JPH0341019A - Bathing agent and its production - Google Patents
Bathing agent and its productionInfo
- Publication number
- JPH0341019A JPH0341019A JP17648689A JP17648689A JPH0341019A JP H0341019 A JPH0341019 A JP H0341019A JP 17648689 A JP17648689 A JP 17648689A JP 17648689 A JP17648689 A JP 17648689A JP H0341019 A JPH0341019 A JP H0341019A
- Authority
- JP
- Japan
- Prior art keywords
- culture
- lactic acid
- acid bacteria
- bath
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000004519 manufacturing process Methods 0.000 title claims description 12
- 238000003287 bathing Methods 0.000 title abstract description 7
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims abstract description 45
- 241000894006 Bacteria Species 0.000 claims abstract description 28
- 239000004310 lactic acid Substances 0.000 claims abstract description 22
- 235000014655 lactic acid Nutrition 0.000 claims abstract description 22
- 108010046377 Whey Proteins Proteins 0.000 claims abstract description 17
- 102000007544 Whey Proteins Human genes 0.000 claims abstract description 17
- 239000005862 Whey Substances 0.000 claims abstract description 16
- 239000007787 solid Substances 0.000 claims abstract description 6
- 241000186000 Bifidobacterium Species 0.000 claims description 23
- 239000000654 additive Substances 0.000 claims description 11
- 239000003788 bath preparation Substances 0.000 claims description 8
- 239000013040 bath agent Substances 0.000 claims description 7
- 238000012258 culturing Methods 0.000 claims description 7
- 230000000996 additive effect Effects 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 3
- 239000006071 cream Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 10
- 239000002609 medium Substances 0.000 abstract description 6
- 239000003795 chemical substances by application Substances 0.000 abstract description 4
- 239000001963 growth medium Substances 0.000 abstract description 4
- 239000000203 mixture Substances 0.000 abstract 3
- 229940068140 lactobacillus bifidus Drugs 0.000 abstract 2
- 208000010201 Exanthema Diseases 0.000 abstract 1
- 230000001877 deodorizing effect Effects 0.000 abstract 1
- 201000005884 exanthem Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 206010037844 rash Diseases 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 18
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 8
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 7
- 206010012444 Dermatitis diaper Diseases 0.000 description 6
- 208000003105 Diaper Rash Diseases 0.000 description 6
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 6
- 241000186660 Lactobacillus Species 0.000 description 6
- 229940001447 lactate Drugs 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 239000002207 metabolite Substances 0.000 description 5
- 235000018102 proteins Nutrition 0.000 description 5
- 102000004169 proteins and genes Human genes 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 229910021529 ammonia Inorganic materials 0.000 description 4
- 230000001580 bacterial effect Effects 0.000 description 4
- 239000005018 casein Substances 0.000 description 4
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 4
- 235000021240 caseins Nutrition 0.000 description 4
- 229940039696 lactobacillus Drugs 0.000 description 4
- 235000013336 milk Nutrition 0.000 description 4
- 239000008267 milk Substances 0.000 description 4
- 210000004080 milk Anatomy 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 229940088598 enzyme Drugs 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 230000002503 metabolic effect Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 241000186016 Bifidobacterium bifidum Species 0.000 description 2
- 241001608472 Bifidobacterium longum Species 0.000 description 2
- 244000068988 Glycine max Species 0.000 description 2
- 235000010469 Glycine max Nutrition 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 229940002008 bifidobacterium bifidum Drugs 0.000 description 2
- 229940009291 bifidobacterium longum Drugs 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 235000013351 cheese Nutrition 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 239000002781 deodorant agent Substances 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 230000003020 moisturizing effect Effects 0.000 description 2
- 229930014626 natural product Natural products 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 229940108461 rennet Drugs 0.000 description 2
