JP2007055926A - Humectant - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a humectant capable of making the skin preserve an enough water content, capable of maintaining softness and moisture retaining properties of the skin, and not causing deterioration in a sense of use, such as a sticky feeling, agreeability with the skin or the like, even when mixed into a cosmetic. <P>SOLUTION: This humectant comprises a component (a) carboxymethyl-β-glucan or its salt and a component (b) a culture solution of lactic acid bacteria and/or a culture solution of bifidobacteria as active ingredients. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a moisturizing agent having a high moisture retention effect and a good feeling of use, and more specifically, a moisturizing agent that enhances the moisturizing effect on the skin and at the same time does not cause a decrease in feeling of use such as a feeling of stickiness and skin familiarity. The present invention relates to a cosmetic containing a humectant.

  Since healthy skin has a function of keeping moisture physiologically, if sufficient moisture is held in the skin, the flexibility of the skin can be maintained and a good skin state can be maintained.

  However, when the moisture content of the skin is reduced due to various factors such as ultraviolet rays, drying, and oxidation, the flexibility of the skin is impaired and the skin becomes rough. In order to improve such rough skin, first, natural moisturizing factors, water-soluble polymers, polyhydric alcohols and the like have been used as moisturizing ingredients in order to maintain the moisture content of the skin. In addition, when a vicious cycle occurs in which inflammation is caused by rough skin and the rough skin is further deteriorated by inflammation, licorice extract, vitamins and the like are also administered as a rough skin improving agent (Non-patent Document 1). ).

  However, there is a limit to using a moisturizing component to give the skin a moisturizing action, and the effect has not been sufficient. In addition, if a large amount of moisturizing ingredients are used in order to provide a sufficient moisturizing action, there is a problem that a feeling of stickiness, a decrease in familiarity with the skin, etc. occur, and the feeling of use is impaired.

Cosmetics Dictionary, pages 90-95, edited by Japan Cosmetics Engineers Association, Maruzen Co., Ltd., issued on December 15, 2003

  Therefore, the present invention can maintain a sufficient amount of moisture in the skin, maintains skin flexibility and moisture retention, and causes a decrease in feeling of use such as stickiness and skin familiarity even when blended in cosmetics. It is an object of the present invention to provide a moisturizing agent that does not occur.

  In order to solve the above-mentioned problems, the present inventors have conducted extensive research on components having moisture retention, and as a result, a combination of a specific β-glucan and a culture solution of lactic acid bacteria or bifidobacteria has a high moisture retention effect. However, the present inventors have found that a moisturizing agent that does not cause a decrease in feeling of use can be obtained, and thus completed the present invention.

That is, the present invention includes the following components (a) and (b),
(A) Carboxymethyl-β-glucan and / or salt thereof (b) A humectant comprising a lactic acid bacteria culture solution and / or a bifidobacteria culture solution as an active ingredient is provided.

  Moreover, this invention provides the cosmetics containing the said moisturizer.

  The moisturizing agent of the present invention can maintain a sufficient amount of water in the skin and can maintain the flexibility and moisturizing properties of the skin. Moreover, even when the moisturizing agent of the present invention is blended in a cosmetic, it is excellent in that the feeling of use such as a sticky feeling and a skin familiarity does not deteriorate.

  The component (a) carboxymethyl-β-glucan or a salt thereof used in the humectant of the present invention is β-, which is one of natural polysaccharides obtained from yeast, moss, fungi, seaweed, cereals and the like. This is obtained by substituting the carboxymethyl group for the hydroxyl group of glucan or a salt thereof (hereinafter referred to as “carboxymethylation”).

  A method for carboxymethylating β-glucan or a salt thereof for producing component (a) is not particularly limited, and examples thereof include those described in JP-A-3-204804 and JP-T-2002-529549. Methods and the like. In the methods disclosed in these publications, in addition to carboxymethylation, a crosslinking treatment is also performed. However, in order to obtain the component (a) of the present invention, the crosslinking treatment may not be performed.

  The proportion (hereinafter referred to as “carboxymethylation rate”) of the hydroxyl group of β-glucan in the component (a) of the present invention is not particularly limited, but is 40% or more, preferably 50 to 100%, More preferably, it is 70 to 100%. Among the components (a), carboxymethyl-β-glucan sodium is particularly preferred because of its high solubility in water and easy availability. As this carboxymethyl-β-glucan sodium, CM-glucan J and CM-glucan J-P (both carboxymethylation rate: 70 to 100%) and Cosmo Farm (Netherlands) sold by Mibel (Switzerland). Commercially available products such as Glucea S (GluCare S: carboxymethylation rate 50-75%) sold by

  The amount of these components (a) in the moisturizing agent is not particularly limited, and may be appropriately adjusted according to the final dosage form and purpose. For example, final products such as cosmetics and skin external preparations. What is necessary is just to mix | blend 0.0002-0.4 mass% with respect to the whole quantity, Preferably 0.001-0.1 mass%. If the blending amount is less than 0.0002% by mass, the effects of the present invention may not be expected. If the blending amount exceeds 0.4% by mass or more, the cost may increase, which may not be preferable.

