Gaiger Compositions and methods for WT1 specific immunotherapy
US20080050393A1 (en) 1998-12-03 2008-02-28 Tang Y Tom Novel nucleic acids and polypeptides
CA2354374A1 (fr) 1998-12-07 2000-06-15 U.S. Medical Research Institute Of Infectious Diseases Vaccin vivant attenue de l'encephalomyelite equine du venezuela
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
WO2000061770A2 (fr) 1999-04-08 2000-10-19 Chiron Corporation Stimulation de la reponse immune pour applications dans des vaccins et en therapie genique
US8647864B2 (en) 1999-04-14 2014-02-11 Novartis Ag Compositions and methods for generating an immune response utilizing alphavirus-based vector systems
CA2373300C (fr) 1999-04-14 2012-02-21 Chiron Corporation Compositions et procedes permettant de generer une reponse immunitaire au moyen de systemes de vecteurs a base d'alphavirus
US6365394B1 (en) 1999-09-29 2002-04-02 The Trustees Of The University Of Pennsylvania Cell lines and constructs useful in production of E1-deleted adenoviruses in absence of replication competent adenovirus
US6703494B2 (en) * 2000-03-16 2004-03-09 Genentech, Inc. Anti-tissue factor antibodies with enhanced anticoagulant potency
AU2001252945A1 (en) 2000-03-24 2001-10-08 Corixa Corporation Compositions and methods for therapy and diagnosis of colon cancer
US6436703B1 (en) 2000-03-31 2002-08-20 Hyseq, Inc. Nucleic acids and polypeptides
US20040115625A1 (en) 2000-10-02 2004-06-17 Reinhard Ebner Cancer gene determination and therapeutic screening using signature gene sets
US6783939B2 (en) 2000-07-07 2004-08-31 Alphavax, Inc. Alphavirus vectors and virosomes with modified HIV genes for use in vaccines
AU2001291162A1 (en) 2000-09-25 2002-04-08 Regents Of The University Of Michigan Production of viral vectors
PT2316940E (pt) 2000-12-18 2013-10-16 Dyax Corp Bibliotecas orientadas de pacotes genéticos
US20020137081A1 (en) 2001-01-08 2002-09-26 Olga Bandman Genes differentially expressed in vascular tissue activation
EP1363660A4 (fr) 2001-02-01 2006-06-21 Univ Johns Hopkins Vaccin moleculaire superieur a base d'arn autoreplicatif, d'adn suicide ou de vecteur d'adn nu, qui lie un antigene a un polypeptide qui favorise la presentation de l'antigene
US20030232324A1 (en) 2001-05-31 2003-12-18 Chiron Corporation Chimeric alphavirus replicon particles
EP1399183B1 (fr) 2001-05-31 2010-06-30 Novartis Vaccines and Diagnostics, Inc. Particules de replicon d'alphavirus chimerique
AU2002322285A1 (en) 2001-06-22 2003-01-08 The Trustees Of The University Of Pennsylvania Method for rapid screening of bacterial transformants and novel simian adenovirus proteins
HUP0600342A3 (en) 2001-10-25 2011-03-28 Genentech Inc Glycoprotein compositions
BR0309145A (pt) 2002-04-09 2005-02-01 Kyowa Hakko Kogyo Kk Células das quais o genoma é modificado
PL215165B1 (pl) 2002-04-25 2013-10-31 Crucell Holland Bv Rekombinowany wektor adenowirusowy oraz sposób wytwarzania rekombinowanego wektora adenowirusowego
US7285265B2 (en) 2002-04-25 2007-10-23 Crucell Holland B.V. Stable adenoviral vectors and methods for propagation thereof
AU2003289716A1 (en) 2002-09-12 2004-04-30 Incyte Corporation Molecules for diagnostics and therapeutics
JP2006516089A (ja) 2002-10-02 2006-06-22 ジェネンテック・インコーポレーテッド 腫瘍の診断と治療のための組成物と方法
TWI335821B (en) 2002-12-16 2011-01-11 Genentech Inc Immunoglobulin variants and uses thereof
GB2398300A (en) 2003-02-17 2004-08-18 Isis Innovation Method and compositions for boosting immune response