- 108010058314 rennet Proteins 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 235000000346 sugar Nutrition 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 1
- 241000186012 Bifidobacterium breve Species 0.000 description 1
- 241000186015 Bifidobacterium longum subsp. infantis Species 0.000 description 1
- 208000035985 Body Odor Diseases 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 229930182843 D-Lactic acid Natural products 0.000 description 1
- JVTAAEKCZFNVCJ-UWTATZPHSA-N D-lactic acid Chemical compound C[C@@H](O)C(O)=O JVTAAEKCZFNVCJ-UWTATZPHSA-N 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 240000001046 Lactobacillus acidophilus Species 0.000 description 1
- 235000013956 Lactobacillus acidophilus Nutrition 0.000 description 1
- 244000199885 Lactobacillus bulgaricus Species 0.000 description 1
- 235000013960 Lactobacillus bulgaricus Nutrition 0.000 description 1
- 241000186869 Lactobacillus salivarius Species 0.000 description 1
- 241000194034 Lactococcus lactis subsp. cremoris Species 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000054812 Microbacterium gubbeenense Species 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 206010039897 Sedation Diseases 0.000 description 1
- 206010040904 Skin odour abnormal Diseases 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 235000014962 Streptococcus cremoris Nutrition 0.000 description 1
- 244000057717 Streptococcus lactis Species 0.000 description 1
- 235000014897 Streptococcus lactis Nutrition 0.000 description 1
- 241000194020 Streptococcus thermophilus Species 0.000 description 1
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 1
- 108010046334 Urease Proteins 0.000 description 1
- 229940022663 acetate Drugs 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229940004120 bifidobacterium infantis Drugs 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 229910021538 borax Inorganic materials 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 229940041514 candida albicans extract Drugs 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 239000007952 growth promoter Substances 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 229940039695 lactobacillus acidophilus Drugs 0.000 description 1
- 229940004208 lactobacillus bulgaricus Drugs 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 238000010979 pH adjustment Methods 0.000 description 1
- -1 parabens Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- PHZLMBHDXVLRIX-UHFFFAOYSA-M potassium lactate Chemical compound [K+].CC(O)C([O-])=O PHZLMBHDXVLRIX-UHFFFAOYSA-M 0.000 description 1
- 239000001521 potassium lactate Substances 0.000 description 1
- 235000011085 potassium lactate Nutrition 0.000 description 1
- 229960001304 potassium lactate Drugs 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 230000036280 sedation Effects 0.000 description 1
- 230000037307 sensitive skin Effects 0.000 description 1
- 235000020183 skimmed milk Nutrition 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000004328 sodium tetraborate Substances 0.000 description 1
- 235000010339 sodium tetraborate Nutrition 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 210000002820 sympathetic nervous system Anatomy 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 241001148471 unidentified anaerobic bacterium Species 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000021119 whey protein Nutrition 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
- 235000013618 yogurt Nutrition 0.000 description 1
Abstract
Description
【発明の詳細な説明】
「産業上の利用分野」
本発明は、浴用剤に関し、詳しくは天然物、特に乳酸菌
及び／又はビフィズス菌を利用した浴用剤及びその製造
法に関する。DETAILED DESCRIPTION OF THE INVENTION "Field of Industrial Application" The present invention relates to bath additives, and more particularly to bath additives using natural products, particularly lactic acid bacteria and/or bifidobacteria, and a method for producing the same.
「従来の技術Ｊ
人は温湯に入浴することによって、身体が温まり、皮膚
表面の汚れを洗浄除去するが、同時に、その際の温熱刺
激によって、血圧、血液の循環、呼吸による酸素清貧量
並びに皮膚表面の状態等が変化し、更には鎮静作用や開
音作用といった交換神経系にも変化が生じて、健康が増
進され、疲労回復が促進され、且つ精神的な安らぎが得
られるのである。``Conventional Technology J'' When people take a bath in hot water, their bodies warm up and the dirt on the skin surface is washed and removed, but at the same time, the thermal stimulation at that time increases blood pressure, blood circulation, oxygen depletion through breathing, and the skin. The state of the surface changes, and changes occur in the sympathetic nervous system, such as sedation and openness, which improves health, promotes recovery from fatigue, and provides mental peace.
