KR100534185B1 - Moisturizing cosmetic compositions containing a beta-1,6-branched-beta-1,3-glucan - Google Patents

Abstract

The present invention is beta-1,6-branched-beta-1,3-glucan (β-1,6-branched-β-1,3-glucan) prepared by the liquid culture of Schizophyllum commune Fr. The present invention relates to a moisturizing cosmetic composition containing or further containing hyaluronic acid which is a known moisturizing agent.

Description

Moisturizing cosmetic compositions containing a beta-1,6-branched-beta-1,3-glucan}

The present invention relates to a cosmetic composition having a skin moisturizing effect, and more particularly contains beta-1,6-branch-beta-1,3-glucan prepared by liquid culture of Schizophyllum commune Fr. In addition, the present invention relates to a cosmetic composition capable of providing an excellent skin moisturizing effect by further containing hyaluronic acid which is a known moisturizing agent.

Dermatologically, the most important role of the skin is the membrane function, to prevent the loss of biological components such as water, electrolytes, etc. and at the same time to prevent invasion of harmful substances in the skin. In other words, the skin is exposed to a much drier external environment than in vivo and plays an important role as a membrane to protect the living body from the external environment. In particular, the stratum corneum of the skin's outermost layer, which is in direct contact with the external environment, prevents the invasion of mechanically and chemically harmful ingredients and prevents the loss of internal moisture in the dry environment, which is drier than in vivo. Maintaining flexibility

However, despite this function of the skin, the skin is vulnerable to the harsh external environment, wind, cold weather, sunlight, face wash, shaving, etc., with the addition of the aging factor, which easily loses moisture and becomes dry and rough skin.

Therefore, it is the most important purpose of using cosmetics to prevent such a phenomenon to maintain a smooth and moist skin. In other words, applying cosmetics to the skin creates an artificial membrane on the skin, which prevents external irritation, prevents water loss from inside the skin, and supplies a certain amount of moisture to the skin.

Therefore, many researches have been made in the art about substances that can be moisturized to the skin by being included in cosmetics. As a result, when mushroom extracts are contained in cosmetics, the moisturizing function of the mushroom cell wall material is moisturized. It has been found that the cosmetic composition having can be provided. For example, a cosmetic composition having a whitening effect and a moisturizing effect using a mixture extracted and concentrated from a cultivated mushroom of a mushroom is disclosed in Japanese Patent Application Laid-Open No. 05-286843. However, it has not yet been identified which substance of the skirt mushroom extract has a whitening or moisturizing effect in cosmetics.

Thus, the present inventors attempted to identify the components exhibiting the activity in the cosmetics of the ingredients of the skirt mushroom, As a result, beta-1,6-branch-beta-1,3-glucan produced by the liquid culture of the skirt mushroom It has been found that it has a skin moisturizing effect, and furthermore, it has been found that beta-1,6-branch-beta-1,3-glucan may provide an elevated moisturizing effect than other known moisturizers such as hyaluronic acid. The present invention has been completed regarding a moisturizing cosmetic composition which can provide excellent skin moisturizing effect.

Accordingly, it is an object of the present invention to provide a moisturizing cosmetic composition.

In order to achieve the above object, the moisturizing cosmetic composition of the present invention is 0.1 to 10% by weight of the beta-1,6-branch-beta-1,3-glucan prepared by liquid culture of the skirt mushroom It is characterized by containing in the amount of.

In addition, the moisturizing cosmetic composition according to the invention is characterized in that it further contains a known hyaluronic acid in an amount of 0.1 to 10% by weight based on the total weight of the composition.

Other objects and applications of the present invention will become apparent from the following detailed description.

Hereinafter, the present invention will be described in more detail.

Beta-1,6-branch-beta-1,3-glucan (hereinafter referred to as "SC-glucan") prepared by the liquid culture of Schizophyllum commune Fr. Is a glucan having beta-1,6-residues at every three residues of the beta-1,3 main sugar chain, and is uniformly branched compared to the beta-glucan of other mushrooms having a heterogeneous sugar composition and structure. It has a unique structure, stable neutral polysaccharides secreted extracellularly, and consists only of glucose. In addition, the molecular weight (MW) of SC-glucan is 2 to 5 million, which is considerably larger than that of beta-glucan produced from other mushrooms in the range of several hundred thousand to 2 million.

