JP2009235010A - Skincare preparation for external use - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a skincare preparation for external use, which comprises β-1,3-1,6-glucan, is free from aggregation, is excellent in the stability after the elapse of time, and is excellent in springy feeling and moisturizing effect. <P>SOLUTION: The skincare preparation for external use is characterized in that it has been prepared by subjecting a composition comprising (A) β-1,3-1,6-glucan, (B) phospholipid(s) and (C) water to a high pressure treatment. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to an external preparation for skin obtained by high-pressure treatment of a composition containing β-1,3-1,6-glucan, phospholipid, and water, and more specifically, not only a moisturizing effect on the skin. Further, the present invention relates to a skin external preparation having an excellent elasticity effect and excellent stability over time. Moreover, it is related with the skin external preparation which can obtain a moisturizing effect and a firm feeling effect more effectively by impregnating a nonwoven fabric.

  Human skin loses its elasticity as it ages, and wrinkles and sagging appear. A large number of external preparations for skin, such as cosmetics, have been put on the market for people who have developed such symptoms to supplement the skin with moisture, give it a gloss, and raise the sagging of the skin. As a technique for realizing a sense of elasticity, a technique for blending highly polymerized silicone oil (for example, see Patent Document 1), a technique for blending a film-forming water-soluble polymer (for example, see Patent Document 2), a specific technique There are techniques for blending drugs (for example, see Patent Document 3) and the like.

  β-1,3-1,6-glucan has characteristics such as excellent film-forming properties and excellent moisturizing effect (for example, see Patent Document 4). There is also a technique (for example, see Patent Document 5) related to a sheet-like pack containing β-1,3-1,6-glucan.

On the other hand, phospholipids are not only used as emulsifiers, but also have physiological activity and pharmacological action. Therefore, phospholipids are widely used for pharmaceuticals, health foods, food additives, cosmetics and the like. In particular, they are used as dispersants, emulsifiers, humectants, and antioxidants. There is a technology as a dispersant for dispersed cosmetics.

  In addition, there is a technique of using a high-pressure processing device for manufacturing cosmetics, external preparations for skin, and the like. For example, there exists a technique used for manufacture of a liposome (for example, refer patent document 6).

JP 2005008540 A JP 2000-239139 A JP 2004-168785 A JP-A-62-205008 Japanese Patent Laid-Open No. 10-95708 JP 2007-291035 A

  However, with the techniques of Patent Document 1 and Patent Document 2, although a firm feeling effect can be obtained with a highly polymerized silicone oil or a film-based preparation, there are cases where the moisturizing effect on the skin is not sufficient. With the technique of Patent Document 3, although a moisturizing effect can be obtained, it may be difficult to obtain a sufficient tension depending on the amount to be blended. On the other hand, the technique of Patent Document 4 is a technique that uses β-1,3-1,6-glucan as an additive in cosmetics, but it aggregates depending on the blended concentration, and β-1,3- In some cases, the effect of 1,6-glucan could not be obtained. The technique of Patent Document 5 is a technique for fixing β-1,3-1,6-glucan to the sheet surface. However, depending on the problem in production cost and the cosmetic to be impregnated, β-1,3-1, There was a case where 6-glucan aggregation was a concern.

  It is an object of the present invention to develop a technique for stably dispersing and blending β-1,3-1,6-glucan, and to develop a skin external preparation excellent in imparting a moisturizing effect and a firm feeling.

  In view of such a situation, the present inventors have conducted intensive research. As a result, a skin external preparation obtained by subjecting a composition containing β-1,3-1,6-glucan, phospholipid, and water to a high pressure has been applied to the skin. Not only the moisturizing effect but also the skin feeling effect, it is found that it is an external preparation for skin with excellent stability over time, and further impregnated into a nonwoven fabric to further improve the moisturizing effect and the skin feeling effect The headline and the present invention were completed.