特に入浴中は皮膚の角質が水分を吸収してふやけて温湯
中に溶解している物質の吸収が速く、刺激を受けやすい
状態になっている。この様なことから、従来から浴湯に
種々の薬効成分を浴用剤として添加して、上記した生理
的効果の一層の増進を図ると共に、皮膚炎等の炎症の治
療を行なっていた。Particularly during bathing, the dead skin cells of the skin absorb water and become soft, and the substances dissolved in the hot water are absorbed quickly, making the body susceptible to irritation. For this reason, various medicinal ingredients have been conventionally added to bath water as bath additives to further enhance the above-mentioned physiological effects and to treat inflammation such as dermatitis.
ところで、乳酸菌はグルコースなどの糖類から多量の乳
酸を生成する、ダラム陽性で、運動性がなく、通性嫌気
性の細菌であって、酒類醸造、ヨーグルト、バター、チ
ーズの製造、漬は物の製造、乳酸菌製剤、デキストラン
の製造等に利用されている。By the way, lactic acid bacteria are Durham-positive, non-motile, facultatively anaerobic bacteria that produce large amounts of lactic acid from sugars such as glucose. It is used in the production of lactic acid bacteria preparations, dextran, etc.
また、乳酸菌の代謝産物である乳酸塩が肌に対して保温
性等の効果を有することが知られ、化粧品の原料として
用いられている。Furthermore, lactate, which is a metabolic product of lactic acid bacteria, is known to have effects such as heat retention on the skin, and is used as a raw material for cosmetics.
ビフィズス菌は人の腸内細菌叢を構成する主要な細菌の
一つで、人や動物に対し、種々の有益な役割を持ち、ビ
フィズスヨーグルト、ビフィズス菌末等に用いられてい
る。Bifidobacterium is one of the major bacteria that constitutes the human intestinal flora, and has various beneficial roles for humans and animals, and is used in products such as Bifidobacterium yogurt and Bifidobacterium powder.
「発明が解決しようとする課題」
従来の浴用剤は、無機塩や生薬抽出エキス等を有効成分
としたものが多く、天然物、特に微生物およびその代謝
産物を有効成分にしたものは少ない。``Problems to be Solved by the Invention'' Many conventional bath additives have active ingredients such as inorganic salts and herbal medicine extracts, but few have natural products, especially microorganisms and their metabolites, as active ingredients.
また、従来の浴用剤は、入浴中に皮膚を通して薬効成分
を吸収させ、血液の循環等を促進することに着眼してな
されたものが多く、皮膚の表面状態を良好にするという
観点から開発されたものは少ない。In addition, many conventional bath additives were developed with the aim of promoting blood circulation by absorbing medicinal ingredients through the skin during bathing, and were developed with the aim of improving the surface condition of the skin. There are few things.
一方、乳酸菌の代謝産物である乳酸塩などは、肌に対し
て効果を有することが知られており、化粧品の原料とし
て利用されているが、これを浴用剤に利用しようとする
試みはなされていない。On the other hand, lactate, which is a metabolic product of lactic acid bacteria, is known to have effects on the skin and is used as a raw material for cosmetics, but no attempt has been made to use it in bath additives. do not have.
本発明の目的は、入浴時に体の皮膚全体にコーティング
され、それによって皮膚の状態を良好に保つことができ
る浴用剤及びその製造法を提供することにある。An object of the present invention is to provide a bath additive that coats the entire skin of the body during bathing, thereby keeping the skin in good condition, and a method for producing the same.
「課題を解決するための手段」
上記目的を達成するため、本発明の浴用剤は、乳酸菌及
び／又はビフィズス菌の培養物を主成分とする。"Means for Solving the Problems" In order to achieve the above object, the bath preparation of the present invention contains a culture of lactic acid bacteria and/or bifidobacteria as a main component.
また、本発明の浴用剤の製造法は、乳酸菌及び／又はビ
フィズス菌を、ホエーを培地として、ｐＨを調整しなが
ら培養することを特徴とする。Furthermore, the method for producing a bath agent of the present invention is characterized by culturing lactic acid bacteria and/or bifidobacteria using whey as a medium while adjusting the pH.
以下、本発明について、詳細に説明する。The present invention will be explained in detail below.
