GB2164624A - Process for preparing liposome compositions - Google Patents

Process for preparing liposome compositions Download PDF

Info

Publication number
GB2164624A
GB2164624A GB08523309A GB8523309A GB2164624A GB 2164624 A GB2164624 A GB 2164624A GB 08523309 A GB08523309 A GB 08523309A GB 8523309 A GB8523309 A GB 8523309A GB 2164624 A GB2164624 A GB 2164624A
Authority
GB
United Kingdom
Prior art keywords
vesicles
aqueous medium
freeze
cation
divalent cation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB08523309A
Other languages
English (en)
Other versions
GB8523309D0 (en
Inventor
Hiroaki Jizomoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Publication of GB8523309D0 publication Critical patent/GB8523309D0/en
Publication of GB2164624A publication Critical patent/GB2164624A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
GB08523309A 1984-09-21 1985-09-20 Process for preparing liposome compositions Withdrawn GB2164624A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59199011A JPS6176414A (ja) 1984-09-21 1984-09-21 リポソーム製剤の製法

Publications (2)

Publication Number Publication Date
GB8523309D0 GB8523309D0 (en) 1985-10-23
GB2164624A true GB2164624A (en) 1986-03-26

Family

ID=16400622

Family Applications (1)

Application Number Title Priority Date Filing Date
GB08523309A Withdrawn GB2164624A (en) 1984-09-21 1985-09-20 Process for preparing liposome compositions

Country Status (4)

Country Link
US (1) US4762720A (https=)
EP (1) EP0179237A1 (https=)
JP (1) JPS6176414A (https=)
GB (1) GB2164624A (https=)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988007852A1 (en) * 1987-04-06 1988-10-20 Innovative Therapeutics Corporation Liposome entrapped magnesium
WO1995009610A1 (en) * 1993-10-07 1995-04-13 The Secretary Of State For Defence In Her Britannic Majesty's Government Of The United Kingdom Of Great Britain And Northern Ireland Liposomes containing particulate materials
US5738868A (en) * 1995-07-18 1998-04-14 Lipogenics Ltd. Liposome compositions and kits therefor
WO2003000232A3 (en) * 2001-06-25 2004-02-26 Yissum Res Dev Co Method for preparation of vesicles loaded with immunostimulator y oligodeoxynucleotides
US7381421B2 (en) * 1999-12-13 2008-06-03 Lipoxen Technologies Limited Liposomes

