JPS62126185A - イソフラボン誘導体含有溶液の製造方法 - Google Patents
イソフラボン誘導体含有溶液の製造方法Info
- Publication number
- JPS62126185A JPS62126185A JP26612485A JP26612485A JPS62126185A JP S62126185 A JPS62126185 A JP S62126185A JP 26612485 A JP26612485 A JP 26612485A JP 26612485 A JP26612485 A JP 26612485A JP S62126185 A JPS62126185 A JP S62126185A
- Authority
- JP
- Japan
- Prior art keywords
- solvent
- organic solvent
- pueraria
- root
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229930012930 isoflavone derivative Natural products 0.000 title claims abstract description 19
- 150000002515 isoflavone derivatives Chemical class 0.000 title claims abstract description 19
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000003960 organic solvent Substances 0.000 claims abstract description 16
- 229920005989 resin Polymers 0.000 claims abstract description 16
- 239000011347 resin Substances 0.000 claims abstract description 16
- 239000002904 solvent Substances 0.000 claims abstract description 9
- 239000012046 mixed solvent Substances 0.000 claims abstract description 8
- 229920003002 synthetic resin Polymers 0.000 claims abstract description 5
- 238000000034 method Methods 0.000 claims description 18
- 238000001179 sorption measurement Methods 0.000 claims description 14
- 235000010575 Pueraria lobata Nutrition 0.000 claims description 4
- 239000000057 synthetic resin Substances 0.000 claims description 2
- 241000219781 Pueraria montana var. lobata Species 0.000 claims 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract description 36
- 238000010828 elution Methods 0.000 abstract description 7
- 241000219780 Pueraria Species 0.000 abstract description 6
- 229920002472 Starch Polymers 0.000 abstract description 5
- 235000019698 starch Nutrition 0.000 abstract description 5
- 239000008107 starch Substances 0.000 abstract description 5
- 239000003463 adsorbent Substances 0.000 abstract description 4
- 239000003814 drug Substances 0.000 abstract description 4
- 239000002952 polymeric resin Substances 0.000 abstract description 3
- CHRJZRDFSQHIFI-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;styrene Chemical compound C=CC1=CC=CC=C1.C=CC1=CC=CC=C1C=C CHRJZRDFSQHIFI-UHFFFAOYSA-N 0.000 abstract description 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 235000010804 Maranta arundinacea Nutrition 0.000 description 15
- 244000145580 Thalia geniculata Species 0.000 description 15
- 235000012419 Thalia geniculata Nutrition 0.000 description 15
- ZQSIJRDFPHDXIC-UHFFFAOYSA-N daidzein Chemical compound C1=CC(O)=CC=C1C1=COC2=CC(O)=CC=C2C1=O ZQSIJRDFPHDXIC-UHFFFAOYSA-N 0.000 description 14
- 239000000243 solution Substances 0.000 description 13
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- 235000007240 daidzein Nutrition 0.000 description 7
- 238000000605 extraction Methods 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- 239000003125 aqueous solvent Substances 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 244000046146 Pueraria lobata Species 0.000 description 3
- 238000000746 purification Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 239000002699 waste material Substances 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 241000220485 Fabaceae Species 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- RXUWDKBZZLIASQ-UHFFFAOYSA-N Puerarin Natural products OCC1OC(Oc2c(O)cc(O)c3C(=O)C(=COc23)c4ccc(O)cc4)C(O)C(O)C1O RXUWDKBZZLIASQ-UHFFFAOYSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 238000004440 column chromatography Methods 0.000 description 2
- 239000012156 elution solvent Substances 0.000 description 2
- HKEAFJYKMMKDOR-VPRICQMDSA-N puerarin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1C1=C(O)C=CC(C2=O)=C1OC=C2C1=CC=C(O)C=C1 HKEAFJYKMMKDOR-VPRICQMDSA-N 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- HIBWGGKDGCBPTA-UHFFFAOYSA-N C=CC1=CC=CC=C1.C=CC1=CC=CC=C1 Chemical compound C=CC1=CC=CC=C1.C=CC1=CC=CC=C1 HIBWGGKDGCBPTA-UHFFFAOYSA-N 0.000 description 1
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 230000002921 anti-spasmodic effect Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 229920001429 chelating resin Polymers 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229910003460 diamond Inorganic materials 0.000 description 1