本発明において、乳酸菌としては、例えばストレプトコ
ッカス・ラクチス（Ｓｔｒｅｐｔｏｃｏｃｃｕｓｌａｃ
ｔｉｓｌ 、 ストレプトコッカス・サーモフィルス
（Ｓｔｒｅｐｔｏｃｏｃｃｕｓ ｔｈｅｒｍｏｐｈｉｌ
ｕｓｌ、ストレプトコッカス・クレモリス（Ｓｔｒｅｐ
ｔｏｃｏｃｃｕｓ ｃｒｅｍｏｌｉｓｌ等の乳・酸球菌
、ラクトバチルス・ブルガリクス（Ｌａｃｔｏｂａｃｉ
ｌｌｕｓ ｂｕｌｇａｒｉｃｕｓｌ、ラクトバチルス・
カゼイ（Ｌａｃｔｏｂａｃｉｌｌｕｓ ｃａｓｅｉｌ
、ラクトバチルス・ブランタルムｆＬａｃｔｏｂａｃｉ
ｌｌｕｓ ｐｌａｎｔａｒｕｍｌ ＋ラクトバチルス・
サリバリウス（Ｌａｃｔｏｂａｃｉｌｌｕｓｓａｌｉｖ
ａｒｉｕｓｌ 、ラクトバチルス・アシドフィルスｆＬ
ａｃｔｏｂａｃｉｌｌｕｓ ａｃｉｄｏｐｈｉｌｕｓｌ
等の乳酸桿菌などの公知のものが使用される。また、ビ
フィズス菌として１よ、ビフィドバクテリウム・ビフィ
ダム（Ｂｉｆｉｄｏｂａｃｔｅｒｉｕｍ ｂｉｆｉｄｕ
ｍｌ 、 ビフィドバクテリウム・ブレーベ（Ｂｉｆｉ
ｄｏｂａｃｔｅｒｉｕｗ＋ ｂｒｅｖｅｌ 、ビフィド
バクテリウム・ロンガム（Ｂｉｆｉｄｏｂａｃｔｅｒｉ
ｕｍｌｏｎｇｕｍｌ 、ビフィドバクテリウム・アドレ
スセンチイス（Ｂｉｆｉｄｏｂａｃｔｅｒｉｕｍ ａｄ
ｏｌｅｓｃｅｎｔｉｓｌ。In the present invention, examples of lactic acid bacteria include Streptococcus lactis.
tisl, Streptococcus thermophilus
usl, Streptococcus cremoris (Strep
Lactobacillus and acidococci such as tococcus cremolisl, Lactobacillus bulgaricus
llus bulgaricusl, lactobacillus
Lactobacillus caseil
, Lactobacillus brantarum fLactobacii
llus plantarum + lactobacillus
Lactobacillus salivarius
ariusl, Lactobacillus acidophilus fL
actobacillus acidophilus
Known lactobacilli such as Lactobacillus are used. In addition, Bifidobacterium bifidum (Bifidobacterium bifidu)
ml, Bifidobacterium breve (Bifi
dobacteriuw+ brevel, Bifidobacterium longum (Bifidobacterium longum)
umlonguml, Bifidobacterium adrescentis
olescentisl.
ビフィドバクテリウム・インファンティス（Ｂｉｆｉｄ
ｏｂａｃｔｅｒｉｕｍ ｊｎｆａｎｔｉｓ）などの公知
のものが使用される。これらはいずれも容易に入手でき
る菌である。Bifidobacterium infantis (Bifid
Known species such as (obacterium jnfantis) are used. All of these bacteria are easily available.
本発明において、乳ｒ！ａ菌及び／又はビフィズス菌を
培養する培地としては、ホエーを用いる。In the present invention, milk r! Whey is used as a medium for culturing A bacterium and/or Bifidobacterium.
