JPS6191196A - 新規な５―フルオロ―２´―デオキシウリジン―５´―ホスフェート誘導体およびその塩並びにそれらを含有する抗腫瘍剤 - Google Patents

新規な５―フルオロ―２´―デオキシウリジン―５´―ホスフェート誘導体およびその塩並びにそれらを含有する抗腫瘍剤

Info

Publication number
JPS6191196A
JPS6191196A JP21052584A JP21052584A JPS6191196A JP S6191196 A JPS6191196 A JP S6191196A JP 21052584 A JP21052584 A JP 21052584A JP 21052584 A JP21052584 A JP 21052584A JP S6191196 A JPS6191196 A JP S6191196A
Authority
JP
Japan
Prior art keywords
fluoro
general formula
salts
compound represented
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP21052584A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0153879B2 (enrdf_load_stackoverflow
Inventor
Takako Hori
堀　孝子
Isao Myokan
勇雄 明官
Maki Miyahara
宮原　真樹
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyama Chemical Co Ltd
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Priority to JP21052584A priority Critical patent/JPS6191196A/ja
Priority to US06/781,988 priority patent/US4684631A/en
Priority to GB08524309A priority patent/GB2166740B/en
Priority to DE19853535766 priority patent/DE3535766A1/de
Priority to FR8514854A priority patent/FR2571374B1/fr
Priority to DK457985A priority patent/DK166830B1/da
Priority to CH4339/85A priority patent/CH670091A5/de
Priority to SE8504657A priority patent/SE466151B/sv
Priority to BE0/215692A priority patent/BE903389A/fr
Priority to NL8502739A priority patent/NL8502739A/nl
Publication of JPS6191196A publication Critical patent/JPS6191196A/ja
Priority to US07/050,559 priority patent/US4740503A/en
Publication of JPH0153879B2 publication Critical patent/JPH0153879B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP21052584A 1984-10-09 1984-10-09 新規な５―フルオロ―２´―デオキシウリジン―５´―ホスフェート誘導体およびその塩並びにそれらを含有する抗腫瘍剤 Granted JPS6191196A (ja)

Priority Applications (11)

Application Number Priority Date Filing Date Title
JP21052584A JPS6191196A (ja) 1984-10-09 1984-10-09 新規な５―フルオロ―２´―デオキシウリジン―５´―ホスフェート誘導体およびその塩並びにそれらを含有する抗腫瘍剤
US06/781,988 US4684631A (en) 1984-10-09 1985-09-30 Novel 5-fluoro-2-deoxyuridine derivatives and salts thereof, process for producing the same, and antitumor agents containing the same
GB08524309A GB2166740B (en) 1984-10-09 1985-10-02 5-fluoro-2-deoxyuridine derivatives
DE19853535766 DE3535766A1 (de) 1984-10-09 1985-10-07 Neue 5-fluor-2'-desoxyuridin-derivate und salze derselben, verfahren zur herstellung derselben und anti-tumormittel mit einem gehalt derselben
DK457985A DK166830B1 (da) 1984-10-09 1985-10-08 5-fluor-2'-deoxyuridin-3',5'-derivater, hydrater og salte heraf, fremgangsmaade til fremstilling af disse samt antitumorpraeparater indeholdende disse derivater
FR8514854A FR2571374B1 (fr) 1984-10-09 1985-10-08 Nouveaux derives de 5-fluoro-2'-desoxyuridine et leurs sels, leur procede de preparation, et agents antitumoraux les contenant
CH4339/85A CH670091A5 (enrdf_load_stackoverflow) 1984-10-09 1985-10-08
SE8504657A SE466151B (sv) 1984-10-09 1985-10-08 Nya 5-fluor-2'-deoxiuridinderivat och salter daerav, foerfarande foer deras framstaellning och antitumoermedel innehaallande dessa
BE0/215692A BE903389A (fr) 1984-10-09 1985-10-08 Nouveaux derives de 5-fluoro-2'-desoxyuridine et leurs sels, leur procede de preparation, etagents antitumoraux les contenant
NL8502739A NL8502739A (nl) 1984-10-09 1985-10-08 Nieuwe 5-fluor-2'-deoxyuridine-derivaten en zouten daarvan, werkwijze voor het bereiden daarvan en antitumor-preparaten die ze bevatten.
US07/050,559 US4740503A (en) 1984-10-09 1987-05-18 Novel 5-fluoro-2'-deoxyuridine derivatives and salts thereof, process for producing the same, and antitumor agents containing the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP21052584A JPS6191196A (ja) 1984-10-09 1984-10-09 新規な５―フルオロ―２´―デオキシウリジン―５´―ホスフェート誘導体およびその塩並びにそれらを含有する抗腫瘍剤

Publications (2)

Publication Number Publication Date
JPS6191196A true JPS6191196A (ja) 1986-05-09
JPH0153879B2 JPH0153879B2 (enrdf_load_stackoverflow) 1989-11-15

Family

ID=16590805

Family Applications (1)