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5916588A (en) * 1984-04-12 1999-06-29 The Liposome Company, Inc. Peptide-containing liposomes, immunogenic liposomes and methods of preparation and use
US6090406A (en) * 1984-04-12 2000-07-18 The Liposome Company, Inc. Potentiation of immune responses with liposomal adjuvants
US4885172A (en) * 1985-06-26 1989-12-05 The Liposome Company, Inc. Composition for targeting, storing and loading of liposomes
US5171578A (en) * 1985-06-26 1992-12-15 The Liposome Company, Inc. Composition for targeting, storing and loading of liposomes
US5252263A (en) * 1986-06-16 1993-10-12 The Liposome Company, Inc. Induction of asymmetry in vesicles
US5204112A (en) * 1986-06-16 1993-04-20 The Liposome Company, Inc. Induction of asymmetry in vesicles
EP0274219A3 (en) * 1986-12-04 1988-08-03 Takeda Chemical Industries, Ltd. Interleukin-2-containing liposome composition and method for the production thereof
US4963297A (en) * 1987-12-22 1990-10-16 The Liposome Company, Inc. Spontaneous vesticulation of multilamellar liposomes
US5830498A (en) * 1987-10-16 1998-11-03 Board Of Regents, The University Of Texas System Liposomal-polyene preliposomal powder and method for its preparation
US5178875A (en) * 1991-01-14 1993-01-12 The Board Of Regents, The University Of Texas System Liposomal-polyene preliposomal powder and method for its preparation
US4950432A (en) * 1987-10-16 1990-08-21 Board Of Regents, The University Of Texas System Polyene microlide pre-liposomal powders
JPH03502574A (ja) * 1987-12-03 1991-06-13 ザ　リポソーム　カンパニー，インコーポレイテッド メチルセルロース製薬学的組成物
ATE118348T1 (de) * 1987-12-04 1995-03-15 Liposome Co Inc Liposome hoher stabilität und verfahren zur herstellung und verwendung.
JPH03501732A (ja) * 1987-12-22 1991-04-18 ザ　リポソーム　カンパニー，インコーポレイテッド 多重ラメラリポソームの自発的小胞化方法
US4921644A (en) * 1988-02-29 1990-05-01 Technology Unlimited, Inc. Mucin directed lipsome
FR2638639A1 (fr) * 1988-11-08 1990-05-11 Parincos Parfumerie Cosmet Int Composition et procede d'obtention de liposomes oligolamellaires en vue d'une application en cosmetologie et dermatologie topique
ATE135200T1 (de) * 1989-05-17 1996-03-15 Res Corp Technologies Inc Verfahren und zusammensetzung zur thrombosebehandlung beim säugetier
US5227170A (en) * 1989-06-22 1993-07-13 Vestar, Inc. Encapsulation process
JP2880800B2 (ja) * 1989-06-22 1999-04-12 ネクスター・フアーマシユーテイカルズ・インコーポレイテツド カプセル化方法
US5290563A (en) * 1989-07-27 1994-03-01 Laboratoire Des Stallergenes Method for combining a mixture of heterogeneous substances with liposomes
US5246707A (en) * 1990-04-26 1993-09-21 Haynes Duncan H Sustained release delivery of water-soluble bio-molecules and drugs using phospholipid-coated microcrystals, microdroplets and high-concentration liposomes
US5091188A (en) * 1990-04-26 1992-02-25 Haynes Duncan H Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs
FR2677248B1 (fr) * 1991-06-04 1995-06-16 Lvmh Rech Gie Composition cosmetique ou pharmaceutique, notamment dermatologique, contenant un extrait de brunelle.
US5665381A (en) * 1992-02-25 1997-09-09 Nexstar Pharmaceuticals, Inc. Inhibition of aggregation of drug containing particles
WO1994012155A1 (en) * 1992-12-02 1994-06-09 Vestar, Inc. Antibiotic formulation and process
US5958449A (en) * 1992-12-02 1999-09-28 Nexstar Pharmaceuticals, Inc. Antibiotic formulation and use for bacterial infections
US5759571A (en) * 1993-05-11 1998-06-02 Nexstar Pharmaceuticals, Inc. Antibiotic formulation and use for drug resistant infections
US5501859A (en) * 1994-03-22 1996-03-26 Walter T. Woods, Jr. Absorbable magnesium composition and method of using same
US5756122A (en) * 1995-06-07 1998-05-26 Georgetown University Liposomally encapsulated nucleic acids having high entrapment efficiencies, method of manufacturer and use thereof for transfection of targeted cells
ATE386506T1 (de) 1995-10-17 2008-03-15 Jagotec Ag Verabreichung unlöslicher arzneistoffe
US6465016B2 (en) 1996-08-22 2002-10-15 Research Triangle Pharmaceuticals Cyclosporiine particles
US7255877B2 (en) * 1996-08-22 2007-08-14 Jagotec Ag Fenofibrate microparticles
WO1998046632A2 (de) * 1997-04-11 1998-10-22 Wilex Biotechnology Gmbh Inhibitoren für den urokinaserezeptor
DE69908304T2 (de) * 1998-02-11 2004-02-19 Rtp Pharma Corp. Ungesättigte fettsäure und steroide enthaltende kombinationspräparate zur behandlung von entzündungen
US6979456B1 (en) 1998-04-01 2005-12-27 Jagotec Ag Anticancer compositions
KR100635456B1 (ko) 1998-05-29 2006-10-18 스키에파마 캐나다 인코포레이티드 열보호화 마이크로입자 조성물 및 그의 말단의 스팀멸균방법
DE69912441T2 (de) 1998-08-19 2004-08-19 Skyepharma Canada Inc., Verdun Injizierbare wässerige propofoldispersionen
IL143197A0 (en) 1998-11-20 2002-04-21 Rtp Pharma Inc Dispersible phospholipid stabilized microparticles
AU7984200A (en) * 1999-09-21 2001-04-24 Skyepharma Canada Inc. Surface modified particulate compositions of biologically active substances
EP1276465B1 (en) 2000-04-20 2014-03-12 Jagotec AG Improved water-insoluble drug particle process
WO2001082892A2 (de) * 2000-05-02 2001-11-08 Pharmacept Gmbh Wirkstoffhaltige liposome
JP4969761B2 (ja) 2000-08-31 2012-07-04 オバン・エナジー・リミテッド 所望粒度を持つ固体基材の小粒子および第一材料の小粒状物を含む相乗作用性混合物を製造する方法
US8586094B2 (en) 2000-09-20 2013-11-19 Jagotec Ag Coated tablets
NZ527408A (en) * 2001-02-22 2005-04-29 Skyepharma Canada Inc Hydroxymethylglutarylcoenzyme A (HMG CoA) reductase inhibitor (or a statin) and a fibrate in a single effective oral dosage form to treat dyslipidaemia and dyslipoproteinaemia
AU2002331481B2 (en) * 2001-10-03 2008-04-24 Celator Pharmaceuticals, Inc. Liposome loading with metal ions
US20040018237A1 (en) * 2002-05-31 2004-01-29 Perricone Nicholas V. Topical drug delivery using phosphatidylcholine
FI120642B (fi) 2007-10-19 2010-01-15 Biomed Oy Mikrokapseloidut liposomikoostumukset
US20100260830A1 (en) * 2009-04-08 2010-10-14 Brian A Salvatore Liposomal Formulations of Tocopheryl Amides
CA2922002A1 (en) 2013-09-13 2015-03-19 Arbor Therapeutics, LLC Nanoparticulate compositions for targeted delivery of lipophilic drugs and acid labile, lipophilic prodrugs of cancer chemotherapeutics and their preparation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4078052A (en) * 1976-06-30 1978-03-07 The United States Of America As Represented By The Secretary Of Health, Education And Welfare Large unilamellar vesicles (LUV) and method of preparing same
US4310506A (en) * 1979-02-22 1982-01-12 California Institute Of Technology Means of preparation and applications of liposomes containing high concentrations of entrapped ionic species

