JPS6176414A - リポソーム製剤の製法 - Google Patents

リポソーム製剤の製法

Info

Publication number
JPS6176414A
JPS6176414A JP59199011A JP19901184A JPS6176414A JP S6176414 A JPS6176414 A JP S6176414A JP 59199011 A JP59199011 A JP 59199011A JP 19901184 A JP19901184 A JP 19901184A JP S6176414 A JPS6176414 A JP S6176414A
Authority
JP
Japan
Prior art keywords
liposome
active ingredients
freeze
liposomes
dried
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP59199011A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0468284B2 (https=
Inventor
Hiroaki Jizoumoto
地蔵本　博章
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Priority to JP59199011A priority Critical patent/JPS6176414A/ja
Priority to EP85111012A priority patent/EP0179237A1/en
Priority to US06/777,675 priority patent/US4762720A/en
Priority to GB08523309A priority patent/GB2164624A/en
Publication of JPS6176414A publication Critical patent/JPS6176414A/ja
Publication of JPH0468284B2 publication Critical patent/JPH0468284B2/ja
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP59199011A 1984-09-21 1984-09-21 リポソーム製剤の製法 Granted JPS6176414A (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP59199011A JPS6176414A (ja) 1984-09-21 1984-09-21 リポソーム製剤の製法
EP85111012A EP0179237A1 (en) 1984-09-21 1985-08-31 Process for preparing liposome compositions
US06/777,675 US4762720A (en) 1984-09-21 1985-09-19 Process for preparing liposome compositions
GB08523309A GB2164624A (en) 1984-09-21 1985-09-20 Process for preparing liposome compositions

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59199011A JPS6176414A (ja) 1984-09-21 1984-09-21 リポソーム製剤の製法

Publications (2)

Publication Number Publication Date
JPS6176414A true JPS6176414A (ja) 1986-04-18
JPH0468284B2 JPH0468284B2 (https=) 1992-11-02

Family

ID=16400622

Family Applications (1)

Application Number Title Priority Date Filing Date
JP59199011A Granted JPS6176414A (ja) 1984-09-21 1984-09-21 リポソーム製剤の製法

Country Status (4)

Country Link
US (1) US4762720A (https=)
EP (1) EP0179237A1 (https=)
JP (1) JPS6176414A (https=)
GB (1) GB2164624A (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005508921A (ja) * 2001-10-03 2005-04-07 セレイター テクノロジーズ インコーポレーティッド 金属イオンをローディングするリポソーム