  On the other hand, the lactic acid bacteria culture solution and / or bifidobacteria culture solution which is the component (b) used in the moisturizing agent of the present invention is obtained by culturing lactic acid bacteria or bifidobacteria in various media.

  The lactic acid bacterium or bifidobacteria used to obtain this component (b) is not particularly limited, but Lactobacillus lactis, Lactobacillus bulgaricus, Lactobacillus bulgaricus, Lactobacillus bulgaricus Lactobacillus acidophilus, Lactobacillus casei and other Lactobacillus lactic acid bacteria, Bifidobacterium bifidum, Bifidobacterium breve and other bifidobacteria .

  Moreover, as a culture medium used for culture | cultivation for obtaining a component (b), the culture medium containing plant extracts, such as soymilk and aloe other than animal milk culture media, such as a milk culture medium and a milk-like culture medium, is mentioned, These These media may be used in combination of two or more. Furthermore, culture of the lactic acid bacteria or bifidobacteria using these media can be carried out by a conventional method. For example, as a method for culturing lactic acid bacteria in a medium containing milk, for example, JP-A-56-147706, The method for culturing bifidobacteria in a medium containing soy milk is described in Japanese Patent Publication No. 58-192811, and is described in Japanese Patent No. 3184114, Japanese Patent No. 3618296, etc., and lactic acid bacteria in a medium containing aloe As a method for cultivating, it is described in Japanese Patent Application Laid-Open No. 2004-196664 and the like, and can be cultured with reference to this.

  The culture broth thus obtained may be used as it is as the component (b), but it is preferable to use the filtrate supernatant of the culture broth as the component (b) from the viewpoint of storage stability. Moreover, you may use these culture solutions in combination of 1 or more types. Furthermore, as the lactic acid bacteria culture solution, whey (1), whey (2), whey (3), and whey powder described in the cosmetic raw material non-standard component specifications can be used.

  The blending amount of these components (b) in the moisturizing agent is not particularly limited, and may be appropriately blended according to the final dosage form and purpose. For example, final products such as cosmetics and skin external preparations. It is preferable to mix | blend 0.0002-30 mass% with respect to the whole quantity, More preferably, it is 0.001-20 mass%, Most preferably, it is 0.01-20 mass%. If the blending amount is less than 0.0002% by mass, the effect of the present invention may not be expected. If the blending amount is 30% by mass or more, there is a problem that costs increase, which is not preferable.

  In addition to the above components (a) and (b), the humectant of the present invention can further contain a water-soluble polymer and / or a polyhydric alcohol as the component (c).

  Examples of the water-soluble polymer and / or polyhydric alcohol which is component (c) include hyaluronic acid, sodium hyaluronate, carboxyvinyl polymer, alkyl-modified carboxyvinyl polymer, carrageenan, xanthan gum, hydroxypropylcellulose, hydroxyethylcellulose, quince seed , Polyacrylic acid amide, polyvinyl alcohol, water-soluble polymers such as polyvinylpyrrolidone, butylene glycol, pentylene glycol, glycerin, polyethylene glycol, diglycerin, propylene glycol, dipropylene glycol, polyoxypropylene diglyceryl ether Mention may be made of alcohol.

  These components (c) can be used in combination of one or more, and the blending amount in the humectant is preferably 0.0006 to 30% by mass with respect to the total amount of the final product such as cosmetics and skin external preparations. In particular, 0.006 to 10% by mass is preferable. When the blending amount is less than 0.006% by mass, the effect of the invention may not be expected, and when it is 30% by mass or more, the feeling in use may be impaired.

  Furthermore, the moisturizing agent of the present invention can contain a component having a skin function improving action as the component (d).

  This component (d), which has a skin function improving action, includes (1) lipids such as ceramide, cholesterol, phytosterol, fatty acids and derivatives of lipids, and (2) natural moisturizing factors such as amino acids and pyrrolidone carboxylic acids. And derivatives and salts thereof, (3) antioxidants that are vitamin C and vitamin E or derivatives thereof, (4) vitamin A, vitamin B, licorice extract, or anti-inflammatory agents that are derivatives thereof, and the like Is mentioned. Among these components having an effect of improving skin function, vitamin A, vitamin B, vitamin E and licorice extract are preferable.

