JPS6345371B2 - - Google Patents
Info
- Publication number
- JPS6345371B2 JPS6345371B2 JP1073780A JP1073780A JPS6345371B2 JP S6345371 B2 JPS6345371 B2 JP S6345371B2 JP 1073780 A JP1073780 A JP 1073780A JP 1073780 A JP1073780 A JP 1073780A JP S6345371 B2 JPS6345371 B2 JP S6345371B2
- Authority
- JP
- Japan
- Prior art keywords
- lecithin
- pantethine
- lcat
- nephropathy
- administration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 10
- 239000000787 lecithin Substances 0.000 claims description 10
- 229940067606 lecithin Drugs 0.000 claims description 10
- 235000010445 lecithin Nutrition 0.000 claims description 10
- DJWYOLJPSHDSAL-UHFFFAOYSA-N Pantethine Natural products OCC(C)(C)C(O)C(=O)NCCC(=O)NCCSSCCNC(=O)CCNC(=O)C(O)C(C)(C)CO DJWYOLJPSHDSAL-UHFFFAOYSA-N 0.000 claims description 9
- DJWYOLJPSHDSAL-ROUUACIJSA-N pantethine Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSSCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)CO DJWYOLJPSHDSAL-ROUUACIJSA-N 0.000 claims description 9
- 229960000903 pantethine Drugs 0.000 claims description 9
- 235000008975 pantethine Nutrition 0.000 claims description 9
- 239000011581 pantethine Substances 0.000 claims description 9
- 230000004913 activation Effects 0.000 claims description 3
- 108010011964 Phosphatidylcholine-sterol O-acyltransferase Proteins 0.000 claims description 2
- 102000014190 Phosphatidylcholine-sterol O-acyltransferase Human genes 0.000 claims description 2
- 239000004480 active ingredient Substances 0.000 claims description 2
- 239000003623 enhancer Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 description 12
- 101001130226 Homo sapiens Phosphatidylcholine-sterol acyltransferase Proteins 0.000 description 11
- 102100031538 Phosphatidylcholine-sterol acyltransferase Human genes 0.000 description 11
- 208000017169 kidney disease Diseases 0.000 description 5
- 208000029078 coronary artery disease Diseases 0.000 description 3
- 206010012601 diabetes mellitus Diseases 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 229930194190 pantocin Natural products 0.000 description 2
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Enzymes And Modification Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1073780A JPS56108712A (en) | 1980-01-31 | 1980-01-31 | Lecithin cholesterol acyl transferase activator |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1073780A JPS56108712A (en) | 1980-01-31 | 1980-01-31 | Lecithin cholesterol acyl transferase activator |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS56108712A JPS56108712A (en) | 1981-08-28 |
| JPS6345371B2 true JPS6345371B2 (US20100268047A1-20101021-C00003.png) | 1988-09-09 |
Family
ID=11758600
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1073780A Granted JPS56108712A (en) | 1980-01-31 | 1980-01-31 | Lecithin cholesterol acyl transferase activator |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS56108712A (US20100268047A1-20101021-C00003.png) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU7104994A (en) * | 1993-06-11 | 1996-01-05 | Massachusetts Institute Of Technology | Protein condensation inhibitors and methods related thereto |
| WO2015050148A1 (ja) * | 2013-10-04 | 2015-04-09 | 第一三共株式会社 | ３－アリールピラゾロピリジン誘導体 |
| WO2015076353A1 (ja) * | 2013-11-25 | 2015-05-28 | 第一三共株式会社 | ３－アルキルピラゾロピリジン誘導体 |
-
1980
- 1980-01-31 JP JP1073780A patent/JPS56108712A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS56108712A (en) | 1981-08-28 |
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