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5916588A (en) * 1984-04-12 1999-06-29 The Liposome Company, Inc. Peptide-containing liposomes, immunogenic liposomes and methods of preparation and use
US6090406A (en) * 1984-04-12 2000-07-18 The Liposome Company, Inc. Potentiation of immune responses with liposomal adjuvants
US4885172A (en) * 1985-06-26 1989-12-05 The Liposome Company, Inc. Composition for targeting, storing and loading of liposomes
US5171578A (en) * 1985-06-26 1992-12-15 The Liposome Company, Inc. Composition for targeting, storing and loading of liposomes
US5252263A (en) * 1986-06-16 1993-10-12 The Liposome Company, Inc. Induction of asymmetry in vesicles
US5204112A (en) * 1986-06-16 1993-04-20 The Liposome Company, Inc. Induction of asymmetry in vesicles
EP0274219A3 (en) * 1986-12-04 1988-08-03 Takeda Chemical Industries, Ltd. Interleukin-2-containing liposome composition and method for the production thereof
US4963297A (en) * 1987-12-22 1990-10-16 The Liposome Company, Inc. Spontaneous vesticulation of multilamellar liposomes
WO1988007852A1 (en) * 1987-04-06 1988-10-20 Innovative Therapeutics Corporation Liposome entrapped magnesium
US5830498A (en) * 1987-10-16 1998-11-03 Board Of Regents, The University Of Texas System Liposomal-polyene preliposomal powder and method for its preparation
US5178875A (en) * 1991-01-14 1993-01-12 The Board Of Regents, The University Of Texas System Liposomal-polyene preliposomal powder and method for its preparation
US4950432A (en) * 1987-10-16 1990-08-21 Board Of Regents, The University Of Texas System Polyene microlide pre-liposomal powders
JPH03502574A (ja) * 1987-12-03 1991-06-13 ザ　リポソーム　カンパニー，インコーポレイテッド メチルセルロース製薬学的組成物
ATE118348T1 (de) * 1987-12-04 1995-03-15 Liposome Co Inc Liposome hoher stabilität und verfahren zur herstellung und verwendung.
JPH03501732A (ja) * 1987-12-22 1991-04-18 ザ　リポソーム　カンパニー，インコーポレイテッド 多重ラメラリポソームの自発的小胞化方法
US4921644A (en) * 1988-02-29 1990-05-01 Technology Unlimited, Inc. Mucin directed lipsome
FR2638639A1 (fr) * 1988-11-08 1990-05-11 Parincos Parfumerie Cosmet Int Composition et procede d'obtention de liposomes oligolamellaires en vue d'une application en cosmetologie et dermatologie topique
ATE135200T1 (de) * 1989-05-17 1996-03-15 Res Corp Technologies Inc Verfahren und zusammensetzung zur thrombosebehandlung beim säugetier
US5227170A (en) * 1989-06-22 1993-07-13 Vestar, Inc. Encapsulation process
JP2880800B2 (ja) * 1989-06-22 1999-04-12 ネクスター・フアーマシユーテイカルズ・インコーポレイテツド カプセル化方法
US5290563A (en) * 1989-07-27 1994-03-01 Laboratoire Des Stallergenes Method for combining a mixture of heterogeneous substances with liposomes
US5246707A (en) * 1990-04-26 1993-09-21 Haynes Duncan H Sustained release delivery of water-soluble bio-molecules and drugs using phospholipid-coated microcrystals, microdroplets and high-concentration liposomes
US5091188A (en) * 1990-04-26 1992-02-25 Haynes Duncan H Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs
FR2677248B1 (fr) * 1991-06-04 1995-06-16 Lvmh Rech Gie Composition cosmetique ou pharmaceutique, notamment dermatologique, contenant un extrait de brunelle.
US5665381A (en) * 1992-02-25 1997-09-09 Nexstar Pharmaceuticals, Inc. Inhibition of aggregation of drug containing particles
WO1994012155A1 (en) * 1992-12-02 1994-06-09 Vestar, Inc. Antibiotic formulation and process
US5958449A (en) * 1992-12-02 1999-09-28 Nexstar Pharmaceuticals, Inc. Antibiotic formulation and use for bacterial infections
US5759571A (en) * 1993-05-11 1998-06-02 Nexstar Pharmaceuticals, Inc. Antibiotic formulation and use for drug resistant infections
GB9320668D0 (en) 1993-10-07 1993-11-24 Secr Defence Liposomes containing particulare materials
US5501859A (en) * 1994-03-22 1996-03-26 Walter T. Woods, Jr. Absorbable magnesium composition and method of using same
US5756122A (en) * 1995-06-07 1998-05-26 Georgetown University Liposomally encapsulated nucleic acids having high entrapment efficiencies, method of manufacturer and use thereof for transfection of targeted cells
US5738868A (en) * 1995-07-18 1998-04-14 Lipogenics Ltd. Liposome compositions and kits therefor
ATE386506T1 (de) 1995-10-17 2008-03-15 Jagotec Ag Verabreichung unlöslicher arzneistoffe
US6465016B2 (en) 1996-08-22 2002-10-15 Research Triangle Pharmaceuticals Cyclosporiine particles
US7255877B2 (en) * 1996-08-22 2007-08-14 Jagotec Ag Fenofibrate microparticles
WO1998046632A2 (de) * 1997-04-11 1998-10-22 Wilex Biotechnology Gmbh Inhibitoren für den urokinaserezeptor
DE69908304T2 (de) * 1998-02-11 2004-02-19 Rtp Pharma Corp. Ungesättigte fettsäure und steroide enthaltende kombinationspräparate zur behandlung von entzündungen
US6979456B1 (en) 1998-04-01 2005-12-27 Jagotec Ag Anticancer compositions
KR100635456B1 (ko) 1998-05-29 2006-10-18 스키에파마 캐나다 인코포레이티드 열보호화 마이크로입자 조성물 및 그의 말단의 스팀멸균방법
DE69912441T2 (de) 1998-08-19 2004-08-19 Skyepharma Canada Inc., Verdun Injizierbare wässerige propofoldispersionen
IL143197A0 (en) 1998-11-20 2002-04-21 Rtp Pharma Inc Dispersible phospholipid stabilized microparticles
AU7984200A (en) * 1999-09-21 2001-04-24 Skyepharma Canada Inc. Surface modified particulate compositions of biologically active substances
US7381421B2 (en) * 1999-12-13 2008-06-03 Lipoxen Technologies Limited Liposomes
EP1276465B1 (en) 2000-04-20 2014-03-12 Jagotec AG Improved water-insoluble drug particle process
WO2001082892A2 (de) * 2000-05-02 2001-11-08 Pharmacept Gmbh Wirkstoffhaltige liposome
JP4969761B2 (ja) 2000-08-31 2012-07-04 オバン・エナジー・リミテッド 所望粒度を持つ固体基材の小粒子および第一材料の小粒状物を含む相乗作用性混合物を製造する方法
US8586094B2 (en) 2000-09-20 2013-11-19 Jagotec Ag Coated tablets
NZ527408A (en) * 2001-02-22 2005-04-29 Skyepharma Canada Inc Hydroxymethylglutarylcoenzyme A (HMG CoA) reductase inhibitor (or a statin) and a fibrate in a single effective oral dosage form to treat dyslipidaemia and dyslipoproteinaemia
AU2002311617A1 (en) * 2001-06-25 2003-01-08 The Regents Of The University Of California Method for preparation of vesicles loaded with immunostimulatory oligodeoxynucleotides
US20040018237A1 (en) * 2002-05-31 2004-01-29 Perricone Nicholas V. Topical drug delivery using phosphatidylcholine
FI120642B (fi) 2007-10-19 2010-01-15 Biomed Oy Mikrokapseloidut liposomikoostumukset
US20100260830A1 (en) * 2009-04-08 2010-10-14 Brian A Salvatore Liposomal Formulations of Tocopheryl Amides
CA2922002A1 (en) 2013-09-13 2015-03-19 Arbor Therapeutics, LLC Nanoparticulate compositions for targeted delivery of lipophilic drugs and acid labile, lipophilic prodrugs of cancer chemotherapeutics and their preparation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4078052A (en) * 1976-06-30 1978-03-07 The United States Of America As Represented By The Secretary Of Health, Education And Welfare Large unilamellar vesicles (LUV) and method of preparing same
US4310506A (en) * 1979-02-22 1982-01-12 California Institute Of Technology Means of preparation and applications of liposomes containing high concentrations of entrapped ionic species

