JPS6317841B2 - - Google Patents

Info

Publication number
JPS6317841B2
JPS6317841B2 JP52057512A JP5751277A JPS6317841B2 JP S6317841 B2 JPS6317841 B2 JP S6317841B2 JP 52057512 A JP52057512 A JP 52057512A JP 5751277 A JP5751277 A JP 5751277A JP S6317841 B2 JPS6317841 B2 JP S6317841B2
Authority
JP
Japan
Prior art keywords
support material
groups
isocyanate
reactive groups
biologically active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP52057512A
Other languages
English (en)
Japanese (ja)
Other versions
JPS52140588A (en
Inventor
Biipuritsuheru Kurisutofu
Ruuche Ryuudeigaa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MATSUKUSU PURANKU G TSUA FUERUDERUNKU DERU UITSUSENSHAFUTEN EE FUAU
Original Assignee
MATSUKUSU PURANKU G TSUA FUERUDERUNKU DERU UITSUSENSHAFUTEN EE FUAU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MATSUKUSU PURANKU G TSUA FUERUDERUNKU DERU UITSUSENSHAFUTEN EE FUAU filed Critical MATSUKUSU PURANKU G TSUA FUERUDERUNKU DERU UITSUSENSHAFUTEN EE FUAU
Publication of JPS52140588A publication Critical patent/JPS52140588A/ja
Publication of JPS6317841B2 publication Critical patent/JPS6317841B2/ja
Granted legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00Polymeric products of isocyanates or isothiocyanates
    • C08G18/06Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40High-molecular-weight compounds
    • C08G18/62Polymers of compounds having carbon-to-carbon double bonds
    • C08G18/6216Polymers of alpha-beta ethylenically unsaturated carboxylic acids or of derivatives thereof
    • C08G18/6266Polymers of amides or imides from alpha-beta ethylenically unsaturated carboxylic acids
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00Polymeric products of isocyanates or isothiocyanates
    • C08G18/06Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/30Low-molecular-weight compounds
    • C08G18/38Low-molecular-weight compounds having heteroatoms other than oxygen
    • C08G18/3893Low-molecular-weight compounds having heteroatoms other than oxygen containing silicon
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00Polymeric products of isocyanates or isothiocyanates
    • C08G18/06Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40High-molecular-weight compounds
    • C08G18/64Macromolecular compounds not provided for by groups C08G18/42 - C08G18/63
    • C08G18/6484Polysaccharides and derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/06Enzymes or microbial cells immobilised on or in an organic carrier attached to the carrier via a bridging agent
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S8/00Bleaching and dyeing; fluid treatment and chemical modification of textiles and fibers
    • Y10S8/11Isocyanate and carbonate modification of fibers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Peptides Or Proteins (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Enzymes And Modification Thereof (AREA)
JP5751277A 1976-05-18 1977-05-18 Vehicle substance capable of covalent combination with biologically active substance* and process for preparing the same Granted JPS52140588A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19762621974 DE2621974A1 (de) 1976-05-18 1976-05-18 Verfahren zur herstellung eines zur kovalenten bindung mit biologisch aktivem material befaehigten traegermaterials

Publications (2)

Publication Number Publication Date
JPS52140588A JPS52140588A (en) 1977-11-24
JPS6317841B2 true JPS6317841B2 (en, 2012) 1988-04-15

Family

ID=5978226

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5751277A Granted JPS52140588A (en) 1976-05-18 1977-05-18 Vehicle substance capable of covalent combination with biologically active substance* and process for preparing the same

Country Status (8)