ホエーは、牛乳から脂肪を除去した脱脂乳に酸またはレ
ンネットを添加して、牛乳の主蛋白質であるカゼインを
除いて得られる透明な黄緑色の水溶液で、乳清ともいう
。また、牛乳に酸またはレンネットを直接作用させて、
脂肪とカゼインとからなるカードを除去して得られる水
溶液もホエーという。ホエーは乳糖を主成分とし、乳清
蛋白質及び無機質を含む。工業的には、チーズやカゼイ
ン製造の際の廃液として捨てられているものを用いるこ
とができる。また、大豆製品を製造する際に得られる大
豆ホエーを用いることもできる。本発明に培地として用
いるホエーは、できるだけ蛋白質含量の少ないものが好
ましく、例えば蛋白分解酵素を作用させて蛋白質を更に
除去したものが好ましい、また、近年、ホエー中の蛋白
質を回収することを目的として、ホエーを限外濾過する
方法が行なわれているが、この際に副産物として得られ
るホエーパーミエートは蛋白質を含まないので、より好
ましい発酵原料となりつる。蛋白質をできるだけ除去す
ることにより、皮膚に対する刺激性、アレルギー性がな
くなり、皮膚が敏感な人に対しても悪影響がなくなる。Whey is a clear yellow-green aqueous solution obtained by adding acid or rennet to skimmed milk to remove casein, the main protein in milk, and is also called whey. Also, by directly applying acid or rennet to milk,
The aqueous solution obtained by removing the curd consisting of fat and casein is also called whey. Whey has lactose as its main component and also contains whey protein and minerals. Industrially, it is possible to use what is discarded as waste liquid during the production of cheese or casein. Moreover, soybean whey obtained when manufacturing soybean products can also be used. The whey used as a culture medium in the present invention preferably has as low a protein content as possible, for example, it is preferably one that has been treated with a proteolytic enzyme to further remove protein. , a method of ultrafiltration of whey has been carried out, but whey permeate obtained as a by-product at this time does not contain protein, so it is a more preferable fermentation raw material. By removing as much protein as possible, irritation and allergy to the skin are eliminated, and there are no adverse effects on people with sensitive skin.
牛乳を直接培地としてもちいないのはそのためである。That is why milk is not used directly as a culture medium.
次に、本発明の乳酸菌及び／又はビフィズス菌の好まし
い培養方法を説明する。Next, a preferred method for culturing lactic acid bacteria and/or bifidobacteria of the present invention will be explained.
ホエーに、必要に応じてイーストエキス等の増殖促進剤
を０．２〜１％添加した培地に、嫌気状態で、乳酸菌及
び／又はビフィズス菌を植菌して、ｐＨ５〜７．５、好
ましくは６〜７の条件下、３０〜５０℃、好ましくは３
５〜４５℃で、撹拌培養し、ホエー中の糖を完全に消費
させる。培養中、ｐＨが下がるので、水酸化カリウム、
水酸化ナトリウム等のアルカリで調整する。ｐＨ調整に
用いるアルカリは、肌に対する作用から、水酸化カリウ
ムが最も好ましい、このようにして１２〜４８時間培養
し、ｐＨが下がらなくなって安定したら、培養を終了す
る。In an anaerobic state, lactic acid bacteria and/or bifidobacteria are inoculated into a medium prepared by adding 0.2 to 1% of a growth promoter such as yeast extract to whey as necessary, and the pH is preferably 5 to 7.5. 6 to 7, 30 to 50°C, preferably 3
Culture is carried out with stirring at 5 to 45°C to completely consume the sugar in the whey. During cultivation, the pH decreases, so potassium hydroxide,
Adjust with alkali such as sodium hydroxide. Potassium hydroxide is most preferable as the alkali used for pH adjustment due to its effect on the skin. Cultivation is performed in this manner for 12 to 48 hours, and when the pH no longer decreases and becomes stable, the cultivation is terminated.
次いで、得られた培養液を、エバポレーターなどで、１
１５〜ｌ／１０程度に濃縮して、固形分濃度３０〜６０
％程度のクリーム状の液を得る。濃縮することにより、
保存性がよくなる。Next, the obtained culture solution is evaporated with an evaporator etc.
Concentrate to about 15 to 1/10 to achieve a solid concentration of 30 to 60
% of the creamy liquid obtained. By concentrating
It keeps better.