That is, the present invention
(A) It is related with the skin external preparation characterized by carrying out the high-pressure process of the composition containing (beta) -1,3-1,6-glucan (B) phospholipid (C) water.

Furthermore, it is related with the skin external preparation characterized by using it by impregnating a nonwoven fabric.

The external preparation for skin of the present invention has not only a moisturizing effect on the skin, but also has a firm feeling effect, and is further excellent in stability over time. It has excellent quality in terms of effect and elasticity.

The present invention will be described in detail below.
The component (A) β-1,3-1,6-glucan used in the present invention refers to a polysaccharide composed of glucose in which glucose is bound in a β-type structure, and glucose is β- It has a structure in which glucose is branched by a β-1,6 bond from a 1,3-bonded main chain. In the present invention, it is contained for the purpose of not only a moisturizing effect but also a firm feeling effect. Although it does not specifically limit in what is used also as a hair skin external preparation, (beta) -1, 3- glucan obtained from Sclerothium olfsii is preferable. Commercially available products include Tinocare GL (Ciba Specialty Chemicals) and SymGlucane (Symrise).

  The content of the component (A) used in the present invention is not particularly limited, but is preferably 0.001 to 0.5% by mass (hereinafter simply referred to as “%”), more preferably 0.004 to 0.1%. If it is this range, it can be set as the skin external preparation excellent also in the moisturizing effect and the elasticity effect.

  The phospholipid of the component (B) used in the present invention is contained for the purpose of dispersing the moisturizing effect and the β-1,3-1,6-glucan of the component (A). Soy lecithin, egg yolk lecithin and / or hydrogenated lecithin hydrogenated from these, hydrogenated soybean lecithin, hydrogenated egg yolk lecithin, synthetic phospholipids, and the like can be used. As the type of phospholipid, for example, phosphatidylcholine, phosphatidylethanolol amine, phosphatidylserine, phosphatidic acid, phosphatidylinositol and the like are preferably used. Examples of the fatty acid constituting the phospholipid include saturated and unsaturated carboxylic acids having 7 to 22 carbon atoms. Examples of commercially available products include Resinol S-10EZ (Nikko Chemicals Co., Ltd.), HSL-70 (YMC Corporation), Basis LS-60HR (Nisshin Oilio Group Co., Ltd.), and the like.

  Although content of the component (B) used for this invention is not specifically limited, Preferably it is 0.1 to 10%, More preferably, it is 0.2 to 5%. If it is this range, it can be set as the skin external preparation excellent also in the moisturizing effect and the elasticity effect.

  The water of component (C) of the present invention is used as a dispersion medium for component (A) and component (B), and is not particularly limited as long as it is used for a skin external preparation. For example, purified water, hot spring Water, deep water, steam distilled water such as plants, and the like can be mentioned. Purified water such as ion-exchanged water or distilled water is particularly preferable because there are few impurities such as metal ions.

  Although content of the component (C) of this invention is suitably determined by content of a component (A) and a component (B), it is 50 to 99% in general.

  In this invention, it can be set as a desired skin external preparation by carrying out the high pressure process of the composition containing (beta) -1,3-1,6 glucan, phospholipid, and water. The high-pressure treatment method is generally a method of dispersing and pulverizing by using a high shearing force and impact force. In the present invention, the dispersion stability of β-1,3-1,6 glucan can be enhanced by high pressure treatment. When high pressure treatment is not performed, β-1,3-1,6 glucan aggregates over time and becomes a viscous gel state as an external preparation for skin, so that high pressure treatment is an essential condition. Although the pressure at the time of such treatment is not particularly limited, it is preferable to perform the treatment by applying a pressure of 30 MPa or more, and by further increasing the pressure to 70 MPa or more, the dispersion stability can be improved more effectively. . In the present invention, by including a phospholipid as a dispersing agent, not only can β-1,3-1,6 glucan be uniformly dispersed, but also there is no reaggregation and excellent stability over time. It becomes possible to make a composition. Specific examples of such high-pressure processing equipment include a microfluidizer (manufactured by Mizuho Kogyo Co., Ltd.), an optimizer (manufactured by Sugino Machine Co., Ltd.) and the like, but are not limited thereto. . In addition, the high pressure treatment not only improves the dispersibility of β-1,3-1,6 glucan but also can reduce the viscosity of the external preparation for skin, so that the nonwoven fabric can be easily impregnated. be able to.