Country Link
US (1) US4177038A (en, 2012)
JP (1) JPS52140588A (en, 2012)
CH (1) CH641479A5 (en, 2012)
DE (1) DE2621974A1 (en, 2012)
FR (1) FR2351990A1 (en, 2012)
GB (1) GB1569446A (en, 2012)
IL (1) IL52119A (en, 2012)
SE (1) SE7705543L (en, 2012)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1083508A (fr) * 1975-11-13 1980-08-12 Jacques Grange Supports porteurs de chaines laterales, procedes d'obtention de ces supports, procedes de fixation de composes organiques comportant un residu glucidique sur lesdits supports, produits et reactifs resultant de ladite fixation chimique
US4267280A (en) * 1977-02-07 1981-05-12 Mccormick Charles L Controlled release pesticides and method of preparation
DE2834539A1 (de) 1978-08-07 1980-02-21 Basf Ag Makroporoese polymere als traegermaterial zur kovalenten bindung von proteinen
SE450834B (sv) * 1980-11-19 1987-08-03 Biocompat Inc Sett att binda ett protein till en berare innehallande hydroxylgrupper
US4582805A (en) * 1982-05-03 1986-04-15 The Dow Chemical Company Immobilization of biological matter via copolymers of isocyanatoalkyl esters
US4496479A (en) * 1983-05-18 1985-01-29 Syntex (U.S.A.) Company Chloramphenicol derivatives, antigens and antibodies
GB8334499D0 (en) * 1983-12-24 1984-02-01 Beecham Group Plc Derivatives
US4530905A (en) * 1984-10-25 1985-07-23 The Dow Chemical Company Crosslinked gelatin foams
US4478938A (en) * 1984-03-02 1984-10-23 The Dow Chemical Company Process for crosslinking polyamines
US4748121A (en) * 1984-11-30 1988-05-31 Ppg Industries, Inc. Porous glass fibers with immobilized biochemically active material
EP0263184B1 (en) * 1986-03-28 1992-10-28 Toray Industries, Inc. Immobilized physiologically active material
US5144013A (en) * 1986-09-24 1992-09-01 Ube Industries, Ltd. Body fluid purifying material and method for purifying body fluid by use thereof
US4933285A (en) * 1986-10-07 1990-06-12 Environmental Technologies Group, Inc. Multiple monolayers of polymeric linkages on a solid phase for immobilizing macromolecules
US4954444A (en) * 1987-03-02 1990-09-04 E. I. Du Pont De Nemours And Company Enzyme immobilization and bioaffinity separations with perfluorocarbon polymer-based supports
US6251278B1 (en) * 1987-06-08 2001-06-26 Chromatochem, Inc. Process for separating a substance from a mixture
US5240602A (en) * 1987-06-08 1993-08-31 Chromatochem, Inc. Chromatographic material
CA1336077C (en) * 1987-11-10 1995-06-27 Ruben G. Carbonell Chromatography apparatus and method and material for making the same
JP2761881B2 (ja) * 1988-03-10 1998-06-04 チッソ株式会社 抗体を固定化したアフイニテイクロマトグラフイ用担体
US5277813A (en) * 1988-06-17 1994-01-11 S.A.C. Corporation Shielded stationary phases
US4940737A (en) * 1988-11-02 1990-07-10 W. R. Grace & Co.-Conn Chemically modified hydrophilic prepolymers and polymers
US4929706A (en) * 1988-11-02 1990-05-29 W. R. Grace & Co.-Conn. Cell growth enhancers and/or antibody production stimulators comprising chemically modified hydrophilic polyurea-urethane prepolymers and polymers
US5091176A (en) * 1988-11-02 1992-02-25 W. R. Grace & Co.-Conn. Polymer-modified peptide drugs having enhanced biological and pharmacological activities
US5045190A (en) * 1988-11-08 1991-09-03 Carbonell Ruben G Chromatography apparatus
US5149425A (en) * 1988-11-09 1992-09-22 Chembiomed, Ltd. Affinity supports for hemoperfusion
US5240601A (en) * 1988-11-09 1993-08-31 Chembiomed, Ltd. Affinity supports for hemoperfusion
US5043062A (en) * 1989-02-21 1991-08-27 Eastman Kodak Company High performance affinity chromatography column comprising non-porous, nondisperse polymeric packing material
EP0386926A3 (en) * 1989-03-02 1991-12-18 Supelco, Inc. Silica gel supports suitable for chromatographic separations
US5092992A (en) * 1989-06-07 1992-03-03 J. T. Baker Inc. Polyethyleneimine matrixes for affinity chromatography
US5085779A (en) * 1989-06-07 1992-02-04 J. T. Baker, Inc. Polyethyleneimine matrixes for affinity chromatography
US5270193A (en) * 1989-10-27 1993-12-14 E. I. Dupont De Nemours And Company Immobilization of biomolecules on perfluorocarbon surfaces
