JPS62205008A - Additive for cosmetic or the like - Google Patents

Abstract

PURPOSE:An additive for cosmetics, hairdressings, soaps, ointments, etc., containing glucan having beta-1,3-1,6 bond form and utilizing improved film-forming, humectant, nonblocking, anti-inflammatory properties, etc., thereof. CONSTITUTION:An additive, containing glucan of beta-1,3-1,6 bond form and useful for cosmetics, hairdressings, soaps, ointments, etc. The beta-1,3-1,6 glucan has the molecular structure expressed by the formula (G is glucose) and the nonreducing terminal (38-43%) branched through the beta-1,6 bond and is produced by liquid cultivation of a microorganism Aureobacidium sp. The beta-1,3-1,6 glucan has improved film-forming, humectant, nonblocking, dispersing, nonadhesive, anti-inflammatory and nontoxic properties and is capable of imparting comfortable feeling of use with good extensibility to the cosmetics, etc., and holding the flexibility of the skin.

Description

DETAILED DESCRIPTION OF THE INVENTION [11c Field of Industrial Application] The present invention relates to additives for cosmetics and the like. More specifically, the excellent film-forming properties of β-1,3-1,8 glucan obtained by culturing microorganisms (genus Aureobacidium);
Moisturizing, non-adhesive, dispersible, non-adhesive, anti-inflammatory and non-stick
The present invention relates to additives for cosmetics, hair styling products, bath soaps, shampoos, ointments, etc. that utilize the properties of 1j.

[Conventional technology] For cosmetics, etc., in order to increase the added value of the product, it is necessary to
It is necessary to have excellent b-forming properties and moisture retention properties. Conventionally, starch or similar materials, as well as pullulan, hyaluronic acid, etc., have been added to impart skin-forming properties and moisturizing properties.

[Problems to be Solved by the Invention] However, cosmetics containing these ingredients may not be suitable for some people's skin, and may cause itching or rash.

[Unable to solve the problem - "dead" The name of the present invention, etc. is disclosed in Japanese Patent Application Laid-Open No. 80-27395 and
In No. 0-414!37, Aureobacidium sp. FERN-P
, No. 457, ATCC, No. 20524, IF
O, No, 7757C
scorbic acid), β-
Contains 1,3-1,8 glucan and fructooligosaccharide (r is l-quesdose, nystose), β-1,3
It has been proposed that a viscous jBa liquid unique to -1,8 glucan can be produced.

The present inventors have found that when this β-1,3-1,8 glucan is made into an aqueous solution (e.g. 0.1 to 0.2% aqueous solution) and applied to the skin or hair as it is, it can be used as a conventional cosmetic, hair conditioner, softener, etc. ;(
: Compared with additives, it has been found that it has superior film-forming properties and moisturizing properties on the skin and hair surface, prevents dryness, maintains suppleness, and is comfortable to use.

Fourth, the present invention was completed based on the discovery that it is highly safe, with no acute toxicity or subacute toxicity, and no local irritation, no harmful effects, and no cumulative irritation.

That is, the present invention is an additive for cosmetics and the like containing a β-1, 3-1, [1 glucan in a binding mode.

The main constituent sugar of β-1,3-1,8 glucan is glucose, the bonding mode is β-linkage, and the chain is β-1,3
At the bond, the non-reducing end is branched by a β-1,8 bond.

Its non-reducing end is 38-43%, and 4% phosphoric acid is added.
It is a high molecular weight polysaccharide containing 0 to B, 0%.

Its molecular structure is as follows.

The phosphorus S group has an ester bond with the non-reducing terminal glucose bonded with β-1,B. Also, its main chain is a triple helix Mha
One molecule of darkness (several f average) is 100,000 to 5
00,000 (IP average 370.0 GO), and the intrinsic viscosity of the aqueous solution is [η] = 1.0 to 3.5 (2
The main physicochemical characteristics of wood polysaccharide are β-1
, 6-linked non-reducing terminal glucose, and is the non-reducing terminal of ordinary polymeric polysaccharides (plants or microorganisms).
(is 1.0% or less.