The skin external preparation of the present invention can further enhance the moisturizing effect and the tension effect by impregnating the nonwoven fabric. The nonwoven fabric used in the present invention is not particularly limited, and examples of the material include rayon, polyamide fiber, acrylic fiber, olefin fiber, glass fiber, and carbon fiber which are chemical fibers. , Hemp, pulp, silk, wool and the like. The manufacturing method, shape, etc. of the nonwoven fabric are not particularly limited. The basis weight (weight per unit area) of the nonwoven fabric is preferably 10 to 300 g / m ² , particularly preferably 30 to 200 g / m ² . The amount of the skin external preparation impregnated is preferably 3 to 50 times, particularly preferably 5 to 30 times the weight of the nonwoven fabric.

  Various methods can be used as the method for producing the external preparation for skin of the present invention. As an example, β-1,3-1,6-glucan, phospholipid, and water are dispersed with a disper mixer, and this is subjected to high-pressure treatment using a microfluidizer or the like to obtain a target composition.

In the present invention, the viscosity is not particularly limited. For example, the viscosity may be 10 to 1000 mPa · s at 25 ° C. For the measurement of the viscosity value, a Brookfield viscometer can be used. As an example, a “single cylindrical rotational viscometer—Bismetron” (manufactured by Shibaura System Co., Ltd.) can be used.

  The skin external preparation of the present invention can further contain cholesterol / and / or phytosterol, and by previously containing it in a composition to be subjected to high pressure treatment, β-1,3-1,6 glucan into water is added. The dispersibility can be further improved, and the skin external preparation can be further improved in moisturizing effect and firmness effect. Cholesterol and / or phytosterol can be used alone, but in the present invention, it can also be used as a mixture with component (A) in advance. Examples of commercially available phospholipid / cholesterol mixtures include EXTRASOME MMC (NOF Corporation) and PRESOME CS2-101 (Nippon Seika Co., Ltd.). Examples of commercially available phospholipid / phytosterol mixtures include PHYTOPRESOME (Nippon Seika Co., Ltd.). ), PYTOCOMPO-PP (Nippon Seika Co., Ltd.).

  The mixing ratio of the phospholipid / cholesterol mixture in the present invention is not particularly limited, but it is preferably 1: 1 to 10: 1, more preferably 2: 1 to 5: 1 in weight ratio. Within this range, the dispersibility of β-1,3-1,6 glucan in water can be further improved, and the skin external preparation can be further improved in moisturizing effect and elasticity effect.

  In the external preparation for skin of the present invention, optional components blended in the normal external preparation for skin within the range of not impeding the effects of the present invention, that is, oils other than the components of the present invention, alcohols, powders, water-soluble polymers , Film forming agents, surfactants, oil-soluble gelling agents, organically modified clay minerals, resins, UV absorbers, antiseptics, antibacterial agents, perfumes, antioxidants, pH adjusters, chelating agents, etc. it can.

  The use of the external preparation for skin of the present invention can be exemplified by skin care cosmetics such as lotion, milky lotion, cream, eye cream, cosmetic liquid, massage fee, pack fee, hand cream, body cream and the like.

  Hereinafter, the present invention will be described in more detail with reference to examples. Note that these do not limit the present invention.

Invention products 1 to 8 and comparative products 1 to 7: Cosmetic liquids were prepared by the compositions shown in Tables 1 and 2 and the following production method. The obtained materials were evaluated for (1) stability over time, (2) moisturizing effect, and (3) imparted firmness by the following methods, and the results are shown in Tables 1 and 2. The stability over time described here was observed for the presence or absence of aggregation.

