JPS6361960B2 - - Google Patents
Info
- Publication number
- JPS6361960B2 JPS6361960B2 JP56103123A JP10312381A JPS6361960B2 JP S6361960 B2 JPS6361960 B2 JP S6361960B2 JP 56103123 A JP56103123 A JP 56103123A JP 10312381 A JP10312381 A JP 10312381A JP S6361960 B2 JPS6361960 B2 JP S6361960B2
- Authority
- JP
- Japan
- Prior art keywords
- leif
- interferon
- fragment
- dna
- plasmid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
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- 230000001568 sexual effect Effects 0.000 description 1
- 238000001542 size-exclusion chromatography Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- NZVYCXVTEHPMHE-ZSUJOUNUSA-N thymalfasin Chemical compound CC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O NZVYCXVTEHPMHE-ZSUJOUNUSA-N 0.000 description 1
- 229960004231 thymalfasin Drugs 0.000 description 1
- 229940104230 thymidine Drugs 0.000 description 1
- 230000005026 transcription initiation Effects 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 150000005691 triesters Chemical class 0.000 description 1
- 239000001226 triphosphate Substances 0.000 description 1
- 235000011178 triphosphate Nutrition 0.000 description 1
- 125000002264 triphosphate group Chemical class [H]OP(=O)(O[H])OP(=O)(O[H])OP(=O)(O[H])O* 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 108010084932 tryptophyl-proline Proteins 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 238000005199 ultracentrifugation Methods 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 229940035893 uracil Drugs 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16498680A | 1980-07-01 | 1980-07-01 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5779897A JPS5779897A (en) | 1982-05-19 |
| JPS6361960B2 true JPS6361960B2 (da) | 1988-11-30 |
Family
ID=22596929
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP56103123A Granted JPS5779897A (en) | 1980-07-01 | 1981-07-01 | Polypeptide containing amino acid arrangement of aged human corpuscle interferone |
| JP25393784A Granted JPS60221094A (ja) | 1980-07-01 | 1984-11-30 | 発現ビヒクル |
| JP59253936A Granted JPS60221093A (ja) | 1980-07-01 | 1984-11-30 | Ｄｎａ配列 |
| JP59253935A Granted JPS60227694A (ja) | 1980-07-01 | 1984-11-30 | ヒト成熟白血球インタフエロンのアミノ酸配列を含むポリペプチドの製造方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP25393784A Granted JPS60221094A (ja) | 1980-07-01 | 1984-11-30 | 発現ビヒクル |
| JP59253936A Granted JPS60221093A (ja) | 1980-07-01 | 1984-11-30 | Ｄｎａ配列 |
| JP59253935A Granted JPS60227694A (ja) | 1980-07-01 | 1984-11-30 | ヒト成熟白血球インタフエロンのアミノ酸配列を含むポリペプチドの製造方法 |
Country Status (3)
| Country | Link |
|---|---|
| JP (4) | JPS5779897A (da) |
| MW (1) | MW2581A1 (da) |
| ZA (1) | ZA814375B (da) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4582800A (en) * | 1982-07-12 | 1986-04-15 | Hoffmann-La Roche Inc. | Novel vectors and method for controlling interferon expression |
| WO1984001149A1 (en) * | 1982-09-22 | 1984-03-29 | Takeda Chemical Industries Ltd | Novel polypeptide and its use |
| DE3247922A1 (de) * | 1982-12-24 | 1984-06-28 | Boehringer Ingelheim International GmbH, 6507 Ingelheim | Dna-sequenzen, deren herstellung, diese sequenzen enthaltende plasmide und deren verwendung zur synthese eukaryotischer genprodukte in prokaryoten |
| GB8303383D0 (en) * | 1983-02-08 | 1983-03-16 | Biogen Nv | Sequences recombinant dna molecules |
| JPH088870B2 (ja) * | 1985-02-05 | 1996-01-31 | サイナ−ゲン バイオロジカルズ，インコ−ポレ−テツド | メタロプロテイナ−ゼ阻害剤の配列をもつ組換ベクタ−系及びメタロプロテイナ−ゼ阻害剤製造のための組換ｄｎａ |
| DE3515336C2 (de) * | 1985-04-27 | 1994-01-20 | Boehringer Ingelheim Int | Verfahren zur Herstellung und Reinigung von â-Interferon |
| JPS62100292A (ja) * | 1985-10-28 | 1987-05-09 | Sumitomo Chem Co Ltd | バチラス・チユリンゲンシス・アイザワイｉｐｌ株の殺虫性蛋白遺伝子 |
| JPS63242397A (ja) * | 1987-03-31 | 1988-10-07 | Kubota Ltd | 廃水処理方法 |
| JPH0753113B2 (ja) * | 1987-05-21 | 1995-06-07 | 農業生物遺伝子構造解析技術研究組合 | キュウリモザイクウイルスの外被蛋白質をコ−ドする遺伝子 |
| JPH0753114B2 (ja) * | 1987-07-06 | 1995-06-07 | 農業生物遺伝子構造解析技術研究組合 | キユウリモザイクウイルスの３ａ蛋白質をコ−ドする遺伝子 |
| FR2825716B1 (fr) | 2001-06-11 | 2004-09-24 | Genodyssee | Nouveaux polynucleotides et polypeptides de l'ifn alpha 7 |
-
1981
- 1981-06-26 ZA ZA814375A patent/ZA814375B/xx unknown
- 1981-06-30 MW MW2581A patent/MW2581A1/xx unknown
- 1981-07-01 JP JP56103123A patent/JPS5779897A/ja active Granted
-
1984
- 1984-11-30 JP JP25393784A patent/JPS60221094A/ja active Granted
- 1984-11-30 JP JP59253936A patent/JPS60221093A/ja active Granted
- 1984-11-30 JP JP59253935A patent/JPS60227694A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| ZA814375B (en) | 1982-07-28 |
| JPS6361920B2 (da) | 1988-11-30 |
| JPS5779897A (en) | 1982-05-19 |
| JPS60227694A (ja) | 1985-11-12 |
| MW2581A1 (en) | 1982-10-13 |
| JPS6363199B2 (da) | 1988-12-06 |
| JPS60221094A (ja) | 1985-11-05 |
| JPS6363198B2 (da) | 1988-12-06 |
| JPS60221093A (ja) | 1985-11-05 |
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