JPS6339566B2 - - Google Patents
Info
- Publication number
- JPS6339566B2 JPS6339566B2 JP15460978A JP15460978A JPS6339566B2 JP S6339566 B2 JPS6339566 B2 JP S6339566B2 JP 15460978 A JP15460978 A JP 15460978A JP 15460978 A JP15460978 A JP 15460978A JP S6339566 B2 JPS6339566 B2 JP S6339566B2
- Authority
- JP
- Japan
- Prior art keywords
- coenzyme
- solution
- soft capsules
- manufactured
- oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 claims description 45
- 239000007901 soft capsule Substances 0.000 claims description 22
- 239000000203 mixture Substances 0.000 claims description 15
- 238000011049 filling Methods 0.000 claims description 8
- 230000007935 neutral effect Effects 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- 239000004094 surface-active agent Substances 0.000 claims description 7
- 238000010438 heat treatment Methods 0.000 claims description 4
- 235000017471 coenzyme Q10 Nutrition 0.000 claims description 3
- 239000003921 oil Substances 0.000 description 8
- 235000019198 oils Nutrition 0.000 description 8
- -1 medium-chain fatty acid triglycerides Chemical class 0.000 description 6
- 238000003756 stirring Methods 0.000 description 6
- CUNWUEBNSZSNRX-RKGWDQTMSA-N (2r,3r,4r,5s)-hexane-1,2,3,4,5,6-hexol;(z)-octadec-9-enoic acid Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O CUNWUEBNSZSNRX-RKGWDQTMSA-N 0.000 description 5
- 238000003860 storage Methods 0.000 description 5
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 4
- XZIIFPSPUDAGJM-UHFFFAOYSA-N 6-chloro-2-n,2-n-diethylpyrimidine-2,4-diamine Chemical compound CCN(CC)C1=NC(N)=CC(Cl)=N1 XZIIFPSPUDAGJM-UHFFFAOYSA-N 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 239000002775 capsule Substances 0.000 description 4
- 239000013078 crystal Substances 0.000 description 4
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 4
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 4
- 229920000053 polysorbate 80 Polymers 0.000 description 4
- 229940035044 sorbitan monolaurate Drugs 0.000 description 4
- 235000011069 sorbitan monooleate Nutrition 0.000 description 4
- 239000001593 sorbitan monooleate Substances 0.000 description 4
- 229940035049 sorbitan monooleate Drugs 0.000 description 4
- 229960005078 sorbitan sesquioleate Drugs 0.000 description 4
- 108010010803 Gelatin Proteins 0.000 description 3
- 229920000159 gelatin Polymers 0.000 description 3
- 239000008273 gelatin Substances 0.000 description 3
- 235000019322 gelatine Nutrition 0.000 description 3
- 235000011852 gelatine desserts Nutrition 0.000 description 3
- 150000004667 medium chain fatty acids Chemical class 0.000 description 3
- 239000002244 precipitate Substances 0.000 description 3
- 238000004080 punching Methods 0.000 description 3
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 3
- 239000004359 castor oil Substances 0.000 description 2
- 235000019438 castor oil Nutrition 0.000 description 2
- 239000005515 coenzyme Substances 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 235000005687 corn oil Nutrition 0.000 description 2
- 239000002285 corn oil Substances 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000155 melt Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- FDDZTBYOCCYZRR-UHFFFAOYSA-N 2-[2-(diethylamino)ethyl]-3-phenyl-3h-isoindol-1-one;phosphoric acid Chemical compound OP(O)(O)=O.C12=CC=CC=C2C(=O)N(CCN(CC)CC)C1C1=CC=CC=C1 FDDZTBYOCCYZRR-UHFFFAOYSA-N 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 235000019483 Peanut oil Nutrition 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000010775 animal oil Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 235000012343 cottonseed oil Nutrition 0.000 description 1
