JPS627916B2 - - Google Patents
Info
- Publication number
- JPS627916B2 JPS627916B2 JP54107814A JP10781479A JPS627916B2 JP S627916 B2 JPS627916 B2 JP S627916B2 JP 54107814 A JP54107814 A JP 54107814A JP 10781479 A JP10781479 A JP 10781479A JP S627916 B2 JPS627916 B2 JP S627916B2
- Authority
- JP
- Japan
- Prior art keywords
- absorption
- around
- reaction
- anticancer substance
- sulfuric acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000126 substance Substances 0.000 claims description 34
- 230000001093 anti-cancer Effects 0.000 claims description 30
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 27
- 239000000243 solution Substances 0.000 claims description 22
- 238000010521 absorption reaction Methods 0.000 claims description 21
- 238000006243 chemical reaction Methods 0.000 claims description 18
- 239000006228 supernatant Substances 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 12
- 241000605909 Fusobacterium Species 0.000 claims description 12
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 12
- 241000894006 Bacteria Species 0.000 claims description 11
- 239000007864 aqueous solution Substances 0.000 claims description 11
- 238000012258 culturing Methods 0.000 claims description 10
- 238000004519 manufacturing process Methods 0.000 claims description 10
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims description 9
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 9
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 9
- 239000000843 powder Substances 0.000 claims description 9
- 241000699670 Mus sp. Species 0.000 claims description 8
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- 238000000862 absorption spectrum Methods 0.000 claims description 8
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- 241000605986 Fusobacterium nucleatum Species 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 7
- MYKOKMFESWKQRX-UHFFFAOYSA-N 10h-anthracen-9-one;sulfuric acid Chemical compound OS(O)(=O)=O.C1=CC=C2C(=O)C3=CC=CC=C3CC2=C1 MYKOKMFESWKQRX-UHFFFAOYSA-N 0.000 claims description 6
- 201000009030 Carcinoma Diseases 0.000 claims description 6
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 6
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 6
- 239000003480 eluent Substances 0.000 claims description 6
- OQUKIQWCVTZJAF-UHFFFAOYSA-N phenol;sulfuric acid Chemical compound OS(O)(=O)=O.OC1=CC=CC=C1 OQUKIQWCVTZJAF-UHFFFAOYSA-N 0.000 claims description 6
- 239000011800 void material Substances 0.000 claims description 6
- 206010003445 Ascites Diseases 0.000 claims description 5
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- 230000003308 immunostimulating effect Effects 0.000 claims description 4
- 108091003079 Bovine Serum Albumin Proteins 0.000 claims description 3
- 239000002246 antineoplastic agent Substances 0.000 claims description 3
- 229940098773 bovine serum albumin Drugs 0.000 claims description 3
- 239000012153 distilled water Substances 0.000 claims description 3
- 238000000921 elemental analysis Methods 0.000 claims description 3
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- 229910052739 hydrogen Inorganic materials 0.000 claims description 3
- RJTZUHVCZIGJMB-UHFFFAOYSA-N hydron;1h-indole;chloride Chemical compound Cl.C1=CC=C2NC=CC2=C1 RJTZUHVCZIGJMB-UHFFFAOYSA-N 0.000 claims description 3
- 238000002844 melting Methods 0.000 claims description 3
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- FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 claims description 3
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- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 4
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- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 description 4
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- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
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- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 description 2
- LEVWYRKDKASIDU-IMJSIDKUSA-N L-cystine Chemical compound [O-]C(=O)[C@@H]([NH3+])CSSC[C@H]([NH3+])C([O-])=O LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 description 2
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- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
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- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
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- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 1
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 1
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- 239000012588 trypsin Substances 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
Priority Applications (20)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10781479A JPS5630995A (en) | 1979-08-24 | 1979-08-24 | Carcinostatic substance tf-100, its preparation, and carcinostatic comprizing it |