US5354461A (en) * 1991-02-20 1994-10-11 Eisai Co., Ltd. Packings combining protein to a support via a spacer
CA2061519C (en) * 1991-02-20 2004-05-18 Naoki Asakawa Packings combining protein to a support via a spacer
US5403750A (en) * 1991-03-06 1995-04-04 W. R. Grace & Co.-Conn. Biocompatible, low protein adsorption affinity matrix
US5178756A (en) * 1991-06-25 1993-01-12 Jarrett Iii Harry W Glucose-silica medium for high-pressure gel filtration chromatography
FR2678380B1 (fr) * 1991-06-28 1993-10-08 Sebia Dispositif permettant l'etalement d'un ou plusieurs reactifs sur un gel.
CA2064683A1 (en) * 1992-03-26 1993-09-27 Krishna Mohan Rao Kallury Formation of thermostable enzymes with extra-ordinary heat tolerance by immobilization on phospholipid matrices
US5334640A (en) * 1992-04-08 1994-08-02 Clover Consolidated, Ltd. Ionically covalently crosslinked and crosslinkable biocompatible encapsulation compositions and methods
GB9407886D0 (en) * 1994-04-21 1994-06-15 Ici Plc Purification process
US5662802A (en) * 1994-07-07 1997-09-02 Ionics, Incorporated Solvent extraction process using water absorbing solvent at preselected temperature
US5869127A (en) * 1995-02-22 1999-02-09 Boston Scientific Corporation Method of providing a substrate with a bio-active/biocompatible coating
US6558798B2 (en) 1995-02-22 2003-05-06 Scimed Life Systems, Inc. Hydrophilic coating and substrates coated therewith having enhanced durability and lubricity
CA2214088A1 (en) * 1995-03-03 1996-09-12 Metabolex Inc. Novel encapsulation process by a gelling polymer
US5916790A (en) * 1995-03-03 1999-06-29 Metabolex, Inc. Encapsulation compositions, and methods
US5741462A (en) * 1995-04-25 1998-04-21 Irori Remotely programmable matrices with memories
US5751629A (en) * 1995-04-25 1998-05-12 Irori Remotely programmable matrices with memories
US5874214A (en) * 1995-04-25 1999-02-23 Irori Remotely programmable matrices with memories
US6331273B1 (en) 1995-04-25 2001-12-18 Discovery Partners International Remotely programmable matrices with memories
US6329139B1 (en) 1995-04-25 2001-12-11 Discovery Partners International Automated sorting system for matrices with memory
US6416714B1 (en) 1995-04-25 2002-07-09 Discovery Partners International, Inc. Remotely programmable matrices with memories
US6247995B1 (en) 1996-02-06 2001-06-19 Bruce Bryan Bioluminescent novelty items
US5876995A (en) * 1996-02-06 1999-03-02 Bryan; Bruce Bioluminescent novelty items
US6416960B1 (en) 1996-08-08 2002-07-09 Prolume, Ltd. Detection and visualization of neoplastic tissues and other tissues
CA2271717A1 (en) 1996-12-12 1998-06-18 Prolume, Ltd. Apparatus and method for detecting and identifying infectious agents
US6232107B1 (en) 1998-03-27 2001-05-15 Bruce J. Bryan Luciferases, fluorescent proteins, nucleic acids encoding the luciferases and fluorescent proteins and the use thereof in diagnostics, high throughput screening and novelty items
EP1925320A3 (en) 1998-03-27 2008-09-03 Prolume, Ltd. Luciferases, fluorescent proteins, nucleic acids encoding the luciferases and fluorescent proteins and the use thereof in diagnostics
FR2785200B1 (fr) 1998-10-30 2001-03-30 Centre Nat Rech Scient Utilisation d'un gel adsorbant pour eliminer et purifier les biomolecules
GB9909245D0 (en) 1999-04-22 1999-06-16 Univ Cranfield Reactive polymers and their application in reactions and assays
US7192729B2 (en) 1999-07-06 2007-03-20 General Atomics Methods for assaying homocysteine
SE9904197D0 (sv) * 1999-11-22 1999-11-22 Amersham Pharm Biotech Ab A method for anion exchange adsorption on matrices carrying mixed mode ligands
AU2001227679A1 (en) * 2000-02-25 2001-09-03 General Atomics Mutant nucleic binding enzymes and use thereof in diagnostic, detection and purification methods
WO2001068240A2 (en) * 2000-03-14 2001-09-20 Hammen Corporation Composite matrices with interstitial polymer networks
US7109315B2 (en) 2000-03-15 2006-09-19 Bruce J. Bryan Renilla reniformis fluorescent proteins, nucleic acids encoding the fluorescent proteins and the use thereof in diagnostics, high throughput screening and novelty items
US7102024B1 (en) 2000-08-01 2006-09-05 Schwartz David A Functional biopolymer modification reagents and uses thereof
