JPWO2019050815A5 - - Google Patents
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- Publication number
- JPWO2019050815A5 JPWO2019050815A5 JP2020513549A JP2020513549A JPWO2019050815A5 JP WO2019050815 A5 JPWO2019050815 A5 JP WO2019050815A5 JP 2020513549 A JP2020513549 A JP 2020513549A JP 2020513549 A JP2020513549 A JP 2020513549A JP WO2019050815 A5 JPWO2019050815 A5 JP WO2019050815A5
- Authority
- JP
- Japan
- Prior art keywords
- polysaccharide
- carrier protein
- protein conjugate
- immunogenic composition
- conjugate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000004676 glycans Chemical class 0.000 claims description 38
- 229920001282 polysaccharide Polymers 0.000 claims description 38
- 239000005017 polysaccharide Substances 0.000 claims description 38
- 239000000203 mixture Substances 0.000 claims description 22
- 230000002163 immunogen Effects 0.000 claims description 19
- 102000014914 Carrier Proteins Human genes 0.000 claims description 15
- 108010078791 Carrier Proteins Proteins 0.000 claims description 15
- 108010071134 CRM197 (non-toxic variant of diphtheria toxin) Proteins 0.000 claims description 7
- 108090000623 proteins and genes Proteins 0.000 claims 52
- 102000004169 proteins and genes Human genes 0.000 claims 52
- 239000002671 adjuvant Substances 0.000 claims 8
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 6
- 241000193998 Streptococcus pneumoniae Species 0.000 claims 5
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims 5
- 230000021615 conjugation Effects 0.000 claims 5
- 229940031000 streptococcus pneumoniae Drugs 0.000 claims 5
- 125000003172 aldehyde group Chemical group 0.000 claims 4
- 229960002885 histidine Drugs 0.000 claims 3
- 230000028993 immune response Effects 0.000 claims 3
- 239000011780 sodium chloride Substances 0.000 claims 3
- 125000003277 amino group Chemical group 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical group [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims 1
- 229910052782 aluminium Inorganic materials 0.000 claims 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims 1
- DIZPMCHEQGEION-UHFFFAOYSA-H aluminium sulfate (anhydrous) Chemical compound [Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O DIZPMCHEQGEION-UHFFFAOYSA-H 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 235000000346 sugar Nutrition 0.000 description 5
- 150000008163 sugars Chemical class 0.000 description 2
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024019152A JP2024056835A (ja) | 2017-09-07 | 2024-02-13 | 肺炎球菌多糖体および免疫原性多糖体－キャリアタンパク質コンジュゲートでのその使用 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762555461P | 2017-09-07 | 2017-09-07 | |
| US62/555,461 | 2017-09-07 | ||
| US201862645252P | 2018-03-20 | 2018-03-20 | |
| US62/645,252 | 2018-03-20 | ||
| PCT/US2018/049308 WO2019050815A1 (en) | 2017-09-07 | 2018-09-04 | ANTI-PNEUMOCOCCAL POLYSACCHARIDES AND THEIR USE IN IMMUNOGENIC CONJUGATES POLYSACCHARIDE-PROTEIN CARRIER |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024019152A Division JP2024056835A (ja) | 2017-09-07 | 2024-02-13 | 肺炎球菌多糖体および免疫原性多糖体－キャリアタンパク質コンジュゲートでのその使用 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2020533439A JP2020533439A (ja) | 2020-11-19 |
| JP2020533439A5 JP2020533439A5 (ru) | 2021-08-19 |
| JPWO2019050815A5 true JPWO2019050815A5 (ru) | 2023-11-27 |
| JP7438102B2 JP7438102B2 (ja) | 2024-02-26 |
Family
ID=65634964
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020513549A Active JP7438102B2 (ja) | 2017-09-07 | 2018-09-04 | 肺炎球菌多糖体および免疫原性多糖体－キャリアタンパク質コンジュゲートでのその使用 |
| JP2024019152A Pending JP2024056835A (ja) | 2017-09-07 | 2024-02-13 | 肺炎球菌多糖体および免疫原性多糖体－キャリアタンパク質コンジュゲートでのその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024019152A Pending JP2024056835A (ja) | 2017-09-07 | 2024-02-13 | 肺炎球菌多糖体および免疫原性多糖体－キャリアタンパク質コンジュゲートでのその使用 |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP3678654B1 (ru) |
| JP (2) | JP7438102B2 (ru) |
| KR (1) | KR20200051004A (ru) |
| CN (2) | CN111093650B (ru) |
| AU (2) | AU2018328037B2 (ru) |
| BR (1) | BR112020004509A8 (ru) |
| CA (1) | CA3074708A1 (ru) |
| MX (1) | MX2020002555A (ru) |
| WO (1) | WO2019050815A1 (ru) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7186166B2 (ja) | 2016-12-30 | 2022-12-08 | バックスサイト・インコーポレイテッド | 非天然アミノ酸とのポリペプチド抗原接合体 |