Such SC-glucan can be provided by liquid culture of the chia mushroom, the liquid culture method for separating the SC- glucan from the chia mushroom and a method for increasing its productivity have already been developed and applied by the applicant [ Patent Application No. 1998-49026.

Therefore, the moisturizing cosmetic composition of the present invention contains SC-glucan obtained by liquid culture by the method described in the patent application specification in an amount of 0.1 to 10% by weight based on the total weight of the composition.

On the other hand, the moisturizing cosmetic composition of the present invention further contains 0.1 to 10% by weight of hyaluronic acid, which is a known moisturizer, based on the total weight of the composition, thereby further improving the moisturizing effect.

The moisturizing cosmetic composition of the present invention is not particularly limited in its formulation, and for example, has a formulation of a cream foundation, a liquid foundation, a solid foundation, a makeup lotion, a makeup base, an emollient cream, a moisturizing cream, and a skin lotion.

In addition, in the cosmetic composition of each formulation, other components other than the above-mentioned SC-glucan, hyaluronic acid can be appropriately selected and blended by those skilled in the art without difficulty according to the formulation or purpose of use of other cosmetics.

Hereinafter, the present invention will be described in more detail with reference to test examples and formulation examples. However, the present invention is not limited only to these formulation examples.

<Test Example 1> Moisturizing effect measurement

Capacitance measurement method using Corneometer CM820 was used, and the sample was prepared by dissolving beta-1,6-branch-beta-1,3-glucan in an amount of 0.4% by weight and a moisturizing substance as a control. Moisturize using a known 0.5% of hyaluronic acid dissolved with 0.2% concentration of hyaluronic acid in 0.3% by weight of beta-1,6-branch-beta-1,3-glucan to determine the synergy effect. The effect was measured. That is, a total of 40 men and 20 men and women each were subjected to adaptation for 20 minutes in the constant temperature and humidity chamber for 20 minutes immediately before the start of the test. Subsequently, the initial moisture retention amount of each sample application site was measured using the Corneo Meta CM820, and then the sample was applied. The application of the sample was applied while varying the position of the sample to be applied to each subject in order to minimize the error according to the Habakku region 60 μl sample. 20 minutes after application of the target, the rate of increase in moisture was measured first, and the rate of increase in moisture was again measured after 2 hours. Each measurement site was repeatedly measured three times, and the skin moisture increase and decrease rate was calculated according to Equation 1 as the average value, and the results are shown in Table 1 and FIG. 1.

Where Tdi is the nth measured value of the sample coating area.

Tdo: Measured value before application of sample application site

NTdi: nth measurement of the area where the sample is not applied

NTdo: Measured value before application of the sample unapplied

0.5% hyaluronic acid 0.4% beta-1,6-branch-beta-1,3-glucan 0.2% hyaluronic acid + 0.3% beta-1,6-branch-beta-1,3-glucan 20 minutes 32.82 43.79 54.56 120 minutes 10.28 27.49 35.45

From Table 1 and Figure 1, it can be seen that beta-1,6-branch-beta-1,3-glucan derived from the skirt mushroom is a material having excellent water retention. Furthermore, beta-1,6-branch-beta-l, 3-glucan can further enhance the moisturizing effect when used with hyaluronic acid, a known moisturizer.

<Test Example 2> Improvement of skin moisturizing effect on human body

The cream foundation of the following composition was compared and evaluated for the effect of improving skin moisturizing for 40 subjects with dry skin of 35 to 45 years old.