As mentioned above, the polysaccharide has completely unique physical properties defined by its chemical structure. Specifically, they are film-forming, moisturizing, non-adhesive, dispersible, non-adhesive, anti-inflammatory, and non-toxic.

This β-1,3-1,fl glucan is dissolved in an aqueous solution, for example, 0
．． When made into a 1 to 0.2% aqueous solution and applied directly to the skin or hair, it has superior film-forming and moisturizing properties on the skin and hair surface compared to conventional cosmetics, hair styling products, and ointment additives, and helps prevent dryness. Not only does it maintain its suppleness and is comfortable to use, but it is also highly safe, with no acute or subacute toxicity, and no local irritation, no damaging effects, and no cumulative irritation.

In this way, when β-1,3-1,13 glucan is used as an additive in cosmetics, etc., it can be applied to any cosmetic product by taking advantage of its physicochemical properties.
Among these, it is suitable for use as a component of lotions, hair styling products, and softening/gloss additives.

In other words, its viscosity (in addition to its thickening properties as water's mucilaginous substance), its non-contact properties, make it comfortable to use, and make makeup spread easily, and its moisturizing properties prevent dryness and make it supple. It is possible to take advantage of the property of holding . Non-adhesive properties, film-forming properties, and moisturizing properties can be used as hair styling products. Furthermore, anti-inflammatory properties and film-forming properties can be used as the soft 1'f additive.

In the uninvented state, β can be used as cosmetics, hair styling products, and pasture additives.
When using -1,3-1,8 glucan,

There are no restrictions on the use of at in combination with other polymeric substances used during product sorting.

Furthermore, there are no restrictions on the use in combination with other low-molecular compounds, inorganic compounds, fragrances, preservatives, etc., and on the combination with various substances.

β-1,3-1,8 glucan is produced by microorganisms using blood sugar as a carbon source, specifically Aureobacidium sp.
It is also possible to liquid culture and then sterilize the culture solution, centrifuging the culture solution, further separating the polysaccharide with an organic solvent, and using it as a purified water solution, or the centrifuged solution can be used as it is. Further, the purification purity can be determined depending on the method used.

[Effect of the invention] When the additive according to the present invention is added to cosmetics, etc., the thickening property can be improved.
;1 Not only that, but the non-adhesive and non-adhesive properties make it comfortable to use. In addition, makeup lingers well, and cJA moisture prevents dryness and maintains suppleness.

In addition, non-adhesive properties, film-forming properties, and moisturizing properties can be used as hair styling products.

Furthermore, the soft-Fl additive has anti-inflammatory 5 film-forming properties.

[Examples] Hereinafter, the present invention will be explained in more detail with reference to Examples. In addition, the mixing ratio is the co-weight percentage of each example.

Example 1 A lotion was obtained using β-1,3-1,8 glucan as an additive at the following mixing ratio.

The lotion according to this example is produced by combining the above ingredients in a normal state.

Although the lotion obtained in this example was viscous, it was not sticky and had a comfortable feel when used. In addition, it has a good relationship, is resistant to drying out, and is supple.

Example 2 A hair cream was obtained using β-1,3-1,8 glucan as an additive at the mixing ratio shown below.

Manufactured by mixing the above ingredients.

Although the hair cream obtained in this example had viscosity, it did not leave a sticky residue and was comfortable to use. It also has a good relationship and is hard to dry out, making it supple.

Example 3 A hair prosthesis was obtained using β-1, 3-1, and Ei glucan as additives at the following mixing ratio.

Manufactured by mixing the ingredients.

The hair blow obtained in this example has a viscosity of 1.
It was comfortable to use and didn't stick. It also has a good texture and is resistant to dryness and is supple.

Example 4 β-1,3-1,fl glucan was used as VfS and as a Mn agent, moisture milk was prepared at the mixing ratio shown below.

The moisture milk according to this example is usually 1 ml,
Manufactured by mixing the components h.

The moisture milk obtained in this example was not viscous or sticky and had a comfortable feel when used.

We also got along well and didn't want to dry out.

Example 5 An emollient cream was obtained using β-1,3-1,8 glucan as an additive at the following mixing ratio.