以上のようにしてえられた濃縮液をそのまま浴用剤とし
て用いることも出来るが、必要に応じてヒアルロン酸、
コラーゲンなどの他の保湿剤、香料、色素、酸化チタン
等の白濁剤、ホウ砂、硫酸ナトリウム、炭酸ナトリウム
などの無機塩パラベン等ノ防腐安定剤を添加することが
できる。The concentrate obtained as described above can be used as a bath agent as it is, but if necessary, hyaluronic acid,
Other humectants such as collagen, fragrances, pigments, clouding agents such as titanium oxide, preservative stabilizers such as parabens, borax, inorganic salts such as sodium sulfate, sodium carbonate, etc. can be added.
本発明の浴用剤１０〜２０ｍ１を風呂に入れると、湯は
乳白色で、細かい粒子がキラキラと光り、半透明の状態
になる。When 10 to 20 ml of the bath agent of the present invention is poured into a bath, the water is milky white, the fine particles sparkle, and the water becomes translucent.
「作用」
本発明の浴用剤は、乳酸菌及び／又はビフィズス菌の菌
体と、乳酸菌及び／又はビフィズス菌の代謝産物とｐＨ
調整に使用したアルカリとの塩、例えば乳酸カリウム、
乳酸ナトリウム等の乳酸塩、ビフィズス菌の場合は乳酸
塩、酢酸塩と、その他の代謝産物と、無機塩、アミノ酸
、ペプチド、ビタミン類等からなる。"Effect" The bath preparation of the present invention has the ability to combine bacterial cells of lactic acid bacteria and/or bifidobacteria, metabolites of lactic acid bacteria and/or bifidobacteria, and pH
Salts with alkalis used for preparation, such as potassium lactate,
It consists of lactate such as sodium lactate, lactate and acetate in the case of bifidobacteria, other metabolites, inorganic salts, amino acids, peptides, vitamins, etc.
本発明の浴用剤を入れた風呂に入ると、肌がしっとりす
る。これは、乳酸菌及び／又はビフィズス菌が、０．５
〜数μｍの非常に小さい粒子であるため、皮膚の表面に
均一に広がって被膜を形成すると共に、代謝産物として
含まれる乳酸塩、酢酸塩などが保湿効果をもたらすため
であると考えられる。When you take a bath containing the bath preparation of the present invention, your skin becomes moist. This means that lactic acid bacteria and/or bifidobacteria are 0.5
This is thought to be because the particles are very small, ranging in size from several micrometers, so they spread uniformly over the skin surface to form a film, and the lactate, acetate, etc. contained as metabolites have a moisturizing effect.
また、乳酸菌及び／又はビフィズス菌、あるいはこれら
の菌体酵素や代謝産物は、汗などに含まれるアンモニア
等による体臭成分を消費、中和させて清具するデオドラ
ント効果があるので、湯上がり後、爽やかきを維持でき
る。In addition, lactic acid bacteria and/or bifidobacteria, or their bacterial enzymes and metabolic products, have a deodorant effect that cleanses the body by consuming and neutralizing body odor components such as ammonia contained in sweat, so you will feel refreshed after taking a bath. It is possible to maintain the
更に、乳児のおむつかぶれは、尿中のウレアが便中のウ
レアーゼを有する菌によって分解され。Furthermore, diaper rash in infants is caused by urea in the urine being broken down by bacteria containing urease in the stool.
アンモニアを発生し、このアンモニアが皮膚を刺激する
ために起こる炎症であると考えられるが、本発明の浴用
剤を用いると、乳酸菌及び／又はビフィズス菌、あるい
はこれらの菌体酵素や代謝産物が、アンモニアを消費し
、中和させるため、おむつかぶれ等を防止することがで
きる。このおむつかぶれの防止作用は、ビフィズス菌の
培養物のほうがより強いので、乳児の浴用剤としてはビ
フィズス菌から得られたものを用いるほうが好ましい。It is thought that inflammation occurs because ammonia is generated and this ammonia irritates the skin, but when the bath preparation of the present invention is used, lactic acid bacteria and/or bifidobacteria, or their bacterial enzymes and metabolites, Since ammonia is consumed and neutralized, diaper rash can be prevented. Since a culture of Bifidobacterium has a stronger effect of preventing diaper rash, it is preferable to use a product obtained from Bifidobacterium as a bath additive for infants.