- 239000002385 cottonseed oil Substances 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000007902 hard capsule Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 150000002711 medium chain fatty acid esters Chemical class 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 229920000259 polyoxyethylene lauryl ether Polymers 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15460978A JPS5581813A (en) | 1978-12-16 | 1978-12-16 | Composition containing coenzyme q10 and its perparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15460978A JPS5581813A (en) | 1978-12-16 | 1978-12-16 | Composition containing coenzyme q10 and its perparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5581813A JPS5581813A (en) | 1980-06-20 |
| JPS6339566B2 true JPS6339566B2 (enExample) | 1988-08-05 |
Family
ID=15587913
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP15460978A Granted JPS5581813A (en) | 1978-12-16 | 1978-12-16 | Composition containing coenzyme q10 and its perparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5581813A (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0236472U (enExample) * | 1988-08-31 | 1990-03-09 | ||
| US10950329B2 (en) | 2015-03-13 | 2021-03-16 | Mmodal Ip Llc | Hybrid human and computer-assisted coding workflow |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5877810A (ja) * | 1981-11-01 | 1983-05-11 | Taiho Yakuhin Kogyo Kk | ポリグリセロ−ル不飽和脂肪酸エステルを含む経口薬剤組成物 |
| JPS61221131A (ja) * | 1985-03-28 | 1986-10-01 | Eisai Co Ltd | 吸収促進したユビデカレノン含有組成物 |
| JPH0665645B2 (ja) * | 1985-09-18 | 1994-08-24 | 日清製粉株式会社 | 自己乳化型軟カプセル薬液 |
| US5258179A (en) * | 1989-10-27 | 1993-11-02 | Nestec S.A. | Protection of a food, cosmetic or pharmaceutical product against oxidation |
| IT1263840B (it) * | 1993-03-30 | 1996-09-04 | Giuseppe Furiosi | Formulazioni orali di ubidecarenone in forma di capsule |
| US6616942B1 (en) * | 1999-03-29 | 2003-09-09 | Soft Gel Technologies, Inc. | Coenzyme Q10 formulation and process methodology for soft gel capsules manufacturing |
| US6623734B2 (en) * | 2000-06-22 | 2003-09-23 | Soft Gel Technologies, Inc. | Super absorption coenzyme Q10 |
| DE10133305B4 (de) | 2001-07-12 | 2004-06-03 | Aquanova German Solubilisate Technologies (Agt) Gmbh | Ubichinon Konzentrat |
| CN100335045C (zh) * | 2001-07-17 | 2007-09-05 | 出光兴产株式会社 | 家禽腹水预防剂 |
| TW200302056A (en) * | 2002-01-18 | 2003-08-01 | Kaneka Corp | Method for stabilizing reduced coenzyme Q10 and composition therefor |
| KR100724326B1 (ko) * | 2003-01-17 | 2007-06-04 | 타이요 카가꾸 가부시키가이샤 | 코엔자임 ｑ10 함유 조성물 |
| JP2005047851A (ja) * | 2003-07-29 | 2005-02-24 | Nisshin Pharma Inc | ユビデカレノン含有組成物 |
| US7169385B2 (en) | 2003-09-29 | 2007-01-30 | Ronald G. Udell | Solubilized CoQ-10 and carnitine |
| US8124072B2 (en) | 2003-09-29 | 2012-02-28 | Soft Gel Technologies, Inc. | Solubilized CoQ-10 |
| EP1670325A1 (en) | 2003-09-29 | 2006-06-21 | Soft Gel Technologies, Inc. | SOLUBILIZED CoQ-10 |
| MY153288A (en) * | 2006-06-28 | 2015-01-29 | Hovid Berhad | An effective pharmaceutical carrier for poorly bioavailable drugs |
| JP2008005813A (ja) * | 2006-06-30 | 2008-01-17 | Ezaki Glico Co Ltd | コエンザイムｑ１０含有チョコレート |
-
1978
- 1978-12-16 JP JP15460978A patent/JPS5581813A/ja active Granted
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0236472U (enExample) * | 1988-08-31 | 1990-03-09 | ||
| US10950329B2 (en) | 2015-03-13 | 2021-03-16 | Mmodal Ip Llc | Hybrid human and computer-assisted coding workflow |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5581813A (en) | 1980-06-20 |
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