  The blending amount of the component (d) in the moisturizing agent is preferably 0.001 to 5% by mass, and particularly preferably 0.01 to 3% by mass with respect to the total amount of the final product such as cosmetics and skin external preparations. If the blending amount is less than 0.001% by mass, the effect may not be confirmed. If the blending amount is 5% by mass or more, there is a problem in terms of cost.

  The moisturizing agent of the present invention can be produced according to a conventional method except that the component (a) and the component (b) described above are blended as essential components, and the component (c) and the component (d) are blended as necessary. .

  Furthermore, in addition to the above components, the moisturizing agent has a surfactant, a sticking agent, an oil agent, a powder, an antiseptic, a fragrance, a moisturizing agent, a drug, a chelating agent, in addition to the above components. Coloring agents, salts, pH adjusting agents and the like can be blended.

  The moisturizing agent of the present invention is used by blending it with a composition required to moisturize the skin, for example, a cosmetic or an external preparation for skin. Among these, any cosmetic can be used without particular limitation as long as it is a cosmetic in which a conventional moisturizing agent is blended, and examples thereof include skin lotion, cream, and emulsion.

  The moisturizing agent of the present invention thus obtained retains the moisture content of the skin and maintains the flexibility and moisturizing property of the skin when applied to the skin by blending it with cosmetics or external preparations for skin. Is something that can be done. In addition, even when this is blended in cosmetics or skin external preparations in such a quantity that a sufficient effect is recognized, it is excellent that the feeling of use such as stickiness and familiarity with the skin does not deteriorate.

  EXAMPLES Next, although an Example and a reference example are given and this invention is demonstrated in more detail, this invention is not restrict | limited at all by these Examples.

Reference example 1
Production of lactic acid bacteria culture supernatant:
About 3.7% by mass of skimmed milk powder was sterilized by heating and then inoculated with lactic acid bacteria (Streptococcus thermophilus) and cultured at 37 ° C. for 48 hours to obtain a lactic acid bacteria culture.

  The obtained culture was centrifuged with a centrifuge at 4,000 rpm for 10 minutes to remove a precipitate consisting almost exclusively of bacterial cells to obtain a transparent lactic acid bacteria culture supernatant. This corresponds to whey (2) described in the cosmetic raw material non-standard standard.

Reference example 2
Production of lactic acid bacteria aloe culture supernatant:
Thaw frozen aloe vera (Aloe barbadensis Miller) leaves, crush them, add twice the amount of water and 0.05% citric acid, and treat at 40 ° C with cellulase (cellulase "Onozuka"3S; Yakult Yakuhin) Kogyo) was performed for 3 hours. Then, it heated to 90 degreeC once, then cooled to room temperature, filtered, and concentrated under reduced pressure until it became Brix3.5, and the aloe vera extract was obtained.

  The obtained aloe vera extract (pH 3.7) was steam sterilized at 121 ° C. for 15 minutes. This was inoculated with 1% of a bacterial solution of lactic acid bacteria (Lactobacillus plantarum YIT0102), then allowed to stand at 30 ° C. for 72 hours, and further filtered (filter plate, Advantech NA-12, retained particle size 0.8 μm). ) To obtain a lactic acid bacteria aloe culture supernatant.

Reference example 3
Production of Bifidobacterium soymilk supernatant:
The soybeans were washed with water and immersed in water overnight to sufficiently absorb water, and then 4 times the amount of water was added and pulverized into a paste using a mixer. This was heated at 100 ° C. for 30 minutes, cooled, and then filtered to obtain soy milk (solid content concentration of about 10% by mass). The obtained soymilk was steam sterilized at 100 ° C. for 90 minutes to prepare a soymilk for fermentation.

  A bacterial solution of Bifidobacteria (Bifidobacterium breve YIT 4065) that had been pre-cultured was inoculated into this, and then allowed to stand at 37 ° C. for 24 hours to obtain fermented soymilk. Three times the amount of butylene glycol as the culture solution was added to this fermented soymilk, and further filtered (filter paper, Advantech No.131, retention particle size: 3.0 μm) to obtain a Bifidobacterium soymilk culture supernatant.

Example 1
Makeup lotion:
A lotion having the composition shown in Table 1 below was produced by the following production method. First, 7 is heated and dissolved, then mixed with 8 to 10 and added to 12. Further, 1 to 6 were sequentially added and dissolved to obtain a skin lotion. For these lotions, the moist and sticky feeling was evaluated according to the following evaluation criteria, and the keratin water content was measured by the following method.

