JPWO2005063291A1 - 抗体を含有する安定な水性医薬製剤 - Google Patents

抗体を含有する安定な水性医薬製剤 Download PDF

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Publication number
JPWO2005063291A1
JPWO2005063291A1 JP2005516616A JP2005516616A JPWO2005063291A1 JP WO2005063291 A1 JPWO2005063291 A1 JP WO2005063291A1 JP 2005516616 A JP2005516616 A JP 2005516616A JP 2005516616 A JP2005516616 A JP 2005516616A JP WO2005063291 A1 JPWO2005063291 A1 JP WO2005063291A1
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Japan
Prior art keywords
antibody
aqueous pharmaceutical
pharmaceutical preparation
preparation according
stable
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JP2005516616A
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English (en)
Japanese (ja)
Inventor
智世至 石川
智世至 石川
哲寛 上野
哲寛 上野
木村　聡
聡 木村
洋祐 植木
洋祐 植木
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Kirin Brewery Co Ltd
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Kirin Brewery Co Ltd
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Application filed by Kirin Brewery Co Ltd filed Critical Kirin Brewery Co Ltd
Publication of JPWO2005063291A1 publication Critical patent/JPWO2005063291A1/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
JP2005516616A 2003-12-25 2004-12-22 抗体を含有する安定な水性医薬製剤 Pending JPWO2005063291A1 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2003431400 2003-12-25
JP2003431400 2003-12-25
PCT/JP2004/019259 WO2005063291A1 (ja) 2003-12-25 2004-12-22 抗体を含有する安定な水性医薬製剤

Publications (1)

Publication Number Publication Date
JPWO2005063291A1 true JPWO2005063291A1 (ja) 2007-07-19

Family

ID=34736431

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2005516616A Pending JPWO2005063291A1 (ja) 2003-12-25 2004-12-22 抗体を含有する安定な水性医薬製剤

Country Status (6)

Country Link
US (1) US20070184050A1 (https=)
EP (1) EP1712240B1 (https=)
JP (1) JPWO2005063291A1 (https=)
ES (1) ES2553987T3 (https=)
TW (1) TW200526247A (https=)
WO (1) WO2005063291A1 (https=)

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CA2790018C (en) * 2006-12-21 2015-02-03 Amgen Inc. Formulations
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US8420081B2 (en) * 2007-11-30 2013-04-16 Abbvie, Inc. Antibody formulations and methods of making same
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RU2011126338A (ru) * 2008-11-28 2013-01-10 Эбботт Лэборетриз Стабильные композиции антител и способы их стабилизации
US20100278822A1 (en) * 2009-05-04 2010-11-04 Abbott Biotechnology, Ltd. Stable high protein concentration formulations of human anti-tnf-alpha-antibodies
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US20120294866A1 (en) * 2010-01-19 2012-11-22 F. Hoffmann-La Roche Ag Pharmaceutical formulation for proteins
AR080428A1 (es) * 2010-01-20 2012-04-11 Chugai Pharmaceutical Co Ltd Formulaciones liquidas estabilizadas contentivas de anticuerpos
EP3409289B1 (en) 2010-02-26 2020-09-30 Novo Nordisk A/S Stable antibody containing compositions
PT3345615T (pt) 2010-03-01 2020-01-17 Bayer Healthcare Llc Anticorpos monoclonais otimizados contra inibidor da via do fator tecidual (tfpi)
RU2012153786A (ru) 2010-05-28 2014-07-10 Ново Нордиск А/С Стабильные многодозовые композиции, содержащие антитело и консервант
US8821865B2 (en) 2010-11-11 2014-09-02 Abbvie Biotechnology Ltd. High concentration anti-TNFα antibody liquid formulations
EP2471554A1 (en) * 2010-12-28 2012-07-04 Hexal AG Pharmaceutical formulation comprising a biopharmaceutical drug
JP5458188B2 (ja) * 2011-02-17 2014-04-02 協和発酵キリン株式会社 抗ｃｄ４０抗体の高濃度製剤
UY34105A (es) * 2011-06-03 2012-07-31 Lg Life Sciences Ltd Formulación líquida estable de etanercept
CN104582719B (zh) * 2012-08-17 2017-09-15 英特维特国际股份有限公司 灭活钩端螺旋体细菌的免疫原性组合物
US8613919B1 (en) 2012-08-31 2013-12-24 Bayer Healthcare, Llc High concentration antibody and protein formulations
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PE20150964A1 (es) 2012-09-07 2015-07-25 Coherus Biosciences Inc Formulaciones acuosas estables de adalimumab
UA117466C2 (uk) 2012-12-13 2018-08-10 Мерк Шарп Енд Доме Корп. СТАБІЛЬНИЙ СКЛАД У ВИГЛЯДІ РОЗЧИНУ АНТИТІЛА ДО IL-23p19
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DK3334747T5 (da) 2015-08-13 2024-10-07 Amgen Inc Ladet dybdefiltrering af antigenbindende proteiner
US11229702B1 (en) 2015-10-28 2022-01-25 Coherus Biosciences, Inc. High concentration formulations of adalimumab
MX2018011675A (es) * 2016-03-25 2019-01-10 Astellas Pharma Inc Composicion farmaceutica que comprende un fragmento fab' pegilado de anticuerpo anti-ngf humano.
US11071782B2 (en) 2016-04-20 2021-07-27 Coherus Biosciences, Inc. Method of filling a container with no headspace
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BR112019018401A2 (pt) * 2017-03-06 2020-04-07 Merck Patent Gmbh formulação aquosa de anticorpo anti-pd-l1
US10799597B2 (en) 2017-04-03 2020-10-13 Immunomedics, Inc. Subcutaneous administration of antibody-drug conjugates for cancer therapy
JOP20190260A1 (ar) 2017-05-02 2019-10-31 Merck Sharp & Dohme صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها
JP7382232B2 (ja) 2017-05-02 2023-11-16 メルク・シャープ・アンド・ドーム・エルエルシー 抗ｌａｇ３抗体の製剤および抗ｌａｇ３抗体と抗ｐｄ－１抗体との共製剤
CN119161488A (zh) 2017-11-01 2024-12-20 中外制药株式会社 具有降低的生物活性的抗体变体和同种型
WO2020081408A1 (en) 2018-10-18 2020-04-23 Merck Sharp & Dohme Corp. Formulations of anti-rsv antibodies and methods of use thereof
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Also Published As

Publication number Publication date
US20070184050A1 (en) 2007-08-09
EP1712240A1 (en) 2006-10-18
WO2005063291A1 (ja) 2005-07-14
EP1712240B1 (en) 2015-09-09
TWI353253B (https=) 2011-12-01
EP1712240A4 (en) 2012-08-22
ES2553987T3 (es) 2015-12-15
TW200526247A (en) 2005-08-16

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