US7425328B2 (en) * 2003-04-22 2008-09-16 Purdue Pharma L.P. Tissue factor antibodies and uses thereof
US7605235B2 (en) * 2003-05-30 2009-10-20 Centocor, Inc. Anti-tissue factor antibodies and compositions
BRPI0411099A (pt) 2003-06-05 2006-07-18 Wyeth Corp composições imunogênicas que compreendem os vetores de replicon do vìrus da encefalite eqüina venezuelana e antìgenos de proteìnas de paramixovìrus
US7291498B2 (en) 2003-06-20 2007-11-06 The Trustees Of The University Of Pennsylvania Methods of generating chimeric adenoviruses and uses for such chimeric adenoviruses
DE10347710B4 (de) 2003-10-14 2006-03-30 Johannes-Gutenberg-Universität Mainz Rekombinante Impfstoffe und deren Verwendung
ATE449105T1 (de) 2004-01-23 2009-12-15 Angeletti P Ist Richerche Bio Impfstoffträger für schimpansen-adenovirus
US8119336B2 (en) 2004-03-03 2012-02-21 Ibis Biosciences, Inc. Compositions for use in identification of alphaviruses
US20050221414A1 (en) 2004-03-31 2005-10-06 Katalin Varadi Kit for measuring the thrombin generation in a sample of a patient's blood or plasma
US9024001B2 (en) 2004-05-25 2015-05-05 Novartis Vaccines And Diagnostics, Inc. Alphavirus replicon packaging constructs
US20060198854A1 (en) 2004-12-28 2006-09-07 Peter Pushko Vector platforms derived from the alphavirus vaccines
KR20130114758A (ko) 2005-05-27 2013-10-17 오스페달레 산 라파엘 에스.알.엘. Mi-rna를 포함하는 유전자 벡터
ES2735531T3 (es) 2005-08-23 2019-12-19 Univ Pennsylvania ARN que contiene nucleósidos modificados y métodos de uso del mismo
WO2007047749A1 (fr) 2005-10-18 2007-04-26 Novartis Vaccines And Diagnostics Inc. Immunisations mucosiques et systemiques avec particules de replicon d’alphavirus
WO2007056352A2 (fr) * 2005-11-07 2007-05-18 The Scripps Research Institute Compositions et procedes destines a controler la specificite de la signalisation du facteur tissulaire
JP5538729B2 (ja) 2006-02-27 2014-07-02 ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム 偽感染性フラビウイルスおよびそれらの使用
US9085638B2 (en) 2007-03-07 2015-07-21 The Johns Hopkins University DNA vaccine enhancement with MHC class II activators
GB0706914D0 (en) 2007-04-10 2007-05-16 Isis Innovation Novel adenovirus vectors
CA2687141C (fr) 2007-05-22 2014-04-01 Amgen Inc. Compositions et procedes pour produire des proteines de fusion bioactives
EP2167137B1 (fr) 2007-05-31 2013-10-16 GENimmune N.V. Polyépitopes recombinants du vhp et utilisations
WO2009034190A2 (fr) 2007-09-14 2009-03-19 Genimmune N.V. Marqueur d'affinité
US8691730B2 (en) 2007-09-14 2014-04-08 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
US8877688B2 (en) 2007-09-14 2014-11-04 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
GB0719526D0 (en) 2007-10-05 2007-11-14 Isis Innovation Compositions and methods
US20100285050A1 (en) 2007-10-05 2010-11-11 Isis Innovation Limited Compositions and Methods
US9234181B2 (en) 2007-11-26 2016-01-12 Novartis Ag RNA expression cassette and cells for making alphavirus particles
DK2235064T3 (en) 2008-01-07 2016-01-11 Amgen Inc A process for the preparation of heterodimeric Fc molecules using electrostatic control effects
US20090253184A1 (en) 2008-01-23 2009-10-08 Introgen Therapeutics, Inc. Compositions and methods related to an adenoviral trans-complementing cell line
WO2010005704A2 (fr) 2008-06-13 2010-01-14 New York University Nouveaux vecteurs viraux sindbis défectueux, à plasmide assistant, et leurs procédés d'utilisation