| US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
| CN116870144A (zh) | 2017-01-31 | 2023-10-13 | 默沙东有限责任公司 | 制备多糖-蛋白缀合物的方法 |
| US11400162B2 (en) | 2017-02-24 | 2022-08-02 | Merck Sharp & Dohme Llc | Processes for the formulation of pneumococcal polysaccharides for conjugation to a carrier protein |
| KR20240011879A (ko) | 2017-02-24 | 2024-01-26 | 머크 샤프 앤드 돔 엘엘씨 | 스트렙토코쿠스 뉴모니아에 폴리사카라이드-단백질 접합체의 면역원성의 증진 |
| AU2018328038B2 (en) | 2017-09-07 | 2024-03-07 | Merck Sharp & Dohme Llc | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
| KR20200051003A (ko) | 2017-09-07 | 2020-05-12 | 머크 샤프 앤드 돔 코포레이션 | 폐렴구균 폴리사카라이드 및 면역원성 폴리사카라이드-담체 단백질 접합체에서의 그의 용도 |
| CN111093649B (zh) | 2017-09-07 | 2023-08-25 | 默沙东有限责任公司 | 肺炎球菌多糖及其在免疫原性多糖-载体蛋白缀合物中的用途 |
| US11524076B2 (en) | 2017-09-07 | 2022-12-13 | Merck Sharp & Dohme Llc | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
| KR20230130153A (ko) | 2017-12-06 | 2023-09-11 | 머크 샤프 앤드 돔 엘엘씨 | 스트렙토코쿠스 뉴모니아에 폴리사카라이드-단백질 접합체를 포함하는 조성물 및 그의 사용 방법 |
| AU2019215216A1 (en) | 2018-02-05 | 2020-07-23 | Sk Bioscience Co., Ltd. | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| BR112020021296A2 (pt) | 2018-04-18 | 2021-01-26 | Sk Bioscience Co., Ltd. | polissacarídeo capsular de streptococcus pneumoniae e conjugado imunogênico do mesmo |
| EP3787673A4 (en) | 2018-04-30 | 2022-04-27 | Merck Sharp & Dohme Corp. | METHODS FOR PRODUCING CAPSULAR CARRIER PROTEIN-POLYSACCHARIDE CONJUGATES OF STREPTOCOCCUS PNEUMONIAE |
| US11896656B2 (en) | 2018-04-30 | 2024-02-13 | Merck Sharp & Dohme Llc | Methods for providing a homogenous solution of lyophilized mutant diptheria toxin in dimethylsulfoxide |
| US20220296695A1 (en) | 2018-12-19 | 2022-09-22 | Merck Sharp & Dohme Corp. | Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof |
| JP2023537945A (ja) * | 2020-08-10 | 2023-09-06 | インベントプライズ・インコーポレイテッド | 出現血清型２４ｆを含む多価肺炎球菌複合糖質ワクチン |
| US20240181028A1 (en) | 2022-11-22 | 2024-06-06 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| WO2024116096A1 (en) | 2022-12-01 | 2024-06-06 | Pfizer Inc. | Pneumococcal conjugate vaccine formulations |
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| RU2721128C2 (ru) | 2015-07-21 | 2020-05-18 | Пфайзер Инк. | Иммуногенные композиции, содержащие конъюгированные антигены капсульного сахарида, наборы, содержащие эти композиции, и их применения |
| JP2018532696A (ja) * | 2015-08-25 | 2018-11-08 | カレイド・バイオサイエンシズ・インコーポレイテッド | グリカン組成物およびその使用 |
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| US11058757B2 (en) * | 2016-03-31 | 2021-07-13 | Pogona, LLC | Saccharide-polypeptide conjugate compositions and methods of use thereof |
| AU2018328040A1 (en) * | 2017-09-07 | 2020-03-19 | Merck Sharp & Dohme Llc | Processes for the formulation of pneumococcal polysaccharides for conjugation to a carrier protein |
| KR20200051003A (ko) * | 2017-09-07 | 2020-05-12 | 머크 샤프 앤드 돔 코포레이션 | 폐렴구균 폴리사카라이드 및 면역원성 폴리사카라이드-담체 단백질 접합체에서의 그의 용도 |
| AU2018328038B2 (en) * | 2017-09-07 | 2024-03-07 | Merck Sharp & Dohme Llc | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
| CN111093649B (zh) * | 2017-09-07 | 2023-08-25 | 默沙东有限责任公司 | 肺炎球菌多糖及其在免疫原性多糖-载体蛋白缀合物中的用途 |
| KR20230130153A (ko) * | 2017-12-06 | 2023-09-11 | 머크 샤프 앤드 돔 엘엘씨 | 스트렙토코쿠스 뉴모니아에 폴리사카라이드-단백질 접합체를 포함하는 조성물 및 그의 사용 방법 |
-
2018
- 2018-09-04 EP EP18853342.6A patent/EP3678654B1/en active Active
- 2018-09-04 WO PCT/US2018/049308 patent/WO2019050815A1/en active Application Filing
- 2018-09-04 CN CN201880058217.4A patent/CN111093650B/zh active Active
- 2018-09-04 BR BR112020004509A patent/BR112020004509A8/pt unknown
- 2018-09-04 AU AU2018328037A patent/AU2018328037B2/en active Active
- 2018-09-04 CA CA3074708A patent/CA3074708A1/en active Pending
- 2018-09-04 JP JP2020513549A patent/JP7438102B2/ja active Active
- 2018-09-04 KR KR1020207009614A patent/KR20200051004A/ko not_active Application Discontinuation
- 2018-09-04 CN CN202410181167.6A patent/CN118063638A/zh active Pending
- 2018-09-04 MX MX2020002555A patent/MX2020002555A/es unknown
-
2024
- 2024-02-13 JP JP2024019152A patent/JP2024056835A/ja active Pending
- 2024-03-07 AU AU2024201518A patent/AU2024201518A1/en active Pending
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