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005508921A (ja) * 2001-10-03 2005-04-07 セレイター テクノロジーズ インコーポレーティッド 金属イオンをローディングするリポソーム
JP4822666B2 (ja) * 2001-10-03 2011-11-24 セレーター ファーマシューティカルズ インコーポレイテッド 金属イオンをローディングするリポソーム

Also Published As

Publication number Publication date
GB2164624A (en) 1986-03-26
EP0179237A1 (en) 1986-04-30
US4762720A (en) 1988-08-09
JPH0468284B2 (https=) 1992-11-02
GB8523309D0 (en) 1985-10-23

Similar Documents

Publication Publication Date Title
JPS6176414A (ja) リポソーム製剤の製法
JPS6150912A (ja) リポソ−ム製剤の製造法
JP3026271B2 (ja) 活性薬剤の制御放出に用いる多小胞リポソームの調製
Yatvin et al. Clinical prospects for liposomes
US4844904A (en) Liposome composition
US4078052A (en) Large unilamellar vesicles (LUV) and method of preparing same
US4515736A (en) Method for encapsulating materials into liposomes
CA1339008C (en) Amphotericin b liposome preparation
CA1314481C (en) Liposomal preparation and antibiotic
US4485054A (en) Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV)
JPH08505882A (ja) リポソーム調製法及び物質のカプセル化方法
MXPA05001312A (es) Agregados de platino y proceso para producir los mismos.
JPH0761947B2 (ja) リン脂質ミセル粒子に被包されたアントラサイクリン抗腫瘍薬
JP2003327526A (ja) 封入された化合物のパーセントが増加したリポソーム
JP2000086501A (ja) ヒトカルシトニンのリポソーム製剤
JPH11507628A (ja) 改良されたリポソーム製剤
JPS6111931B2 (https=)
JP5126874B2 (ja) リポソーム製剤の製造方法
JP2003513901A (ja) タンパク質又はペプチドをリポソームに封入するための方法及びこの方法で調製されたリポソーム及びその使用
RU2223764C1 (ru) Способ получения липосомальной формы рифампицина
JPH06502427A (ja) 合成肺表面活性剤
WO1995026185A1 (en) Liposome with increased retention volume
JPH0363226A (ja) アドリアマイシン内包リポソーム製剤
JPH04356421A (ja) プロスタグランジン類含有脂肪小体組成物
JPH0482839A (ja) 蛋白質類・脂質小体複合体