| DE19803031152 DE3031152A1 (de) | 1979-08-24 | 1980-08-18 | Carcinostatische substanzen, verfahren zur herstellung derselben und mittel mit einem gehalt derselben |
| GB8027026A GB2059969B (en) | 1979-08-24 | 1980-08-19 | Fusobacterium culture extracts |
| ZA00805111A ZA805111B (en) | 1979-08-24 | 1980-08-20 | Substances having carcinostatic and immuno-stimulating activity, process for preparing the same and carcinostatic agent containing the same |
| CA000358667A CA1174618A (en) | 1979-08-24 | 1980-08-20 | Substances having carcinostatic and immunostimulating activity, process for preparing the same and carcinostatic agent containing the same |
| CH6297/80A CH648042A5 (de) | 1979-08-24 | 1980-08-21 | Carcinostatische substanzen, verfahren zur herstellung derselben und mittel mit einem gehalt derselben. |
| BE0/201815A BE884864A (fr) | 1979-08-24 | 1980-08-21 | Nouvelles substances produites par des bacteries du genre fusobacterium, leur procede de preparation et leur application en therapeutique |
| US06/180,040 US4744985A (en) | 1979-08-24 | 1980-08-21 | Novel substances having carcinostatic and immunostimulating activity, process for preparing the same and carcinostatic agent containing the same |
| AT0426480A AT375674B (de) | 1979-08-24 | 1980-08-21 | Verfahren zur herstellung neuer carcinostatischer substanzen |
| AU61646/80A AU529076B2 (en) | 1979-08-24 | 1980-08-21 | Carcinostatic agents |
| FI802641A FI68080C (fi) | 1979-08-24 | 1980-08-21 | Foerfarande foer framstaellning av karcinostatiska och immunostimulerande substansen |
| IT49541/80A IT1181595B (it) | 1979-08-24 | 1980-08-22 | Sostanze carcinostatiche ed immuno stimolanti procedimento per prepararle ed agente carcinostatico che le contiene |
| DD22346380A DD153999A5 (de) | 1979-08-24 | 1980-08-22 | Verfahren zur herstellung von substanzen mit carcinostatischer und immunstimulierender wirkung |
| PT71730A PT71730A (en) | 1979-08-24 | 1980-08-22 | Process for preparing novel substances having carcinostatic immunostimulating activity and a carcinostatic agent containing the same |
| NZ194744A NZ194744A (en) | 1979-08-24 | 1980-08-22 | Preparation of carcinostatic and immunostimulating tf-substances from fusobacterium |
| NO802499A NO155697C (no) | 1979-08-24 | 1980-08-22 | Fremgangsmaate for fremstilling av fysiologisk aktive forbindelser ved fermentering. |
| NL8004759A NL8004759A (nl) | 1979-08-24 | 1980-08-22 | Nieuwe stoffen met carcinostatische en immuno- stimulerende werking, werkwijze voor de bereiding daarvan en carcinostatische preparaten die deze stoffen bevatten. |
| SE8005921A SE446406B (sv) | 1979-08-24 | 1980-08-22 | Nya foreningar med karcinostatisk och immunostimulerande verkan framstellda genom odling av fusobacterium nucleatum tf-031(ferm 5077, atcc 31647), forfarande for framstellning av desamma och karcinostatiskt medel inneha |
| FR8018396A FR2463619A1 (fr) | 1979-08-24 | 1980-08-22 | Nouvelles substances produites par des bacteries du genre fusobacterium, leur procede de preparation et leur application en therapeutique |
| DK361680A DK151639C (da) | 1979-08-24 | 1980-08-22 | Fremgangsmaade til fremstilling af tf-100 eller fraktioner heraf med carcinostatisk og immunostimulerende aktivitet |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10781479A JPS5630995A (en) | 1979-08-24 | 1979-08-24 | Carcinostatic substance tf-100, its preparation, and carcinostatic comprizing it |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5630995A JPS5630995A (en) | 1981-03-28 |
| JPS627916B2 true JPS627916B2 (it) | 1987-02-19 |
Family
ID=14468704
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10781479A Granted JPS5630995A (en) | 1979-08-24 | 1979-08-24 | Carcinostatic substance tf-100, its preparation, and carcinostatic comprizing it |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JPS5630995A (it) |
| ZA (1) | ZA805111B (it) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0516976Y2 (it) * | 1988-02-15 | 1993-05-07 |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0645917Y2 (ja) * | 1986-01-20 | 1994-11-24 | シャープ株式会社 | カード式予約タイマー装置 |
| JP2556399B2 (ja) * | 1991-04-11 | 1996-11-20 | デイエツクスアンテナ株式会社 | 遠隔制御増幅器及びその制御装置 |
| JP2556400B2 (ja) * | 1991-04-11 | 1996-11-20 | デイエツクスアンテナ株式会社 | 遠隔制御増幅器及びその制御装置 |
-
1979
- 1979-08-24 JP JP10781479A patent/JPS5630995A/ja active Granted
-
1980
- 1980-08-20 ZA ZA00805111A patent/ZA805111B/xx unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0516976Y2 (it) * | 1988-02-15 | 1993-05-07 |
Also Published As
| Publication number | Publication date |
|---|---|
| ZA805111B (en) | 1981-08-26 |
| JPS5630995A (en) | 1981-03-28 |
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