! E: Manufactured by mixing the components listed in 4.

The emollient cream obtained on the Moku-C flow side was viscous and did not leave a sticky impression and was comfortable to use.

We also got along well and had a hard time hanging out.

Example 6 A nourishing cream was obtained using β-1,3-1,6 glucan as an additive at the following mixing ratio.

The nourishing cream obtained in this example, which was manufactured by mixing the ingredients described above, had viscosity but was not sticky and had a comfortable feel when used. We also got along well and didn't get along easily.

Example 7 Cree-1 and masks were obtained using β-1,3-1,8 glucan as an additive at the mixing ratio shown below.

The cream mask according to the general practice side was produced by mixing the above ingredients in the normal state.The cream mask obtained in this example had viscosity but was not sticky and had a comfortable feel when used. They also got along well and didn't get dry easily.

Example 8 Softness was obtained using β-1,3-1,8 glucan as an additive at the mixing ratio shown below.

Manufactured together.

That is, after heating the ■ component to 80℃, (the ψ component to 82℃,
While stirring the IS) ingredients, add the oven ingredients to the (ii) ingredients and stir to emulsify. When the addition is complete, continue stirring and cooling until the temperature reaches 42°C, but if you are adding Kone 4, add it at about 55°C.

The ointment obtained in this example had anti-inflammatory and film-forming properties.

Example 9 Bath soap was obtained using β-1,3-1,8 glucan as an additive at the following mixing ratio.

It is manufactured by mixing the components listed below in the following manufacturing method according to this example.

In other words, when manufacturing this bath soap, we adjusted the concentration in advance so that it would be easy to mix in when the ingredients of the soap dough (in the dissolved state).
The component β-1,3-1, El glucan is 0 for soap.
．． Add 01 to 2% and stir thoroughly to obtain bath soap.

The bath soap obtained in this example was non-sticky and had a comfortable feel when used. Shin was also good.

Example 10 A shampoo was obtained using β-1,3-1,8 glucan as an additive at the mixing ratio described above.

Manufactured together.

That is, in manufacturing this shampoo, β-1,3-1,13 glucan is added to purified water in advance, and then preservatives and
Add coloring matter and fragrance and stir thoroughly to prepare β-1,3-1,8
A glucan mixture (6) component was obtained, and this (b) component (
Add to a mixture of one component to obtain a shampoo.

Although the shampoo obtained in this example has viscosity, 1.
It was comfortable to use and didn't stick. They also got along well and gave my hair suppleness.

Reference Example 1 A combination of β-1,3-1,8 glue obtained in Example 1! Skin irritation controls and IT values of 1L water and emollient cream were performed.

Method: Subjects: 22 healthy subjects (20 to 40 years old) A patch test plaster (pJ Iyaku KK9a, small size) was applied closed for 24 hours, and judgment was made visually 1 hour after the sample was removed.

Judgment criteria: -: Negative +: 1j1 Definite erythema ±: Slight erythema Judgment result: % Skin irritation is alleviated.

Reference Example 2 An experiment was conducted to examine the usefulness of a lotion containing β-1,3-1,8-glucone. Method: Subjects: 22 women (20-40 years old) complaining of dry skin and rough skin Twice daily (+JI evening) 30-day usage test Judgment =
After one month of use, the degree of improvement in skin compared to before use will be evaluated by interview regarding the following items.

・F'+ Effect on skin roughness 1 Effect on skin elasticity ・3) Effect on skin smoothness 4) Effect on skin fineness 5) Effect on fine wrinkles ・Effect on 61 age spots and freckles ・E〉Make-up Effects As shown below, the lotion containing β-1,3-1,8 glucone does not cause any skin disorders. We were able to recognize the effect of the combination on all items 11 of the 1 interview in w4 authors.

judgment result

Claims (1)

[Claims] 1. An additive for cosmetics, etc., containing a β-1,3-1,6 glucan in a binding mode. 2. β-1,3-1,6 glucan is β produced by microorganisms.
The additive according to claim 1, which contains -1,3-1,6 glucan.