JPS63500799A - 持続性オピオイド拮抗作用を得るための方法および組成物 - Google Patents

持続性オピオイド拮抗作用を得るための方法および組成物

Info

Publication number
JPS63500799A
JPS63500799A JP61505302A JP50530286A JPS63500799A JP S63500799 A JPS63500799 A JP S63500799A JP 61505302 A JP61505302 A JP 61505302A JP 50530286 A JP50530286 A JP 50530286A JP S63500799 A JPS63500799 A JP S63500799A
Authority
JP
Japan
Prior art keywords
methylene
anesthetic
opioid
cyclopropylmethyl
subject
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP61505302A
Other languages
English (en)
Japanese (ja)
Inventor
タットル，ロナルド・アール
ハウズ，ジョン
Original Assignee
ベーカー・カミンス・ファーマシューティカルス・インコーポレーテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ベーカー・カミンス・ファーマシューティカルス・インコーポレーテッド filed Critical ベーカー・カミンス・ファーマシューティカルス・インコーポレーテッド
Publication of JPS63500799A publication Critical patent/JPS63500799A/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine

Landscapes

  • Health & Medical Sciences (AREA)
  • Emergency Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
JP61505302A 1985-09-06 1986-09-08 持続性オピオイド拮抗作用を得るための方法および組成物 Pending JPS63500799A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77321385A 1985-09-06 1985-09-06
US773213 1985-09-06

Publications (1)

Publication Number Publication Date
JPS63500799A true JPS63500799A (ja) 1988-03-24

Family

ID=25097554

Family Applications (1)

Application Number Title Priority Date Filing Date
JP61505302A Pending JPS63500799A (ja) 1985-09-06 1986-09-08 持続性オピオイド拮抗作用を得るための方法および組成物

Country Status (5)

Country Link
EP (1) EP0236477B1 (enExample)
JP (1) JPS63500799A (enExample)
AT (1) ATE84717T1 (enExample)
DE (2) DE3690457T1 (enExample)
WO (1) WO1987001282A2 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2412409T3 (es) 1997-12-22 2013-07-11 Euro-Celtique S.A. Forma farmacéutica para dosificación oral que comprende una combinación de un agonista opiáceo y un antagonista opiáceo
SI1299104T1 (sl) 2000-02-08 2009-10-31 Euro Celtique Sa Oralne formulacije opioidnih agonistov, varne pred zlorabo
US20030065002A1 (en) 2001-05-11 2003-04-03 Endo Pharmaceuticals, Inc. Abuse-resistant controlled-release opioid dosage form
US7914818B2 (en) 2001-08-06 2011-03-29 Purdue Pharma L.P. Opioid agonist formulations with releasable and sequestered antagonist
ES2320748T5 (es) 2002-04-05 2017-02-20 Euro-Celtique S.A. Matriz para la liberación sostenida, invariable e independiente de compuestos activos
EP2422773A3 (en) 2002-09-20 2012-04-18 Alpharma, Inc. Sequestering subunit and related compositions and methods
MY135852A (en) 2003-04-21 2008-07-31 Euro Celtique Sa Pharmaceutical products
EP1702558A1 (en) 2005-02-28 2006-09-20 Euro-Celtique S.A. Method and device for the assessment of bowel function
ES2636657T3 (es) 2006-06-19 2017-10-06 Alpharma Pharmaceuticals Llc Composición farmacéutica
US8623418B2 (en) 2007-12-17 2014-01-07 Alpharma Pharmaceuticals Llc Pharmaceutical composition
UY32487A (es) 2009-03-10 2010-06-30 Euro Celtique Sa Composiciones farmacéuticas de liberación inmediata comprendiendo oxicodona y naloxona
UA116567C2 (uk) 2013-07-23 2018-04-10 Євро-Селтік С.А. Комбінація оксикодону та налоксону для застосування в лікуванні болю у пацієнтів, які страждають від болю та захворювання, що призводить до дисбактеріозу кишечнику та/або підвищує ризик кишкової бактеріальної транслокації

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4858000A (enExample) * 1971-11-26 1973-08-14
JPS56167687A (en) * 1980-04-28 1981-12-23 Du Pont 17-substituted-6-desoxy-7,8-dihydro-6 alpha- methyl-noroxymorphone anesthetic antagonist substance

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB769517A (en) * 1953-10-20 1957-03-06 Merck & Co Inc Analgesic compositions
US3493657A (en) * 1961-03-14 1970-02-03 Mozes Juda Lewenstein Therapeutic compositions of n-allyl-14-hydroxy - dihydronormorphinane and morphine
JPS59500418A (ja) * 1982-03-16 1984-03-15 ザ　ロツクフエラ−　ユニバ−シテイ 胃腸能動作用障害を回復する方法
US4567185A (en) * 1983-05-13 1986-01-28 Key Pharmaceuticals, Inc. Endorphin blockage
US4535157A (en) * 1983-11-01 1985-08-13 Key Pharmaceuticals, Inc. Process for making 6-desoxy-6-methylenenaloxone and 6-desoxy-6-methylenenaltrexone
GB8332556D0 (en) * 1983-12-06 1984-01-11 Reckitt & Colmann Prod Ltd Analgesic compositions

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4858000A (enExample) * 1971-11-26 1973-08-14
JPS56167687A (en) * 1980-04-28 1981-12-23 Du Pont 17-substituted-6-desoxy-7,8-dihydro-6 alpha- methyl-noroxymorphone anesthetic antagonist substance

Also Published As

Publication number Publication date
DE3690457T1 (enExample) 1987-08-06
EP0236477A1 (en) 1987-09-16
EP0236477B1 (en) 1993-01-20
WO1987001282A3 (en) 1987-08-13
DE3687575T2 (de) 1993-07-01
ATE84717T1 (de) 1993-02-15
WO1987001282A2 (en) 1987-03-12
DE3687575D1 (de) 1993-03-04

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