US6686461B1 (en) 2000-03-22 2004-02-03 Solulink Bioscience, Inc. Triphosphate oligonucleotide modification reagents and uses thereof
US6610504B1 (en) 2000-04-10 2003-08-26 General Atomics Methods of determining SAM-dependent methyltransferase activity using a mutant SAH hydrolase
AU2001275957B2 (en) 2000-07-17 2007-01-11 President And Fellows Of Harvard College Surfaces that resist the adsorption of biological species
GB0027047D0 (en) * 2000-11-06 2000-12-20 Ici Plc Process for reducing the concentration of undesired compounds in a composition
US7201844B1 (en) 2001-03-14 2007-04-10 Hammen Corporation Composite matrices with interstital polymer networks
US6802966B2 (en) * 2001-08-14 2004-10-12 W. R. Grace & Co. Conn. Solid compositions for selective adsorption from complex mixtures
US6987079B2 (en) * 2001-08-14 2006-01-17 W.R. Grace & Co.-Conn. Supported catalyst systems
WO2003062402A2 (en) * 2002-01-24 2003-07-31 Pointilliste, Inc. Use of collections of binding sites for sample profiling and other applications
US20060000772A1 (en) * 2002-11-29 2006-01-05 Toru Sano Separation apparatus and separation method
KR100528959B1 (ko) * 2003-02-11 2005-11-16 학교법인 포항공과대학교 쿠커비투릴이 결합된 실리카 겔
US7384760B2 (en) * 2004-04-30 2008-06-10 General Atomics Methods for assaying inhibitors of S-adenosylhomocysteine (SAH) hydrolase and S-adenosylmethionine (SAM)-dependent methyltransferase
US7402243B2 (en) 2004-09-10 2008-07-22 Dionex Corporation Organosilanes and substrate bonded with same
US7439062B2 (en) * 2004-12-23 2008-10-21 Biocept, Inc. Beads for capturing target cells from bodily fluid
US7468130B2 (en) * 2005-02-15 2008-12-23 Dionex Corporation Organosilanes and substrates covalently bonded with same and methods for synthesis and use same
US7557232B2 (en) * 2007-05-25 2009-07-07 Dionex Corporation Compositions useful as chromatography stationary phases
CN102348974B (zh) * 2009-03-12 2015-06-10 株式会社资生堂 填充剂的制造方法、填充剂及柱体
WO2011146775A1 (en) * 2010-05-19 2011-11-24 Dionex Corporation Functionalized substrates with aromatic stacking properties
DE102016001407A1 (de) 2016-02-09 2017-08-24 Fresenius Medical Care Deutschland Gmbh Blutbehandlung mit Inaktivierung von freien Nukleinsäuren
EP3390671B1 (en) * 2016-02-11 2019-10-09 HTG Molecular Diagnostics, Inc. Method of direct target sequencing using nuclease protection
JP7306985B2 (ja) * 2016-07-22 2023-07-11 ニュートリション・アンド・バイオサイエンシーズ・ユーエスエー・フォー,インコーポレイテッド 多糖含有ポリウレタンポリマー
CN110951273A (zh) * 2019-12-24 2020-04-03 黑龙江幸福人生态农业开发股份有限公司 一种生物质表面改性方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3574062A (en) * 1967-04-20 1971-04-06 Beckman Instruments Inc Method of immobilizing enzymes and product
US3705084A (en) * 1970-03-18 1972-12-05 Monsanto Co Macroporous enzyme reactor
US3672955A (en) * 1970-05-20 1972-06-27 Us Agriculture Preparation of an insoluble active enzyme
CS167530B1 (en) * 1972-03-29 1976-04-29 Jiri Coupek Method of insoluble biologically active compounds preparation
US3929574A (en) * 1972-05-03 1975-12-30 Grace W R & Co Use of enzymes bound to polyurethane
JPS4928031A (en, 2012) * 1972-07-18 1974-03-13
JPS5118518B2 (en, 2012) * 1973-03-07 1976-06-10
JPS5117197B2 (en, 2012) * 1973-10-23 1976-05-31
US3905923A (en) * 1974-04-04 1975-09-16 Minnesota Mining & Mfg Poly (urea-urethane) foams containing immobilized active enzymes
US3947352A (en) * 1974-05-31 1976-03-30 Pedro Cuatrecasas Polysaccharide matrices for use as adsorbents in affinity chromatography techniques
US4063017A (en) * 1976-04-22 1977-12-13 Purdue Research Foundation Porous cellulose beads and the immobilization of enzymes therewith
SE434848B (sv) * 1976-04-22 1984-08-20 Purdue Research Foundation Forfaringssett for framstellning av porosa cellulosaperlor

Also Published As

Publication number Publication date
JPS52140588A (en) 1977-11-24
GB1569446A (en) 1980-06-18
IL52119A (en) 1980-12-31
FR2351990B1 (en, 2012) 1983-06-24
FR2351990A1 (fr) 1977-12-16
SE7705543L (sv) 1977-11-19
IL52119A0 (en) 1977-07-31
US4177038A (en) 1979-12-04
DE2621974A1 (de) 1977-11-24
CH641479A5 (de) 1984-02-29

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