- 239000010432 diamond Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 229910000037 hydrogen sulfide Inorganic materials 0.000 description 1
- 229940046892 lead acetate Drugs 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- KKCBUQHMOMHUOY-UHFFFAOYSA-N sodium oxide Chemical compound [O-2].[Na+].[Na+] KKCBUQHMOMHUOY-UHFFFAOYSA-N 0.000 description 1
- 229910001948 sodium oxide Inorganic materials 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
Landscapes
- Saccharide Compounds (AREA)
- Pyrane Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP26612485A JPS62126185A (ja) | 1985-11-28 | 1985-11-28 | イソフラボン誘導体含有溶液の製造方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP26612485A JPS62126185A (ja) | 1985-11-28 | 1985-11-28 | イソフラボン誘導体含有溶液の製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS62126185A true JPS62126185A (ja) | 1987-06-08 |
| JPH0421669B2 JPH0421669B2 (enrdf_load_stackoverflow) | 1992-04-13 |
Family
ID=17426658
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP26612485A Granted JPS62126185A (ja) | 1985-11-28 | 1985-11-28 | イソフラボン誘導体含有溶液の製造方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS62126185A (enrdf_load_stackoverflow) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5919921A (en) * | 1996-06-11 | 1999-07-06 | Protein Technologies International, Inc. | Recovery of isoflavones from soy molasses |
| US6083553A (en) * | 1998-06-05 | 2000-07-04 | Protein Technologies International, Inc. | Recovery of isoflavones from soy molasses |
| JP2002097149A (ja) * | 2000-09-20 | 2002-04-02 | Noevir Co Ltd | 皮膚外用剤 |
| US6703051B1 (en) | 1998-10-13 | 2004-03-09 | Solae, Llc | Process for separating and recovering protein and isoflavones from a plant material |
| CN1296049C (zh) * | 2004-02-25 | 2007-01-24 | 北京同仁堂科技发展股份有限公司制药厂 | 治疗心血管疾病的缓释制剂及其制备方法、质量控制方法 |
| CN103145858A (zh) * | 2013-03-19 | 2013-06-12 | 湖南省强生药业有限公司 | 一种从葛根中提取富含黄酮的葛根淀粉的方法 |
| CN103554276A (zh) * | 2013-10-15 | 2014-02-05 | 温天文 | 用有机膜提取葛根中淀粉、纤维素及总黄酮的工艺方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5133167A (enrdf_load_stackoverflow) * | 1974-06-05 | 1976-03-22 | Sarubadooru Montagyuto Gy Hose | |
| JPS59187746A (ja) * | 1983-04-11 | 1984-10-24 | Hayashibara Biochem Lab Inc | 飲食物とその製造方法 |
-
1985
- 1985-11-28 JP JP26612485A patent/JPS62126185A/ja active Granted
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5133167A (enrdf_load_stackoverflow) * | 1974-06-05 | 1976-03-22 | Sarubadooru Montagyuto Gy Hose | |
| JPS59187746A (ja) * | 1983-04-11 | 1984-10-24 | Hayashibara Biochem Lab Inc | 飲食物とその製造方法 |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6706292B2 (en) | 1996-06-11 | 2004-03-16 | Solae, Llc | Recovery of isoflavones from soy molasses |
| US6323018B1 (en) | 1996-06-11 | 2001-11-27 | Protein Technologies Int'l Lnc. | Recovery of isoflavones from soy molasses |
| US5919921A (en) * | 1996-06-11 | 1999-07-06 | Protein Technologies International, Inc. | Recovery of isoflavones from soy molasses |
| US6495141B2 (en) | 1996-06-11 | 2002-12-17 | Protein Technologies International, Inc. | Recovery of isoflavones from soy molasses |
| US6664382B2 (en) | 1996-06-11 | 2003-12-16 | Solae, Llc | Recovery of isoflavones from soy molasses |
| US6680381B1 (en) | 1996-06-11 | 2004-01-20 | Solae, Llc | Recovery of isoflavones from soy molasses |
| US6083553A (en) * | 1998-06-05 | 2000-07-04 | Protein Technologies International, Inc. | Recovery of isoflavones from soy molasses |
| US6703051B1 (en) | 1998-10-13 | 2004-03-09 | Solae, Llc | Process for separating and recovering protein and isoflavones from a plant material |
| JP2002097149A (ja) * | 2000-09-20 | 2002-04-02 | Noevir Co Ltd | 皮膚外用剤 |
| CN1296049C (zh) * | 2004-02-25 | 2007-01-24 | 北京同仁堂科技发展股份有限公司制药厂 | 治疗心血管疾病的缓释制剂及其制备方法、质量控制方法 |
| CN103145858A (zh) * | 2013-03-19 | 2013-06-12 | 湖南省强生药业有限公司 | 一种从葛根中提取富含黄酮的葛根淀粉的方法 |
| CN103145858B (zh) * | 2013-03-19 | 2015-07-01 | 湖南省强生药业有限公司 | 一种从葛根中提取富含黄酮的葛根淀粉的方法 |
| CN103554276A (zh) * | 2013-10-15 | 2014-02-05 | 温天文 | 用有机膜提取葛根中淀粉、纤维素及总黄酮的工艺方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0421669B2 (enrdf_load_stackoverflow) | 1992-04-13 |
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