「実施例」
実施例１
ホエー１０００＋ｍｌに増殖促進剤であるイーストエキ
ス１０ｇを添加した培地に、乳酸菌（ラクトバチルス・
カゼイ）の培養液１＋＋＋１を植菌し、嫌気状態で、３
７℃の温度下に、ｐＨを６．３に維持しながら、撹拌培
養した。培養中ｐＨが下がるので、２０％水酸化カリウ
ム水溶液を添加してｐＨ調整をする。２４時間培養後、
ｐＨが下がらなくなって安定した時点で、培養を終了し
、培養液１２００ｍ１を得た。"Example" Example 1 Lactic acid bacteria (Lactobacillus spp.
Inoculate 1+++1 culture of M. casei) and grow 3 in an anaerobic condition.
The culture was carried out with stirring at a temperature of 7° C. while maintaining the pH at 6.3. Since the pH decreases during culturing, adjust the pH by adding a 20% aqueous potassium hydroxide solution. After culturing for 24 hours,
When the pH stopped dropping and became stable, the culture was terminated and 1200 ml of culture solution was obtained.
次いで、この培養液を、エバポレーターで１５０＋ｍｌ
に濃縮して、固形分濃度５０重量％のクリーム状の浴用
剤を得た。Next, add 150+ml of this culture solution using an evaporator.
A cream bath agent with a solid content concentration of 50% by weight was obtained.
実施例２
実施例１で用いた乳酸菌をビフィズス菌（ビフィドバク
テリウム・ビフィダム）の培養液１ｍｌに代えて実施例
１と同様に培養し、この培養液を、エバポレーターで１
５ｋｌに濃縮して、固形分濃度５０重量％のクリーム状
の浴用剤を得た。Example 2 The lactic acid bacteria used in Example 1 were cultured in the same manner as in Example 1, except that 1 ml of the culture solution of Bifidobacterium (Bifidobacterium bifidum) was used.
It was concentrated to 5kl to obtain a creamy bath agent with a solid content concentration of 50% by weight.
実施例１．２で得られた浴用剤２０ｍ１を、それぞれ別
の風呂に入れ、ｌＯ大の人に入浴してもらったところ、
湯上がりに大部分の人が肌がしっとりしたと感じた。When 20ml of the bath preparation obtained in Example 1.2 was placed in separate baths and 10000 people were asked to take a bath,
Most people felt that their skin felt moisturized after taking a bath.
また、おむつかぶれのある乳児の入浴に、実施例２で得
られた浴用剤を２週間連続して使用したところ、おむつ
かぶれの症状が軽減した。Furthermore, when the bath additive obtained in Example 2 was used for two consecutive weeks to bathe an infant with diaper rash, the symptoms of diaper rash were alleviated.
「発明の効果」
以上説明したように、本発明の浴用剤は、入浴した際に
体の皮膚全体に均一にコーティングされ、代謝産物とし
て含まれる乳酸塩、酢酸塩などが保湿効果をもたらし、
これらの菌や菌体酵素がデオドラント効果をもたらすの
で、湯上がりに肌がしっとりし、デオドラント効果によ
り爽やかになる。また、乳児に対しておむつかぶれ防止
効果を得ることもできる。更に、本発明の浴用剤の製造
法によれば、人体に無害な乳酸菌及び／又はビフィズス
菌を蛋白質の非常に少ないホエーを培地として培養する
ので、皮膚に対して非常に安全な浴用剤を得ることがで
きる。また、製造工程が簡便であり５培地に用いるホエ
ーは、チーズやカゼイン製造の際に廃液として破棄され
ているもの等を使用することができるので、安価に得る
ことができる。"Effects of the Invention" As explained above, the bath additive of the present invention uniformly coats the entire skin of the body when taking a bath, and the lactate, acetate, etc. contained as metabolites have a moisturizing effect.
These bacteria and bacterial enzymes create a deodorant effect, so your skin will feel moisturized and refreshed after taking a bath. Moreover, the effect of preventing diaper rash can also be obtained for infants. Furthermore, according to the method for manufacturing bath preparations of the present invention, lactic acid bacteria and/or bifidobacteria, which are harmless to the human body, are cultured using whey, which has very little protein, as a medium, resulting in bath preparations that are extremely safe for the skin. be able to. In addition, the manufacturing process is simple, and the whey used in the culture medium 5 can be obtained at low cost because it can be discarded as waste liquid during the production of cheese or casein.