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988007852A1 (en) * 1987-04-06 1988-10-20 Innovative Therapeutics Corporation Liposome entrapped magnesium
WO1995009610A1 (en) * 1993-10-07 1995-04-13 The Secretary Of State For Defence In Her Britannic Majesty's Government Of The United Kingdom Of Great Britain And Northern Ireland Liposomes containing particulate materials
GB2297907A (en) * 1993-10-07 1996-08-21 Secr Defence Liposomes containing particulate materials
GB2297907B (en) * 1993-10-07 1997-12-10 Secr Defence Liposomes containing particulate materials
RU2145212C1 (ru) * 1993-10-07 2000-02-10 Министр обороны Объединенного королевства Великобритании и Северной Ирландии Липосомы, содержащие материалы, состоящие из частиц
US6322809B1 (en) 1993-10-07 2001-11-27 The Secretary Of State For Defence In Her Brittanic Majesty's Government Of The United Kingdom Of Great Britain And Northern Ireland Liposomes containing particulate materials
US5738868A (en) * 1995-07-18 1998-04-14 Lipogenics Ltd. Liposome compositions and kits therefor
US7381421B2 (en) * 1999-12-13 2008-06-03 Lipoxen Technologies Limited Liposomes
WO2003000232A3 (en) * 2001-06-25 2004-02-26 Yissum Res Dev Co Method for preparation of vesicles loaded with immunostimulator y oligodeoxynucleotides

Also Published As

Publication number Publication date
JPS6176414A (ja) 1986-04-18
EP0179237A1 (en) 1986-04-30
US4762720A (en) 1988-08-09
JPH0468284B2 (https=) 1992-11-02
GB8523309D0 (en) 1985-10-23

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Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)