(Measurement of feeling of use)
The feeling of use of the lotion was evaluated by five healthy subjects after applying the lotion on the inner side of the forearm and in accordance with the following five-step evaluation criteria. Furthermore, the average score was determined according to a three-level evaluation standard.
<5-level evaluation>
(Score) (Content)
2 points: Very good 1 point: Good 0 point: Neither can be said -1 point: Slightly bad -2 points: Bad << 3 level judgment >>
(Average score) (Evaluation)
1.5 points or more: ◎ (very good)
0 points or more: ○ (Good)
Less than 0 points: × (defect)

(Measurement of keratin water content)
For horny water content, apply lotion on the inner part of the forearm of five healthy subjects, apply it well to the skin, and 15 minutes after applying the lotion, using a keratin moisture meter (SKICON-20EX, manufactured by IBS). It was measured. In addition, a measured value measured 5 times and rounded off the average value.

  From the test results, it was found that the lotions of the present invention of Examples 1 to 4 can maintain sufficient moisture in the keratin or contribute to a high moisturizing feeling without impairing the feeling of use.

Example 2
Makeup lotion:
A lotion having the composition shown in Table 2 below was produced by the following method. First, 5 is heated and dissolved, then mixed with 6 to 8 and added to 10. Further, 1 to 4 were sequentially added and dissolved to obtain a skin lotion. For these lotions, the moist and sticky feeling was evaluated in the same manner as in Example 1, and the keratin water content was also measured in the same manner.

  From this test result, it is clear that the lotion of the present invention containing carboxymethyl-β-glucan sodium (Example 5) can maintain sufficient moisture in the keratin or contribute to a high moisturizing feeling without impairing the feeling of use. It was.

Example 3
Cream production:
Creams having the compositions shown in Table 3 below were produced by the following production method. First, of the following components, the oil phase components (7 to 10) are dissolved by heating, and the water phase components (1 to 6, 13) are also dissolved by heating. An oil layer is added to the heated aqueous phase and stirred with a homogenizer, and then alkali (11) is added and cooled. During the cooling, the additive (12) was added and mixed to obtain a cream. For these creams, the moist and sticky feeling was evaluated in the same manner as in Example 1, and the keratin water content was also measured in the same manner.

  From the test results of the cream, it was revealed that the present invention (Example 7) containing sodium carboxymethyl-β-glucan can maintain sufficient moisture in the keratin or contribute to a high moisturizing feeling without impairing the feeling of use.

Example 4
Lotion:
Among the components shown in Table 4, 12 is heated and dissolved, then mixed with 13 to 16 and added to 18. Further, 1 to 11 are sequentially added and dissolved. Finally, the pH was adjusted to a weak acid using 17 to obtain a lotion.

  This lotion was excellent in moisturizing effect and had a moist feeling. In addition, this lotion did not feel sticky.

Example 5
Latex:
Of the components listed in Table 5, the oil phase components (11 to 15) were dissolved by heating. Similarly, the water phase components (1 to 9, 18) are also dissolved by heating. An oil layer is added to the heated aqueous phase and stirred with a homogenizer, and then alkali (10) is added and cooled. During the cooling, additives (16, 17) were added and mixed to obtain an emulsion.

  This emulsion was excellent in moisturizing effect and had a moist feeling. Moreover, there was no stickiness in this emulsion.

Example 6
cream:
Of the components shown in Table 6, the oil phase components (12 to 19) were dissolved by heating. Similarly, the aqueous phase components (1 to 10, 21) are also dissolved by heating. An oil layer is added to the heated aqueous phase and stirred with a homogenizer, and then alkali (11) is added and cooled. During the cooling, the additive (20) was added and mixed to obtain a cream.

  This cream had a moisturizing effect and a moist feeling. In addition, this lotion did not feel sticky.

The moisturizing agent of the present invention can maintain a sufficient amount of moisture in the skin, and can maintain skin flexibility and moisture retention. Therefore, the moisturizing agent of the present invention can give a moisturizing effect to the skin by blending in cosmetics such as lotion, milky lotion, cream and the like and external preparations for skin.

Claims (5)

The following components (a) and (b),
(A) Carboxymethyl-β-glucan or a salt thereof (b) A humectant comprising a lactic acid bacteria culture solution and / or a bifidobacteria culture solution as an active ingredient.   The humectant according to claim 1, further comprising a water-soluble polymer and / or a polyhydric alcohol as component (c).   The humectant according to claim 1 or 2, further comprising a component having a skin function improving action as the component (d).   4. The component (d) having an action of improving skin function is one or more selected from the group consisting of vitamins A, vitamins B, vitamins E and licorice extract. Moisturizer. A cosmetic comprising the humectant according to any one of claims 1 to 4.