Claims (4)
とする浴用剤。(1) A bath agent containing a culture of lactic acid bacteria and/or bifidobacteria as a main component.
す請求項１記載の浴用剤。(2) The bath preparation according to claim 1, which is in the form of a cream having a solid content concentration of 30 to 60% by weight.
として、ｐＨを調整しながら培養することを特徴とする
浴用剤の製造法。(3) A method for producing a bath agent, which comprises culturing lactic acid bacteria and/or bifidobacteria in whey as a medium while adjusting the pH.
〜６０重量％とする請求項３記載の浴用剤の製造法。(4) After the culturing, concentrate the culture to a solid content concentration of 30.
4. The method for producing a bath additive according to claim 3, wherein the amount is 60% by weight.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17648689A JP2832042B2 (en) | 1989-07-07 | 1989-07-07 | Bath agent and method for producing the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17648689A JP2832042B2 (en) | 1989-07-07 | 1989-07-07 | Bath agent and method for producing the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0341019A true JPH0341019A (en) | 1991-02-21 |
| JP2832042B2 JP2832042B2 (en) | 1998-12-02 |
Family
ID=16014509
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP17648689A Expired - Lifetime JP2832042B2 (en) | 1989-07-07 | 1989-07-07 | Bath agent and method for producing the same |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2832042B2 (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06199651A (en) * | 1992-12-28 | 1994-07-19 | Shimadzu Corp | Bathing agent |
| JP2005139198A (en) * | 2004-12-11 | 2005-06-02 | Koichi Takezaki | Life-related goods with added odor suppression effect |
| JP2007055926A (en) * | 2005-08-24 | 2007-03-08 | Yakult Honsha Co Ltd | Humectant |
| JP2009530360A (en) * | 2006-03-24 | 2009-08-27 | ジボーダン ネーデルランド サービシーズ ビー．ヴィ． | Use of fermented dairy products for skin treatment |
| DE102011009798A1 (en) * | 2011-01-31 | 2012-08-02 | Merz Pharma Gmbh & Co. Kgaa | Balneological lipid-containing probiotic preparations for cosmetic / dermatological / medical applications |
-
1989
- 1989-07-07 JP JP17648689A patent/JP2832042B2/en not_active Expired - Lifetime
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06199651A (en) * | 1992-12-28 | 1994-07-19 | Shimadzu Corp | Bathing agent |
| JP2005139198A (en) * | 2004-12-11 | 2005-06-02 | Koichi Takezaki | Life-related goods with added odor suppression effect |
| JP2007055926A (en) * | 2005-08-24 | 2007-03-08 | Yakult Honsha Co Ltd | Humectant |
| JP2009530360A (en) * | 2006-03-24 | 2009-08-27 | ジボーダン ネーデルランド サービシーズ ビー．ヴィ． | Use of fermented dairy products for skin treatment |
| JP2014208672A (en) * | 2006-03-24 | 2014-11-06 | ジボダン ネーデルランド サービシーズ ビー．ヴイ．Ｇｉｖａｕｄａｎ Ｎｅｄｅｒｌａｎｄ Ｓｅｒｖｉｃｅｓ Ｂ．Ｖ． | Use of fermented milk product for skin treatment |
| DE102011009798A1 (en) * | 2011-01-31 | 2012-08-02 | Merz Pharma Gmbh & Co. Kgaa | Balneological lipid-containing probiotic preparations for cosmetic / dermatological / medical applications |
| WO2012104025A2 (en) | 2011-01-31 | 2012-08-09 | Merz Pharma Gmbh & Co. Kgaa | Balneotherapeutic lipid-containing probiotic preparations and their applications |
| DE102011009798B4 (en) * | 2011-01-31 | 2015-03-05 | Merz Pharma Gmbh & Co. Kgaa | Balneological lipid-containing probiotic preparations for cosmetic / dermatological / medical applications |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2832042B2 (en) | 1998-12-02 |
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