(Production method)
A: Components 1 to 5 are heated to 70 ° C.
B: Components 6 to 8 are heated to 70 ° C.
C: Add B to A and disperse.
D: After cooling C, it was filtered through a mesh and subjected to high pressure treatment of 35 MPa or 70 MPa with a microfluidizer to obtain a skin external preparation.

(Evaluation method: Stability over time)
Each sample was stored for 1 month in a constant temperature bath at 50 ° C. and 25 ° C., and the stability with time was determined using the following four-step criteria based on the state stored at 25 ° C. The stability with time was determined by visual observation.
[4-step criteria]
[Evaluation results] [Judgment]
Aggregates are not observed: ◎
There is a slight agglomerate but no problem level: ○
There is an aggregate and there is a tendency to gel: △
There are aggregates and gelled as a whole: ×

(Evaluation method: moisturizing effect, elasticity imparting effect)
After the face wash once a day by a professional evaluation panel, and after cleaning the face with commercially available lotion and milky lotion, each sample of the cosmetic liquid of the present invention is taken to the extent of pearl grains and applied to the entire face. We had you apply. This is carried out for 2 weeks, and for each sample, (1) moisturizing effect and (2) firmness are sensory-evaluated in five stages according to the following (a) evaluation criteria, and the average score of each sample is as follows: (B) Judgment was made using a four-step criterion.

Five-level evaluation criteria (moisturizing effect)
[Evaluation Result]: [Score]
Feel very moisturized: Feel 5 points moisturized feel: Feel slightly 4 points moisturized feel: Do not feel slightly 3 points moisturized feeling: Feel almost no 2 points moisturized feeling: 1 point 5 grade evaluation criteria Grant effect)
[Evaluation Result]: [Score]
Feels very firm: feels 5-point firmness: feels slightly 4-point firmness: feels slightly 3-point firmness: hardly feels 2-point firmness: 1 point (4-step criteria)
[Average score]: [Judgment]
4.5 or more: ◎
3.5 or more and less than 4.5: ○
1.5 to less than 3.5: △
Less than 1.5: ×

As is clear from the results of Tables 1 and 2, the products 1 to 7 of the present invention subjected to high pressure treatment at 35 MPa or 70 MPa were lotions excellent in any of moisturizing effect, firmness effect and stability over time. . In any of the invention products, the stability over time was better when the high pressure treatment at 70 MPa was performed than at 35 MPa. On the other hand, the comparative product 1 that is not subjected to high-pressure treatment (the same formulation as the product 1 of the present invention) is not excellent in dispersibility of β-1,3-1,6 glucan, and aggregates are observed over time. There was a problem with stability. In Comparative Product 2 containing no phospholipid, the dispersibility of β-1,3-1,6-glucan was poor, and the stability over time, the feeling of elasticity, and the moisturizing effect were all inferior. The comparative product 3 containing no β-1,3-1,6-glucan was inferior in the firmness effect. Also, polyoxyethylene alkyl (12-15) ether phosphate (8EO) or polyoxyethylene (20EO) sorbitan monooleate was used as a dispersant for β-1,3-1,6-glucan instead of phospholipid. In the comparative product 4 and the comparative product 5, the dispersibility of β-1,3-1,6-glucan was poor, and the moisturizing effect and elasticity effect were not excellent. Even when the high-pressure treatment was set to 70 MPa, dispersibility of β-1,3-1,6-glucan and stability over time were improved, but sufficient effects of moisturizing effect and firmness were not obtained. . Further, the comparative product 6 using sclerotium gum instead of β-1,3-1,6-glucan was not sufficient as a harsh feeling effect.
From the above, it was revealed that the external preparation for skin of the present invention containing β-1,3-1,6-glucan and phospholipid and subjected to high pressure treatment was particularly excellent.

