JPS62289181A - 新規化合物、その製法およびそれを含む医薬組成物 - Google Patents
新規化合物、その製法およびそれを含む医薬組成物Info
- Publication number
- JPS62289181A JPS62289181A JP62080870A JP8087087A JPS62289181A JP S62289181 A JPS62289181 A JP S62289181A JP 62080870 A JP62080870 A JP 62080870A JP 8087087 A JP8087087 A JP 8087087A JP S62289181 A JPS62289181 A JP S62289181A
- Authority
- JP
- Japan
- Prior art keywords
- plasminogen activator
- modified
- dna
- sequence
- residues
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- GVUGOAYIVIDWIO-UFWWTJHBSA-N nepidermin Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CS)NC(=O)[C@H](C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C(C)C)C(C)C)C1=CC=C(O)C=C1 GVUGOAYIVIDWIO-UFWWTJHBSA-N 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- OJMIONKXNSYLSR-UHFFFAOYSA-N phosphorous acid Chemical compound OP(O)O OJMIONKXNSYLSR-UHFFFAOYSA-N 0.000 description 1
- 229940012957 plasmin Drugs 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 235000011056 potassium acetate Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 235000004252 protein component Nutrition 0.000 description 1
- 230000006337 proteolytic cleavage Effects 0.000 description 1
- 238000010188 recombinant method Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000008227 sterile water for injection Substances 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- NMGNJWORLGLLHQ-UHFFFAOYSA-M sulcofuron-sodium Chemical compound [Na+].[O-]S(=O)(=O)C1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1NC(=O)NC1=CC=C(Cl)C(Cl)=C1 NMGNJWORLGLLHQ-UHFFFAOYSA-M 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001732 thrombotic effect Effects 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000759 toxicological effect Toxicity 0.000 description 1
- 230000010474 transient expression Effects 0.000 description 1
- 239000001226 triphosphate Substances 0.000 description 1
- 235000011178 triphosphate Nutrition 0.000 description 1
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 description 1
- 241001515965 unidentified phage Species 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 125000002987 valine group Chemical group [H]N([H])C([H])(C(*)=O)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB868608020A GB8608020D0 (en) | 1986-04-02 | 1986-04-02 | Compounds |
| GB8608020 | 1986-04-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS62289181A true JPS62289181A (ja) | 1987-12-16 |
Family
ID=10595544
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62080870A Pending JPS62289181A (ja) | 1986-04-02 | 1987-04-01 | 新規化合物、その製法およびそれを含む医薬組成物 |
Country Status (11)
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02215384A (ja) * | 1988-10-24 | 1990-08-28 | Boehringer Mannheim Gmbh | 組織プラスミノーゲンアクチベーターミユーテイン、その製造方法および該ミユーテインを含有する凝血塊溶解剤 |
| JP2016127839A (ja) * | 1999-09-28 | 2016-07-14 | バクスアルタ・イノベイションズ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｘａｌｔａ Ｉｎｎｏｖａｔｉｏｎｓ ＧｍｂＨ | 細胞の無タンパク質かつ無血清の培養のための培地 |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1295088A (en) * | 1987-01-30 | 1988-08-24 | American Home Products Corporation | Des-epidermal growth factor plasminogen activators |
| NO882226L (no) * | 1987-05-22 | 1988-11-23 | Zymogenetics Inc | Fibrinolytiske proteiner. |
| SE8702562L (sv) * | 1987-06-18 | 1988-12-19 | Kabigen Ab | Nya fibrinolytiska enzymer |
| EP0340573A3 (de) * | 1988-04-30 | 1990-05-30 | BASF Aktiengesellschaft | Neue Proteine, ihre Herstellung und Verwendung |
| DE4123845A1 (de) * | 1991-07-18 | 1993-01-21 | Boehringer Mannheim Gmbh | Pharmazeutische verpackungseinheit enthaltend plasminogenaktivatoren zur mehrfachbolusgabe |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL68561A (en) * | 1982-05-05 | 1991-01-31 | Genentech Inc | Preparation of polypeptide with human tissue plasminogen activator function,processes for making it,and dna and transformed cell intermediates thereof |
| US4753879A (en) * | 1984-08-27 | 1988-06-28 | Biogen N.V. | Modified tissue plasminogen activators |
| AU7090787A (en) * | 1986-02-19 | 1987-10-08 | Beecham Group Plc | Tissue plasminogen activator |
| PT84588B (en) * | 1986-04-02 | 1989-05-09 | Beecham Group Plc | Process for preparing a fibrinolytic enzyme |
| NZ219829A (en) * | 1986-04-02 | 1990-05-28 | Beecham Group Plc | Tissue-type plasminogen activator modified in the region of amino acids 67-69 and pharmaceutical compositions thereof |
-
1986
- 1986-04-02 GB GB868608020A patent/GB8608020D0/en active Pending
-
1987
- 1987-03-31 PT PT84590A patent/PT84590B/pt not_active IP Right Cessation
- 1987-03-31 AU AU70905/87A patent/AU602681B2/en not_active Ceased
- 1987-03-31 NZ NZ219828A patent/NZ219828A/xx unknown
- 1987-03-31 ZA ZA872334A patent/ZA872334B/xx unknown
- 1987-04-01 JP JP62080870A patent/JPS62289181A/ja active Pending
- 1987-04-01 DE DE8787302837T patent/DE3780199T2/de not_active Expired - Fee Related
- 1987-04-01 EP EP87302837A patent/EP0241210B1/en not_active Expired - Lifetime
- 1987-04-01 DK DK165887A patent/DK165887A/da not_active IP Right Cessation
- 1987-04-01 ES ES87302837T patent/ES2042553T3/es not_active Expired - Lifetime
-
1992
- 1992-08-31 GR GR920401907T patent/GR3005571T3/el unknown
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02215384A (ja) * | 1988-10-24 | 1990-08-28 | Boehringer Mannheim Gmbh | 組織プラスミノーゲンアクチベーターミユーテイン、その製造方法および該ミユーテインを含有する凝血塊溶解剤 |
| JP2016127839A (ja) * | 1999-09-28 | 2016-07-14 | バクスアルタ・イノベイションズ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｘａｌｔａ Ｉｎｎｏｖａｔｉｏｎｓ ＧｍｂＨ | 細胞の無タンパク質かつ無血清の培養のための培地 |
| JP2017212977A (ja) * | 1999-09-28 | 2017-12-07 | バクスアルタ・イノベイションズ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｘａｌｔａ Ｉｎｎｏｖａｔｉｏｎｓ ＧｍｂＨ | 細胞の無タンパク質かつ無血清の培養のための培地 |
Also Published As
| Publication number | Publication date |
|---|---|
| NZ219828A (en) | 1990-08-28 |
| DE3780199D1 (de) | 1992-08-13 |
| EP0241210A1 (en) | 1987-10-14 |
| GB8608020D0 (en) | 1986-05-08 |
| DK165887A (da) | 1987-10-02 |
| GR3005571T3 (US07579456-20090825-P00002.png) | 1993-06-07 |
| DK165887D0 (da) | 1987-04-01 |
| EP0241210B1 (en) | 1992-07-08 |
| DE3780199T2 (de) | 1993-01-21 |
| AU7090587A (en) | 1987-10-08 |
| ES2042553T3 (es) | 1993-12-16 |
| PT84590B (pt) | 1989-11-30 |
| AU602681B2 (en) | 1990-10-25 |
| ZA872334B (en) | 1987-12-30 |
| PT84590A (en) | 1987-04-01 |
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