EP2310510B1 (fr) 2008-07-17 2015-05-06 Medigen, Inc. Vaccins à adni et procédés pour leur utilisation
CN102317308A (zh) 2008-11-26 2012-01-11 美国国有健康与人类服务部 类病毒组合物颗粒及其使用方法
UA109633C2 (uk) 2008-12-09 2015-09-25 Антитіло людини проти тканинного фактора
DE102008061522A1 (de) 2008-12-10 2010-06-17 Biontech Ag Verwendung von Flt3-Ligand zur Verstärkung von Immunreaktionen bei RNA-Immunisierung
CN102666582B (zh) 2009-12-22 2016-03-30 弗·哈夫曼-拉罗切有限公司 序列依赖性聚集
US9101572B2 (en) 2009-12-31 2015-08-11 Medigen, Inc. Infectious DNA vaccines against chikungunya virus
GB201006405D0 (en) 2010-04-16 2010-06-02 Isis Innovation Poxvirus expression system
KR102095670B1 (ko) 2010-05-14 2020-03-31 더 제너럴 하스피톨 코포레이션 종양 특이적 신생항원을 확인하는 조성물 및 방법
NO2582728T3 (fr) 2010-06-15 2018-01-20
US9192661B2 (en) 2010-07-06 2015-11-24 Novartis Ag Delivery of self-replicating RNA using biodegradable polymer particles
JP6025721B2 (ja) 2010-07-06 2016-11-16 ノバルティス アーゲー カチオン性水中油型エマルジョン
US9770463B2 (en) 2010-07-06 2017-09-26 Glaxosmithkline Biologicals Sa Delivery of RNA to different cell types
RS63817B1 (sr) 2010-07-06 2023-01-31 Glaxosmithkline Biologicals Sa Čestice za isporuku slične virionu za molekule samoreplicirajuće rnk
EP2590626B1 (fr) 2010-07-06 2015-10-28 GlaxoSmithKline Biologicals SA Liposomes à lipides ayant une valeur de pka avantageuse pour la délivrance d'arn
WO2012006369A2 (fr) 2010-07-06 2012-01-12 Novartis Ag Immunisation de grands mammifères à l'aide de faibles doses d'arn
DK3243526T3 (da) 2010-07-06 2020-02-17 Glaxosmithkline Biologicals Sa Levering af rna til at udløse flere immunsignalveje
CN105734678B (zh) 2010-07-16 2019-11-05 阿迪马布有限责任公司 合成多核苷酸文库
BR112013004865A2 (pt) 2010-08-31 2016-06-07 Novartis Ag lípidos adequados para entrega lipossomal de codificadores de proteínas rna
EP4119155A1 (fr) 2010-08-31 2023-01-18 GlaxoSmithKline Biologicals S.A. Liposomes pegylés pour la délivrance d'arn codant pour un immunogène
PL2611467T3 (pl) 2010-08-31 2022-08-16 Glaxosmithkline Biologicals Sa Małe liposomy do dostarczania rna kodującego immunogen
US9487563B2 (en) 2011-01-31 2016-11-08 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Virus-like particles and methods of use
US8722044B2 (en) * 2011-03-15 2014-05-13 Janssen Biotech, Inc. Human tissue factor antibody and uses thereof
CA2835644C (fr) 2011-05-13 2021-06-15 Novartis Ag Antigenes de pre-fusion f du vrs
SI3892295T1 (sl) 2011-05-24 2023-09-29 BioNTech SE Individualizirana cepiva proti raku
GB201108879D0 (en) 2011-05-25 2011-07-06 Isis Innovation Vector
WO2012171541A1 (fr) 2011-06-15 2012-12-20 Scil Proteins Gmbh Protéines hybrides humaines comportant des interférons et des protéines hétérodimériques modifiées par ubiquitine
JP2014520806A (ja) 2011-07-06 2014-08-25 ノバルティス アーゲー Rna分子の送達のための有用なn:p比を有するリポソーム
ES2702318T3 (es) 2011-07-06 2019-02-28 Glaxosmithkline Biologicals Sa Emulsiones catiónicas de aceite en agua
CA2840989A1 (fr) 2011-07-06 2013-01-10 Novartis Ag Compositions de combinaisons immunogenes et utilisations de celles-ci
CA2841047A1 (fr) 2011-07-06 2013-01-10 Novartis Ag Compositions immunogenes et leurs utilisations
US8859507B2 (en) 2011-08-16 2014-10-14 Samsung Electronics Co., Ltd. Protein complex for intracellular delivery and uses thereof
MX366055B (es) 2011-08-31 2019-06-26 Novartis Ag Liposomas pegilados para admistracion de acido ribonucleico (arn) que codifica para inmunogeno.