Example 1 Example 2 Comparative Example 1 Comparative Example 2  1.beta-1,6-branch-beta-1,3-glucan 4.0 3.0 0 0  2. Hyaluronic Acid 0 2.0 5.0 0  3. ceresin 1.0 1.0 1.0 1.0  4. Candelilla Wax 2.0 2.0 2.0 2.0  5. Ozokerite 2.0 2.0 2.0 2.0  6. Hexyllaurate 3.0 3.0 3.0 3.0  7. Sesquioleate Sorbitane 1.0 1.0 1.0 1.0  8. Squalane 3.0 3.0 3.0 3.0  9. Cetyl Dimethicone Copolyol 2.0 2.0 2.0 2.0 10. Dimethicone 1.0 1.0 1.0 1.0 11.silicone gel 15.0 15.0 15.0 15.0 12. Cyclomethicone 10.0 10.0 10.0 10.0 13. Colorant 15.0 15.0 15.0 15.0 14. Distilled Water to 100 to 100 to 100 to 100 15. Glycerin 5.0 5.0 5.0 5.0 16. Preservative Quantity Quantity Quantity Quantity 17. Incense Quantity Quantity Quantity Quantity * Coloring agent: 70.0% of phosphate only, iron oxide 20.0%, talc 10.0% are mixed uniformly, and then pulverized twice.

That is, in Example 1 for the right side of the face of the subjects of Group 1, Example 2 for the left quartile, Comparative Example 1 for the right side of the subject of another group 2, Comparative Example 2 for the left quartile, respectively. After applying to all 40 persons, the moisturizing power against the change of the skin moisturizing state was measured in the same manner as in Test Example 1, and the results are shown in Table 2 and FIG. 2.

Example 1 Example 2 Comparative Example 1 Comparative Example 2 20 minutes 21.59 28.65 14.55 4.56 120 minutes 13.85 18.75 5.88 0.55

From Table 2 and Figure 2, the cosmetics of Example 1 containing beta-1,6-branch-beta-1,3-glucan derived from the skirt mushroom has a superior moisturizing effect than the cosmetics of Comparative Examples 1 and 2 It can be seen that the cosmetic of Example 2, which further contains hyaluronic acid in beta-1,6-branch-beta-1,3-glucan, has an increased moisturizing effect than Example 1.

Hereinafter, the structure of the moisturizing cosmetic composition containing the formulation examples 1-11 containing beta-1,6- branched-beta-1,3- glucan is demonstrated more concretely. However, the composition of the present invention is not limited to these formulation examples.

<Formulation Examples 1 to 4> Water-in-oil type emulsion foundation

Formulation Example 1 Formulation Example 2 Formulation Example 3 Formulation Example 4 Cream Foundation Liquid Foundation Makeup lotion Makeup base  1.beta-1,6-branch-beta-1,3-glucan 1.0 1.0 1.0 1.0  2. ceresin 1.0 0.5 0.5 1.0  3. Candelilla Wax 2.0 0.5 0.5 1.0  4. Ozokerite 2.0 0.5 0.5 2.0  5. Hexyllaurate 3.0 2.0 2.0 3.0  6. Sesquioleate Sorbitane 1.0 1.0 1.0 1.0  7. Squalane 3.0 2.0 2.0 3.0  8. Cetyl Dimethicone Copolyol 2.0 2.0 2.0 2.0  9. Dimethicone 1.0 0.5 0.5 1.0 10. Silicone gel 15.0 5.0 5.0 10.0 11. Cyclomethicone 10.0 5.0 5.0 10.0 12. Colorant 15.0 10.0 5.0 7.0 13. Distilled Water to 100 to 100 to 100 to 100 14. Glycerin 5.0 7.0 10.0 10.0 15. Preservative Quantity Quantity Quantity Quantity 16. Incense Quantity Quantity Quantity Quantity * Coloring agent: 70.0% of phosphate only, iron oxide 20.0%, talc 10.0% are mixed uniformly, and then pulverized twice.