Application Number Title Priority Date Filing Date
JP21052584A Granted JPS6191196A (ja) 1984-10-09 1984-10-09 新規な５―フルオロ―２´―デオキシウリジン―５´―ホスフェート誘導体およびその塩並びにそれらを含有する抗腫瘍剤

Country Status (1)

Country Link
JP (1) JPS6191196A (enrdf_load_stackoverflow)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5032680A (en) * 1988-02-29 1991-07-16 Kuraray Co., Ltd. 2'-deoxy-5-fluorouridine derivatives
US7749983B2 (en) 2006-05-03 2010-07-06 Chimerix, Inc. Metabolically stable alkoxyalkyl esters of antiviral or antiproliferative phosphonates, nucleoside phosphonates and nucleoside phosphates

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57106696A (en) * 1980-12-25 1982-07-02 Teijin Ltd 1-(beta-d-arabinofuranosyl)cytosine derivative and its preparation
JPS58192899A (ja) * 1982-05-06 1983-11-10 Teijin Ltd ３′−アシル−５−フルオロ−２′−デオキシウリジン誘導体及びその製造法
JPS5970699A (ja) * 1982-10-13 1984-04-21 Teijin Ltd ５−フルオロ−２′−デオキシウリジン誘導体及びその製造法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57106696A (en) * 1980-12-25 1982-07-02 Teijin Ltd 1-(beta-d-arabinofuranosyl)cytosine derivative and its preparation
JPS58192899A (ja) * 1982-05-06 1983-11-10 Teijin Ltd ３′−アシル−５−フルオロ−２′−デオキシウリジン誘導体及びその製造法
JPS5970699A (ja) * 1982-10-13 1984-04-21 Teijin Ltd ５−フルオロ−２′−デオキシウリジン誘導体及びその製造法

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5032680A (en) * 1988-02-29 1991-07-16 Kuraray Co., Ltd. 2'-deoxy-5-fluorouridine derivatives
US7749983B2 (en) 2006-05-03 2010-07-06 Chimerix, Inc. Metabolically stable alkoxyalkyl esters of antiviral or antiproliferative phosphonates, nucleoside phosphonates and nucleoside phosphates
US7994143B2 (en) 2006-05-03 2011-08-09 Chimerix, Inc. Metabolically stable alkoxyalkyl esters of antiviral or antiproliferative phosphonates, nucleoside phosphonates and nucleoside phosphates

Also Published As

Publication number Publication date
JPH0153879B2 (enrdf_load_stackoverflow) 1989-11-15

Similar Documents

Publication Publication Date Title
US9315523B2 (en) Cyclic dinucleosides
AU2016240117B2 (en) Novel compound of 4'-thionucleoside, as well as preparation method therefor, pharmaceutical composition thereof and application thereof
KR102695300B1 (ko) 인산염 유도체의 합성
US10774104B2 (en) Diastereoselective synthesis of phosphate derivatives
KR20170073649A (ko) 치환된 뉴클레오시드 유사체의 제조 방법
JPH03145497A (ja) 抗ウイルス性化合物
WO2017045583A1 (zh) 一种富集了nuc‐1031单一异构体的组合物及其制备方法和用途
US11414451B2 (en) Floxuridine synthesis
JPH06228186A (ja) ２’−デオキシ−（２’ｓ）−アルキルピリミジンヌクレオシド誘導体
WO1984000759A1 (fr) Derives de desoxyuridine, leurs procedes de preparation et leur utilisation comme produits pharmaceutiques
SK14842001A3 (sk) Aromatické amidy substituované ribózou, spôsob a medziprodukty na ich výrobu, ich použitie a farmaceutické kompozície na ich báze
JPH0136838B2 (enrdf_load_stackoverflow)
JPS6191196A (ja) 新規な５―フルオロ―２´―デオキシウリジン―５´―ホスフェート誘導体およびその塩並びにそれらを含有する抗腫瘍剤
CN111393405B (zh) 一类含氟取代的苯并噻吩类化合物及其药物组合物及应用
JPH0517920B2 (enrdf_load_stackoverflow)
JPH06211890A (ja) ２’−デオキシ−２’（ｓ）−置換アルキルシチジン誘導体
US4740503A (en) Novel 5-fluoro-2'-deoxyuridine derivatives and salts thereof, process for producing the same, and antitumor agents containing the same
GB2025419A (en) M 1 d-arabinofuranosylcytosine-5-oleyl phosphate
JPS61238797A (ja) 新規な５−フルオロ−２′−デオキシウリジン−３′−ホスフエ−ト誘導体およびその塩
JPS61171498A (ja) 新規な５−フルオロ−２′−デオキシウリジン−３′−ホスフエ−ト誘導体およびその塩
Páv et al. A new class of phosphanucleosides containing a 3-hydroxy-1-hydroxymethylphospholane 1-oxide ring
EP0355899B1 (en) Nucleotide derivatives
JP4211901B2 (ja) ４’−メチルヌクレオシド化合物
JPH02157292A (ja) ２’−デオキシ−２’−メチリデンピリミジンヌクレオチド化合物
JPS6191195A (ja) 新規な５−フルオロ−２′−デオキシウリジン−５′−ホスフエ−ト誘導体およびその塩