AU2012322704B2 (en) 2011-10-11 2017-09-07 Novartis Ag Recombinant self-replicating polycistronic RNA molecules
NZ628206A (en) 2012-02-16 2016-03-31 Vlp Therapeutics Llc Virus like particle composition
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
US20160289674A1 (en) 2012-04-02 2016-10-06 Moderna Therapeutics, Inc. Modified polynucleotides for the production of membrane proteins
SG10201609511XA (en) 2012-05-18 2016-12-29 Univ Pennsylvania Subfamily e simian adenoviruses a1302, a1320, a1331 and a1337 and uses thereof
EP2870236B1 (fr) 2012-07-04 2018-01-10 Sirion Biotech GmbH Supports et procédés pour accroître la production d'adénovirus
CN104853770A (zh) 2012-07-06 2015-08-19 诺华股份有限公司 免疫原性组合物及其应用
EP2759570B1 (fr) 2012-10-11 2016-01-13 LG Chem, Ltd. Copolymère acrylate d'alkyle-composé aromatique vinylique-composé cyanure de vinyle ayant une résistance à l'impact à basse température améliorée, et composition de polycarbonate le comprenant
GB201220119D0 (en) 2012-11-08 2012-12-26 Univ Cork Vector
EP2991679A4 (fr) 2013-04-29 2016-12-07 Adimab Llc Réactifs multispécificité, procédés de préparation et d'utilisation associés
JP6734651B2 (ja) 2013-06-03 2020-08-05 ブイエルピー・セラピューティクス・リミテッド・ライアビリティ・カンパニーVLP Therapeutics, LLC マラリアワクチン
BR112016008806A2 (pt) 2013-11-01 2017-10-03 Pfizer Vetores para expressão de antígenos associados à próstata
GB201319446D0 (en) 2013-11-04 2013-12-18 Immatics Biotechnologies Gmbh Personalized immunotherapy against several neuronal and brain tumors
WO2015075201A1 (fr) 2013-11-21 2015-05-28 Genmab A/S Formulation lyophilisée de conjugués anticorps-médicaments
JP5957637B2 (ja) * 2014-02-03 2016-07-27 国立研究開発法人国立がん研究センター 抗TissueFactorモノクローナル抗体
EP4029873A1 (fr) 2014-09-17 2022-07-20 Zymeworks Inc. Composés cytotoxiques et antimitotiques et leurs procédés d'utilisation
US20180030140A1 (en) 2015-02-06 2018-02-01 Navigo Proteins Gmbh Novel binding proteins comprising a ubiquitin mutein and antibodies or antibody fragments
PL3280441T3 (pl) 2015-04-07 2022-02-21 Alector Llc Przeciwciała przeciwko sortilinie i sposoby ich stosowania
US20190030178A1 (en) 2015-09-11 2019-01-31 Genmab A/S Dosing regimens for anti-tf-antibody drug-conjugates
PE20181535A1 (es) 2015-12-16 2018-09-26 Gritstone Oncology Inc Identificacion, fabricacion y uso de neoantigeno
SG11201909652WA (en) 2017-04-19 2019-11-28 Gritstone Oncology Inc Neoantigen identification, manufacture, and use
CN111094352A (zh) 2017-08-25 2020-05-01 戊瑞治疗有限公司 B7-h4抗体及其使用方法
CN111727075B (zh) 2017-11-27 2024-04-05 普渡制药公司 靶向人组织因子的人源化抗体
CN111818943A (zh) 2018-01-04 2020-10-23 伊科尼克治疗公司 抗组织因子抗体、抗体-药物缀合物及相关方法

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