Formulation Examples 5 to 8 Oil-in-water Emulsion Foundation

Formulation Example 5 Formulation Example 6 Formulation Example 7 Formulation Example 8 Cream Foundation Liquid Foundation Makeup lotion Makeup base  1.beta-1,6-branch-beta-1,3-glucan 1.0 1.0 1.0 1.0  2. Beeswax 1.0 0.5 0.5 1.0  3. Paraffin Wax 1.0 0.5 0.5 1.0  4. Stearic acid 2.0 2.0 1.0 2.0  5. Glyceryl Monostearic Acid 2.5 1.0 0.5 2.0  6. Sesquioleate Sorbitane 0.5 0.5 0.5 0.5  7. Sorbent monostearate 2.0 1.0 1.0 2.0  8. Squalane 3.0 2.0 2.0 2.0  9. Tri (capryl, caprylic acid) glycerin 3.0 2.0 2.0 3.0 10. Lanolin 5.0 3.0 2.0 4.0 11.silicone gel 5.0 3.0 3.0 4.0 12. Dimethicone 1.0 0.5 0.5 1.0 13. Cyclomethicone 5.0 2.0 2.0 5.0 14. Colorant 15.0 10.0 5.0 7.0 15. Distilled Water to 100 to 100 to 100 to 100 16. Glycerin 5.0 5.0 5.0 5.0 17. 1,3 butylene glycol 5.0 5.0 5.0 5.0 18. Triethanolamine 0.2 0.2 0.1 0.2 19. Preservatives Quantity Quantity Quantity Quantity 20. Incense Quantity Quantity Quantity Quantity * Coloring agent: 70.0% of phosphate only, iron oxide 20.0%, talc 10.0% are mixed uniformly, and then pulverized twice.

<Formulation Examples 9-11>

Formulation Example 9 Formulation Example 10 Formulation Example 11 Emollient cream Moisturizing lotion Skin lotion  1.beta-1,6-branch-beta-1,3-glucan 1.0 1.0 1.0  2. Cetostearyl Alcohol 3.0 1.5 0  3. Glyceryl Monostearic Acid 2.0 0.5 0  4. Stearic acid 2.0 0.5 0  5. Squalane 10.0 5.0 0  6. Sesquioleate Sorbitane 0.5 0.3 0  7. Polysorbate 1.5 1.0 0  8. Tri (capryl, caprylic acid) glycerin 5.0 2.0 0  9. Dimethicone 1.0 1.0 0 10. Polyoxyethylene Cured Castor Oil 0 0 0.5 11.Ethyl Alcohol (95%) 0 0 10.0 12. Distilled Water to 100 to 100 to 100 13. Carboxyvinyl Polymer 0 0.2 0.2 14. Xanthan Gum 0 0.1 0.1 15. Glycerin 7.0 5.0 10.0 16. 1,3 butylene glycol 2.0 5.0 5.0 17. Triethanolamine 0.2 0.2 0.2 18. Preservative Quantity Quantity Quantity 19. Incense Quantity Quantity Quantity

As described above, beta-1,6-branch-beta-1,3-glucan prepared by the liquid culture of Schizophyllum commune Fr. in a cosmetic composition can provide excellent skin moisturizing effect. Can be. Moreover, beta-1,6-branch-beta-1,3-glucan can provide a more elevated moisturizing effect when used in cosmetics with known moisturizers.

1 is a skin moisturizing efficacy test results of beta-1,6-branch-beta-1,3-glucan.

Figure 2 is a skin moisturizing efficacy test results of the human body of the cosmetic composition containing beta-1,6-branch-beta-1,3-glucan.

Claims (3)

Beta-1,6-branched-beta-1,3-glucan (β-1,6-branched-β-1,3-glucan) prepared by liquid culture of Schizophyllum commune Fr. Moisturizing cosmetic composition, characterized in that contained in an amount of 0.1 to 10% by weight based on the weight. The moisturizing cosmetic composition according to claim 1, further comprising hyaluronic acid in an amount of 0.1 to 10% by weight based on the total weight of the composition. The moisturizing cosmetic composition according to claim 1 or 2, wherein the composition has a formulation of a cream foundation, a liquid foundation, a solid foundation, a makeup lotion, an emollient cream, a moisturizing cream, and a skin lotion.