  Example 1 (Products 1 to 7 of the present invention, Comparative products 2 to 6) was impregnated into a non-woven fabric made of 100% cotton to obtain a non-woven fabric impregnated cosmetic. In addition, it evaluated using what impregnated the nonwoven fabric of 24g per 100g of each prescription of an Example. The evaluation results are listed in Table 3 and Table 4.

(Evaluation method: moisturizing effect, elasticity imparting effect)
The moisturizing effect and the elasticity imparting effect were evaluated in the same manner as in Example 1.

As is apparent from the results of Tables 3 and 4, the product of the present invention was a non-woven fabric-impregnated cosmetic material, which became an excellent cosmetic material by imparting a moisturizing effect and a feeling of elasticity (present products 1 to 7, Comparative products 2 to 6 have the same formulation as Tables 1 and 2.) For reference, the results of high pressure treatment (70 MPa) not used as impregnated cosmetics are also shown.
On the other hand, some of the comparative products have improved moisturizing effect and firmness effect due to impregnation, but were inferior to the products of the present invention.

Emulsion (component) (%)
1. Hydrogenated soybean phospholipid 2
2, glyceryl isooctanoate 5
3. Liquid paraffin 5
4 、 Squalane 3
5, cetyl alcohol 0.5
6, β-1,3-1,6-glucan 1.0
7. Glycerin 1.0
8. Xanthan gum 0.2
9. Carboxyvinyl polymer 0.2
10, Preservative appropriate amount 11, Fragrance appropriate amount 12, Purified water remaining

(Production method)
A: Components 1 to 5 are heated to 75 ° C. and mixed uniformly.
B: Ingredients 6, 7 and 12 are heated to 75 ° C. and mixed uniformly.
C: B is added to A and emulsified and mixed at 75 ° C.
D: C is cooled to 40 ° C., and a high pressure treatment of 70 MPa is performed using a microfluidizer.
E: 8 and 9 and 10, 11 dispersed in 70 ° C. hot water were added to D and mixed with D to obtain an emulsion.

The emulsion of Example 3 was an external preparation for skin having excellent moisturizing effect and imparting firmness and excellent stability over time.

Nonwoven fabric impregnated serum (oil-in-water type)
(Ingredient) (%)
1. Hydrogenated soybean phospholipid 5.0
2, cholesterol 0.5
3. Glyceryl monolinoleate (Iodine number 1, 2, 3) 1.0
4. Liquid paraffin 10.0
5. Cyclomethicone 5.0
6. Hydroxy stearic acid hydrogenated castor oil 2.0
7. Glycerin 10.0
8. Dipropylene glycol 5.0
9, β-1,3-1,6-glucan 1.0
10. Vitamin E 0.1
11. Phenoxyethanol 0.1
12. Ethyl alcohol 5.0
13, remaining amount of purified water

(Production method)
A: Components 1 to 6 are heated to 75 ° C. and mixed uniformly.
B: Components 7, 8, 9 and 13 are heated to 75 ° C. and mixed uniformly.
C: B is added to A and emulsified and mixed at 75 ° C.
D: C is cooled to 40 ° C. and a 70 MPa high pressure treatment is performed using a microfluidizer.
E: 10, 11, and 12 are added and mixed with D, and a cosmetic liquid is obtained.
F: E was impregnated into a non-woven fabric and hermetically sealed in an aluminum laminate bag-like container to obtain a non-woven fabric-impregnated cosmetic liquid.

  The non-woven fabric-impregnated cosmetic liquid of Example 4 was an external preparation for skin having excellent moisturizing effect and imparting firmness and excellent stability over time.

Claims (2)

(A) An external preparation for skin, which is obtained by subjecting a composition containing β-1,3-1,6-glucan (B) phospholipid (C) water to high pressure. The skin external preparation according to claim 1, which is used by impregnating a nonwoven fabric.